Published in Proc Natl Acad Sci U S A on April 19, 2010
The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell (2012) 6.80
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The Hippo pathway and human cancer. Nat Rev Cancer (2013) 5.17
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Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev (2012) 4.19
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Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer (2011) 3.06
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The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev (2010) 3.02
Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology (2013) 2.81
YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol (2012) 2.59
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Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. Gastroenterology (2013) 1.58
Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development. Br J Cancer (2010) 1.53
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol (2015) 1.53
Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma. Proc Natl Acad Sci U S A (2013) 1.51
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol (2012) 1.51
AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol (2015) 1.47
Mechanisms of Hippo pathway regulation. Genes Dev (2016) 1.45
Organ size control by Hippo and TOR pathways. Curr Biol (2012) 1.45
cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J (2013) 1.42
Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc Natl Acad Sci U S A (2013) 1.38
YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14. Oncogene (2012) 1.36
An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene (2013) 1.35
Disease implications of the Hippo/YAP pathway. Trends Mol Med (2015) 1.32
Deregulation of Hippo kinase signalling in human hepatic malignancies. Liver Int (2011) 1.31
Mechanisms and mechanics of cell competition in epithelia. Nat Rev Mol Cell Biol (2013) 1.22
Yes-associated protein regulates the hepatic response after bile duct ligation. Hepatology (2012) 1.15
Bile acids activate YAP to promote liver carcinogenesis. Cell Rep (2013) 1.14
Hippo signaling at a glance. J Cell Sci (2010) 1.14
KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. J Biol Chem (2011) 1.14
Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev (2015) 1.12
Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma. BMC Cancer (2011) 1.12
Drosophila cancer models. Dev Dyn (2011) 1.10
Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells. Nat Commun (2015) 1.09
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Cell Rep (2015) 1.08
Regulation of the Hippo pathway and implications for anticancer drug development. Trends Pharmacol Sci (2013) 1.07
The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells. J Cell Sci (2012) 1.04
Molecular insights into NF2/Merlin tumor suppressor function. FEBS Lett (2014) 1.03
A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness. Nat Commun (2015) 1.02
The hippo-yes association protein pathway in liver cancer. Gastroenterol Res Pract (2013) 1.02
A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. Oncotarget (2015) 1.00
Intraovarian control of early folliculogenesis. Endocr Rev (2014) 0.99
Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador/Warts/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemia. Epigenetics (2011) 0.99
Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer. J Hepatol (2015) 0.95
Expression and clinical significance of YAP, TAZ, and AREG in hepatocellular carcinoma. J Immunol Res (2014) 0.94
Merlin in organ size control and tumorigenesis: Hippo versus EGFR? Genes Dev (2010) 0.94
Bmi1 is required for hepatic progenitor cell expansion and liver tumor development. PLoS One (2012) 0.93
YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. Oncogene (2015) 0.92
The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells. Mol Cell Biol (2015) 0.91
Actin cytoskeleton regulates Hippo signaling. PLoS One (2013) 0.91
The hippo pathway in heart development, regeneration, and diseases. Circ Res (2015) 0.91
Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. EMBO J (2012) 0.90
Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions. J Biol Chem (2011) 0.90
The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. EMBO Mol Med (2015) 0.90
Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A (2013) 0.90
A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis. Cell Res (2015) 0.89
Molecular mechanism of size control in development and human diseases. Cell Res (2011) 0.88
Hippo pathway in intestinal homeostasis and tumorigenesis. Protein Cell (2012) 0.88
Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies. Hum Pathol (2012) 0.88
RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer. Oncogenesis (2013) 0.87
Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway. Mol Cancer Res (2015) 0.87
YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues. Mol Cell Biol (2015) 0.87
The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation. Protein Cell (2012) 0.86
NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition. Cancer Discov (2015) 0.86
Mst1 and Mst2 kinases: regulations and diseases. Cell Biosci (2013) 0.85
EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration. Int J Hepatol (2012) 0.84
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches. Front Physiol (2012) 0.84
MST kinases in development and disease. J Cell Biol (2015) 0.84
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development. Nat Commun (2016) 0.83
Hippo and rassf1a Pathways: A Growing Affair. Mol Biol Int (2012) 0.83
Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol (2014) 0.83
α-catenin. A tumor suppressor beyond adherens junctions. Cell Cycle (2014) 0.83
The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol (2016) 0.82
Increased expression of Yes-associated protein 1 in hepatocellular carcinoma with stemness and combined hepatocellular-cholangiocarcinoma. PLoS One (2013) 0.82
Single tumor-initiating cells evade immune clearance by recruiting type II macrophages. Genes Dev (2017) 0.82
Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Sci Signal (2015) 0.81
Two-signal requirement for growth-promoting function of Yap in hepatocytes. Elife (2015) 0.81
YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells. Oncogene (2015) 0.81
A perspective on molecular therapy in cholangiocarcinoma: present status and future directions. Hepat Oncol (2014) 0.81
Lats2 modulates adipocyte proliferation and differentiation via hippo signaling. PLoS One (2013) 0.81
The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer. Oncotarget (2016) 0.80
Prostaglandin E2 Activates YAP and a Positive-signaling Loop to Promote Colon Regeneration Following Colitis but Also Carcinogenesis in Mice. Gastroenterology (2016) 0.79
Emerging role of Hpo signaling and YAP in hepatocellular carcinoma. J Hepatocell Carcinoma (2015) 0.79
Functional role of Mst1/Mst2 in embryonic stem cell differentiation. PLoS One (2013) 0.79
Emerging role of Hippo pathway in gastric and other gastrointestinal cancers. World J Gastroenterol (2016) 0.79
The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget (2016) 0.79
WW45, a Gli1 binding protein, negatively regulated Hedgehog signaling in lung cancer. Oncotarget (2016) 0.78
The centrosomal component CEP161 of Dictyostelium discoideum interacts with the Hippo signaling pathway. Cell Cycle (2015) 0.78
Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Hepatology (2015) 0.78
An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2. Oncotarget (2016) 0.77
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05
Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell (2002) 7.15
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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature (2004) 5.61
Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem (2007) 5.49
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Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1. Am J Physiol Gastrointest Liver Physiol (2007) 1.34
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The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles. J Biol Chem (2004) 1.21
Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1. J Immunol (2010) 1.20
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ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood (2012) 1.14
Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Mol Cell Biol (2006) 1.13
Central lymph node metastasis of unilateral papillary thyroid carcinoma: patterns and factors predictive of nodal metastasis, morbidity, and recurrence. Ann Surg Oncol (2011) 1.12
On the role of notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development. Hepatology (2013) 1.12
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Prediction of occult central lymph node metastasis in papillary thyroid carcinoma by preoperative BRAF analysis using fine-needle aspiration biopsy: a prospective study. J Clin Endocrinol Metab (2012) 1.09
Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: implications for the treatment of human liver cancer. Cell Cycle (2013) 1.08
SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage. Cell Rep (2013) 1.07
Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. Carcinogenesis (2012) 1.07
MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment. Curr Biol (2010) 1.06
Retinoic acids and hepatic stellate cells in liver disease. J Gastroenterol Hepatol (2012) 1.05
Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice. Hepatology (2011) 1.05
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats. Int J Cancer (2004) 1.05
Synergistic role of Sprouty2 inactivation and c-Met up-regulation in mouse and human hepatocarcinogenesis. Hepatology (2010) 1.05
Identification of genes related to Parkinson's disease using expressed sequence tags. DNA Res (2007) 1.05
Genetic analyses of H5N1 avian influenza virus in Mongolia, 2009 and its relationship with those of eastern Asia. Vet Microbiol (2010) 1.05
Electrospinning of chitin nanofibers: degradation behavior and cellular response to normal human keratinocytes and fibroblasts. Biomaterials (2006) 1.04
Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice. J Pathol (2009) 1.04
Protective effect of ginseng polysaccharides on influenza viral infection. PLoS One (2012) 1.03
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Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy. Autophagy (2010) 1.01
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CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice. Hepatology (2012) 1.01
Reversing the intractable nature of pancreatic cancer by selectively targeting ALDH-high, therapy-resistant cancer cells. PLoS One (2013) 1.00
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