Published in J Immunol on October 17, 2011
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity (2012) 1.61
Once a Treg, always a Treg? Immunol Rev (2014) 1.27
Treg and CTLA-4: two intertwining pathways to immune tolerance. J Autoimmun (2013) 1.18
Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection. J Immunol (2013) 1.16
Interleukin 35: a key mediator of suppression and the propagation of infectious tolerance. Front Immunol (2013) 1.03
Regulatory T cells in radiotherapeutic responses. Front Oncol (2012) 0.98
The role of regulatory T cells in the biology of graft versus host disease. Front Immunol (2013) 0.96
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro. PLoS One (2012) 0.92
Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells. Cytokine (2015) 0.85
Interleukin-35: Expanding Its Job Profile. J Interferon Cytokine Res (2015) 0.83
T Cells: Soldiers and Spies-The Surveillance and Control of Effector T Cells by Regulatory T Cells. Clin J Am Soc Nephrol (2015) 0.82
Mechanisms of T(reg) Suppression: Still a Long Way to Go. Front Immunol (2012) 0.80
Cardanol isolated from Thai Apis mellifera propolis induces cell cycle arrest and apoptosis of BT-474 breast cancer cells via p21 upregulation. Daru (2015) 0.77
Ex-vivo tolerogenic F4/80⁺ antigen-presenting cells (APC) induce efferent CD8⁺ regulatory T cell-dependent suppression of experimental autoimmune uveitis. Clin Exp Immunol (2014) 0.76
Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression. Front Immunol (2016) 0.76
Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study. Mediators Inflamm (2017) 0.75
Comment on "Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways". J Immunol (2012) 0.75
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy. Nat Rev Cancer (2017) 0.75
Regulatory T Cells in Allergy and Asthma. Front Pediatr (2017) 0.75
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med (1998) 19.03
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 14.15
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol (2009) 8.32
The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 7.82
Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev (2001) 7.60
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity (2000) 6.97
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med (2005) 6.87
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol (2007) 6.80
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 6.65
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol (2008) 6.56
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (2009) 6.14
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol (2003) 5.94
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev (2006) 4.40
Adaptor-related proteins. Curr Opin Cell Biol (2001) 3.60
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med (2006) 3.57
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. Blood (2006) 3.04
TRAIL and apoptosis induction by TNF-family death receptors. Oncogene (2003) 2.75
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem (2006) 2.75
Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur J Immunol (1989) 2.58
Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol (2005) 2.34
Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells. J Immunol (2007) 2.32
Approximate variance-stabilizing transformations for gene-expression microarray data. Bioinformatics (2003) 2.20
Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs. J Exp Med (1999) 2.13
Treg cells suppress osteoclast formation: a new link between the immune system and bone. Arthritis Rheum (2007) 2.12
Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol (2009) 1.89
TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice. Eur J Immunol (2008) 1.80
The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells. J Immunol (1987) 1.67
Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc Natl Acad Sci U S A (1996) 1.59
In vitro Treg suppression assays. Methods Mol Biol (2011) 1.46
How many mechanisms do regulatory T cells need? Eur J Immunol (2008) 1.34
Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells. J Immunol (2001) 1.33
Following a TRAIL: update on a ligand and its five receptors. Cell Res (2004) 1.33
Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells. Cell Death Differ (2007) 1.22
Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage. Eur J Immunol (1998) 1.19
Mina, an Il4 repressor, controls T helper type 2 bias. Nat Immunol (2009) 1.18
Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors. J Cell Physiol (1999) 1.10
Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation. Cell Death Differ (2003) 1.07
Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Res (2007) 1.07
Cathepsin E: a mini review. Biochem Biophys Res Commun (2008) 1.06
Plasticity of T reg at infected sites. Mucosal Immunol (2010) 0.98
In vivo Treg suppression assays. Methods Mol Biol (2011) 0.95
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in central nervous system inflammation. J Mol Med (Berl) (2009) 0.90
Protective role of interleukin-10 in ozone-induced pulmonary inflammation. Environ Health Perspect (2010) 0.90
CD4(+)CD25(+) regulatory T cells attenuate Hypersensitivity Pneumonitis by suppressing IFN-gamma production by CD4(+) and CD8(+) T cells. J Leukoc Biol (2009) 0.87
Systemic immunological tolerance to ocular antigens is mediated by TRAIL-expressing CD8+ T cells. J Immunol (2010) 0.87
Natural cathepsin E deficiency in the immune system of C57BL/6J mice. Immunogenetics (2007) 0.86
Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis. Biol Chem (2010) 0.79
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat Biotechnol (2004) 10.60
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol (2008) 10.26
The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 7.82
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity (2011) 6.00
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol (2006) 5.96
Subtypes of medulloblastoma have distinct developmental origins. Nature (2010) 5.94
The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med (2006) 5.94
Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol (2005) 5.40
Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks. J Virol (2004) 5.17
Novel mutations target distinct subgroups of medulloblastoma. Nature (2012) 4.82
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity (2008) 4.37
Role of LAG-3 in regulatory T cells. Immunity (2004) 4.36
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol (2008) 4.33
Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor. J Infect Dis (2002) 4.21
The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci (2012) 4.11
The sepsis seesaw: tilting toward immunosuppression. Nat Med (2009) 3.95
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet (2005) 3.93
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature (2005) 3.81
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res (2011) 3.81
Inefficient transmission of H5N1 influenza viruses in a ferret contact model. J Virol (2007) 3.79
Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature (2010) 3.70
IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol (2010) 3.43
Generation of T-cell receptor retrogenic mice. Nat Protoc (2006) 3.05
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science (2008) 2.99
Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Nat Methods (2006) 2.87
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol (2009) 2.73
Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell (2007) 2.61
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol (2009) 2.52
Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol (2005) 2.34
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med (2002) 2.34
Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat Immunol (2008) 2.34
T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity (2009) 2.34
Development of 2A peptide-based strategies in the design of multicistronic vectors. Expert Opin Biol Ther (2005) 2.31
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol (2009) 2.27
Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biol (2009) 2.24
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A (2005) 2.19
Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med (2006) 2.18
The plasticity and stability of regulatory T cells. Nat Rev Immunol (2013) 2.15
A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell (2012) 2.15
Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses. J Gen Virol (2005) 2.15
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev (2005) 2.14
Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13
Protection and compensation in the influenza virus-specific CD8+ T cell response. Proc Natl Acad Sci U S A (2003) 2.13
Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread. Proc Natl Acad Sci U S A (2008) 2.11
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature (2008) 2.10
Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. J Virol (2009) 2.08
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo. Proc Natl Acad Sci U S A (2003) 2.07
Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays. BMC Genomics (2004) 2.05
Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol (2004) 2.00
Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza. Comp Med (2007) 1.99
Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature (2013) 1.99
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol (2009) 1.91
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res (2006) 1.90
Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol (2009) 1.89
The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol (2003) 1.80
Regulatory T cells and inhibitory cytokines in autoimmunity. Curr Opin Immunol (2009) 1.79
Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J Immunol (2002) 1.79
CD8 T cells utilize TRAIL to control influenza virus infection. J Immunol (2008) 1.75
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol (2013) 1.74
Noncanonical autophagy promotes the visual cycle. Cell (2013) 1.74
Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest (2007) 1.72
EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol (2007) 1.72
Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res (2002) 1.72
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol (2008) 1.72
Increased pathogenicity of a reassortant 2009 pandemic H1N1 influenza virus containing an H5N1 hemagglutinin. J Virol (2011) 1.69
Does pandemic A/H1N1 virus have the potential to become more pathogenic? MBio (2010) 1.68
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J (2005) 1.68
Interaction of ICP34.5 with Beclin 1 modulates herpes simplex virus type 1 pathogenesis through control of CD4+ T-cell responses. J Virol (2009) 1.67
Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression. Cancer Biol Ther (2005) 1.66
The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol (2013) 1.65
The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol (2012) 1.63
Neurovirulence in mice of H5N1 influenza virus genotypes isolated from Hong Kong poultry in 2001. J Virol (2003) 1.62
On the pathogenicity of autoantigen-specific T-cell receptors. Diabetes (2008) 1.61
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity (2012) 1.61
Interleukin-35: odd one out or part of the family? Immunol Rev (2008) 1.60
Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells. J Immunol (2009) 1.60
A knowledge-based clustering algorithm driven by Gene Ontology. J Biopharm Stat (2004) 1.59
Retracted Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol (2011) 1.56
Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics. Am J Physiol Cell Physiol (2013) 1.56
Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res (2007) 1.51
TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies. Eur J Pharmacol (2009) 1.51
Bacterial sinusitis and otitis media following influenza virus infection in ferrets. Infect Immun (2006) 1.51
Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol Cell Biol (2006) 1.48
Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration. Invest Ophthalmol Vis Sci (2013) 1.48