PubRank

Lori Sussel

Author PubWeight™ 54.52‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell 2012 4.88
2 Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A 2004 2.91
3 Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab 2012 2.22
4 Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab 2010 1.88
5 A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 2006 1.79
6 The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol 2004 1.59
7 Gata6 is an important regulator of mouse pancreas development. Dev Biol 2006 1.58
8 FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol 2006 1.58
9 Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest 2012 1.55
10 Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev 2011 1.48
11 Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. J Biol Chem 2002 1.33
12 Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol 2007 1.27
13 Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development 2007 1.18
14 Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development 2009 1.11
15 Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol 2011 1.10
16 Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem 2009 1.09
17 A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development 2010 1.07
18 Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol 2007 1.06
19 Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development 2011 1.03
20 Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol 2009 1.02
21 Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol 2010 0.99
22 Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One 2012 0.97
23 Nkx2.2 regulates beta-cell function in the mature islet. Diabetes 2007 0.96
24 Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet 2013 0.96
25 The endocrine pancreas: insights into development, differentiation, and diabetes. Wiley Interdiscip Rev Dev Biol 2012 0.94
26 Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis 2012 0.93
27 GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2. Cereb Cortex 2009 0.92
28 The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development 2011 0.90
29 β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab 2014 0.90
30 Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept 2009 0.88
31 Pancreatic β cell identity requires continual repression of non-β cell programs. J Clin Invest 2016 0.88
32 Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine. Am J Pathol 2009 0.88
33 LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest 2016 0.87
34 ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol 2012 0.87
35 Generation of mice encoding a conditional allele of Nkx2.2. Transgenic Res 2013 0.87
36 Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol Endocrinol 2009 0.87
37 Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development. Dev Dyn 2014 0.86
38 Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. BMC Bioinformatics 2011 0.86
39 Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Development 2014 0.85
40 A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PLoS Genet 2013 0.85
41 Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One 2013 0.84
42 Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Genesis 2013 0.80
43 Pancreatic islet cell development and regeneration. Curr Opin Endocrinol Diabetes Obes 2015 0.79
44 The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Membr Transp Signal 2012 0.78
45 Engineering islets: lessons from stem cells and embryonic development. Endocrinol Metab Clin North Am 2004 0.75
46 Noncoding RNAs in β cell biology. Curr Opin Endocrinol Diabetes Obes 2015 0.75
47 Advances in pancreas development: generation informs regeneration. Semin Cell Dev Biol 2012 0.75
48 Time to look back and to look forward. Diabetes 2014 0.75