Published in Biophys J on October 21, 2009
Cardiac titin: a multifunctional giant. Circulation (2010) 1.84
Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function. Proc Natl Acad Sci U S A (2014) 1.18
The giant protein titin: a regulatory node that integrates myocyte signaling pathways. J Biol Chem (2011) 1.11
Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole. Circulation (2014) 1.05
Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy. J Gen Physiol (2014) 0.96
Rbm20 regulates titin alternative splicing as a splicing repressor. Nucleic Acids Res (2013) 0.95
Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development. J Struct Biol (2010) 0.91
Anatomical, architectural, and biochemical diversity of the murine forelimb muscles. J Anat (2012) 0.87
Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome. J Appl Physiol (1985) (2012) 0.86
Mechanical properties of respiratory muscles. Compr Physiol (2013) 0.84
Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading? Am J Physiol Lung Cell Mol Physiol (2010) 0.82
Activation and stretch-induced passive force enhancement--are you pulling my chain? Focus on "Regulation of muscle force in the absence of actin-myosin-based cross-bridge interaction". Am J Physiol Cell Physiol (2010) 0.78
The passive properties of muscle fibers are velocity dependent. J Biomech (2013) 0.77
Contribution of stretch to the change of activation properties of muscle fibers in the diaphragm at the transition from fetal to neonatal life. Front Physiol (2011) 0.77
Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol. BMC Neurol (2013) 0.76
The effects of a skeletal muscle titin mutation on walking in mice. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2016) 0.75
Titins: giant proteins in charge of muscle ultrastructure and elasticity. Science (1995) 6.67
Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev (1996) 5.47
Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments. Biophys J (1995) 3.71
The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ Res (2001) 3.68
The giant protein titin: a major player in myocardial mechanics, signaling, and disease. Circ Res (2004) 3.30
The positional stability of thick filaments in activated skeletal muscle depends on sarcomere length: evidence for the role of titin filaments. J Cell Biol (1987) 2.56
Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins. Electrophoresis (2003) 2.46
Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circ Res (2004) 2.38
Calcium-dependent molecular spring elements in the giant protein titin. Proc Natl Acad Sci U S A (2003) 2.16
The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol (2003) 2.12
The complete primary structure of human nebulin and its correlation to muscle structure. J Mol Biol (1995) 1.98
Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments. J Cell Biol (1998) 1.93
Elastic energy storage in tendons: mechanical differences related to function and age. J Appl Physiol (1985) (1990) 1.91
Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart. Circ Res (2004) 1.70
Molecular mechanics of cardiac titin's PEVK and N2B spring elements. J Biol Chem (2002) 1.61
Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner. J Gen Physiol (2005) 1.61
Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction. Circulation (2005) 1.50
Immunocytochemical studies using a monoclonal antibody to bovine cardiac titin on intact and extracted myofibrils. J Muscle Res Cell Motil (1985) 1.45
Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance. J Mol Cell Cardiol (2006) 1.28
Identification of new repeating motifs in titin. Proteins (2001) 1.26
Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Am J Physiol Cell Physiol (2007) 1.25
Titin isoform changes in rat myocardium during development. Mech Dev (2004) 1.18
Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway. Circ Res (2007) 1.12
Developmental changes in passive stiffness and myofilament Ca2+ sensitivity due to titin and troponin-I isoform switching are not critically triggered by birth. Am J Physiol Heart Circ Physiol (2006) 1.11
PEVK extension of human soleus muscle titin revealed by immunolabeling with the anti-titin antibody 9D10. J Struct Biol (1998) 1.06
Effect of ageing on ultrastructure of slow and fast skeletal muscle tendon in rabbit Achilles tendons. Acta Physiol Scand (1994) 1.00
Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle. Am J Physiol Regul Integr Comp Physiol (2007) 0.98
Age-related changes in biomechanical properties of the Achilles tendon in rabbits. Eur J Appl Physiol Occup Physiol (1996) 0.97
Hierarchical extensibility in the PEVK domain of skeletal-muscle titin. Biophys J (2005) 0.93
Carp, a cardiac ankyrin-repeated protein, and its new homologue, Arpp, are differentially expressed in heart, skeletal muscle, and rhabdomyosarcomas. Am J Pathol (2002) 0.92
The serum triiodothyronine to thyroxine (T3/T4) ratio in various thyroid disorders and after Levothyroxine replacement therapy. Hormones (Athens) (2006) 0.87
Effects of thyroid hormone on the androgenic expression of KAP gene in mouse kidney. Mol Cell Endocrinol (1996) 0.85
Passive dynamics of the knee joint in healthy children and children affected by spastic paresis. Clin Biomech (Bristol, Avon) (1999) 0.85
Resting tension characteristics in differentiating intact rat fast- and slow-twitch muscle fibers. J Appl Physiol (1985) (2003) 0.83
Effect of propylthiouracil-induced hypothyroidism on the onset of skeletal muscle necrosis in dystrophin-deficient mdx mice. Clin Sci (Lond) (1998) 0.80
Soleus muscle length, stretch reflex excitability, and the contractile properties of muscle in children and adults: a study of the functional joint angle. Dev Med Child Neurol (1997) 0.77
The giant protein titin: a major player in myocardial mechanics, signaling, and disease. Circ Res (2004) 3.30
Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation (2004) 3.29
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy. Nat Genet (2002) 2.67
Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation (2002) 2.43
Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circ Res (2004) 2.38
Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. EMBO J (2006) 2.17
Calcium-dependent molecular spring elements in the giant protein titin. Proc Natl Acad Sci U S A (2003) 2.16
Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin. Am J Hum Genet (2002) 2.14
MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. J Mol Biol (2005) 2.13
The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol (2003) 2.12
Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. Neurology (2013) 2.09
Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy. J Mol Med (Berl) (2006) 2.05
Titin and its associated proteins: the third myofilament system of the sarcomere. Adv Protein Chem (2005) 2.00
Survey of prophylactic intracameral antibiotic use in cataract surgery in an Australian context. Clin Experiment Ophthalmol (2013) 1.98
PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res (2009) 1.91
Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol (2010) 1.88
Cardiac titin: a multifunctional giant. Circulation (2010) 1.84
Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction. Circulation (2013) 1.83
Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury. Circulation (2010) 1.80
Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency. Hum Mol Genet (2009) 1.73
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proc Natl Acad Sci U S A (2007) 1.70
Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling. J Muscle Res Cell Motil (2005) 1.62
Molecular mechanics of cardiac titin's PEVK and N2B spring elements. J Biol Chem (2002) 1.61
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. EMBO J (2007) 1.61
Cardiac titin: an adjustable multi-functional spring. J Physiol (2002) 1.56
Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients. Am J Respir Crit Care Med (2015) 1.52
Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation (2011) 1.51
C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy. Ann Neurol (2007) 1.47
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem (2002) 1.47
The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles. Structure (2007) 1.45
Nebulin: the nebulous, multifunctional giant of striated muscle. Trends Cardiovasc Med (2003) 1.44
Actin-related myopathy without any missense mutation in the ACTA1 gene. J Child Neurol (2004) 1.42
Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost. J Biol Chem (2009) 1.41
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol (2007) 1.41
Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle. J Physiol (2003) 1.39
Association of the chaperone alphaB-crystallin with titin in heart muscle. J Biol Chem (2003) 1.31
Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease. J Mol Cell Cardiol (2009) 1.30
Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells. Muscle Nerve (2007) 1.29
M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol (2006) 1.29
Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction. Circ Res (2009) 1.29
Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance. J Mol Cell Cardiol (2006) 1.28
Molecular dissection of the interaction of desmin with the C-terminal region of nebulin. J Struct Biol (2002) 1.27
The sensitive giant: the role of titin-based stretch sensing complexes in the heart. Trends Cell Biol (2004) 1.26
The complete mouse nebulin gene sequence and the identification of cardiac nebulin. J Mol Biol (2003) 1.26
Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments. J Struct Biol (2002) 1.22
ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol (2009) 1.22
Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility. J Mol Biol (2007) 1.21
Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin. FASEB J (2007) 1.21
Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Hum Mol Genet (2008) 1.21
Cardiac titin: structure, functions and role in disease. Clin Chim Acta (2006) 1.20
Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2). J Struct Biol (2009) 1.20
Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Cardiovasc Res (2009) 1.18
MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies. J Mol Biol (2008) 1.17
Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle. FASEB J (2008) 1.17
Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility. Cardiovasc Res (2006) 1.16
Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. Hum Mol Genet (2011) 1.16
Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice. J Mol Biol (2008) 1.16
Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling. J Mol Biol (2004) 1.15
Single molecule force spectroscopy of the cardiac titin N2B element: effects of the molecular chaperone alphaB-crystallin with disease-causing mutations. J Biol Chem (2009) 1.13
Titin and diaphragm dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.13
Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells. J Gen Physiol (2011) 1.12
Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3. J Biol Chem (2003) 1.11
Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Hum Mol Genet (2012) 1.10
MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. J Struct Biol (2010) 1.10
Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle. J Biol Chem (2008) 1.10
Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect. Biochem J (2003) 1.09
Selective diaphragm muscle weakness after contractile inactivity during thoracic surgery. Ann Surg (2011) 1.09
Titin-based modulation of active tension and interfilament lattice spacing in skinned rat cardiac muscle. Pflugers Arch (2004) 1.09
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. Circulation (2007) 1.08
A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain. Proc Natl Acad Sci U S A (2008) 1.08
Effect of diastolic pressure on MLC2v phosphorylation in the rat left ventricle. Arch Biochem Biophys (2006) 1.08
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07
Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development. J Cell Sci (2004) 1.07
Nebulin, a major player in muscle health and disease. FASEB J (2010) 1.06