Published in Blood on October 07, 2009
The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol (2010) 4.26
Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-. J Exp Med (2011) 3.89
The importance of natural IgM: scavenger, protector and regulator. Nat Rev Immunol (2010) 2.23
B-1 B cell development in the fetus and adult. Immunity (2012) 1.47
Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen. Proc Natl Acad Sci U S A (2011) 1.25
Natural IgM in immune equilibrium and harnessing their therapeutic potential. J Immunol (2012) 1.23
Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proc Natl Acad Sci U S A (2011) 1.21
Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period. Nat Commun (2015) 1.09
The natural and the inducible: interleukin (IL)-17-producing γδ T cells. Trends Immunol (2012) 1.04
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med (2014) 1.04
Human B-1 cells take the stage. Ann N Y Acad Sci (2013) 0.97
Splenic B-1a Cells Expressing CD138 Spontaneously Secrete Large Amounts of Immunoglobulin in Naïve Mice. Front Immunol (2014) 0.93
Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions. Proc Natl Acad Sci U S A (2012) 0.87
B1b cells recognize protective antigens after natural infection and vaccination. Front Immunol (2014) 0.86
A CD25⁻ positive population of activated B1 cells expresses LIFR and responds to LIF. Front Immunol (2011) 0.86
Severe Developmental B Lymphopoietic Defects in Foxp3-Deficient Mice are Refractory to Adoptive Regulatory T Cell Therapy. Front Immunol (2012) 0.85
Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol (2017) 0.85
B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location. J Immunol (2014) 0.84
Ontogeny of Innate T Lymphocytes - Some Innate Lymphocytes are More Innate than Others. Front Immunol (2014) 0.83
Characteristics of natural antibody-secreting cells. Ann N Y Acad Sci (2015) 0.83
B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS. Proc Natl Acad Sci U S A (2014) 0.82
Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment. Stem Cell Reports (2015) 0.80
Autoantibodies: Focus on anti-DNA antibodies. Self Nonself (2011) 0.79
The role of B-1 cells in inflammation. Immunol Res (2015) 0.78
Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age. J Immunol (2016) 0.78
A conserved enhancer element differentially regulates developmental expression of CD5 in B and T cells. J Immunol (2010) 0.77
B cells in the aging immune system: time to consider B-1 cells. Ann N Y Acad Sci (2015) 0.76
Human-derived natural antibodies: biomarkers and potential therapeutics. Future Neurol (2015) 0.76
B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production. Front Immunol (2016) 0.76
Fetal Lymphoid Progenitors Become Restricted to B-1 Fates Coincident with IL-7Rα Expression. PLoS One (2016) 0.75
Human B-1 and B-2 B Cells Develop from Lin-CD34+CD38lo Stem Cells. J Immunol (2016) 0.75
Defining Natural Antibodies. Front Immunol (2017) 0.75
Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells. J Exp Med (2017) 0.75
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature (2011) 6.14
Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods (2005) 5.59
Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 4.44
Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med (2005) 4.42
DNA methylation controls Foxp3 gene expression. Eur J Immunol (2008) 4.19
Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity (2006) 3.74
Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science (2011) 3.66
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest (2008) 3.64
Differential roles of macrophages in diverse phases of skin repair. J Immunol (2010) 3.56
Selective erasure of a fear memory. Science (2009) 3.34
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature (2002) 3.21
Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol (2004) 3.09
A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells. Nature (2013) 3.07
Yin Yang 1 is a critical regulator of B-cell development. Genes Dev (2007) 3.06
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev (2008) 2.76
Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS One (2008) 2.69
D2R striatopallidal neurons inhibit both locomotor and drug reward processes. Nat Neurosci (2009) 2.65
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol (2007) 2.60
Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell (2012) 2.50
Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol (2009) 2.48
Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors. Eur J Immunol (2005) 2.46
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity (2011) 2.39
The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat Immunol (2002) 2.35
Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc Natl Acad Sci U S A (2010) 2.30
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol (2008) 2.29
Genetic proof for the transient nature of the Th17 phenotype. Eur J Immunol (2010) 2.24
Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity (2012) 2.23
Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat Rev Immunol (2009) 2.19
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol Cell (2002) 2.10
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol (2003) 2.04
Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse. Nat Genet (2005) 1.99
A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol (2009) 1.99
Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest (2010) 1.96
Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci (2011) 1.96
The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med (2009) 1.95
Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol (2004) 1.91
La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J Virol (2007) 1.90
Cellular mechanisms of IL-17-induced blood-brain barrier disruption. FASEB J (2009) 1.82
Protective role of beta interferon in host defense against influenza A virus. J Virol (2006) 1.80
Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A (2006) 1.78
Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction. Circulation (2011) 1.76
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. J Immunol (2009) 1.69
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med (2009) 1.69
Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem (2002) 1.66
The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. J Biol (2004) 1.61
Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity. J Exp Med (2006) 1.59
NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med (2007) 1.57
Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci U S A (2009) 1.54
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice. J Hepatol (2012) 1.52
Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. Immunity (2012) 1.52
Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses. J Virol (2007) 1.50
Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE. Eur J Immunol (2014) 1.49
Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis (2004) 1.48
Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J (2008) 1.47
Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha. PLoS One (2009) 1.47
Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J Immunol (2008) 1.46
Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J Immunol (2013) 1.45
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. Proc Natl Acad Sci U S A (2002) 1.45
Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs. J Clin Invest (2008) 1.44
IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol (2010) 1.43
Containment of tumor-colonizing bacteria by host neutrophils. Cancer Res (2008) 1.42
B cell signaling and tumorigenesis. Annu Rev Immunol (2005) 1.40
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest (2012) 1.40
Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Nature (2003) 1.39
Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice. Inflamm Bowel Dis (2014) 1.38
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO J (2008) 1.37
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. Brain (2011) 1.37
Importance of TRF1 for functional telomere structure. J Biol Chem (2003) 1.37
Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf. Oncogene (2003) 1.37
Germinal center B cells govern their own fate via antibody feedback. J Exp Med (2013) 1.36
NONO couples the circadian clock to the cell cycle. Proc Natl Acad Sci U S A (2012) 1.34
Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol (2005) 1.34
Potentiation of epithelial innate host responses by intercellular communication. PLoS Pathog (2010) 1.31
Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep (2013) 1.28
Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments. PLoS One (2010) 1.28
Oligomeric organization of the B-cell antigen receptor on resting cells. Nature (2010) 1.27
Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice. J Exp Med (2010) 1.27
Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis. Brain (2013) 1.27
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell (2013) 1.25