Published in J Immunol on September 01, 2004
RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature (2011) 6.03
Programmed cell death in animal development and disease. Cell (2011) 5.07
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med (2011) 4.68
The many roles of FAS receptor signaling in the immune system. Immunity (2009) 4.67
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest (2005) 4.07
Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol (2013) 3.55
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nat Rev Immunol (2011) 2.40
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J Exp Med (2008) 2.40
The diverse role of RIP kinases in necroptosis and inflammation. Nat Immunol (2015) 2.36
Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol (2011) 2.09
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell (2011) 2.06
Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep (2012) 2.06
Old, new and emerging functions of caspases. Cell Death Differ (2014) 2.01
RIP3: a molecular switch for necrosis and inflammation. Genes Dev (2013) 1.94
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol (2014) 1.89
The Jekyll and Hyde functions of caspases. Dev Cell (2009) 1.87
Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. J Virol (2006) 1.86
No death without life: vital functions of apoptotic effectors. Cell Death Differ (2008) 1.80
CD95, BIM and T cell homeostasis. Nat Rev Immunol (2009) 1.73
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ (2013) 1.73
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity (2009) 1.73
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med (2009) 1.69
Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis. J Immunol (2005) 1.69
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J (2011) 1.64
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun (2015) 1.54
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proc Natl Acad Sci U S A (2014) 1.54
The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells. J Immunol (2006) 1.52
Cellular FLICE-inhibitory protein is required for T cell survival and cycling. J Exp Med (2005) 1.52
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation. Blood (2006) 1.48
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A (2014) 1.40
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. J Exp Med (2005) 1.40
Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell Stem Cell (2010) 1.37
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res (2009) 1.30
Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. J Invest Dermatol (2014) 1.30
The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol (2005) 1.27
Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J Biol Chem (2008) 1.25
Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep (2013) 1.23
Viral modulation of programmed necrosis. Curr Opin Virol (2013) 1.20
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling. Proc Natl Acad Sci U S A (2014) 1.18
Ripped to death. Trends Cell Biol (2011) 1.14
FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells. Blood (2005) 1.12
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. J Biol Chem (2007) 1.12
TAK1 control of cell death. Cell Death Differ (2014) 1.09
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem (2008) 1.09
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochim Biophys Acta (2011) 1.04
The executioners sing a new song: killer caspases activate microglia. Cell Death Differ (2011) 1.02
Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia. Cell Death Dis (2013) 1.01
A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. EMBO J (2014) 1.01
FADD deficiency impairs early hematopoiesis in the bone marrow. J Immunol (2010) 1.01
True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity. J Immunol (2014) 0.99
The human cytomegalovirus UL36 gene controls caspase-dependent and -independent cell death programs activated by infection of monocytes differentiating to macrophages. J Virol (2010) 0.97
Cell death-resistance of differentiated myotubes is associated with enhanced anti-apoptotic mechanisms compared to myoblasts. Apoptosis (2011) 0.94
Apoptotic and nonapoptotic caspase functions in animal development. Cold Spring Harb Perspect Biol (2012) 0.94
The death effector domains of caspase-8 induce terminal differentiation. PLoS One (2009) 0.92
FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood (2010) 0.91
Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res (2013) 0.91
Elevated cleaved caspase-3 is associated with shortened overall survival in several cancer types. Int J Clin Exp Pathol (2014) 0.90
Proteolytic fragmentation of inositol 1,4,5-trisphosphate receptors: a novel mechanism regulating channel activity? J Physiol (2015) 0.90
A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death. Cell Death Dis (2016) 0.90
The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis. J Immunol (2007) 0.89
New roles for old enzymes: killer caspases as the engine of cell behavior changes. Front Physiol (2014) 0.89
Caspase-8 as a therapeutic target in cancer. Cancer Lett (2010) 0.89
Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis. Invest Ophthalmol Vis Sci (2011) 0.89
Questions and controversies: the role of necroptosis in liver disease. Cell Death Discov (2016) 0.88
A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS. J Biol Chem (2013) 0.88
A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression. EMBO J (2006) 0.86
Caspase-8 as a regulator of tumor cell motility. Curr Mol Med (2014) 0.85
Olive (Olea europaea) leaf extract induces apoptosis and monocyte/macrophage differentiation in human chronic myelogenous leukemia K562 cells: insight into the underlying mechanism. Oxid Med Cell Longev (2014) 0.85
Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway. J Immunol (2008) 0.85
Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner. Arthritis Res Ther (2015) 0.82
Fine-tuning nucleophosmin in macrophage differentiation and activation. Blood (2011) 0.82
T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis. Nat Immunol (2016) 0.82
Identification and functional characterization of two executioner caspases in Crassostrea gigas. PLoS One (2014) 0.81
Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways. Clin Cancer Res (2013) 0.81
EphA receptors form a complex with caspase-8 to induce apoptotic cell death. Mol Cells (2015) 0.81
Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFalpha in mice lacking RelA. Cell Death Differ (2006) 0.81
FADD and the NF-kappaB family member Bcl-3 regulate complementary pathways to control T-cell survival and proliferation. Immunology (2008) 0.80
RASSF1 Polymorphisms in Cancer. Mol Biol Int (2012) 0.80
Gene expression analysis of ischaemia and reperfusion in human microsurgical free muscle tissue transfer. J Cell Mol Med (2011) 0.80
IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3. Cell Death Differ (2014) 0.79
Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice. J Cell Biol (2011) 0.79
Caspase-8 inhibition represses initial human monocyte activation in septic shock model. Oncotarget (2016) 0.78
Inhibitor of apoptosis proteins as intracellular signaling intermediates. FEBS J (2015) 0.78
Identification of a secondary promoter of CASP8 and its related transcription factor PURα. Int J Oncol (2014) 0.77
Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes. Cell Death Differ (2010) 0.77
DED or alive: assembly and regulation of the death effector domain complexes. Cell Death Dis (2015) 0.77
Non-apoptotic functions of caspases in myeloid cell differentiation. Cell Death Differ (2017) 0.76
Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. PLoS One (2016) 0.76
The enigmatic roles of caspases in tumor development. Cancers (Basel) (2010) 0.76
New insights into the regulation of innate immunity by caspase-8. Arthritis Res Ther (2016) 0.75
The conservation and uniqueness of the caspase family in the basal chordate, amphioxus. BMC Biol (2011) 0.75
A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation. Genes Immun (2015) 0.75
Cell death in genome evolution. Semin Cell Dev Biol (2015) 0.75
Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality. Cell Death Dis (2016) 0.75
The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases. Nat Rev Rheumatol (2016) 0.75
Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells. J Innate Immun (2016) 0.75
It's not over until the FAT lady sings. EMBO J (2014) 0.75
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med (2007) 9.51
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol (2002) 6.22
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature (2003) 6.11
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods (2005) 5.59
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med (2006) 5.33
Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 4.44
Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med (2005) 4.42
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest (2008) 3.64
Differential roles of macrophages in diverse phases of skin repair. J Immunol (2010) 3.56
Selective erasure of a fear memory. Science (2009) 3.34
The CD95 receptor: apoptosis revisited. Cell (2007) 3.13
A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells. Nature (2013) 3.07
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J (2002) 2.99
HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. J Clin Invest (2003) 2.89
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc Natl Acad Sci U S A (2003) 2.85
CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res (2004) 2.84
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood (2004) 2.84
Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer (2012) 2.76
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev (2008) 2.76
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J (2002) 2.73
Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS One (2008) 2.69
D2R striatopallidal neurons inhibit both locomotor and drug reward processes. Nat Neurosci (2009) 2.65
Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity (2012) 2.58
Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol (2009) 2.48
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity (2011) 2.39
Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol (2008) 2.33
Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice. Exp Hematol (2006) 2.32
RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity (2011) 2.29
Genetic proof for the transient nature of the Th17 phenotype. Eur J Immunol (2010) 2.24
Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells. Blood (2005) 2.13
Hsp90 recognizes a common surface on client kinases. J Biol Chem (2006) 2.12
Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep (2012) 2.06
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions. Nat Immunol (2011) 2.05
Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity (2008) 2.04
Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase. Immunity (2004) 1.99
Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling. Nat Immunol (2007) 1.99
A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol (2009) 1.99
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res (2002) 1.96
Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci (2011) 1.96
The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med (2009) 1.95
Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J (2004) 1.90
Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J Immunol (2008) 1.90
Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat Immunol (2005) 1.90
Immune regulation of multiple sclerosis by transdermally applied myelin peptides. Ann Neurol (2010) 1.89
Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol (2006) 1.88
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc Natl Acad Sci U S A (2005) 1.87
A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J Leukoc Biol (2008) 1.87
B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood (2011) 1.82
Cellular mechanisms of IL-17-induced blood-brain barrier disruption. FASEB J (2009) 1.82
miR-146a controls the resolution of T cell responses in mice. J Exp Med (2012) 1.81
Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A (2006) 1.78
Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation. Blood (2003) 1.78
Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction. Circulation (2011) 1.76
Inhibition of Notch signaling enhances tissue repair in an animal model of multiple sclerosis. J Neuroimmunol (2005) 1.76
Caspase-8 is involved in neovascularization-promoting progenitor cell functions. Arterioscler Thromb Vasc Biol (2009) 1.70
A novel day blindness in sheep: epidemiological, behavioural, electrophysiological and histopathological studies. Vet J (2009) 1.69
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med (2009) 1.69
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med (2004) 1.67
Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells. J Exp Med (2010) 1.60
Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity. J Exp Med (2006) 1.59
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice. J Hepatol (2012) 1.52
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts. Cancer Res (2006) 1.48
Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling. Blood (2003) 1.48
S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood (2012) 1.47
Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J (2008) 1.47
Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J Immunol (2008) 1.46
Stem cell mobilization. Hematology Am Soc Hematol Educ Program (2003) 1.45
Intraoperative airway obstruction related to tracheostomy tube malposition in a patient with achondroplasia and Jeune's syndrome. Middle East J Anaesthesiol (2010) 1.44
Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling. Blood (2010) 1.44
IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol (2010) 1.43
Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing. J Biomed Opt (2006) 1.43
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem (2010) 1.41
Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res (2005) 1.40
Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nat Immunol (2012) 1.38
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res (2006) 1.37
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. Brain (2011) 1.37
Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. J Clin Invest (2005) 1.36
Germinal center B cells govern their own fate via antibody feedback. J Exp Med (2013) 1.36
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A (2011) 1.36
Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol (2005) 1.34
Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment. Cell Stem Cell (2008) 1.30
Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. J Exp Med (2002) 1.29
Short report: concurrent Rocky Mountain spotted fever in a dog and its owner. Am J Trop Med Hyg (2002) 1.28
Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants. Oncogene (2003) 1.28
The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization. Annu Rev Immunol (2007) 1.27
Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis. Brain (2013) 1.27
Biology of normal and acute myeloid leukemia stem cells. Int J Hematol (2005) 1.27
The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells. Nat Cell Biol (2012) 1.27
Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci U S A (2010) 1.26