Published in J Biol Chem on December 08, 2009
Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem (2012) 1.10
Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis. J Biol Chem (2013) 1.07
High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Cancer Res (2010) 0.97
Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells. BMC Cancer (2011) 0.96
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J Mol Med (Berl) (2010) 0.96
Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines. Bioorg Med Chem (2012) 0.90
Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. ACS Chem Biol (2012) 0.90
Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis. PLoS One (2014) 0.87
Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise. Chem Res Toxicol (2012) 0.86
Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. J Am Chem Soc (2011) 0.85
Alternative approaches to Hsp90 modulation for the treatment of cancer. Future Med Chem (2014) 0.84
Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat Commun (2016) 0.82
Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges. Pharmaceuticals (Basel) (2011) 0.81
Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease. Expert Opin Ther Targets (2014) 0.81
Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way. Cell Stress Chaperones (2010) 0.78
Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity. Bioorg Med Chem (2014) 0.77
Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease. Curr Top Med Chem (2016) 0.77
Heat shock protein 90: its inhibition and function. Philos Trans R Soc Lond B Biol Sci (2018) 0.77
Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1. Br J Pharmacol (2014) 0.76
Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells. J Biol Chem (2015) 0.76
Alteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase. Plant Signal Behav (2014) 0.75
The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles. Front Microbiol (2016) 0.75
Hsp90 activator Aha1 drives production of pathological tau aggregates. Proc Natl Acad Sci U S A (2017) 0.75
Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases. Front Med (Lausanne) (2017) 0.75
Adapting proteostasis for disease intervention. Science (2008) 13.22
HSP90 and the chaperoning of cancer. Nat Rev Cancer (2005) 11.98
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med (Maywood) (2003) 8.04
Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci (1993) 7.92
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell (1997) 6.12
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell (1997) 5.73
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature (2006) 5.42
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell (2006) 5.01
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell (2006) 4.52
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener (2007) 4.15
The Hsp90 chaperone machinery. J Biol Chem (2008) 3.79
The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem J (2008) 3.33
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res (2006) 3.10
Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23. Science (1996) 2.84
Chaperone function of Hsp90-associated proteins. Science (1996) 2.66
The binding of thioflavin-T to amyloid fibrils: localisation and implications. J Struct Biol (2005) 2.56
Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem (2004) 2.45
Targeting Hsp90: small-molecule inhibitors and their clinical development. Curr Opin Pharmacol (2008) 2.41
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther (2008) 2.07
Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis. Cancer Sci (2007) 1.96
The assembly of progesterone receptor-hsp90 complexes using purified proteins. J Biol Chem (1998) 1.90
Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70. J Biol Chem (1997) 1.81
Hsp90 and Cdc37 -- a chaperone cancer conspiracy. Curr Opin Genet Dev (2005) 1.78
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell (2008) 1.69
Therapeutic strategies for human amyloid diseases. Nat Rev Drug Discov (2002) 1.63
Heat shock proteins and cardiac protection. Cardiovasc Res (2001) 1.55
Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biol (2008) 1.42
Discovery and development of heat shock protein 90 inhibitors. Bioorg Med Chem (2008) 1.36
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones. J Biol Chem (2005) 1.36
Hsp90: the vulnerable chaperone. Drug Discov Today (2004) 1.35
p23, a simple protein with complex activities. Cell Stress Chaperones (2003) 1.34
Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol. Angew Chem Int Ed Engl (2009) 1.34
The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol (2006) 1.28
Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J Biol Chem (2000) 1.23
Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clin Cancer Res (2007) 1.20
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci Biotechnol Biochem (2003) 1.20
Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production. J Nat Prod (2002) 1.18
GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol (2006) 1.17
An unstructured C-terminal region of the Hsp90 co-chaperone p23 is important for its chaperone function. J Mol Biol (1999) 1.14
Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Cancer Lett (2008) 1.11
Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking. J Biol Chem (2006) 1.10
Tripterine inhibits the expression of adhesion molecules in activated endothelial cells. J Leukoc Biol (2006) 1.01
Localization of sites of interaction between p23 and Hsp90 in solution. J Biol Chem (2006) 1.01
The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes. J Steroid Biochem Mol Biol (1996) 0.99
Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR). Cell Stress Chaperones (2007) 0.90
Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
The BRCT domain is a phospho-protein binding domain. Science (2003) 7.42
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Utilization and outcomes of minimally invasive radical prostatectomy. J Clin Oncol (2008) 4.23
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med (2005) 4.00
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. Lancet Neurol (2008) 3.41
Substrate-targeting gamma-secretase modulators. Nature (2008) 3.38
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol (2013) 3.18
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nat Neurosci (2005) 3.17
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet (2011) 3.16
Gonadotropin-releasing hormone agonists and fracture risk: a claims-based cohort study of men with nonmetastatic prostate cancer. J Clin Oncol (2005) 2.87
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J (2012) 2.34
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem (2003) 2.31
The National Report Card on the State of Emergency Medicine: evaluating the emergency care environment state by state 2009 edition. Ann Emerg Med (2009) 2.28
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood (2008) 2.24
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Marine cloud brightening. Philos Trans A Math Phys Eng Sci (2012) 2.23
Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nat Struct Mol Biol (2007) 2.22
Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study. Clin Ther (2010) 2.19
Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay. J Clin Virol (2011) 2.19
Hypothesis testing and power calculations for taxonomic-based human microbiome data. PLoS One (2012) 2.15
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A (2010) 2.06
Investigation of resistive switching in Cu-doped HfO2 thin film for multilevel non-volatile memory applications. Nanotechnology (2009) 2.06
Membrane trafficking of G protein-coupled receptors. Annu Rev Pharmacol Toxicol (2004) 1.94
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet (2013) 1.88
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure (2004) 1.82
19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res (2012) 1.81
CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol Cancer Ther (2007) 1.80
Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A (2007) 1.74
Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci U S A (2012) 1.71
Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood (2008) 1.69
Retracted Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J Immunol (2008) 1.69
Natural history of bone complications in men with prostate carcinoma initiating androgen deprivation therapy. Cancer (2004) 1.64
Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis (2012) 1.62
Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4. Structure (2010) 1.58
Medicago truncatula mutants demonstrate the role of plant calcium oxalate crystals as an effective defense against chewing insects. Plant Physiol (2006) 1.57
Prognostic significance of HER2 expression based on trastuzumab for gastric cancer (ToGA) criteria in gastric cancer: an updated meta-analysis. Tumour Biol (2014) 1.56
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem (2007) 1.55
Clinical manifestation and management of primary malignant tumors of the cervical trachea. Eur Arch Otorhinolaryngol (2013) 1.53
Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J (2011) 1.52
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet (2013) 1.52
Assessment of four DNA fragments (COI, 16S rDNA, ITS2, 12S rDNA) for species identification of the Ixodida (Acari: Ixodida). Parasit Vectors (2014) 1.51
ERCC2/XPD Lys751Gln and Asp312Asn gene polymorphism and lung cancer risk: a meta-analysis involving 22 case-control studies. J Thorac Oncol (2010) 1.51
Altered dimer interface decreases stability in an amyloidogenic protein. J Biol Chem (2008) 1.50
The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex. J Biol Chem (2002) 1.48
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res (2013) 1.48
The effect of concomitant prolapse repair on sling outcomes. J Urol (2008) 1.47
The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem (2006) 1.45
Retracted Ferroportin in the progression and prognosis of hepatocellular carcinoma. Eur J Med Res (2013) 1.43
The effects of sodium sulfate, glycosaminoglycans, and Congo red on the structure, stability, and amyloid formation of an immunoglobulin light-chain protein. Protein Sci (2006) 1.42
Complications of sling surgery among female Medicare beneficiaries. Obstet Gynecol (2007) 1.41
Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis. J Thorac Oncol (2009) 1.41
Thromboembolic complications of sling surgery for stress urinary incontinence among female Medicare beneficiaries. Urology (2009) 1.41
Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II. Biochem Biophys Res Commun (2008) 1.40
Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease. J Alzheimers Dis (2005) 1.39
Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid. Neurobiol Aging (2005) 1.39
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. Am J Hum Genet (2013) 1.39
Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet (2013) 1.38
Characterization of protein kinase CK2 from Trypanosoma brucei. Mol Biochem Parasitol (2006) 1.37
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones. J Biol Chem (2005) 1.36
Direct treatment cost of atrial fibrillation in the elderly American population: a Medicare perspective. J Med Econ (2008) 1.35
Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus. J Biol Chem (2001) 1.34
The effect of age on outcomes of sling surgery for urinary incontinence. J Am Geriatr Soc (2007) 1.34
Systemic amyloidoses. Annu Rev Biochem (2013) 1.34
An exploratory instrumental variable analysis of the outcomes of localized breast cancer treatments in a medicare population. Health Econ (2003) 1.34
Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults. Arch Neurol (2005) 1.33
The NOG1 GTP-binding protein is required for biogenesis of the 60 S ribosomal subunit. J Biol Chem (2003) 1.33
Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report. Blood (2002) 1.32
Molecular chaperones function as steroid receptor nuclear mobility factors. Proc Natl Acad Sci U S A (2004) 1.32
Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells. J Immunol (2006) 1.31
A study of cycling induced degradation mechanisms in Si nanocrystal memory devices. Nanotechnology (2011) 1.30
Structural basis for the recognition of methylated histone H3K36 by the Eaf3 subunit of histone deacetylase complex Rpd3S. Structure (2008) 1.29
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer. J Clin Oncol (2012) 1.29
A group II intron-encoded maturase functions preferentially in cis and requires both the reverse transcriptase and X domains to promote RNA splicing. J Mol Biol (2004) 1.27
Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em. Sci STKE (2007) 1.26
Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer. Cancer Epidemiol Biomarkers Prev (2011) 1.23
Notch regulates cytolytic effector function in CD8+ T cells. J Immunol (2009) 1.22
Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106. Nature (2012) 1.21
Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate. Biochemistry (2003) 1.21
Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2. Blood (2008) 1.21
Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. Proc Natl Acad Sci U S A (2005) 1.20
Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cells. J Immunol (2008) 1.20
In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques. J Neurochem (2007) 1.19
Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ Res (2007) 1.19
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem (2007) 1.19
The role of provider volume on outcomes after sling surgery for stress urinary incontinence. J Urol (2007) 1.18
Activation of Rho kinase isoforms in lung endothelial cells during inflammation. J Immunol (2009) 1.18
GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol (2006) 1.17
Arabidopsis cryptochrome 2 (CRY2) functions by the photoactivation mechanism distinct from the tryptophan (trp) triad-dependent photoreduction. Proc Natl Acad Sci U S A (2011) 1.15