Published in Mol Cell Biol on June 09, 2008
Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet (2010) 2.66
The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol Cell (2009) 2.11
Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell (2009) 1.73
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol (2013) 1.72
Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint. Mol Cell (2012) 1.70
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem (2008) 1.61
Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A (2008) 1.58
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) (2009) 1.29
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J (2011) 1.28
Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae. Genetics (2014) 1.27
Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response. Nat Struct Mol Biol (2010) 1.23
Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae. DNA Repair (Amst) (2009) 1.22
DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9. Nature (2012) 1.22
Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery. Genes Dev (2013) 1.14
Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity. PLoS Genet (2010) 1.12
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res (2014) 1.10
Mind the gap: keeping UV lesions in check. DNA Repair (Amst) (2011) 1.05
A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication. Genes Dev (2014) 1.01
Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1. Proc Natl Acad Sci U S A (2010) 1.00
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle. Cell Cycle (2014) 0.97
A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae. Nucleic Acids Res (2010) 0.96
Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε. PLoS Genet (2011) 0.95
Replication checkpoint: tuning and coordination of replication forks in s phase. Genes (Basel) (2013) 0.95
Activation of protein kinase Tel1 through recognition of protein-bound DNA ends. Mol Cell Biol (2011) 0.93
Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication. Mol Cell (2015) 0.93
Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break. PLoS Genet (2015) 0.93
The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint. J Biol Chem (2011) 0.92
The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner. PLoS Genet (2012) 0.90
Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions. EMBO J (2015) 0.90
Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks. Nucleic Acids Res (2015) 0.89
Four pillars of the S-phase checkpoint. Genes Dev (2013) 0.89
Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation. Cell Cycle (2012) 0.88
Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance. PLoS Genet (2011) 0.86
Yet another job for Dna2: Checkpoint activation. DNA Repair (Amst) (2015) 0.84
Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint. PLoS Genet (2012) 0.83
Assembly of Slx4 signaling complexes behind DNA replication forks. EMBO J (2015) 0.83
Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism. PLoS Genet (2014) 0.83
Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell (2012) 0.82
Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1. PLoS Genet (2013) 0.81
The 9-1-1 checkpoint clamp coordinates resection at DNA double strand breaks. Nucleic Acids Res (2015) 0.81
Role of the checkpoint clamp in DNA damage response. Biomolecules (2013) 0.80
Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase. Genetics (2015) 0.79
TOPBP1(Dpb11) plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1(Rad9). J Cell Biol (2017) 0.78
The many roads to checkpoint activation. Cell Cycle (2012) 0.78
Cell biology of mitotic recombination. Cold Spring Harb Perspect Biol (2015) 0.76
Multi-BRCT scaffolds use distinct strategies to support genome maintenance. Cell Cycle (2016) 0.76
Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection. Elife (2017) 0.75
Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance. Biomolecules (2012) 0.75
A cell cycle-independent mode of the Rad9-Dpb11 interaction is induced by DNA damage. Sci Rep (2017) 0.75
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast (1998) 48.29
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
Cell-cycle checkpoints and cancer. Nature (2004) 13.19
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell (2004) 9.74
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature (2004) 6.72
TopBP1 activates the ATR-ATRIP complex. Cell (2006) 6.29
The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell (2004) 4.99
Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature (2006) 4.94
The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci (2006) 4.67
Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J (1999) 4.64
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science (1998) 4.59
Initiating cellular stress responses. Cell (2004) 4.18
A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol (2002) 4.10
Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc Natl Acad Sci U S A (1995) 3.59
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev (2007) 3.58
Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol (2002) 3.12
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev (2000) 2.82
Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A (2003) 2.72
Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol Cell (2001) 2.70
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem (2007) 2.68
Identification of novel histone post-translational modifications by peptide mass fingerprinting. Chromosoma (2003) 2.67
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol (2005) 2.48
The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. EMBO J (1997) 2.48
Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst) (2005) 2.46
Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J (1998) 2.34
Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae. Mol Cell Biol (2005) 2.33
Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell (2002) 2.30
The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem (2005) 2.27
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev (2006) 2.27
DNA damage checkpoint in budding yeast. EMBO J (1998) 2.25
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell (2002) 2.22
LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J (2000) 2.22
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev (2004) 2.16
The DNA damage response: sensing and signaling. Curr Opin Cell Biol (2004) 2.13
DNA structure dependent checkpoints as regulators of DNA repair. DNA Repair (Amst) (2002) 1.88
Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol (2000) 1.66
Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Rep (2007) 1.66
Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics (2002) 1.66
Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J (2004) 1.65
Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin. J Biol Chem (2003) 1.53
The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1. Genes Cells (2006) 1.42
Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation. DNA Repair (Amst) (2006) 1.40
Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Proc Natl Acad Sci U S A (2006) 1.32
Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain. Yeast (2007) 1.29
De novo synthesis of budding yeast DNA polymerase alpha and POL1 transcription at the G1/S boundary are not required for entrance into S phase. Proc Natl Acad Sci U S A (1993) 1.12
TOPping up ATR activity. Cell (2006) 0.94
Dpb11, the budding yeast homolog of TopBP1, functions with the checkpoint clamp in recombination repair. Nucleic Acids Res (2006) 0.90
Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication. Mol Biol Cell (2006) 0.87
Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet (2010) 2.66
The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem (2005) 2.27
Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair. Mol Cell (2010) 1.90
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J (2008) 1.90
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J (2008) 1.89
RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell (2012) 1.74
Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J (2004) 1.65
DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc Natl Acad Sci U S A (2006) 1.64
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell (2013) 1.44
Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways. DNA Repair (Amst) (2008) 1.33
Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation. Mol Cell (2010) 1.33
The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. J Biol Chem (2005) 1.31
Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage. Mol Cell Biol (2011) 1.23
Checkpoint mechanisms at the intersection between DNA damage and repair. DNA Repair (Amst) (2009) 1.18
Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity. PLoS Genet (2010) 1.12
Yeast Rev1 is cell cycle regulated, phosphorylated in response to DNA damage and its binding to chromosomes is dependent upon MEC1. DNA Repair (Amst) (2006) 1.11
Hedgehogs, humans and high-school science. The benefits of involving high-school students in university research. EMBO Rep (2008) 1.08
One-step high-throughput assay for quantitative detection of beta-galactosidase activity in intact gram-negative bacteria, yeast, and mammalian cells. Biotechniques (2006) 1.07
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol (2009) 1.05
Mind the gap: keeping UV lesions in check. DNA Repair (Amst) (2011) 1.05
Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation. Proc Natl Acad Sci U S A (2011) 1.02
The DNA polymerase alpha-primase complex: multiple functions and interactions. ScientificWorldJournal (2003) 0.99
Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway. PLoS Genet (2010) 0.96
Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε. PLoS Genet (2011) 0.95
NER and DDR: classical music with new instruments. Cell Cycle (2012) 0.94
The self-locating catheter: clinical experience and follow-up. Perit Dial Int (2004) 0.90
A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A (2002) 0.89
14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks. PLoS Genet (2011) 0.87
Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle (2006) 0.83
Yeast haspin kinase regulates polarity cues necessary for mitotic spindle positioning and is required to tolerate mitotic arrest. Dev Cell (2013) 0.83
To trim or not to trim: progression and control of DSB end resection. Cell Cycle (2013) 0.82
Prevalence and progression of cardiovascular calcifications in peritoneal dialysis patients: A prospective study. Bone (2012) 0.82
Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex. DNA Repair (Amst) (2010) 0.82
Saccharomyces CDK1 phosphorylates Rad53 kinase in metaphase, influencing cellular morphogenesis. J Biol Chem (2009) 0.81
DNA decay and limited Rad53 activation after liquid holding of UV-treated nucleotide excision repair deficient S. cerevisiae cells. DNA Repair (Amst) (2004) 0.80
In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae. BMC Syst Biol (2013) 0.78
A blooming resolvase at chromosomal fragile sites. Nat Cell Biol (2013) 0.77
Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1. J Biol Chem (2003) 0.77
Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival. PLoS One (2013) 0.76
Checkpoint response to DNA damage. DNA Repair (Amst) (2009) 0.75
The interplay among chromatin dynamics, cell cycle checkpoints and repair mechanisms modulates the cellular response to DNA damage. Ital J Biochem (2007) 0.75
[Hemoperitoneum after drop-out from peritoneal dialysis]. G Ital Nefrol (2014) 0.75
The human pendrin promoter contains two N(4) GAS motifs with different functional relevance. Cell Physiol Biochem (2013) 0.75
[Pharmacological and nutritional problems in pregnant patient on chronic dialysis]. G Ital Nefrol (2017) 0.75
Sometimes size does matter. Eur J Cancer (2003) 0.75