Published in PLoS One on November 24, 2009
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nat Med (2014) 1.85
The phenotype of human STK4 deficiency. Blood (2012) 1.84
MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival. Blood (2011) 1.76
Protein kinases of the Hippo pathway: regulation and substrates. Semin Cell Dev Biol (2012) 1.61
FOXO transcription factors throughout T cell biology. Nat Rev Immunol (2012) 1.60
Asymmetric cancer cell division regulated by AKT. Proc Natl Acad Sci U S A (2011) 1.52
Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. PLoS One (2012) 1.43
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med (2012) 1.25
Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med (2010) 1.13
Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus. Nat Commun (2012) 1.11
MICALs in control of the cytoskeleton, exocytosis, and cell death. Cell Mol Life Sci (2011) 1.03
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep (2013) 1.01
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Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci U S A (2012) 0.98
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Unraveling the role of FoxOs in bone--insights from mouse models. Bone (2011) 0.96
Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. EMBO J (2012) 0.90
Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A (2013) 0.90
Mst1 and Mst2 kinases: regulations and diseases. Cell Biosci (2013) 0.85
Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver. BMC Bioinformatics (2014) 0.85
Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance. Diabetes (2012) 0.84
Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-α-mediated neuronal damage: implications for human immunodeficiency virus encephalitis. J Neurosci Res (2010) 0.83
Foxo3a: an integrator of immune dysfunction during HIV infection. Cytokine Growth Factor Rev (2012) 0.81
Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling. Curr Opin Immunol (2014) 0.80
Genetic deletion of Mst1 alters T cell function and protects against autoimmunity. PLoS One (2014) 0.80
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest (2016) 0.79
Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells. Oxid Med Cell Longev (2015) 0.78
Germinal center kinases in immune regulation. Cell Mol Immunol (2012) 0.78
Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency. J Clin Immunol (2016) 0.78
FOXO1 and LXRα downregulate the apolipoprotein A-I gene expression during hydrogen peroxide-induced oxidative stress in HepG2 cells. Cell Stress Chaperones (2016) 0.75
MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest (2016) 0.75
Peripheral residence of naïve CD4 T cells induces MHC class II-dependent alterations in phenotype and function. BMC Biol (2014) 0.75
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5. Immunol Cell Biol (2016) 0.75
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol (2000) 12.81
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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell (2003) 6.48
Hippo signaling in organ size control. Genes Dev (2007) 6.29
Persistence of memory CD8 T cells in MHC class I-deficient mice. Science (1999) 6.20
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell (2006) 5.36
Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (1995) 5.26
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science (2002) 4.88
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J (2004) 3.92
Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity (1999) 2.84
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity (2009) 2.82
A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J (2008) 2.46
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol (2004) 2.40
Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat Immunol (2006) 2.34
Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med (2007) 2.33
Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol (2002) 2.27
How alpha beta T cells deal with induced TCR alpha ablation. Proc Natl Acad Sci U S A (2001) 2.19
Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Cell (2005) 2.15
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J (2007) 1.69
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A (2008) 1.61
A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. Mutat Res (1990) 1.58
Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol (2009) 1.58
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J (2009) 1.58
Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem (2009) 1.51
Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering. Nat Immunol (2008) 1.50
Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. J Biol Chem (2007) 1.35
A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol (2009) 1.35
In vivo radioprotective effects of Nigella sativa L oil and reduced glutathione against irradiation-induced oxidative injury and number of peripheral blood lymphocytes in rats. Photochem Photobiol (2007) 0.82
Redox control of T-cell death. Antioxid Redox Signal (2002) 0.80
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol (2002) 4.27
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A (2010) 3.18
An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. Biochem Biophys Res Commun (2008) 2.48
A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J (2008) 2.46
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell (2008) 2.46
The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One (2013) 2.14
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol (2004) 1.99
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med (2013) 1.93
Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis. Cancer Cell (2002) 1.80
Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res (2006) 1.78
Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. PLoS Genet (2009) 1.77
Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol (2009) 1.58
Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology (2003) 1.56
Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proc Natl Acad Sci U S A (2007) 1.50
Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling. Hepatology (2005) 1.48
Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy (2015) 1.42
cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J (2013) 1.42
P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Genes Dev (2003) 1.41
Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet (2013) 1.39
Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J Clin Invest (2007) 1.39
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J (2008) 1.37
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis. Gastroenterology (2009) 1.33
Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. Cancer Res (2006) 1.32
Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas. Blood (2002) 1.30
BRAF and KRAS mutations in stomach cancer. Oncogene (2003) 1.27
A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. J Biol Chem (2004) 1.23
The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles. J Biol Chem (2004) 1.21
Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem (2010) 1.20
Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. PLoS Genet (2011) 1.18
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol Cancer Res (2003) 1.15
ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood (2012) 1.14
SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro. Carcinogenesis (2010) 1.13
Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Mol Cell Biol (2006) 1.13
Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development. J Biol Chem (2007) 1.13
A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. J Biol Chem (2010) 1.09
EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo. Cancer Res (2010) 1.08
SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage. Cell Rep (2013) 1.07
Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One (2012) 1.06
MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment. Curr Biol (2010) 1.06
Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer. APMIS (2003) 1.05
The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J Cell Biochem (2012) 1.05
Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence. Blood (2010) 1.04
Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem Biophys Res Commun (2009) 1.03
DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex. Cancer Res (2006) 1.01
Reversing the intractable nature of pancreatic cancer by selectively targeting ALDH-high, therapy-resistant cancer cells. PLoS One (2013) 1.00
A multifunctional protein, EWS, is essential for early brown fat lineage determination. Dev Cell (2013) 0.98
Genetic analysis of the liver putative tumor suppressor (LPTS) gene in hepatocellular carcinomas. Cancer Lett (2002) 0.97
MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A (2013) 0.97
Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. Mol Cancer Res (2004) 0.96
Inactivating mutations of CASPASE-7 gene in human cancers. Oncogene (2003) 0.96
Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumor. PLoS One (2008) 0.96
Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function. Mol Cells (2009) 0.96
Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics. Nat Commun (2013) 0.95
Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. J Clin Invest (2014) 0.95
Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody. Cancer Res (2009) 0.94
Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma. PLoS One (2011) 0.93
Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer. Oncogene (2002) 0.92
Inactivating mutations of the caspase-10 gene in gastric cancer. Oncogene (2002) 0.92
Synthesis and nonlinear optical properties of 1,3,5-methoxy-2,4,6-tris(styryl)benzene derivatives. Org Lett (2002) 0.92
Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. EMBO J (2012) 0.90
The protease inhibitor, elafin, induces p53-dependent apoptosis in human melanoma cells. Int J Cancer (2010) 0.90
Expression of HGF/SF and Met protein is associated with genetic alterations of VHL gene in primary renal cell carcinomas. APMIS (2002) 0.90
Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A (2013) 0.90
Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity. Cancer Res (2009) 0.89
The Er71 is an important regulator of hematopoietic stem cells in adult mice. Stem Cells (2011) 0.89
ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells. Oncol Rep (2012) 0.87
Control of APC-Cdc20 by the tumor suppressor RASSF1A. Cell Cycle (2004) 0.87
The Laennec staging system for histological sub-classification of cirrhosis is useful for stratification of prognosis in patients with liver cirrhosis. J Hepatol (2012) 0.87
RASSF1A is not appropriate as an early detection marker or a prognostic marker for non-small cell lung cancer. Int J Cancer (2005) 0.87
Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep (2012) 0.86
A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer. J Korean Med Sci (2003) 0.86
Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. EMBO J (2011) 0.85
5-hydroxytryptamine generates tonic inward currents on pacemaker activity of interstitial cells of cajal from mouse small intestine. Korean J Physiol Pharmacol (2011) 0.85
Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns. J Cancer Res Clin Oncol (2004) 0.85
Association of hepatitis B virus polymerase with promyelocytic leukemia nuclear bodies mediated by the S100 family protein p11. Biochem Biophys Res Commun (2003) 0.84
Assessment of a healthy corner store program (FIT Store) in low-income, urban, and ethnically diverse neighborhoods in Michigan. Fam Community Health (2013) 0.83
Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J Biol Chem (2012) 0.83
Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation. Cancer Res (2012) 0.82
A novel role for methyl CpG-binding domain protein 3, a component of the histone deacetylase complex, in regulation of cell cycle progression and cell death. Biochem Biophys Res Commun (2008) 0.82
Mutational analysis of Noxa gene in human cancers. APMIS (2003) 0.81
Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1. J Biol Chem (2008) 0.81
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest (2016) 0.80
Surgical outcomes of early congenital cholesteatoma: minimally invasive transcanal approach. Laryngoscope (2013) 0.80
Retrotransposon-specific DNA hypomethylation and two-step loss-of-imprinting during WW45 haploinsufficiency-induced hepatocarcinogenesis. Biochem Biophys Res Commun (2010) 0.80
Transplantation of patient-derived adipose stem cells in YAC128 Huntington's disease transgenic mice. PLoS Curr (2010) 0.79
Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response. FEBS J (2006) 0.79
The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells. J Clin Invest (2013) 0.79