CRX is a diagnostic marker of retinal and pineal lineage tumors.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 2775954)

Published in PLoS One on November 20, 2009

Authors

Sandro Santagata1, Cecile L Maire, Ahmed Idbaih, Lars Geffers, Mick Correll, Kristina Holton, John Quackenbush, Keith L Ligon

Author Affiliations

1: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

Articles cited by this

The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol (2007) 49.11

ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia (2004) 17.08

Principles of cancer therapy: oncogene and non-oncogene addiction. Cell (2009) 10.96

Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation. Comput Appl Biosci (1993) 9.38

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One (2008) 5.86

GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res (2004) 5.45

Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics (2004) 4.88

Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron (2007) 4.47

Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron (1997) 4.33

Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet (1999) 3.42

Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell (1997) 3.42

The origins of medulloblastoma subtypes. Annu Rev Pathol (2008) 3.36

Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci (2003) 3.08

A DNA microarray survey of gene expression in normal human tissues. Genome Biol (2005) 2.90

Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis. Nat Genet (2000) 2.85

The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol (2004) 2.66

Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration. Neuron (1997) 2.34

Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma. J Clin Oncol (1999) 2.28

Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform. Dev Dyn (2005) 2.01

Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors. Am J Surg Pathol (2007) 1.92

Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function. Hum Mol Genet (1999) 1.80

The cis-regulatory logic of the mammalian photoreceptor transcriptional network. PLoS One (2007) 1.71

Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia. J Neuropathol Exp Neurol (2004) 1.62

The cytological differentiating potential of pineal parenchymal neoplasms (true pinealomas). A clinicopathological study of 28 tumours. Brain (1979) 1.49

Otx5 regulates genes that show circadian expression in the zebrafish pineal complex. Nat Genet (2001) 1.49

CED: a conformational epitope database. BMC Immunol (2006) 1.39

CDX-2, a new marker for adenocarcinoma of gastrointestinal origin. Adv Anat Pathol (2004) 1.35

Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell. Cancer Res (2006) 1.34

Pathology of pineal region tumors. J Neurooncol (2001) 1.34

Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications. J Pathol (2008) 1.33

Retinal degenerations with truncation mutations in the cone-rod homeobox (CRX) gene. Invest Ophthalmol Vis Sci (1998) 1.30

Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol (2000) 1.23

Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum Mol Genet (2001) 1.22

A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX. Proc Natl Acad Sci U S A (1998) 1.19

The 2007 WHO classification of tumors of the nervous system: controversies in surgical neuropathology. Brain Pathol (2008) 1.10

Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat. Exp Eye Res (2007) 1.10

Ultrastructure of a "pineocytoma". J Neuropathol Exp Neurol (1975) 1.09

MyoD1 and myogenin expression in human neoplasia: a review and update. Adv Anat Pathol (2002) 1.08

S-antigen-like immunoreactivity in a human pineocytoma. Acta Neuropathol (1986) 1.06

Pineal gland lesions: a cytopathologic study of 20 specimens. Cancer (2005) 1.06

OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Am J Surg Pathol (2005) 1.02

S-antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study. Acta Neuropathol (1986) 1.01

Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy. J Neurooncol (2008) 1.00

Clinical variations of trilateral retinoblastoma: a report of 13 cases. J Pediatr Ophthalmol Strabismus (1994) 0.98

Expression of developmentally defined retinal phenotypes in the histogenesis of retinoblastoma. Am J Pathol (1992) 0.95

Microarray analysis reveals differential gene expression patterns in tumors of the pineal region. J Neuropathol Exp Neurol (2006) 0.91

alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates. Proc Natl Acad Sci U S A (1986) 0.90

Pathological and molecular heterogeneity of medulloblastoma. Curr Opin Oncol (2008) 0.90

Differentiation in medulloblastomas: correlation between the immunocytochemical demonstration of photoreceptor markers (S-antigen, rod-opsin) and the survival rate in 66 patients. Acta Neuropathol (1989) 0.90

Brachyury and chordoma: the chondroid-chordoid dilemma resolved? J Pathol (2006) 0.89

Tumors of pineal parenchymal cells: a correlation of histological features, including nucleolar organizer regions, with survival in 35 cases. Hum Pathol (1995) 0.88

Primitive neuroectodermal tumors, embryonal tumors, and other small cell and poorly differentiated malignant neoplasms of the central and peripheral nervous systems. Ann Diagn Pathol (2003) 0.86

From integrated genomics to tumor lineage dependency. Cancer Res (2006) 0.86

Trilateral retinoblastoma. A report of five patients. Cancer (1996) 0.85

Specific ultrastructural markers of human pinealomas. A study of four cases. Acta Neuropathol (1983) 0.85

Retinoblastoma-like phenotype expressed in medulloblastomas. J Neuropathol Exp Neurol (1995) 0.85

Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG. Am J Surg Pathol (2006) 0.82

Structural and ultrastructural characteristics of human pineal gland, and pineal parenchymal tumors. Acta Neuropathol (1994) 0.82

New transcription factors in diagnostic hematopathology. Adv Anat Pathol (2007) 0.81

Differential expression of retinal proteins in a pineal parenchymal tumor. J Neuropathol Exp Neurol (1993) 0.79

Neuron-associated class III beta-tubulin isotype, retinal S-antigen, synaptophysin, and glial fibrillary acidic protein in human medulloblastomas: a clinicopathological analysis of 36 cases. Acta Neuropathol (1992) 0.79

Postnatal evolution of the human pineal gland. An immunohistochemical study. Lab Invest (1987) 0.77

Immunohistochemical expression of OCT4 in primary central nervous system germ cell tumours. J Clin Neurosci (2007) 0.76

Immunohistochemical localization of human pineal tissue antigens in normal retina and retinoblastomas. Neuropathology (2003) 0.76

Pathology of tumors of the pineal region. Rev Neurol (Paris) (2008) 0.76

Pathobiology of the pineal gland with emphasis on parenchymal tumors. Brain Tumor Pathol (1999) 0.76

Articles by these authors

Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20

TM4 microarray software suite. Methods Enzymol (2006) 13.78

Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol (2008) 12.96

TIGR Gene Indices clustering tools (TGICL): a software system for fast clustering of large EST datasets. Bioinformatics (2003) 12.00

Multiple-laboratory comparison of microarray platforms. Nat Methods (2005) 11.74

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (2007) 10.60

Genesis: cluster analysis of microarray data. Bioinformatics (2002) 10.50

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol (2007) 10.49

p16INK4a induces an age-dependent decline in islet regenerative potential. Nature (2006) 9.09

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92

Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet (2009) 7.62

A simple spreadsheet-based, MIAME-supportive format for microarray data: MAGE-TAB. BMC Bioinformatics (2006) 7.53

Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17

Independence and reproducibility across microarray platforms. Nat Methods (2005) 6.26

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02

Profiling critical cancer gene mutations in clinical tumor samples. PLoS One (2009) 5.63

Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV. Bioinformatics (2011) 5.45

Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11

Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol (2009) 5.06

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature (2008) 5.00

A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol (2011) 4.84

Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res (2006) 4.80

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell (2008) 4.71

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68

Within the fold: assessing differential expression measures and reproducibility in microarray assays. Genome Biol (2002) 4.67

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature (2012) 4.37

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature (2012) 4.35

Standards for microarray data. Science (2002) 4.11

Cross-referencing eukaryotic genomes: TIGR Orthologous Gene Alignments (TOGA). Genome Res (2002) 3.93

Open source software for the analysis of microarray data. Biotechniques (2003) 3.89

Submission of microarray data to public repositories. PLoS Biol (2004) 3.83

A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry. Brain (2010) 3.53

Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev (2012) 3.44

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol (2008) 3.43

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell (2009) 3.37

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet (2013) 3.19

Standards for microarray data: an open letter. Environ Health Perspect (2004) 3.15

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. Clin Cancer Res (2010) 3.13

The TIGR rice genome annotation resource: annotating the rice genome and creating resources for plant biologists. Nucleic Acids Res (2003) 3.12

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06

Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PLoS One (2008) 2.92

What would you do if you could sequence everything? Nat Biotechnol (2008) 2.89

Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol (2005) 2.88

Somatic activation of AKT3 causes hemispheric developmental brain malformations. Neuron (2012) 2.84

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. Lancet Oncol (2013) 2.82

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature (2011) 2.82

The underlying principles of scientific publication. Bioinformatics (2002) 2.79

Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst (2002) 2.77

GeneSigDB--a curated database of gene expression signatures. Nucleic Acids Res (2009) 2.65

Universal RNA reference materials for gene expression. Clin Chem (2004) 2.53

Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet (2013) 2.42

Primary brain tumours in adults. Lancet (2012) 2.37

A three-gene model to robustly identify breast cancer molecular subtypes. J Natl Cancer Inst (2012) 2.34

Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med (2013) 2.31

Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples. PLoS One (2009) 2.21

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell (2009) 2.18

Development and evaluation of an automated annotation pipeline and cDNA annotation system. Genome Res (2003) 2.15

Multi-platform, multi-site, microarray-based human tumor classification. Am J Pathol (2004) 2.14

Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. Genomics (2008) 2.11

Physiogenomic resources for rat models of heart, lung and blood disorders. Nat Genet (2006) 2.05

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One (2011) 2.04

Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome. Cancer Res (2008) 1.99

Uneven chromosome contraction and expansion in the maize genome. Genome Res (2006) 1.96

Human glioma growth is controlled by microRNA-10b. Cancer Res (2011) 1.96

Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Proc Natl Acad Sci U S A (2013) 1.95

Global transcription profiling reveals comprehensive insights into hypoxic response in Arabidopsis. Plant Physiol (2005) 1.94

Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays. Genome Biol (2003) 1.94

Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors. Am J Surg Pathol (2007) 1.92

The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell (2011) 1.92

Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol (2008) 1.87

Comparative analyses of potato expressed sequence tag libraries. Plant Physiol (2003) 1.84

Chromosome 7p11.2 (EGFR) variation influences glioma risk. Hum Mol Genet (2011) 1.83

Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Res Treat (2009) 1.83

Discrimination of non-protein-coding transcripts from protein-coding mRNA. RNA Biol (2006) 1.82

Integrating computationally assembled mouse transcript sequences with the Mouse Genome Informatics (MGI) database. Genome Biol (2003) 1.82

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A (2003) 1.79

Orthologous gene-expression profiling in multi-species models: search for candidate genes. Genome Biol (2004) 1.77

Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci U S A (2004) 1.76

Comparison and validation of genomic predictors for anticancer drug sensitivity. J Am Med Inform Assoc (2013) 1.73

Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes. BMC Genomics (2006) 1.73

Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. Mol Cancer (2008) 1.72

Classifying human brain tumors by lipid imaging with mass spectrometry. Cancer Res (2011) 1.71

Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics (2009) 1.71

survcomp: an R/Bioconductor package for performance assessment and comparison of survival models. Bioinformatics (2011) 1.70

Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies. Ann Neurol (2007) 1.64

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet (2013) 1.64

Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2014) 1.63

E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci U S A (2009) 1.61

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A (2011) 1.59

Genetic risk profiles identify different molecular etiologies for glioma. Clin Cancer Res (2010) 1.59

ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Cancer Cell Int (2010) 1.54