Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.

PubWeight™: 1.98‹?› | Rank: Top 2%

🔗 View Article (PMC 2267876)

Published in Exp Biol Med (Maywood) on February 01, 2007

Authors

Melinda C Myzak1, Philip Tong, Wan-Mohaiza Dashwood, Roderick H Dashwood, Emily Ho

Author Affiliations

1: Linus Pauling Institute, Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA.

Associated clinical trials:

A 12-weeks Study to Evaluate Sulforaphane in Treatment of Autism Spectrum Disorder | NCT02879110

Articles citing this

Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Res (2012) 2.07

Multi-targeted prevention of cancer by sulforaphane. Cancer Lett (2008) 1.98

Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol (2007) 1.93

Regulation of Nrf2-an update. Free Radic Biol Med (2013) 1.81

Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol (2010) 1.63

Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One (2010) 1.61

Cruciferous vegetable consumption and lung cancer risk: a systematic review. Cancer Epidemiol Biomarkers Prev (2009) 1.38

Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics (2010) 1.33

Epigenetic diet: impact on the epigenome and cancer. Epigenomics (2011) 1.33

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31

Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research. Carcinogenesis (2012) 1.27

Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr (2009) 1.27

Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. Mol Ther (2010) 1.26

Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. BMC Cancer (2009) 1.25

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. Proc Natl Acad Sci U S A (2009) 1.23

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res (2011) 1.22

The role of histone deacetylases in prostate cancer. Epigenetics (2008) 1.21

Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. PLoS One (2011) 1.18

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacol Ther (2012) 1.13

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen (2009) 1.11

A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics. Top Curr Chem (2013) 1.07

Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents. Planta Med (2008) 1.06

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. Biochem Pharmacol (2013) 1.05

Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells. Prostate (2009) 1.04

Vegetable and fruit intake after diagnosis and risk of prostate cancer progression. Int J Cancer (2011) 1.04

Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis (2008) 1.04

Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells. Cancer Prev Res (Phila) (2010) 1.01

Epigenetics Offer New Horizons for Colorectal Cancer Prevention. Curr Colorectal Cancer Rep (2012) 0.97

Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells. Acta Pharmacol Sin (2010) 0.96

Bioactive food components, inflammatory targets, and cancer prevention. Cancer Prev Res (Phila) (2009) 0.96

Overview of major classes of plant-derived anticancer drugs. Int J Biomed Sci (2009) 0.96

Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy. J Nutr Biochem (2011) 0.95

Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol (2011) 0.95

Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent. J Biol Chem (2012) 0.94

A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level. J Biol Chem (2012) 0.94

Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. J Agric Food Chem (2011) 0.94

Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells. J Nutr (2010) 0.93

Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutr Rev (2008) 0.93

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs (2014) 0.92

Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells. Exp Biol Med (Maywood) (2009) 0.92

Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res (2015) 0.92

Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition. Pharmacol Ther (2012) 0.92

Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention. Br J Nutr (2012) 0.91

Targeting the epigenome with bioactive food components for cancer prevention. J Nutrigenet Nutrigenomics (2012) 0.91

The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease. EPMA J (2011) 0.91

Health promoting effects of brassica-derived phytochemicals: from chemopreventive and anti-inflammatory activities to epigenetic regulation. Oxid Med Cell Longev (2013) 0.91

Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion. Mol Nutr Food Res (2012) 0.90

Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. Toxicol Appl Pharmacol (2012) 0.88

Effect of indole ethyl isothiocyanates on proliferation, apoptosis, and MAPK signaling in neuroblastoma cell lines. Bioorg Med Chem Lett (2007) 0.87

Plant phytochemicals as epigenetic modulators: role in cancer chemoprevention. AAPS J (2013) 0.86

The role of dietary histone deacetylases (HDACs) inhibitors in health and disease. Nutrients (2014) 0.85

Dietary epigenetics in cancer and aging. Cancer Treat Res (2014) 0.85

Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. Epigenetics (2012) 0.85

Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention. Cancer Lett (2014) 0.84

Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3'-Diindolylmethane: Anti-Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy. Curr Pharmacol Rep (2015) 0.83

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges. Semin Cancer Biol (2016) 0.83

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer. J Carcinog (2012) 0.83

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition. Antioxid Redox Signal (2014) 0.83

Impact of Epigenetic Dietary Components on Cancer through Histone Modifications. Curr Med Chem (2015) 0.82

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clin Epigenetics (2015) 0.82

Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside. Curr Pharmacol Rep (2015) 0.81

Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention. Curr Pharmacol Rep (2015) 0.81

Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species. Biomed Res Int (2015) 0.81

Off-target effects of sulforaphane include the derepression of long terminal repeats through histone acetylation events. J Nutr Biochem (2014) 0.81

Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS J (2013) 0.81

Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Semin Oncol (2015) 0.80

The Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA Methylation. Int J Mol Sci (2015) 0.80

Roles of autophagy induced by natural compounds in prostate cancer. Biomed Res Int (2015) 0.80

Epigenetic cancer prevention mechanisms in skin cancer. AAPS J (2013) 0.79

Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9. Exp Ther Med (2010) 0.79

The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutr Rev (2013) 0.78

The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One (2014) 0.78

Nutritional genomics, polyphenols, diets, and their impact on dietetics. J Am Diet Assoc (2008) 0.78

Dietary manipulation of histone structure and function. World Rev Nutr Diet (2010) 0.78

Dietary manipulation of histone structure and function. J Nutrigenet Nutrigenomics (2011) 0.77

Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Curr Top Med Chem (2016) 0.77

The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Mol Carcinog (2014) 0.77

Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells. Mol Cell Endocrinol (2015) 0.77

Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells. Evid Based Complement Alternat Med (2015) 0.76

Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy. Cancer Prev Res (Phila) (2015) 0.76

Epigenetic mechanisms underlying diet-sourced compounds in the prevention and treatment of gastrointestinal cancer. Anticancer Agents Med Chem (2012) 0.76

Epigenetic modulators as therapeutic targets in prostate cancer. Clin Epigenetics (2016) 0.76

Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers. Curr Top Med Chem (2016) 0.75

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression. Curr Genomics (2017) 0.75

Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide. PLoS One (2015) 0.75

Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes. Mol Aspects Med (2016) 0.75

Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis. Sci Rep (2016) 0.75

Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. J Nutr Biochem (2017) 0.75

Epigenetic modulation in the treatment of atherosclerotic disease. Front Genet (2014) 0.75

The natural compound sulforaphene, as a novel anticancer reagent, targeting PI3K-AKT signaling pathway in lung cancer. Oncotarget (2016) 0.75

Genome-wide epigenomic profiling for biomarker discovery. Clin Epigenetics (2016) 0.75

Greater efficacy of atorvastatin versus a non-statin lipid-lowering agent against renal injury: potential role as a histone deacetylase inhibitor. Sci Rep (2016) 0.75

The impact of cruciferous vegetable isothiocyanates on histone acetylation and histone phosphorylation in bladder cancer. J Proteomics (2017) 0.75

Sulforaphane (SFN): An Isothiocyanate in a Cancer Chemoprevention Paradigm. Medicines (Basel) (2015) 0.75

Emerging Role of Nutri-Epigenetics in Inflammation and Cancer. Oncol Nurs Forum (2016) 0.75

Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways. Int J Mol Sci (2017) 0.75

Articles cited by this

Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J (2003) 11.27

Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer (2001) 9.12

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov (2002) 6.97

Acetylation and deacetylation of non-histone proteins. Gene (2005) 6.87

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci U S A (1992) 5.74

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst (2000) 5.21

Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms. Clin Cancer Res (2002) 4.90

Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously. Clin Cancer Res (2003) 4.55

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A (1997) 4.29

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res (2000) 3.83

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci U S A (1994) 2.73

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res (2004) 2.71

Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate (2004) 2.49

Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res (2000) 2.42

Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis (2003) 2.33

Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst (2000) 2.07

Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis (2000) 2.06

Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05

A prospective study of cruciferous vegetables and prostate cancer. Cancer Epidemiol Biomarkers Prev (2003) 2.04

Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98

Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomarkers Prev (2000) 1.96

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. J Biol Chem (2004) 1.88

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res (2001) 1.84

Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am J Clin Nutr (2005) 1.70

Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett (2006) 1.50

Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer (2002) 1.46

Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Curr Drug Targets (2006) 1.40

Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int J Oncol (2002) 1.39

The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. Mol Cancer Ther (2004) 1.37

Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. Carcinogenesis (2003) 1.34

Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. Exp Biol Med (Maywood) (2004) 1.31

Histone deacetylase and DNA methyltransferase in human prostate cancer. Biochem Biophys Res Commun (2001) 1.30

Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis (2002) 1.22

Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization. J Nutr (2004) 1.16

Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int J Oncol (2004) 1.12

Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. Prostate (2005) 1.10

Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. Drug Metab Dispos (2004) 1.09

Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells. Nutr Cancer (2004) 1.01

Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. Int J Oncol (2004) 0.99

Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro. Anticancer Drugs (1998) 0.97

Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis. Curr Cancer Drug Targets (2006) 0.93

Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables. Cancer Lett (2004) 0.92

Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes. Cell Mol Life Sci (2002) 0.92

Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells. Oncol Rep (2003) 0.80

Articles by these authors

Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res (2007) 3.43

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res (2004) 2.71

Human hippocampal theta activity during virtual navigation. Hippocampus (2005) 2.37

Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05

Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98

Multi-targeted prevention of cancer by sulforaphane. Cancer Lett (2008) 1.98

Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol (2007) 1.93

Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett (2006) 1.50

Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis (2005) 1.46

Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Curr Drug Targets (2006) 1.40

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31

Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochem Biophys Res Commun (2002) 1.27

Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr (2009) 1.27

In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res (2006) 1.24

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res (2011) 1.22

Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr (2009) 1.21

Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis (2003) 1.21

Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res (2011) 1.21

Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett (2006) 1.15

Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environ Sci Technol (2011) 1.15

Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters. Genomics (2004) 1.15

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics (2011) 1.12

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer (2011) 1.11

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen (2009) 1.11

Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene (2004) 1.10

The natural history of dementia. Psychogeriatrics (2014) 1.04

Endurance exercise results in DNA damage as detected by the comet assay. Free Radic Biol Med (2004) 1.04

MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinog (2011) 1.04

Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis (2008) 1.04

Dietary manipulation of histone structure and function. Annu Rev Nutr (2008) 1.02

Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res (Phila) (2009) 1.01

NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer (2010) 1.01

Aging is associated with altered dendritic cells subset distribution and impaired proinflammatory cytokine production. Exp Gerontol (2009) 1.00

Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr (2011) 1.00

Induction of regulatory T cells by green tea polyphenol EGCG. Immunol Lett (2011) 0.99

Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. J Biol Chem (2004) 0.99

Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res (2003) 0.98

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics (2013) 0.98

Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis (2008) 0.97

Induction of proinflammatory response in prostate cancer epithelial cells by activated macrophages. Cancer Lett (2008) 0.97

Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Mol Carcinog (2003) 0.97

Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutat Res (2002) 0.96

Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr (2008) 0.96

3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol (2012) 0.96

Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacol Res (2011) 0.96

Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice. J Nutr Biochem (2008) 0.95

Dietary agents as histone deacetylase inhibitors. Mol Carcinog (2006) 0.95

Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol (2011) 0.95

Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. J Nutr Biochem (2012) 0.94

Mutations induced by (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells. Environ Mol Mutagen (2003) 0.94

Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. J Agric Food Chem (2011) 0.94

Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairment. Alzheimer Dis Assoc Disord (2011) 0.93

Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutr Rev (2008) 0.93

Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis (2007) 0.93

Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Exp Biol Med (Maywood) (2010) 0.93

Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. Carcinogenesis (2009) 0.93

Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res (2015) 0.92

Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model. J Nutr Biochem (2011) 0.92

Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate. Mutat Res (2005) 0.92

A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clin Epigenetics (2012) 0.92

Effect of a standardized complex mixture derived from coal tar on the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons in human cells in culture. Chem Res Toxicol (2005) 0.91

Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes. J Nutr Biochem (2006) 0.91

3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One (2012) 0.89

Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine. Carcinogenesis (2008) 0.89

A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes. FASEB J (2004) 0.89

Abiotrophia defectiva endocarditis and associated hemophagocytic syndrome--a first case report and review of the literature. Int J Infect Dis (2008) 0.88

Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise. Free Radic Biol Med (2009) 0.88

Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis. Carcinogenesis (2008) 0.88

Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. Biofactors (2006) 0.88

Dietary zinc restriction and repletion affects DNA integrity in healthy men. Am J Clin Nutr (2009) 0.88

Anti-inflammatory activity of soy and tea in prostate cancer prevention. Exp Biol Med (Maywood) (2010) 0.87

Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. J Med Chem (2009) 0.87

Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance. Pharmacol Res (2010) 0.87

MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res (2012) 0.87

Zinc and its role in age-related inflammation and immune dysfunction. Mol Nutr Food Res (2011) 0.86

Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food Chem Toxicol (2007) 0.86