Published in J Nutr on October 07, 2009
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One (2010) 1.61
One-carbon metabolism-genome interactions in folate-associated pathologies. J Nutr (2009) 1.49
Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics (2010) 1.33
Epigenetic diet: impact on the epigenome and cancer. Epigenomics (2011) 1.33
Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents. Molecules (2015) 1.25
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics (2011) 1.12
Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. Biochem Pharmacol (2013) 1.05
Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent. J Biol Chem (2012) 0.94
Repression of transposable elements by histone biotinylation. J Nutr (2009) 0.93
Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells. J Nutr (2010) 0.91
Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery. Int J Cell Biol (2010) 0.90
Epigenetic mechanisms in neurological and neurodegenerative diseases. Front Cell Neurosci (2015) 0.90
Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. Evid Based Complement Alternat Med (2012) 0.89
Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e. Front Genet (2012) 0.87
Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention. Cancer Lett (2014) 0.84
Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells. Toxicol Lett (2011) 0.82
Impact of Epigenetic Dietary Components on Cancer through Histone Modifications. Curr Med Chem (2015) 0.82
Dietary components as epigenetic-regulating agents against cancer. Biomedicine (Taipei) (2016) 0.81
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res (2014) 0.81
High-throughput library screening identifies two novel NQO1 inducers in human lung cells. Am J Respir Cell Mol Biol (2011) 0.80
The Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA Methylation. Int J Mol Sci (2015) 0.80
Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy. Int J Nanomedicine (2013) 0.80
The Epigenetic Impact of Cruciferous Vegetables on Cancer Prevention. Curr Pharmacol Rep (2015) 0.79
Epigenetics and transgenerational inheritance in domesticated farm animals. J Anim Sci Biotechnol (2014) 0.79
The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One (2014) 0.78
Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro. Eur J Nutr (2012) 0.78
Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane. Free Radic Biol Med (2012) 0.78
Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms. Front Genet (2016) 0.77
Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA. Cancer Prev Res (Phila) (2013) 0.77
Relationship between vegetable and carotene intake and risk of prostate cancer: the JACC study. Br J Cancer (2013) 0.76
The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane. Mol Carcinog (2015) 0.76
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol (2013) 0.76
The impact of cruciferous vegetable isothiocyanates on histone acetylation and histone phosphorylation in bladder cancer. J Proteomics (2017) 0.75
Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals. Epigenomics (2016) 0.75
Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications. J Diabetes Res (2015) 0.75
Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success. Bioessays (2016) 0.75
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a co-activator of NQO1 in sulforaphane-treated colon cancer cells. Mol Nutr Food Res (2016) 0.75
The Chemopreventive Phytochemical Moringin Isolated from Moringa oleifera Seeds Inhibits JAK/STAT Signaling. PLoS One (2016) 0.75
Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers. Curr Top Med Chem (2016) 0.75
Sulforaphane, a natural component of broccoli, inhibits vestibular schwannoma growth in vitro and in vivo. Sci Rep (2016) 0.75
Global histone modification patterns predict risk of prostate cancer recurrence. Nature (2005) 7.03
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A (1997) 4.29
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res (2000) 3.83
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. Proc Natl Acad Sci U S A (2003) 3.30
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci U S A (1994) 2.73
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res (2004) 2.71
Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate (2004) 2.49
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis (2003) 2.33
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc Natl Acad Sci U S A (2001) 2.23
Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin Chim Acta (2002) 2.09
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis (2000) 2.06
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood) (2007) 1.98
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98
Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol (2007) 1.93
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis (2007) 1.91
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther (2007) 1.68
In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J Pharmacol Exp Ther (2004) 1.53
One-carbon metabolism-genome interactions in folate-associated pathologies. J Nutr (2009) 1.49
Histone deacetylase and DNA methyltransferase in human prostate cancer. Biochem Biophys Res Commun (2001) 1.30
Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Chem Res Toxicol (1997) 1.28
Nuclear accumulation of histone deacetylase 4 (HDAC4) coincides with the loss of androgen sensitivity in hormone refractory cancer of the prostate. Eur Urol (2004) 1.14
Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. Prostate (2005) 1.10
Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo. Drug Metab Dispos (2003) 1.10
Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J Biol Chem (2001) 1.01
Repression of transposable elements by histone biotinylation. J Nutr (2009) 0.93
Niacin status impacts chromatin structure. J Nutr (2009) 0.91
Overview to symposium "Nutrients and epigenetic regulation of gene expression". J Nutr (2009) 0.86
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res (2007) 3.43
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res (2004) 2.71
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood) (2007) 1.98
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98
Multi-targeted prevention of cancer by sulforaphane. Cancer Lett (2008) 1.98
Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett (2006) 1.50
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Curr Drug Targets (2006) 1.40
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochem Biophys Res Commun (2002) 1.27
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res (2006) 1.24
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res (2011) 1.22
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res (2011) 1.21
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis (2003) 1.21
Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environ Sci Technol (2011) 1.15
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters. Genomics (2004) 1.15
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics (2011) 1.12
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer (2011) 1.11
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen (2009) 1.11
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene (2004) 1.10
Endurance exercise results in DNA damage as detected by the comet assay. Free Radic Biol Med (2004) 1.04
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinog (2011) 1.04
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis (2008) 1.04
Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models. Drug Metab Dispos (2014) 1.04
Dietary manipulation of histone structure and function. Annu Rev Nutr (2008) 1.02
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res (Phila) (2009) 1.01
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer (2010) 1.01
Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr (2011) 1.00
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. J Biol Chem (2004) 0.99
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res (2003) 0.98
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics (2013) 0.98
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis (2008) 0.97
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Mol Carcinog (2003) 0.97
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutat Res (2002) 0.96
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol (2012) 0.96
Dietary agents as histone deacetylase inhibitors. Mol Carcinog (2006) 0.95
Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol (2011) 0.95
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis (2007) 0.93
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. Carcinogenesis (2009) 0.93
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res (2015) 0.92
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate. Mutat Res (2005) 0.92
A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clin Epigenetics (2012) 0.92
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One (2012) 0.89
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine. Carcinogenesis (2008) 0.89
Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis. Carcinogenesis (2008) 0.88
Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. Biofactors (2006) 0.88
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. J Med Chem (2009) 0.87
Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance. Pharmacol Res (2010) 0.87
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res (2012) 0.87
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food Chem Toxicol (2007) 0.86
Heterogeneous reactions of particulate matter-bound PAHs and NPAHs with NO3/N2O5, OH radicals, and O3 under simulated long-range atmospheric transport conditions: reactivity and mutagenicity. Environ Sci Technol (2014) 0.85
Endothelins and their receptors in cancer: identification of therapeutic targets. Pharmacol Res (2011) 0.85
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer (2012) 0.85
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet. Cancer Sci (2008) 0.85
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts. Nutr Cancer (2007) 0.85
Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide. Biochem Biophys Res Commun (2009) 0.85
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. Mutat Res (2006) 0.85
Novel nitro-PAH formation from heterogeneous reactions of PAHs with NO2, NO3/N2O5, and OH radicals: prediction, laboratory studies, and mutagenicity. Environ Sci Technol (2013) 0.84
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. Cancer Lett (2009) 0.82
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. Gene (2002) 0.82
Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells. J Nutr Biochem (2011) 0.82
Tumor-suppressing effects of antioxidants from tea. J Nutr (2004) 0.82
Antimutagenic activity of spearmint. Environ Mol Mutagen (2004) 0.81
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res (2014) 0.81
Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline. Biol Trace Elem Res (2002) 0.80
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study. Food Chem Toxicol (2011) 0.80
(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells. Arch Biochem Biophys (2010) 0.80
The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. J Nutr (2004) 0.80
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. Mutat Res (2003) 0.79
Ischemia-reperfusion injury in the lung: quantitation using electron microscopy. Vasc Endovascular Surg (2009) 0.79
Dietary manipulation of histone structure and function. World Rev Nutr Diet (2010) 0.78
Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin. Adv Exp Med Biol (2002) 0.78
The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutr Rev (2013) 0.78
Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Curr Top Med Chem (2016) 0.77
Dietary manipulation of histone structure and function. J Nutrigenet Nutrigenomics (2011) 0.77
Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver. Hepatol Res (2011) 0.77
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. Int J Cancer (2009) 0.77
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol (2013) 0.76
Metabolism and cancer: old and new players. Int J Cell Biol (2013) 0.76
Selective and cytokine-dependent regulation of hepatic transporters and bile acid homeostasis during infectious colitis in mice. Drug Metab Dispos (2013) 0.76
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. J Carcinog (2006) 0.75
Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin. Dis Aquat Organ (2015) 0.75
Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH. Vasc Endovascular Surg (2011) 0.75
Introduction to Nutrition and physical activity in aging, obesity, and cancer. Ann N Y Acad Sci (2011) 0.75