Published in Proc Natl Acad Sci U S A on January 06, 2012
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest (2012) 1.29
MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas. J Oral Maxillofac Res (2013) 1.22
A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO J (2013) 1.18
p63 regulates glutaminase 2 expression. Cell Cycle (2013) 1.12
MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev (2013) 1.11
MicroRNA-203 contributes to skin re-epithelialization. Cell Death Dis (2012) 1.05
MicroRNAs and p63 in epithelial stemness. Cell Death Differ (2014) 1.03
ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes Dev (2012) 1.02
p53/p63/p73 in the epidermis in health and disease. Cold Spring Harb Perspect Med (2014) 1.01
Role of microRNA-138 as a potential tumor suppressor in head and neck squamous cell carcinoma. Int Rev Cell Mol Biol (2013) 1.00
MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction. J Am Soc Nephrol (2014) 0.99
ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer. Oncogene (2015) 0.95
Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes. Cell Death Dis (2013) 0.93
MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix. Aging (Albany NY) (2012) 0.92
Cellular senescence mediated by p16INK4A-coupled miRNA pathways. Nucleic Acids Res (2013) 0.90
Control by a hair's breadth: the role of microRNAs in the skin. Cell Mol Life Sci (2012) 0.90
miR-24 affects hair follicle morphogenesis targeting Tcf-3. Cell Death Dis (2013) 0.89
Resveratrol induces long-lasting IL-8 expression and peculiar EGFR activation/distribution in human keratinocytes: mechanisms and implications for skin administration. PLoS One (2013) 0.89
MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation. Biochem Biophys Res Commun (2012) 0.88
DNA repair and aging: the impact of the p53 family. Aging (Albany NY) (2015) 0.87
The microRNA feedback regulation of p63 in cancer progression. Oncotarget (2015) 0.86
From cellular senescence to age-associated diseases: the miRNA connection. Longev Healthspan (2012) 0.85
Rapamycin regulates biochemical metabolites. Cell Cycle (2013) 0.84
miR-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging. J Invest Dermatol (2014) 0.84
p63 transcriptionally regulates the expression of matrix metallopeptidase 13. Oncotarget (2014) 0.82
RNA-binding protein RBM24 regulates p63 expression via mRNA stability. Mol Cancer Res (2013) 0.82
Molecular dynamics of the full-length p53 monomer. Cell Cycle (2013) 0.82
miRNA signature of mouse helper T cell hyper-proliferation. PLoS One (2013) 0.81
p63 supports aerobic respiration through hexokinase II. Proc Natl Acad Sci U S A (2015) 0.81
Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63. J Skin Cancer (2013) 0.80
miR-203 regulates progenitor cell proliferation during adult zebrafish retina regeneration. Dev Biol (2014) 0.80
Tumor Protein p63/microRNA Network in Epithelial Cancer Cells. Curr Genomics (2013) 0.80
Noncoding RNA control of cellular senescence. Wiley Interdiscip Rev RNA (2015) 0.79
Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium. Antioxid Redox Signal (2013) 0.79
Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients. Aging (Albany NY) (2015) 0.78
The signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases. Oncotarget (2016) 0.78
Negative feedback between TAp63 and Mir-133b mediates colorectal cancer suppression. Oncotarget (2016) 0.77
ßNp63 controls cellular redox status. Oncoscience (2015) 0.76
ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells. Cell Cycle (2013) 0.76
FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells. Aging (Albany NY) (2016) 0.75
Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. J Leukoc Biol (2016) 0.75
MicroRNAs Modulate Interactions between Stress and Risk for Cocaine Addiction. Front Cell Neurosci (2016) 0.75
Oncogenic Ras: A double-edged sword for human epidermal stem and transient amplifying cells. Small GTPases (2016) 0.75
Natural corneal cell-based microenvironment as prerequisite for balanced 3D corneal epithelial morphogenesis: a promising animal experiment-abandoning tool in ophthalmology. Tissue Eng Part C Methods (2013) 0.75
Interplay between ΔNp63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma. Oncotarget (2017) 0.75
Not miR-ly micromanagers: the functions and regulatory networks of microRNAs in mammalian skin. Wiley Interdiscip Rev RNA (2014) 0.75
Allele-specific silencing of EEC p63 mutant R304W restores p63 transcriptional activity. Cell Death Dis (2016) 0.75
ΔNp63α and microRNAs: leveraging the epithelial-mesenchymal transition. Oncotarget (2016) 0.75
The Role of p16(INK4a) Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer. Int J Mol Sci (2017) 0.75
Advances in the Application and Impact of MicroRNAs as Therapies for Skin Disease. BioDrugs (2017) 0.75
Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND. J Neuroimmune Pharmacol (2017) 0.75
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
The essence of senescence. Genes Dev (2010) 8.21
p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell (2007) 6.50
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell (2009) 6.03
Nucleosome dynamics define transcriptional enhancers. Nat Genet (2010) 5.94
A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66
ENCODE whole-genome data in the UCSC genome browser (2011 update). Nucleic Acids Res (2010) 4.50
Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28
Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell (2010) 3.81
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature (2010) 3.37
hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res (2008) 3.20
TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15
Aging and disease: connections to sirtuins. Aging Cell (2010) 3.15
p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev (2005) 3.02
miR-203 represses 'stemness' by repressing DeltaNp63. Cell Death Differ (2008) 2.86
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res (2010) 2.82
Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell (2009) 2.58
DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49
Senescence comes of age. Nat Med (2005) 2.39
Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ (2006) 2.25
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet (2010) 2.14
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation (2009) 2.05
Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines. Cancer Sci (2008) 2.01
MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines. Cancer Lett (2009) 1.92
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76
Replicative senescence: a critical review. Mech Ageing Dev (2004) 1.66
MicroRNA-mediated control in the skin. Cell Death Differ (2009) 1.30
Cell senescence: hypertrophic arrest beyond the restriction point. J Cell Physiol (2006) 1.25
SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J Cell Mol Med (2008) 1.24
SIRT1 promotes differentiation of normal human keratinocytes. J Invest Dermatol (2008) 1.16
Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias. J Cell Sci (2011) 1.11
Bmi-1 reduction plays a key role in physiological and premature aging of primary human keratinocytes. J Invest Dermatol (2009) 0.95
Identification of senescence-inducing microRNAs in normal human keratinocytes. Int J Oncol (2011) 0.83
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell (2006) 23.59
miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A (2005) 21.51
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci U S A (2004) 13.66
Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol (2007) 8.05
A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A (2008) 7.14
The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol (2005) 6.27
Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol (2009) 5.56
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci U S A (2005) 5.54
MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer (2009) 5.47
Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell (2007) 5.40
MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol (2006) 5.40
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc Natl Acad Sci U S A (2008) 4.79
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest (2009) 4.10
R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet (2006) 3.92
Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88
The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell (2008) 3.35
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA (2011) 3.16
miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy. Clin Cancer Res (2009) 3.07
MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases. Expert Opin Biol Ther (2009) 3.05
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell (2010) 2.78
Reprogramming of miRNA networks in cancer and leukemia. Genome Res (2010) 2.65
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res (2013) 2.57
TSH receptor and thyroid-specific gene expression in human skin. J Invest Dermatol (2010) 2.50
MicroRNA expression profiling using microarrays. Nat Protoc (2008) 2.44
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer. Cancer Res (2008) 2.35
Mechanisms of microRNA deregulation in human cancer. Cell Cycle (2008) 2.30
MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res (2010) 2.28
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A (2011) 2.21
MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res (2009) 2.16
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet (2010) 2.14
The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol (2011) 2.13
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev (2010) 2.06
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation (2009) 2.05
Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med (2009) 2.03
The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A (2006) 2.01
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One (2009) 1.97
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A (2004) 1.91
Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of α-dystroglycan. Nat Genet (2012) 1.90
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90
MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle (2011) 1.89
Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice. Gastroenterology (2011) 1.85
TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle (2007) 1.84
MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality. Clin Cancer Res (2009) 1.84
The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol (2008) 1.76
Breast cancer metastasis: a microRNA story. Breast Cancer Res (2008) 1.70
DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A (2007) 1.70
Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice. J Clin Invest (2010) 1.67
MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer. Cancer Res (2009) 1.64
microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A (2011) 1.60
Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A (2011) 1.58
Epigenetic regulation of learning and memory by Drosophila EHMT/G9a. PLoS Biol (2011) 1.55
Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues. Immunology (2008) 1.54
Regulation of the apoptosis-necrosis switch. Oncogene (2004) 1.54
Cytogenetic and molecular evaluation of 241 small supernumerary marker chromosomes: cooperative study of 19 Italian laboratories. Genet Med (2005) 1.53
FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy. Cell Cycle (2008) 1.52
Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. Am J Hum Genet (2012) 1.51
p63, a story of mice and men. J Invest Dermatol (2011) 1.50
New p63 targets in keratinocytes identified by a genome-wide approach. EMBO J (2006) 1.50
Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells. Proc Natl Acad Sci U S A (2003) 1.48
miRNAs and their potential for use against cancer and other diseases. Future Oncol (2007) 1.47
Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity. Cancer Res (2011) 1.47
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
Advanced glycation end products and bone loss during aging. Ann N Y Acad Sci (2005) 1.45
Regulation of angiogenesis: wound healing as a model. Prog Histochem Cytochem (2007) 1.45
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J Exp Med (2007) 1.43
p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun (2005) 1.42
One, two, three--p53, p63, p73 and chemosensitivity. Drug Resist Updat (2007) 1.41
Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms. Proc Natl Acad Sci U S A (2008) 1.39
A novel recessive connexin 31 (GJB3) mutation in a case of erythrokeratodermia variabilis. J Invest Dermatol (2004) 1.39
Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration. Am J Pathol (2008) 1.38
p63 is upstream of IKK alpha in epidermal development. J Cell Sci (2006) 1.35
TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A (2009) 1.34
A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am J Hum Genet (2005) 1.33
PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol Cell Biol (2004) 1.33
p73 in Cancer. Genes Cancer (2011) 1.33
GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation. Cell Cycle (2013) 1.32
Expression profiling of microRNA using oligo DNA arrays. Methods (2008) 1.31
Expression and function of micro-RNAs in immune cells during normal or disease state. Int J Med Sci (2008) 1.30
p53 is cleaved by caspases generating fragments localizing to mitochondria. J Biol Chem (2006) 1.30