Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

PubWeight™: 18.29‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMID 12791985)

Published in Science on June 06, 2003

Authors

Lee Zou1, Stephen J Elledge

Author Affiliations

1: Verna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Articles citing this

(truncated to the top 100)

The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13

ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86

Human CtIP promotes DNA end resection. Nature (2007) 10.63

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell (2008) 7.63

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature (2004) 6.94

Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53

DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev (2008) 5.07

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54

A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res (2006) 4.49

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol (2004) 4.35

The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J (2003) 3.91

Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A (2003) 3.88

The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J (2004) 3.87

BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol (2009) 3.79

Causes and consequences of replication stress. Nat Cell Biol (2014) 3.70

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev (2003) 3.59

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev (2007) 3.58

The structural determinants of checkpoint activation. Genes Dev (2007) 3.53

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell (2010) 3.51

ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev (2004) 3.44

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35

DNA end resection: many nucleases make light work. DNA Repair (Amst) (2009) 3.28

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol (2008) 3.22

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A (2004) 3.12

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell (2009) 3.12

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell (2005) 3.08

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J (2006) 3.05

Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol Cell (2008) 3.02

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J (2009) 2.99

Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol (2004) 2.97

Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev (2008) 2.86

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev (2005) 2.85

Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J Cell Physiol (2006) 2.83

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature (2010) 2.79

Two faces of p53: aging and tumor suppression. Nucleic Acids Res (2007) 2.78

Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem (2006) 2.76

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell (2006) 2.73

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell (2006) 2.61

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61

Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals. J Cell Biol (2007) 2.55

Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell (2011) 2.50

Homologous recombination and its regulation. Nucleic Acids Res (2012) 2.44

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev (2009) 2.44

DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev (2008) 2.40

ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. Br J Cancer (2008) 2.33

Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev (2004) 2.33

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell (2010) 2.29

The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell (2006) 2.27

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev (2006) 2.27

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J (2006) 2.25

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science (2015) 2.24

Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes. Nat Rev Mol Cell Biol (2009) 2.23

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J (2008) 2.21

Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev (2004) 2.20

The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J (2004) 2.20

The annealing helicase HARP protects stalled replication forks. Genes Dev (2009) 2.19

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature (2011) 2.17

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol (2008) 2.17

Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev (2005) 2.17

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev (2012) 2.16

Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a. Mol Cell (2008) 2.16

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev (2004) 2.16

The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol Cell (2009) 2.11

CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol (2006) 2.09

Rif1 and rif2 inhibit localization of tel1 to DNA ends. Mol Cell (2009) 2.09

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs. Mol Oncol (2011) 2.07

BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol (2009) 2.06

The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol (2010) 2.06

Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol (2007) 2.02

ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci (2010) 1.96

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol Cell (2013) 1.95

Nbs1 is required for ATR-dependent phosphorylation events. EMBO J (2004) 1.95

Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J (2005) 1.94

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell (2008) 1.94

Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1. Mol Cell Biol (2004) 1.94

ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana. Plant Cell (2004) 1.93

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene (2006) 1.93

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO J (2010) 1.92

Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell (2009) 1.92

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A (2003) 1.90

The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling. EMBO Rep (2006) 1.89

Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J (2008) 1.89

Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol Cell Biol (2004) 1.89

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res (2006) 1.88

Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J (2009) 1.88

Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition. Cell Cycle (2011) 1.87

Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol (2007) 1.87

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell (2009) 1.86

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery. Nat Cell Biol (2012) 1.86

RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem (2013) 1.86

The ubiquitin landscape at DNA double-strand breaks. J Cell Biol (2009) 1.86

Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest. Mol Cell Biol (2006) 1.85

Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Res (2006) 1.84

Articles by these authors

(truncated to the top 100)

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11

The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13

Dicer is essential for mouse development. Nat Genet (2003) 15.87

Identification of host proteins required for HIV infection through a functional genomic screen. Science (2008) 12.44

The DNA damage response: ten years after. Mol Cell (2007) 11.80

Principles of cancer therapy: oncogene and non-oncogene addiction. Cell (2009) 10.96

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96

A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell (2009) 8.64

Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88

Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nat Methods (2007) 7.56

MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68

A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36

A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61

Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29

53BP1, a mediator of the DNA damage checkpoint. Science (2002) 5.00

RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93

The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature (2003) 4.79

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A (2007) 4.75

Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev (2004) 4.68

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev (2002) 4.58

Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev (2009) 4.23

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14

Global protein stability profiling in mammalian cells. Science (2008) 3.91

Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A (2003) 3.88

Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol (2002) 3.66

The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol (2007) 3.63

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev (2003) 3.59

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell (2010) 3.51

A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (2011) 3.49

Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science (2012) 3.41

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 3.40

A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A (2009) 3.37

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A (2010) 3.31

Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell (2011) 3.27

Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog (2011) 3.26

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell (2013) 3.26

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev (2009) 3.23

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol (2008) 3.22

Non-oncogene addiction and the stress phenotype of cancer cells. Cell (2007) 3.19

Global identification of modular cullin-RING ligase substrates. Cell (2011) 3.13

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A (2004) 3.12

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08

IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog (2011) 2.99

Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell (2004) 2.94

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86

The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell (2002) 2.85

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature (2008) 2.84

Multiple tumor suppressor pathways negatively regulate telomerase. Cell (2003) 2.82

Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell (2011) 2.82

Lessons from Nature: microRNA-based shRNA libraries. Nat Methods (2006) 2.80

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66

MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules. Nat Genet (2005) 2.63

Design of 240,000 orthogonal 25mer DNA barcode probes. Proc Natl Acad Sci U S A (2009) 2.61

The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev (2002) 2.60

Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science (2008) 2.53

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol (2012) 2.51

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev (2009) 2.44

Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step. Nat Genet (2001) 2.21

An open letter to Elias Zerhouni. Science (2005) 2.19

FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell (2008) 2.14

Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem (2003) 2.03

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol (2007) 2.00

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev (2010) 1.98

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med (2012) 1.97

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell (2008) 1.94

Autoantigen discovery with a synthetic human peptidome. Nat Biotechnol (2011) 1.90

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A (2005) 1.90

Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication. Mol Cell (2009) 1.85

Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep (2012) 1.84

Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc Natl Acad Sci U S A (2006) 1.81

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A (2007) 1.79

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science (2011) 1.79

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell (2012) 1.79

Systematic identification of synergistic drug pairs targeting HIV. Nat Biotechnol (2012) 1.77

Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A (2010) 1.76

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem (2004) 1.74

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev (2010) 1.74

Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev (2010) 1.71

Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics (2002) 1.66

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell (2006) 1.65

An open letter to cancer researchers. Science (2005) 1.65

Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev (2003) 1.64

SLIC: a method for sequence- and ligation-independent cloning. Methods Mol Biol (2012) 1.64

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci U S A (2004) 1.62

The tumor suppressor CYLD regulates entry into mitosis. Proc Natl Acad Sci U S A (2007) 1.61

Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Science (2011) 1.58

The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. J Virol (2013) 1.54

Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. Genes Dev (2006) 1.51

A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell (2010) 1.50

Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Mol Cell (2008) 1.42