Published in Science on March 07, 2002
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Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J (2004) 4.57
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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93
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Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A (2003) 3.28
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From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev (2010) 3.11
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Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J (2004) 2.50
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest (2009) 2.46
Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest (2007) 2.39
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Free radicals and senescence. Exp Cell Res (2008) 1.79
Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages. J Immunol (2008) 1.77
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FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab (2010) 1.72
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FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature (2016) 1.66
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Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan. Am J Pathol (2008) 1.56
In control of biology: of mice, men and Foxes. Biochem J (2006) 1.50
Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1. J Clin Endocrinol Metab (2009) 1.49
Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Mol Cell Biol (2006) 1.45
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A (2004) 1.43
FOXO4-knockdown suppresses oxidative stress-induced apoptosis of early pro-angiogenic cells and augments their neovascularization capacities in ischemic limbs. PLoS One (2014) 1.41
The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis. Mitochondrion (2011) 1.40
Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes. J Biol Chem (2009) 1.40
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity. Nat Chem Biol (2009) 1.40
p66Shc-generated oxidative signal promotes fat accumulation. J Biol Chem (2008) 1.39
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. Mol Cell Biol (2004) 1.38
Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci U S A (2006) 1.37
FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Mol Cell Biol (2009) 1.35
Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression. Am J Pathol (2007) 1.35
Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species. Cancer Res (2009) 1.34
Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm. EMBO Rep (2004) 1.33
Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol Syst Biol (2011) 1.32
FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci (2014) 1.32
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A (2009) 1.32
Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress. Mol Biol Cell (2004) 1.32
Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging. Curr Vasc Pharmacol (2005) 1.29
Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice. PLoS One (2009) 1.28
Forkhead transcription factors and cardiovascular biology. Circ Res (2008) 1.28
Role of forkhead transcription factors in diabetes-induced oxidative stress. Exp Diabetes Res (2012) 1.27
FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts. J Biol Chem (2008) 1.25
Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis. J Biol Chem (2009) 1.24
ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO J (2010) 1.24
Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem (2010) 1.24
FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun (2014) 1.23
SirT3 regulates the mitochondrial unfolded protein response. Mol Cell Biol (2013) 1.23
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. J Cell Biol (2005) 1.22
Mitochondrial reactive oxygen species and cancer. Cancer Metab (2014) 1.20
Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol (2015) 1.19
Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biol (2006) 1.19
A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res (2010) 1.18
A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. PLoS One (2008) 1.18
Long-lived ames dwarf mice are resistant to chemical stressors. J Gerontol A Biol Sci Med Sci (2009) 1.18
P66Shc signals to age. Aging (Albany NY) (2009) 1.18
Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress. Mol Biol Cell (2005) 1.15
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. Circ Res (2009) 1.12
A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun (2014) 1.12
ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress. Mol Biol Cell (2005) 1.11
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Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell (2015) 1.10
Sos-mediated activation of rac1 by p66shc. J Cell Biol (2006) 1.10
P66SHC and ageing: ROS and TOR? Aging (Albany NY) (2010) 1.09
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor. Proc Natl Acad Sci U S A (2011) 1.08
Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells. Mol Cell Biol (2009) 1.07
Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol (2003) 1.07
Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol Cell Biol (2003) 1.07
The role of FOXO1 in β-cell failure and type 2 diabetes mellitus. Nat Rev Endocrinol (2013) 1.07
Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells. PLoS One (2012) 1.06
Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila. EMBO Rep (2011) 1.05
Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res (2010) 1.05
KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS One (2010) 1.05
Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress: modulation by antidepressant treatment. Neuropsychopharmacology (2012) 1.04
Oxidative stress-specific interaction between FANCD2 and FOXO3a. Blood (2009) 1.04
Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt. Mol Biol Cell (2008) 1.04
Permanent embryo arrest: molecular and cellular concepts. Mol Hum Reprod (2008) 1.03
Isotretinoin and FoxO1: A scientific hypothesis. Dermatoendocrinol (2011) 1.02
Redox regulation of FoxO transcription factors. Redox Biol (2015) 1.01
Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system. Antioxid Redox Signal (2012) 1.01
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mitochondria, oxidants, and aging. Cell (2005) 16.11
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med (2003) 13.84
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem (2005) 5.93
Augmented Wnt signaling in a mammalian model of accelerated aging. Science (2007) 5.62
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 4.61
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem (2006) 4.28
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med (2006) 3.81
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol (2013) 3.39
Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med (2008) 3.38
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell (2008) 3.32
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. Proc Natl Acad Sci U S A (2011) 2.73
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab (2011) 2.73
Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease. Arterioscler Thromb Vasc Biol (2004) 2.65
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science (2012) 2.56
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest (2013) 2.50
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging (Albany NY) (2009) 2.45
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
Redox-dependent transcriptional regulation. Circ Res (2005) 2.23
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell (2013) 2.12
Endothelial progenitor cells. Annu Rev Med (2005) 2.11
Free radicals and senescence. Exp Cell Res (2008) 1.79
Regulation of autophagy by the p300 acetyltransferase. J Biol Chem (2009) 1.69
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab (2007) 1.63
Oncogene-induced senescence results in marked metabolic and bioenergetic alterations. Cell Cycle (2012) 1.57
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Rep (2013) 1.56
Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. J Biol Chem (2008) 1.52
Mitochondrial signaling, TOR, and life span. Biol Chem (2006) 1.48
The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism. J Biol Chem (2006) 1.46
Retracted The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature (2012) 1.44
Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha). J Biol Chem (2002) 1.38
Wnt signaling regulates hepatic metabolism. Sci Signal (2011) 1.38
Oxidants painting the cysteine chapel: redox regulation of PTPs. Dev Cell (2002) 1.37
Reactive oxygen species as mediators of cellular senescence. IUBMB Life (2005) 1.34
Redox regulation of Cdc25C. J Biol Chem (2002) 1.32
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res (2008) 1.30
Key tissue targets responsible for anthrax-toxin-induced lethality. Nature (2013) 1.28
Coordination of mitochondrial bioenergetics with G1 phase cell cycle progression. Cell Cycle (2008) 1.27
Mitochondrial metabolism, sirtuins, and aging. Cold Spring Harb Perspect Biol (2012) 1.25
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. J Cell Biol (2005) 1.22
A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol (2011) 1.18
Regulation of cellular oncosis by uncoupling protein 2. J Biol Chem (2002) 1.17
Pharmacology: uncoupling the agony from ecstasy. Nature (2003) 1.17
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nat Med (2013) 1.13
Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2. Circ Res (2004) 1.12
Ageing and the mystery at Arles. Nature (2004) 1.11
BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun (2011) 1.11
Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med (2010) 1.09
Detection and affinity purification of oxidant-sensitive proteins using biotinylated glutathione ethyl ester. Methods Enzymol (2002) 0.96
TOR and aging: less is more. Cell Metab (2007) 0.94
Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules. Hypertension (2009) 0.93
Cell biology: a clean energy programme. Nature (2006) 0.90
Metabolic regulation of the cell cycle. Curr Opin Cell Biol (2013) 0.89
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport. J Biol Chem (2011) 0.89
Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol Cancer Res (2013) 0.88
Cardiac aging and rejuvenation--a sense of humors? N Engl J Med (2013) 0.88
A role for mitochondria as potential regulators of cellular life span. Biochem Biophys Res Commun (2002) 0.86
Oxidants, metabolism, and stem cell biology. Free Radic Biol Med (2011) 0.82
Ageing: a toast to long life. Nature (2003) 0.81
Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A. FEBS Lett (2002) 0.81
Stem cell aging: what bleach can teach. Nat Med (2006) 0.80
GAPDH and the search for alternative energy. Nat Cell Biol (2007) 0.78
Metabolism meets autophagy. Cell Cycle (2010) 0.78
Genetic links between circulating cells and cardiovascular risk. Circ Cardiovasc Genet (2011) 0.77
Preview. The Tortoise, the hare, and the FoxO. Cell Stem Cell (2009) 0.77
Stem cells and oxidants: too little of a bad thing. Cell Metab (2013) 0.76
Effect of a histone deacetylase inhibitor on human cardiac mass. Cardiovasc Drugs Ther (2005) 0.75
The emerging links between sirtuins and autophagy. Methods Mol Biol (2013) 0.75
Cancer gets the Chk'ered flag. Nat Med (2006) 0.75
A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry. Res Sq (2020) 0.75