Regulatory T cells and inhibitory cytokines in autoimmunity.

PubWeight™: 1.79‹?› | Rank: Top 3%

🔗 View Article (PMC 2787714)

Published in Curr Opin Immunol on October 23, 2009

Authors

Maria Bettini1, Dario A A Vignali

Author Affiliations

1: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Articles citing this

Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity (2012) 1.61

IL-35 is a novel responsive anti-inflammatory cytokine--a new system of categorizing anti-inflammatory cytokines. PLoS One (2012) 1.49

Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells. J Exp Med (2013) 1.48

An update on regulatory T cells in transplant tolerance and rejection. Nat Rev Nephrol (2010) 1.35

Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3. J Immunol (2011) 1.28

Once a Treg, always a Treg? Immunol Rev (2014) 1.27

Stat3 phosphorylation mediates resistance of primary human T cells to regulatory T cell suppression. J Immunol (2011) 1.26

Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6. J Leukoc Biol (2010) 1.23

MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity. Front Immunol (2013) 1.22

Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35. Diabetes (2012) 1.21

Induced and natural regulatory T cells in human cancer. Expert Opin Biol Ther (2012) 1.15

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol (2011) 1.10

Preeclampsia: long-term consequences for vascular health. Vasc Health Risk Manag (2015) 1.08

Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4+ T-cell migration and suppression of effector function. Proc Natl Acad Sci U S A (2012) 1.07

Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells. Front Immunol (2011) 0.96

The serum IL-6 profile and Treg/Th17 peripheral cell populations in patients with type 1 diabetes. Mediators Inflamm (2013) 0.96

In vivo Treg suppression assays. Methods Mol Biol (2011) 0.95

Natural regulatory T cells in autoimmunity. Autoimmunity (2010) 0.94

Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients. PLoS One (2011) 0.93

T cell-driven initiation and propagation of autoimmune diabetes. Curr Opin Immunol (2011) 0.92

Regulatory T-cell-associated cytokines in systemic lupus erythematosus. J Biomed Biotechnol (2011) 0.90

Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction. Acta Pharmacol Sin (2013) 0.90

Psoriasis patients exhibit impairment of the high potency CCR5(+) T regulatory cell subset. Clin Immunol (2013) 0.89

Targeting human inducible regulatory T cells (Tr1) in patients with cancer: blocking of adenosine-prostaglandin E₂ cooperation. Expert Opin Biol Ther (2011) 0.89

Control of autoimmune CNS inflammation by astrocytes. Semin Immunopathol (2015) 0.88

Regulatory T cell-derived IL-10 ameliorates crescentic GN. J Am Soc Nephrol (2013) 0.88

Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. PLoS One (2010) 0.88

Mechanism of experimental autoimmune encephalomyelitis in Lewis rats: recent insights from macrophages. Anat Cell Biol (2012) 0.87

Adipocytokine profile, cytokine levels and foxp3 expression in multiple sclerosis: a possible link to susceptibility and clinical course of disease. PLoS One (2013) 0.86

Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model. J Immunol (2010) 0.86

Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency. AIDS Res Hum Retroviruses (2013) 0.85

Humanizing animal models: a key to autoimmune diabetes treatment. Sci Transl Med (2011) 0.85

Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis. PLoS One (2011) 0.84

Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines. J Biomed Sci (2011) 0.84

Scientific Validation of Gentiana kurroo Royle for Anti-Inflammatory and Immunomodulatory Potential. ISRN Inflamm (2014) 0.84

Antigen-specific gene therapy after immunisation reduces the severity of collagen-induced arthritis. Clin Dev Immunol (2013) 0.82

Ribavirin modulates the conversion of human CD4(+)  CD25(-) T cell to CD4(+)  CD25(+)  FOXP3(+) T cell via suppressing interleukin-10-producing regulatory T cell. Immunology (2012) 0.82

T helper cell subsets in arthritis and the benefits of immunomodulation by 1,25(OH)₂ vitamin D. Rheumatol Int (2011) 0.81

Release of B cell-activating factor of the TNF family in bronchoalveolar lavage from Behçet's disease with pulmonary involvement. Oxid Med Cell Longev (2010) 0.81

An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia. Am J Physiol Regul Integr Comp Physiol (2015) 0.80

Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases. Inflamm Bowel Dis (2016) 0.80

Low-level laser reduces the production of TNF-α, IFN-γ, and IL-10 induced by OVA. Lasers Med Sci (2013) 0.80

The dark side of regulatory T cells in psoriasis. J Invest Dermatol (2011) 0.80

Impaired function of regulatory T cells in cord blood of children of allergic mothers. Clin Exp Immunol (2012) 0.79

Transplantation tolerance: Clinical potential of regulatory T cells. Self Nonself (2011) 0.79

Equine CD4(+) CD25(high) T cells exhibit regulatory activity by close contact and cytokine-dependent mechanisms in vitro. Immunology (2011) 0.79

Bioactive Molecules Released From Cells Infected with the Human Cytomegalovirus. Front Microbiol (2016) 0.79

Immunotherapy of malignant gliomas using autologous and allogeneic tissue cells. Anticancer Agents Med Chem (2010) 0.78

CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism. Virol J (2014) 0.78

Infection with feline immunodeficiency virus directly activates CD4+ CD25+ T regulatory cells. J Virol (2013) 0.77

Association between PD-1/PD-L1 and T regulate cells in early recurrent miscarriage. Int J Clin Exp Pathol (2015) 0.77

Regulatory T-cell vaccination independent of auto-antigen. Exp Mol Med (2014) 0.77

Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis. Clin Exp Immunol (2015) 0.77

IKKα is involved in kidney recovery and regeneration of acute ischemia/reperfusion injury in mice through IL10-producing regulatory T cells. Dis Model Mech (2015) 0.77

The immunobiology of apotransferrin in type 1 diabetes. Clin Exp Immunol (2012) 0.76

Transplantation Tolerance Induction: Cell Therapies and Their Mechanisms. Front Immunol (2016) 0.76

Anti-inflammatory and immuno-modulatory studies on LC-MS characterised methanol extract of Gentiana kurroo Royle. BMC Complement Altern Med (2017) 0.75

Effect of regular circus physical exercises on lymphocytes in overweight children. PLoS One (2015) 0.75

The Role of Skin Barrier in the Pathogenesis of Food Allergy. Children (Basel) (2015) 0.75

New Approaches to the Immunotherapy of Type 1 Diabetes Mellitus Using Interleukin-27. Adv Pharm Bull (2015) 0.75

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. Immunogenetics (2016) 0.75

Clinical immunology. Ulster Med J (2011) 0.75

Articles cited by this

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29

Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63

Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (1992) 16.46

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (2007) 12.79

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med (2007) 11.82

How regulatory T cells work. Nat Rev Immunol (2008) 11.66

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A (1993) 10.82

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26

Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev (2006) 10.24

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol (2009) 8.65

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol (2009) 8.32

The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 7.82

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 7.73

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 6.65

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity (2007) 6.61

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol (2008) 6.56

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med (2007) 5.96

Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol (2007) 4.56

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes (2005) 4.34

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28

Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A (2009) 4.25

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity (2006) 4.06

Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol (2006) 4.04

Interleukin-10: new perspectives on an old cytokine. Immunol Rev (2008) 3.94

Regulatory T cells in the control of host-microorganism interactions (*). Annu Rev Immunol (2009) 3.82

Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol (2009) 3.80

Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system. J Immunol (2005) 3.41

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25

CD3-specific antibodies: a portal to the treatment of autoimmunity. Nat Rev Immunol (2007) 3.06

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04

CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med (2008) 2.72

CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol (2008) 2.69

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med (2005) 2.61

A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment. Clin Cancer Res (2007) 2.57

The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med (1998) 2.55

A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol (2006) 2.45

The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol (2008) 2.39

T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity (2009) 2.34

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol (2003) 2.32

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes (2007) 2.27

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes (2005) 2.10

Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol (2009) 1.89

CD4+ T-regulatory cells: toward therapy for human diseases. Immunol Rev (2008) 1.85

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A (2008) 1.85

Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance. J Immunol (2008) 1.71

Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J Immunol (2008) 1.63

Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta. J Immunol (2007) 1.63

Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol (2007) 1.62

Interleukin-35: odd one out or part of the family? Immunol Rev (2008) 1.60

Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis. J Clin Invest (2008) 1.44

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression. J Clin Invest (1996) 1.42

Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells. Immunology (2007) 1.35

How many mechanisms do regulatory T cells need? Eur J Immunol (2008) 1.34

Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells. J Exp Med (2009) 1.27

T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls. J Neurosci Res (2001) 1.14

Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease. Gene Ther (2008) 1.09

Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner. Eur J Immunol (2009) 1.02

Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation. Eur J Immunol (2008) 1.00

Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. J Immunol (1999) 0.99

Cytokines in the induction and resolution of experimental autoimmune encephalomyelitis. Cytokine (2005) 0.98

Lower percentages of T regulatory cells in children with type 1 diabetes - preliminary report. Pediatr Endocrinol Diabetes Metab (2009) 0.88

Articles by these authors

Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat Biotechnol (2004) 10.60

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol (2008) 10.26

The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 7.82

Role of LAG-3 in regulatory T cells. Immunity (2004) 4.36

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol (2008) 4.33

Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res (2011) 3.81

IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol (2010) 3.43

Generation of T-cell receptor retrogenic mice. Nat Protoc (2006) 3.05

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science (2008) 2.99

Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Nat Methods (2006) 2.87

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol (2009) 2.52

Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol (2005) 2.34

Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat Immunol (2008) 2.34

T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity (2009) 2.34

Development of 2A peptide-based strategies in the design of multicistronic vectors. Expert Opin Biol Ther (2005) 2.31

The plasticity and stability of regulatory T cells. Nat Rev Immunol (2013) 2.15

Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13

Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol (2004) 2.00

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature (2013) 1.99

General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90

Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol (2009) 1.89

The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol (2003) 1.80

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol (2013) 1.74

The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol (2013) 1.65

The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol (2012) 1.63

On the pathogenicity of autoantigen-specific T-cell receptors. Diabetes (2008) 1.61

Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity (2012) 1.61

Interleukin-35: odd one out or part of the family? Immunol Rev (2008) 1.60

Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells. J Immunol (2009) 1.60

Retracted Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol (2011) 1.56

In vitro Treg suppression assays. Methods Mol Biol (2011) 1.46

Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur J Immunol (2002) 1.43

Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc Natl Acad Sci U S A (2008) 1.42

Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J Immunol (2002) 1.41

LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol (2009) 1.33

Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J (2007) 1.31

Cutting edge: virus-specific CD4+ memory T cells in nonlymphoid tissues express a highly activated phenotype. J Immunol (2002) 1.28

Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3. J Immunol (2011) 1.28

Once a Treg, always a Treg? Immunol Rev (2014) 1.27

Design and construction of 2A peptide-linked multicistronic vectors. Cold Spring Harb Protoc (2012) 1.26

Organization of proximal signal initiation at the TCR:CD3 complex. Immunol Rev (2009) 1.25

A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system. Mol Ther (2005) 1.23

The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues. J Immunol (2002) 1.22

Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35. Diabetes (2012) 1.21

Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily. Immunol Res (2011) 1.19

Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress. J Immunol (2009) 1.17

The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function. J Immunol (2005) 1.13

Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transfer. J Immunol (2004) 1.13

Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. EMBO J (2010) 1.11

Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4. Eur J Immunol (2010) 1.09

Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade. J Immunol (2012) 1.09

Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice. Diabetes (2012) 1.09

Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells. J Immunol (2010) 1.07

The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling. J Immunol (2008) 1.05

The plasticity of regulatory T cell function. J Immunol (2011) 1.03

T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice. Immunology (2012) 1.03

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc Natl Acad Sci U S A (2011) 0.98

Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223). J Immunol (2004) 0.98

CD40-induced aggregation of MHC class II and CD80 on the cell surface leads to an early enhancement in antigen presentation. J Immunol (2003) 0.98

Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J Immunol (2007) 0.97

In vivo Treg suppression assays. Methods Mol Biol (2011) 0.95

Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells. Proc Natl Acad Sci U S A (2013) 0.94

Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family. Mol Immunol (2012) 0.94

Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways. J Immunol (2011) 0.93

Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells. J Immunol Methods (2002) 0.92

T cell-driven initiation and propagation of autoimmune diabetes. Curr Opin Immunol (2011) 0.92

Development of thymically derived natural regulatory T cells. Ann N Y Acad Sci (2010) 0.91

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. Blood (2011) 0.91

TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx. J Leukoc Biol (2005) 0.91

Generation of T cell receptor-retrogenic mice: improved retroviral-mediated stem cell gene transfer. Nat Protoc (2013) 0.90

Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection. J Immunol (2014) 0.89

STAT heterodimers in immunity: A mixed message or a unique signal? JAKSTAT (2013) 0.89

Interpreting mixed signals: the cell's cytokine conundrum. Curr Opin Immunol (2011) 0.88

The battle against immunopathology: infectious tolerance mediated by regulatory T cells. Cell Mol Life Sci (2011) 0.87

Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice. J Clin Invest (2011) 0.86

Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation. J Immunol (2004) 0.86

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells. J Immunol Methods (2008) 0.85

Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo. Proc Natl Acad Sci U S A (2012) 0.85

Outgrowth of CD4low/negCD25+ T cells with suppressor function in CD4+CD25+ T cell cultures upon polyclonal stimulation ex vivo. J Immunol (2008) 0.84

Plasticity and rigidity in adaptor protein-2-mediated internalization of the TCR:CD3 complex. J Immunol (2005) 0.83

Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind. Diabetes (2012) 0.83

Verification of 2A peptide cleavage. Cold Spring Harb Protoc (2012) 0.82

Generation of 2A-linked multicistronic cassettes by recombinant PCR. Cold Spring Harb Protoc (2012) 0.80

Combinatorial Immunotherapy: PD-1 may not be LAG-ing behind any more. Oncoimmunology (2012) 0.78

LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci Immunol (2017) 0.78

Identity crisis: it's not just Foxp3 anymore. Immunity (2012) 0.77

Mutational analysis of TRAF6 reveals a conserved functional role of the RING dimerization interface and a potentially necessary but insufficient role of RING-dependent TRAF6 polyubiquitination towards NF-κB activation. Cell Signal (2010) 0.77

Retraction. Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol (2013) 0.76

A natural structural variant of the mouse TCR beta-chain displays intrinsic receptor function and antigen specificity. J Immunol (2006) 0.75