Genome mining for ribosomally synthesized natural products.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

BAGEL3: Automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides. Nucleic Acids Res (2013) 3.23

Bacteriocins - a viable alternative to antibiotics? Nat Rev Microbiol (2012) 2.76

A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol (2011) 2.05

Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates. Curr Opin Chem Biol (2011) 1.67

Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A (2012) 1.53

Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44

Primer on agar-based microbial imaging mass spectrometry. J Bacteriol (2012) 1.22

Precursor-centric genome-mining approach for lasso peptide discovery. Proc Natl Acad Sci U S A (2012) 1.14

mMass as a software tool for the annotation of cyclic peptide tandem mass spectra. PLoS One (2012) 1.12

Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria. PLoS One (2011) 1.11

Distribution and properties of the genes encoding the biosynthesis of the bacterial cofactor, pyrroloquinoline quinone. Biochemistry (2012) 1.10

An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc (2012) 1.09

Cloning and analysis of the planosporicin lantibiotic biosynthetic gene cluster of Planomonospora alba. J Bacteriol (2013) 0.99

Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis. ACS Chem Biol (2013) 0.94

ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences. PLoS One (2012) 0.94

Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria. BMC Genomics (2014) 0.93

Prospecting genomes for lasso peptides. J Ind Microbiol Biotechnol (2013) 0.92

Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angew Chem Int Ed Engl (2013) 0.92

Automated genome mining of ribosomal peptide natural products. ACS Chem Biol (2014) 0.91

Genome mining for methanobactins. BMC Biol (2013) 0.90

Circular proteins from plants and fungi. J Biol Chem (2012) 0.89

Genome-derived insights into the biology of the hepatotoxic bloom-forming cyanobacterium Anabaena sp. strain 90. BMC Genomics (2012) 0.89

The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles. BMC Genomics (2015) 0.88

Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation. ACS Chem Biol (2012) 0.86

Genome-based studies of marine microorganisms to maximize the diversity of natural products discovery for medical treatments. Evid Based Complement Alternat Med (2011) 0.85

Nonribosomal peptide synthase gene clusters for lipopeptide biosynthesis in Bacillus subtilis 916 and their phenotypic functions. Appl Environ Microbiol (2014) 0.85

Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. J Proteome Res (2011) 0.85

Lessons learned from the transformation of natural product discovery to a genome-driven endeavor. J Ind Microbiol Biotechnol (2013) 0.83

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem". Mar Drugs (2016) 0.83

In silico identification of bacteriocin gene clusters in the gastrointestinal tract, based on the Human Microbiome Project's reference genome database. BMC Microbiol (2015) 0.82

Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry. J Am Chem Soc (2013) 0.80

Nucleophilic 1,4-additions for natural product discovery. ACS Chem Biol (2014) 0.80

Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid. J Am Chem Soc (2015) 0.79

Structure and mechanism of lanthipeptide biosynthetic enzymes. Curr Opin Struct Biol (2014) 0.79

Distribution and Genetic Diversity of Bacteriocin Gene Clusters in Rumen Microbial Genomes. Appl Environ Microbiol (2015) 0.78

The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis. ACS Chem Biol (2016) 0.78

Thermophilic and alkaliphilic Actinobacteria: biology and potential applications. Front Microbiol (2015) 0.78

Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis. Nat Microbiol (2016) 0.77

Motif-independent de novo detection of secondary metabolite gene clusters-toward identification from filamentous fungi. Front Microbiol (2015) 0.76

Characterization of Methanobactin from Methylosinus sp. LW4. J Am Chem Soc (2016) 0.75

Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species. BMC Genomics (2016) 0.75

The B1 Protein Guides the Biosynthesis of a Lasso Peptide. Sci Rep (2016) 0.75

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes. Chem Rev (2017) 0.75

Radically promoted formation of a molecular lasso. Chem Sci (2017) 0.75

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci U S A (2005) 5.02

Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nat Chem Biol (2006) 4.12

Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00

From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase. Science (1996) 3.74

Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A (2008) 3.20

A global assembly line for cyanobactins. Nat Chem Biol (2008) 3.17

Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16

Synthetic therapeutic peptides: science and market. Drug Discov Today (2009) 2.95

Conus peptides: biodiversity-based discovery and exogenomics. J Biol Chem (2006) 2.55

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds. Nat Prod Rep (2009) 2.32

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A (2009) 2.22

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19

Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J Am Chem Soc (2009) 2.19

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Two enzymes catalyze the maturation of a lasso peptide in Escherichia coli. Chem Biol (2007) 2.10

Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew Chem Int Ed Engl (2008) 2.10

BAGEL2: mining for bacteriocins in genomic data. Nucleic Acids Res (2010) 2.08

Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence. Appl Environ Microbiol (2006) 2.07

Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery. Mol Interv (2007) 1.97

Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95

Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem Biol (2009) 1.93

Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu. J Am Chem Soc (2009) 1.92

Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa. Appl Environ Microbiol (2008) 1.79

Microcins, gene-encoded antibacterial peptides from enterobacteria. Nat Prod Rep (2007) 1.75

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74

Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production. Chembiochem (2005) 1.69

Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. Appl Environ Microbiol (2009) 1.68

Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol (2009) 1.56

Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes. PLoS Pathog (2008) 1.53

Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides. Proc Natl Acad Sci U S A (2010) 1.52

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family. BMC Biol (2010) 1.49

Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensis E264. J Am Chem Soc (2008) 1.47

Gene family encoding the major toxins of lethal Amanita mushrooms. Proc Natl Acad Sci U S A (2007) 1.45

Biosynthesis of circular proteins in plants. Plant J (2007) 1.39

Post-translational modification in microviridin biosynthesis. Chembiochem (2008) 1.31

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels. Biochemistry (2005) 1.31

Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR. Biochemistry (2006) 1.28

Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon (2010) 1.26

Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem (2010) 1.25

Widespread occurrence and lateral transfer of the cyanobactin biosynthesis gene cluster in cyanobacteria. Appl Environ Microbiol (2008) 1.21

Identification of a novel two-peptide lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125. FEMS Microbiol Lett (2007) 1.21

Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon (2008) 1.19

Highly diverse cyanobactins in strains of the genus Anabaena. Appl Environ Microbiol (2009) 1.18

Cloning and expression in Escherichia coli of genetic determinants for production of and immunity to microcin E492 from Klebsiella pneumoniae. J Bacteriol (1997) 1.17

Genes expressed in a turrid venom duct: divergence and similarity to conotoxins. J Mol Evol (2006) 1.15

Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13. PLoS One (2009) 1.14

Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains. J Bacteriol (2009) 1.13

In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification. Angew Chem Int Ed Engl (2010) 1.13

Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species. Appl Environ Microbiol (2010) 1.13

Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob Agents Chemother (2010) 1.08

Isolation, structure elucidation, and synergistic antibacterial activity of a novel two-component lantibiotic lichenicidin from Bacillus licheniformis VK21. Biochemistry (2010) 1.07

Isolation and characterization of two members of the siderophore-microcin family, microcins M and H47. Antimicrob Agents Chemother (2009) 1.06

Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics (2006) 1.06

Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels. Biochemistry (2006) 1.05

A strain-variable bacteriocin in Bacillus anthracis and Bacillus cereus with repeated Cys-Xaa-Xaa motifs. Biol Direct (2009) 1.05

Alpha-conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon (2008) 1.04

Comparative analysis of chromosome-encoded microcins. Antimicrob Agents Chemother (2006) 1.04

Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from Microcystis aeruginosa PCC 7806 and their antiparasite evaluation. J Nat Prod (2008) 1.03

Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. J Am Chem Soc (2007) 1.02

Conantokin-P, an unusual conantokin with a long disulfide loop. Toxicon (2008) 1.01

Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides. Appl Environ Microbiol (2010) 0.98

Discovery of cyclotide-like protein sequences in graminaceous crop plants: ancestral precursors of circular proteins? Plant Cell (2006) 0.98

Maturation of McjA precursor peptide into active microcin MccJ25. Org Biomol Chem (2007) 0.94

Integrating the discovery pipeline for novel compounds targeting ion channels. Curr Opin Chem Biol (2008) 0.94

Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins. Biochimie (2005) 0.90

Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides. Org Biomol Chem (2009) 0.89

Cyclotide proteins and precursors from the genus Gloeospermum: filling a blank spot in the cyclotide map of Violaceae. Phytochemistry (2009) 0.86

Opportunities and challenges of developing peptide drugs in the pharmaceutical industry. Adv Exp Med Biol (2009) 0.84

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity. Phytochemistry (2008) 0.84

Insight into siderophore-carrying peptide biosynthesis: enterobactin is a precursor for microcin E492 posttranslational modification. Antimicrob Agents Chemother (2007) 0.82

Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. BMC Genomics (2010) 0.82

A transcriptional profile of metallophyte Viola baoshanensis involved in general and species-specific cadmium-defense mechanisms. J Plant Physiol (2008) 0.76

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Biosynthesis and mode of action of lantibiotics. Chem Rev (2005) 4.59

Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (2006) 3.29

Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83

Biosynthesis of phosphonic and phosphinic acid natural products. Annu Rev Biochem (2009) 2.19

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem (2012) 2.01

Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95

Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74

Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72

Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56

Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol (2006) 1.56

Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (2012) 1.53

Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A (2012) 1.53

New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (2006) 1.53

An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Nature (2009) 1.51

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47

The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46

Sublancin is not a lantibiotic but an S-linked glycopeptide. Nat Chem Biol (2011) 1.44

Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc (2009) 1.37

Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36

Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33

Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol (2009) 1.32

The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31

Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol (2010) 1.30

Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem (2007) 1.25

Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol (2004) 1.24

Biomimetic stereoselective formation of methyllanthionine. Org Lett (2002) 1.23

SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry (2003) 1.23

Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22

Hydroperoxylation by hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2009) 1.22

Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. Proc Natl Acad Sci U S A (2010) 1.20

Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18

Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster. Chem Biol (2010) 1.17

Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. J Biol Chem (2008) 1.17

Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc (2009) 1.16

In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry (2008) 1.16

On the substrate specificity of dehydration by lacticin 481 synthetase. J Am Chem Soc (2007) 1.16

Biomimetic studies on the mechanism of stereoselective lanthionine formation. Org Biomol Chem (2003) 1.15

Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc (2011) 1.15

Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15

Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol (2009) 1.13

Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. Biochemistry (2003) 1.13

In vitro activity of the nisin dehydratase NisB. Proc Natl Acad Sci U S A (2013) 1.10

Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10

Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. J Am Chem Soc (2002) 1.09

An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc (2012) 1.09

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol (2013) 1.09

The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. J Am Chem Soc (2004) 1.09

The dehydratase activity of lacticin 481 synthetase is highly processive. J Am Chem Soc (2006) 1.08

Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrob Agents Chemother (2008) 1.08

Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin. ACS Chem Biol (2011) 1.06

Regeneration of cofactors for use in biocatalysis. Curr Opin Biotechnol (2003) 1.04

Synthesis of site-specifically labeled arachidonic acids as mechanistic probes for prostaglandin H synthase. Org Lett (2004) 1.04

Heterologous expression and purification of SpaB involved in subtilin biosynthesis. Biochem Biophys Res Commun (2002) 1.03

Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chembiochem (2009) 1.02

Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa. Appl Environ Microbiol (2005) 1.02

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angew Chem Int Ed Engl (2007) 1.02

Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme. Angew Chem Int Ed Engl (2002) 1.02

On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2011) 1.00

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett (2008) 0.98

Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids. Chem Commun (Camb) (2003) 0.98

Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. Antimicrob Agents Chemother (2012) 0.98

On the regioselectivity of thioether formation by lacticin 481 synthetase. Org Lett (2007) 0.98

Biosynthesis of the class III lantipeptide catenulipeptin. ACS Chem Biol (2012) 0.97

Comparison of the properties of prostaglandin H synthase-1 and -2. Prog Lipid Res (2003) 0.96

A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. J Am Chem Soc (2014) 0.96

Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chem Biol (2011) 0.95

A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization. J Am Chem Soc (2013) 0.95

Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. ACS Chem Biol (2011) 0.94

Site-directed mutagenesis of active site residues of phosphite dehydrogenase. Biochemistry (2005) 0.94

Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry. J Am Chem Soc (2011) 0.94

Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family. Biochemistry (2011) 0.94

Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 0.94

Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway. Proc Natl Acad Sci U S A (2013) 0.93

Insights into the evolution of lanthipeptide biosynthesis. Protein Sci (2013) 0.93

Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2. J Biol Chem (2002) 0.93

Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. Biochemistry (2009) 0.93

Model studies of the histidine-tyrosine cross-link in cytochrome C oxidase reveal the flexible substituent effect of the imidazole moiety. Org Lett (2005) 0.92

Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. Curr Opin Chem Biol (2013) 0.92

Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin. Arch Biochem Biophys (2010) 0.92

Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angew Chem Int Ed Engl (2013) 0.92

Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM. J Am Chem Soc (2014) 0.92

Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021. J Biol Chem (2011) 0.91

Lacticin 481 synthetase as a general serine/threonine kinase. ACS Chem Biol (2009) 0.91

Transforming a blue copper into a red copper protein: engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation. J Am Chem Soc (2010) 0.91

Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification. J Am Chem Soc (2005) 0.91

Catalytic promiscuity of a bacterial α-N-methyltransferase. FEBS Lett (2012) 0.90

Site-selective conjugation of thiols with aziridine-2-carboxylic acid-containing peptides. J Am Chem Soc (2004) 0.90

High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis. ACS Chem Biol (2014) 0.90

New developments in lantibiotic biosynthesis and mode of action. Curr Opin Microbiol (2005) 0.90

Structure-activity relationships of the phosphonate antibiotic dehydrophos. Chem Commun (Camb) (2010) 0.89

In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis. Biochemistry (2009) 0.88

Properties and reactivity of chlorovinylcobalamin and vinylcobalamin and their implications for vitamin B12-catalyzed reductive dechlorination of chlorinated alkenes. J Am Chem Soc (2005) 0.88

Bacillus anthracis spore interactions with mammalian cells: relationship between germination state and the outcome of in vitro. BMC Microbiol (2011) 0.88