Published in Mol Cell on December 11, 2009
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Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res (2010) 1.82
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol (2013) 1.72
The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nat Rev Mol Cell Biol (2017) 1.38
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J (2011) 1.28
Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. Cell Rep (2013) 1.19
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Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery. Genes Dev (2013) 1.14
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1. Nucleic Acids Res (2010) 1.13
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Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε. PLoS Genet (2011) 0.95
Replication checkpoint: tuning and coordination of replication forks in s phase. Genes (Basel) (2013) 0.95
ETAA1 acts at stalled replication forks to maintain genome integrity. Nat Cell Biol (2016) 0.95
Activation of the ATR kinase by the RPA-binding protein ETAA1. Nat Cell Biol (2016) 0.94
Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication. Mol Cell (2015) 0.93
The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint. J Biol Chem (2011) 0.92
The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner. PLoS Genet (2012) 0.90
Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex. Genes Dev (2015) 0.90
Four pillars of the S-phase checkpoint. Genes Dev (2013) 0.89
Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks. Nucleic Acids Res (2015) 0.89
An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genet (2013) 0.88
HERC2-USP20 axis regulates DNA damage checkpoint through Claspin. Nucleic Acids Res (2014) 0.88
The yeast mitogen-activated protein kinase Slt2 is involved in the cellular response to genotoxic stress. Cell Div (2012) 0.85
Yet another job for Dna2: Checkpoint activation. DNA Repair (Amst) (2015) 0.84
Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint. PLoS Genet (2012) 0.83
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Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response. J Biol Chem (2013) 0.83
Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism. PLoS Genet (2014) 0.83
Assembly of Slx4 signaling complexes behind DNA replication forks. EMBO J (2015) 0.83
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates. PLoS One (2011) 0.82
Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell (2012) 0.82
Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. J Biol Chem (2011) 0.82
The 9-1-1 checkpoint clamp coordinates resection at DNA double strand breaks. Nucleic Acids Res (2015) 0.81
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. Nucleic Acids Res (2014) 0.81
Genetic instability in budding and fission yeast-sources and mechanisms. FEMS Microbiol Rev (2015) 0.80
Role of the checkpoint clamp in DNA damage response. Biomolecules (2013) 0.80
RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling. Cell Cycle (2015) 0.79
Checkpoint Mec-tivation comes in many flavors. Mol Cell (2009) 0.79
The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast. J Biol Chem (2011) 0.79
Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding. J Biol Chem (2015) 0.78
RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Curr Biol (2016) 0.78
Leveraging DNA damage response signaling to identify yeast genes controlling genome stability. G3 (Bethesda) (2015) 0.78
Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint. PLoS Genet (2017) 0.78
Rad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombe. PLoS One (2014) 0.77
Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides. J Biol Chem (2015) 0.76
Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle (2010) 0.76
Multi-BRCT scaffolds use distinct strategies to support genome maintenance. Cell Cycle (2016) 0.76
The Intra-S Checkpoint Responses to DNA Damage. Genes (Basel) (2017) 0.76
Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance. Biomolecules (2012) 0.75
Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast. PLoS One (2017) 0.75
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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature (2001) 6.55
TopBP1 activates the ATR-ATRIP complex. Cell (2006) 6.29
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Initiating cellular stress responses. Cell (2004) 4.18
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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev (2007) 3.58
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev (2000) 3.40
Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A (2003) 2.72
A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr Biol (2000) 2.59
Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex. DNA Repair (Amst) (2004) 2.55
The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. EMBO J (1997) 2.48
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell (2006) 2.27
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell (2002) 2.22
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev (2004) 2.16
Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions. J Biol Chem (2006) 2.00
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell (2008) 1.94
Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics (2002) 1.66
Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J (2004) 1.65
DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc Natl Acad Sci U S A (2006) 1.64
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem (2008) 1.61
Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A (2008) 1.58
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. Proc Natl Acad Sci U S A (2007) 1.54
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol (2008) 1.54
Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway. Mol Cell Biol (2001) 1.53
Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation. Mol Cell (2009) 1.31
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) (2009) 1.29
Crystal structure of the human rad9-hus1-rad1 clamp. J Mol Biol (2009) 1.27
A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proc Natl Acad Sci U S A (2002) 1.23
His239Arg SNP of HRAD9 is associated with lung adenocarcinoma. Cancer (2006) 0.89
A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A (2002) 0.89
A defined human system that supports bidirectional mismatch-provoked excision. Mol Cell (2004) 3.17
Dividing the workload at a eukaryotic replication fork. Trends Cell Biol (2008) 2.94
Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1. Proc Natl Acad Sci U S A (2005) 2.62
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication. Genes Dev (2004) 2.51
RNase H2-initiated ribonucleotide excision repair. Mol Cell (2012) 2.17
RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell (2012) 1.74
Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis. J Biol Chem (2008) 1.73
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev (2010) 1.71
Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C. Genes Dev (2005) 1.62
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem (2008) 1.61
PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta. Mol Cell (2009) 1.52
The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. Mol Cell Biol (2005) 1.51
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA. Nucleic Acids Res (2007) 1.49
Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Res (2008) 1.39
A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis. Nucleic Acids Res (2012) 1.35
The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta. Nucleic Acids Res (2009) 1.31
Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ. DNA Repair (Amst) (2012) 1.29
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) (2009) 1.29
RNase H2 roles in genome integrity revealed by unlinking its activities. Nucleic Acids Res (2013) 1.19
Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases. DNA Repair (Amst) (2011) 1.15
Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery. Genes Dev (2013) 1.14
Lesion bypass by S. cerevisiae Pol ζ alone. DNA Repair (Amst) (2011) 0.95
The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint. J Biol Chem (2011) 0.92
Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase. Biochem Soc Trans (2011) 0.89
Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint. DNA Repair (Amst) (2005) 0.83
It's all about flaps: Dna2 and checkpoint activation. Cell Cycle (2011) 0.76
Human exonuclease 5 is a novel sliding exonuclease required for genome stability. J Biol Chem (2012) 0.75