Published in Pharmacol Res on January 25, 2007
The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes. Nat Commun (2014) 2.43
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Multi-targeted prevention of cancer by sulforaphane. Cancer Lett (2008) 1.98
Fruit and vegetable intake and risk of breast cancer by hormone receptor status. J Natl Cancer Inst (2013) 1.94
Retracted Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells. J Cell Biochem (2009) 1.60
The impact of the absence of aliphatic glucosinolates on insect herbivory in Arabidopsis. PLoS One (2008) 1.53
Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Lett (2008) 1.42
Cruciferous vegetable consumption and lung cancer risk: a systematic review. Cancer Epidemiol Biomarkers Prev (2009) 1.38
Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence. Microb Biotechnol (2008) 1.38
Human gut bacterial communities are altered by addition of cruciferous vegetables to a controlled fruit- and vegetable-free diet. J Nutr (2009) 1.37
Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prev Res (Phila) (2011) 1.37
The first generation of a BAC-based physical map of Brassica rapa. BMC Genomics (2008) 1.34
Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics (2010) 1.33
Epigenetic diet: impact on the epigenome and cancer. Epigenomics (2011) 1.33
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Top Curr Chem (2013) 1.31
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31
Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies. Ann Oncol (2012) 1.29
The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochim Biophys Acta (2012) 1.26
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res (2011) 1.22
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res (2011) 1.21
Fruit and vegetable intake in relation to risk of breast cancer in the Black Women's Health Study. Am J Epidemiol (2010) 1.16
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen (2009) 1.11
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats. Cancer Prev Res (Phila) (2008) 1.09
Molecular targets of isothiocyanates in cancer: recent advances. Mol Nutr Food Res (2014) 1.08
Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. J Biol Chem (2009) 1.08
Vegetable and fruit intake after diagnosis and risk of prostate cancer progression. Int J Cancer (2011) 1.04
Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells. Prostate (2009) 1.04
Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. J Nutr (2008) 1.04
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinog (2011) 1.04
Glucosinolate engineering identifies a gamma-glutamyl peptidase. Nat Chem Biol (2009) 1.03
Mechanisms of action of isothiocyanates in cancer chemoprevention: an update. Food Funct (2011) 1.01
Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells. BMC Gastroenterol (2009) 1.01
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res (2009) 1.00
Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop. Mol Biol Cell (2010) 1.00
Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anticancer Agents Med Chem (2013) 1.00
The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer. Cancer Metastasis Rev (2010) 1.00
The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. Proc Natl Acad Sci U S A (2008) 1.00
Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane. Evid Based Complement Alternat Med (2011) 1.00
Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr (2011) 1.00
Cytosolic γ-glutamyl peptidases process glutathione conjugates in the biosynthesis of glucosinolates and camalexin in Arabidopsis. Plant Cell (2011) 0.99
Synthesis and anticancer activity comparison of phenylalkyl isoselenocyanates with corresponding naturally occurring and synthetic isothiocyanates. J Med Chem (2008) 0.99
Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A (2013) 0.99
Cruciferous vegetable intake and lung cancer risk: a nested case-control study matched on cigarette smoking. Cancer Epidemiol Biomarkers Prev (2010) 0.98
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. Biochemistry (2009) 0.98
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics (2013) 0.98
Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev (2009) 0.97
DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proc Natl Acad Sci U S A (2013) 0.96
Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacol Res (2011) 0.96
UHPLC-PDA-ESI/HRMS/MS(n) analysis of anthocyanins, flavonol glycosides, and hydroxycinnamic acid derivatives in red mustard greens (Brassica juncea Coss variety). J Agric Food Chem (2011) 0.96
New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med (2014) 0.95
Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis. Ann Oncol (2013) 0.95
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China. Int J Cancer (2009) 0.95
Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol (2011) 0.95
The antioxidant response element and oxidative stress modifiers in airway diseases. Curr Mol Med (2008) 0.94
Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. J Agric Food Chem (2011) 0.94
Intake of fruits and vegetables and risk of pancreatic cancer in a pooled analysis of 14 cohort studies. Am J Epidemiol (2012) 0.93
Developing a mobile produce distribution system for low-income urban residents in food deserts. J Urban Health (2012) 0.92
Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm Drug Dispos (2011) 0.90
2,2'-diphenyl-3,3'-diindolylmethane: a potent compound induces apoptosis in breast cancer cells by inhibiting EGFR pathway. PLoS One (2013) 0.90
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One (2012) 0.89
1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells. Chem Biol Interact (2010) 0.89
Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables. Toxins (Basel) (2010) 0.88
Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms. Biochim Biophys Acta (2014) 0.88
Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent. Cell Stress Chaperones (2012) 0.87
The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1. J Biomed Biotechnol (2011) 0.87
Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity. Int J Cancer (2009) 0.87
3,3'-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutants. Cancer Lett (2010) 0.86
Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer. Bioorg Med Chem Lett (2009) 0.86
Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells. Cell Biol Int (2008) 0.85
Endothelins and their receptors in cancer: identification of therapeutic targets. Pharmacol Res (2011) 0.85
Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer (2011) 0.85
MicroRNA Targeted Therapeutic Approach for Pancreatic Cancer. Int J Biol Sci (2016) 0.84
Urinary total isothiocyanates and colorectal cancer: a prospective study of men in Shanghai, China. Cancer Epidemiol Biomarkers Prev (2008) 0.84
Defining powerhouse fruits and vegetables: a nutrient density approach. Prev Chronic Dis (2014) 0.84
Radiosensitization of head and neck cancer cells by the phytochemical agent sulforaphane. Strahlenther Onkol (2011) 0.84
Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates. Biochemistry (2012) 0.83
Sulforaphane and related mustard oils in focus of cancer prevention and therapy. Wien Med Wochenschr (2012) 0.83
Mechanistic insights into the role of microRNAs in cancer: influence of nutrient crosstalk. Front Genet (2012) 0.83
Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. PLoS One (2011) 0.83
Targeting CSC-related miRNAs for cancer therapy by natural agents. Curr Drug Targets (2012) 0.83
Cruciferous vegetables intake is associated with lower risk of renal cell carcinoma: evidence from a meta-analysis of observational studies. PLoS One (2013) 0.82
Bioavailability of Plant-Derived Antioxidants. Antioxidants (Basel) (2013) 0.82
Phenylbutyl isoselenocyanate modulates phase I and II enzymes and inhibits 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induced DNA adducts in mice. Cancer Prev Res (Phila) (2011) 0.82
BRCA1 mRNA levels following a 4-6-week intervention with oral 3,3'-diindolylmethane. Br J Cancer (2014) 0.82
Attenuation of Carcinogenesis and the Mechanism Underlying by the Influence of Indole-3-carbinol and Its Metabolite 3,3'-Diindolylmethane: A Therapeutic Marvel. Adv Pharmacol Sci (2014) 0.82
What should we tell prostate cancer patients about (secondary) prevention? Curr Opin Urol (2014) 0.82
Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice. Mol Nutr Food Res (2015) 0.81
Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species. Biomed Res Int (2015) 0.81
The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines. Breast Cancer Res (2011) 0.81
Analysis of seven salad rocket (Eruca sativa) accessions: The relationships between sensory attributes and volatile and non-volatile compounds. Food Chem (2016) 0.81
Cruciferous vegetables, isothiocyanates, and prevention of bladder cancer. Curr Pharmacol Rep (2015) 0.81
Erucin exerts anti-inflammatory properties in murine macrophages and mouse skin: possible mediation through the inhibition of NFκB signaling. Int J Mol Sci (2013) 0.81
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res (2014) 0.81
GST polymorphism and excretion of heterocyclic aromatic amine and isothiocyanate metabolites after Brassica consumption. Environ Mol Mutagen (2009) 0.81
Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA. J Immunol (2015) 0.81
Eruca sativa might influence the growth, survival under simulated gastrointestinal conditions and some biological features of Lactobacillus acidophilus, Lactobacillus plantarum and Lactobacillus rhamnosus strains. Int J Mol Sci (2014) 0.80
Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality? Oxid Med Cell Longev (2016) 0.80
Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells. PLoS One (2014) 0.80
Sulforaphane induces oxidative stress and death by p53-independent mechanism: implication of impaired glutathione recycling. PLoS One (2014) 0.80
Simultaneous Determination of Various Isothiocyanates by RP-LC Following Precolumn Derivatization with Mercaptoethanol. Chromatographia (2011) 0.80
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A (2002) 8.01
Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect (2006) 4.46
Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies. JAMA (2001) 3.37
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U S A (2002) 3.18
Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr (2004) 3.11
Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. Am J Epidemiol (1994) 2.72
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res (2004) 2.71
Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas. Cancer Epidemiol Biomarkers Prev (1998) 2.62
Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev (1996) 2.58
Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst (2000) 2.46
Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr (2000) 2.43
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis (2003) 2.33
Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem (2001) 2.26
Is estradiol a genotoxic mutagenic carcinogen? Endocr Rev (2000) 2.25
Urinary estrogen metabolites and breast cancer: a case-control study. Cancer Epidemiol Biomarkers Prev (1997) 2.23
Diet, tobacco use, and fatal prostate cancer: results from the Lutheran Brotherhood Cohort Study. Cancer Res (1990) 2.21
Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle (2005) 2.20
Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst (2000) 2.07
Diet in the epidemiology of cancer of the colon and rectum. J Natl Cancer Inst (1978) 2.05
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05
Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab (2002) 2.04
A prospective study of cruciferous vegetables and prostate cancer. Cancer Epidemiol Biomarkers Prev (2003) 2.04
Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev (2001) 2.03
Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci U S A (1991) 2.03
Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes. Cancer Epidemiol Biomarkers Prev (1998) 2.00
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet (2000) 1.98
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98
Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev (2001) 1.97
Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen (2005) 1.97
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene (2005) 1.96
Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomarkers Prev (2000) 1.96
Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J Nutr (2004) 1.90
Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol Biomarkers Prev (1998) 1.87
Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. J Natl Cancer Inst (1999) 1.85
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res (2001) 1.84
Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene (2001) 1.71
Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. J Natl Cancer Inst (2000) 1.64
Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res (2003) 1.60
Vegetable and fruit intake and pancreatic cancer in a population-based case-control study in the San Francisco bay area. Cancer Epidemiol Biomarkers Prev (2005) 1.59
Induction by estrogen metabolite 16 alpha-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J Natl Cancer Inst (1992) 1.54
Effects of watercress consumption on urinary metabolites of nicotine in smokers. Cancer Epidemiol Biomarkers Prev (1999) 1.53
Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET). Cancer Epidemiol Biomarkers Prev (2003) 1.51
Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort. J Natl Cancer Inst (1999) 1.50
Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat Res (2004) 1.48
Abnormal oxidative metabolism of estradiol in women with breast cancer. Proc Natl Acad Sci U S A (1982) 1.48
Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: The Netherlands Cohort Study on Diet and Cancer. Am J Epidemiol (2000) 1.48
Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol. Carcinogenesis (2002) 1.47
3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. Carcinogenesis (2002) 1.47
Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus (2001) 1.47
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis (2005) 1.46
Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer (2002) 1.46
Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice. Clin Cancer Res (2004) 1.45
Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis (2002) 1.44
A prospective study of whole grains, fruits, vegetables and colon cancer risk. Cancer Causes Control (2003) 1.41
2-hydroxyestrone: the 'good' estrogen. J Endocrinol (1996) 1.40
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Curr Drug Targets (2006) 1.40
Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol (2000) 1.39
Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis (1998) 1.38
Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol Lett (2001) 1.38
Plant foods, antioxidants, and prostate cancer risk: findings from case-control studies in Canada. Nutr Cancer (1999) 1.36
Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins. Drug Metabol Drug Interact (2000) 1.34
A critical review of the bioavailability of glucosinolates and related compounds. Nat Prod Rep (2004) 1.32
Fruits, vegetables and lung cancer: a pooled analysis of cohort studies. Int J Cancer (2003) 1.32
Cell-cycle dysregulation and anticancer therapy. Trends Pharmacol Sci (2003) 1.32
Fruit and vegetable consumption in relation to pancreatic cancer risk: a prospective study. Cancer Epidemiol Biomarkers Prev (2006) 1.32
Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr Cancer (2000) 1.31
Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis (1991) 1.31
Do urinary oestrogen metabolites predict breast cancer? Guernsey III cohort follow-up. Br J Cancer (1998) 1.30
Mechanism-based in vitro screening of potential cancer chemopreventive agents. Mutat Res (2003) 1.26
3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis (2005) 1.26
Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res (1978) 1.26
Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiol Biomarkers Prev (2000) 1.25
Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. Nutr Cancer (2004) 1.24
Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore. Cancer Epidemiol Biomarkers Prev (2001) 1.23
Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables. J Nutr (2002) 1.22
Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice. Cancer Res (1999) 1.21
Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J Biol Chem (1998) 1.20
Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer. Int J Cancer (2004) 1.18
Fruits and vegetables and lung cancer: Findings from the European Prospective Investigation into Cancer and Nutrition. Int J Cancer (2004) 1.16
Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol. Anticancer Res (1995) 1.14
Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas. Gastroenterology (2004) 1.13
Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer (2004) 1.13
Role of histone deacetylase inhibitors in the treatment of cancer (Review). Int J Oncol (2004) 1.12
Case-control study of proximal and distal colon cancer and diet in Wisconsin. Int J Cancer (1988) 1.12
Accelerator mass spectrometry for biomedical research. Methods Enzymol (2005) 1.12
Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs? Biofactors (2003) 1.12
Estrogen metabolites and the risk of breast cancer in older women. Epidemiology (2003) 1.10
Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells. Breast Cancer Res Treat (2000) 1.09
Vegetable and fruit consumption and prostate cancer risk: a cohort study in The Netherlands. Cancer Epidemiol Biomarkers Prev (1998) 1.09
Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Br J Nutr (2006) 1.07
Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study on diet and cancer. Cancer Causes Control (2000) 1.07
Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis (2006) 1.07
Indole-3-carbinol and prostate cancer. J Nutr (2004) 1.07
Association between consumption of cruciferous vegetables and condiments and excretion in urine of isothiocyanate mercapturic acids. J Agric Food Chem (2006) 1.05
Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers. Cancer Epidemiol Biomarkers Prev (2004) 1.04
Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans. Carcinogenesis (2004) 1.04
Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line. Mol Cancer Ther (2002) 1.04
Interplay between dietary inducers of GST and the GSTM-1 genotype in colon cancer. Int J Cancer (2000) 1.03
Dietary intake and colon cancer: sex- and anatomic site-specific associations. Am J Epidemiol (1989) 1.03
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell (2010) 4.16
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
Preceramic adoption of peanut, squash, and cotton in northern Peru. Science (2007) 3.23
Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study. Chem Res Toxicol (2009) 2.80
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res (2004) 2.71
Point of care diagnostics: status and future. Anal Chem (2011) 2.31
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther (2005) 2.30
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood) (2007) 1.98
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98
Multi-targeted prevention of cancer by sulforaphane. Cancer Lett (2008) 1.98
Why stainless steel corrodes. Nature (2002) 1.90
Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout. Toxicol Sci (2005) 1.57
Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett (2006) 1.50
Identification of sokotrasterol sulfate as a novel proangiogenic steroid. Circ Res (2006) 1.41
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Curr Drug Targets (2006) 1.40
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31
Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood (2007) 1.28
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochem Biophys Res Commun (2002) 1.27
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr (2009) 1.27
Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria. Curr Drug Metab (2003) 1.25
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res (2006) 1.24
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res (2011) 1.22
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res (2011) 1.21
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis (2003) 1.21
Spirastrellolide B reveals the absolute configuration of the spirastrellolide macrolide core. J Am Chem Soc (2007) 1.18
Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. J Pharmacol Exp Ther (2006) 1.16
Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species. J Nat Prod (2010) 1.15
Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells. Org Lett (2008) 1.15
Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environ Sci Technol (2011) 1.15
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters. Genomics (2004) 1.15
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets. Free Radic Biol Med (2005) 1.14
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics (2011) 1.12
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer (2011) 1.11
Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour. Neuromolecular Med (2002) 1.11
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen (2009) 1.11
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene (2004) 1.10
Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis (2006) 1.07
Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione. Chem Res Toxicol (2004) 1.07
Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS One (2012) 1.06
Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene. Cancer Prev Res (Phila) (2008) 1.05
Endurance exercise results in DNA damage as detected by the comet assay. Free Radic Biol Med (2004) 1.04
Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3'-diindolylmethane in sprague-dawley rats. Toxicol Sci (2003) 1.04
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinog (2011) 1.04
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis (2008) 1.04
Dietary manipulation of histone structure and function. Annu Rev Nutr (2008) 1.02
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res (Phila) (2009) 1.01
Effect of surface packing density of interfacially adsorbed monoclonal antibody on the binding of hormonal antigen human chorionic gonadotrophin. J Phys Chem B (2006) 1.01
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer (2010) 1.01
Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent. Drug Metab Dispos (2004) 1.00
Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr (2011) 1.00
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. J Biol Chem (2004) 0.99
Indole-3-carbinol is a negative regulator of estrogen. J Nutr (2003) 0.99
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res (2003) 0.98
Liphagal, a Selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga: structure elucidation and biomimetic synthesis. Org Lett (2006) 0.98
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol (2012) 0.98
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics (2013) 0.98
S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2. Biochem Pharmacol (2004) 0.97
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis (2008) 0.97
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Mol Carcinog (2003) 0.97
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutat Res (2002) 0.96
Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol (2008) 0.96
Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging. Cancer Res (2013) 0.96
Identification of a transcriptional fingerprint of estrogen exposure in rainbow trout liver. Toxicol Sci (2007) 0.96
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol (2012) 0.96
Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms. Cytometry A (2011) 0.95
Dietary agents as histone deacetylase inhibitors. Mol Carcinog (2006) 0.95
Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol (2011) 0.95
High density ozone monitoring using gas sensitive semi-conductor sensors in the Lower Fraser Valley, British Columbia. Environ Sci Technol (2014) 0.95
Dhilirolides A-D, meroterpenoids produced in culture by the fruit-infecting fungus Penicillium purpurogenum collected in Sri Lanka. Org Lett (2011) 0.94
Dynamic analysis of drug-induced cytotoxicity using chip-based dielectrophoretic cell immobilization technology. Anal Chem (2011) 0.93
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis (2007) 0.93
Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents. Toxicol Appl Pharmacol (2011) 0.93
Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro. Toxicol Sci (2010) 0.93
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. Carcinogenesis (2009) 0.93
Bafilomycins produced in culture by Streptomyces spp. isolated from marine habitats are potent inhibitors of autophagy. J Nat Prod (2010) 0.92
A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clin Epigenetics (2012) 0.92
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate. Mutat Res (2005) 0.92
Orientation of a monoclonal antibody adsorbed at the solid/solution interface: a combined study using atomic force microscopy and neutron reflectivity. Langmuir (2006) 0.92
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res (2015) 0.92
Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. Drug Metab Dispos (2002) 0.91
Niphatenones, glycerol ethers from the sponge Niphates digitalis block androgen receptor transcriptional activity in prostate cancer cells: structure elucidation, synthesis, and biological activity. J Med Chem (2011) 0.91
Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver. Toxicol Appl Pharmacol (2010) 0.91