Published in Cell on March 10, 2006
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev (2007) 3.58
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol (2011) 3.10
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev (2008) 2.86
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell (2006) 2.73
Eukaryotic DNA replication origins: many choices for appropriate answers. Nat Rev Mol Cell Biol (2010) 2.56
The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol (2007) 2.54
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev (2009) 2.50
Lack of p21 expression links cell cycle control and appendage regeneration in mice. Proc Natl Acad Sci U S A (2010) 2.41
DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev (2008) 2.40
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev (2008) 2.17
The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol (2008) 2.17
The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol Cell (2009) 2.11
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol (2006) 2.09
Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs. Mol Oncol (2011) 2.07
Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell (2010) 2.06
Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol (2007) 2.02
ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci (2010) 1.96
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol Cell (2013) 1.95
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell (2008) 1.94
p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint. Mol Cell Biol (2009) 1.88
Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J (2009) 1.88
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol (2007) 1.87
DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol (2006) 1.84
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res (2011) 1.78
ATR activation and replication fork restart are defective in FANCM-deficient cells. EMBO J (2010) 1.75
Common mechanisms of PIKK regulation. DNA Repair (Amst) (2009) 1.73
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol (2013) 1.72
ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell (2011) 1.70
A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? Biol Psychiatry (2014) 1.68
Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet (2007) 1.68
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell (2010) 1.65
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol (2013) 1.62
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem (2008) 1.61
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation. Mol Cell (2015) 1.60
Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A (2008) 1.58
Facilitating replication under stress: an oncogenic function of MYC? Nat Rev Cancer (2009) 1.56
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. Proc Natl Acad Sci U S A (2007) 1.54
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol (2008) 1.54
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling. Proc Natl Acad Sci U S A (2010) 1.53
The ATR barrier to replication-born DNA damage. DNA Repair (Amst) (2010) 1.50
Coordination of cell cycle, DNA repair and muscle gene expression in myoblasts exposed to genotoxic stress. Cell Cycle (2011) 1.47
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev (2010) 1.47
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. EMBO J (2010) 1.46
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J (2006) 1.45
Pathways for genome integrity in G2 phase of the cell cycle. Biomolecules (2012) 1.44
Akt: a double-edged sword in cell proliferation and genome stability. J Oncol (2012) 1.44
Identification of proteins at active, stalled, and collapsed replication forks using isolation of proteins on nascent DNA (iPOND) coupled with mass spectrometry. J Biol Chem (2013) 1.43
TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks. J Cell Biol (2009) 1.43
MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol (2011) 1.40
The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nat Rev Mol Cell Biol (2017) 1.38
Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A (2009) 1.38
Activating ATR, the devil's in the dETAA1l. Nat Cell Biol (2016) 1.38
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem (2010) 1.37
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1. EMBO J (2008) 1.36
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response. EMBO Rep (2010) 1.36
The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol Cell (2010) 1.35
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell (2009) 1.33
A role for the MRN complex in ATR activation via TOPBP1 recruitment. Mol Cell (2013) 1.31
How ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev (2008) 1.30
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) (2009) 1.29
HIV-1 Vpr: mechanisms of G2 arrest and apoptosis. Exp Mol Pathol (2008) 1.29
Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer. Mol Cell Biol (2009) 1.28
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J (2011) 1.28
Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol (2010) 1.27
DNA strand breaks, neurodegeneration and aging in the brain. Mech Ageing Dev (2008) 1.27
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Res (2007) 1.27
E2F1 localizes to sites of UV-induced DNA damage to enhance nucleotide excision repair. J Biol Chem (2010) 1.26
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73. Mol Cell Biol (2011) 1.25
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J (2009) 1.24
Maintaining genome stability in the nervous system. Nat Neurosci (2013) 1.24
A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol Cell (2010) 1.24
Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. J Biol Chem (2009) 1.21
Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol Cell (2008) 1.21
HARPing on about the DNA damage response during replication. Genes Dev (2009) 1.21
Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. Cell Rep (2013) 1.19
Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase. J Biol Chem (2009) 1.18
Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation. Proc Natl Acad Sci U S A (2010) 1.17
Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol Biol Cell (2009) 1.17
TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability. J Cell Biol (2013) 1.16
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J Biol Chem (2011) 1.16
E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks. Cell Cycle (2011) 1.15
Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery. Genes Dev (2013) 1.14
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1. Nucleic Acids Res (2010) 1.13
Activation of ATR and related PIKKs. Cell Cycle (2008) 1.12
Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis. Mol Cell Biol (2010) 1.12
Targeting the checkpoint kinase Chk1 in cancer therapy. Cell Cycle (2010) 1.11
Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA. Nucleic Acids Res (2009) 1.11
Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. Cell Cycle (2010) 1.11
A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Sci Signal (2011) 1.11
Onset of the DNA replication checkpoint in the early Drosophila embryo. Genetics (2006) 1.11
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res (2014) 1.10
Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks. Mol Biol Cell (2010) 1.10
Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. J Biol Chem (2014) 1.09
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation. J Cell Biol (2012) 1.07
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell (2004) 2.75
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem (2007) 2.68
Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell (2005) 2.54
Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model. Circulation (2007) 2.24
Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int (2013) 2.17
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria. Crit Care Med (2011) 2.11
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell (2003) 2.08
Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell (2010) 2.06
Empirical relationships among oliguria, creatinine, mortality, and renal replacement therapy in the critically ill. Intensive Care Med (2012) 1.86
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem (2004) 1.76
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J Biol Chem (2004) 1.70
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat Cell Biol (2003) 1.68
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J Biol Chem (2007) 1.61
Risk stratification of ICU patients using topic models inferred from unstructured progress notes. AMIA Annu Symp Proc (2012) 1.50
Accessing the public MIMIC-II intensive care relational database for clinical research. BMC Med Inform Decis Mak (2013) 1.42
Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J Cell Biol (2011) 1.37
Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response. Mol Biol Cell (2005) 1.34
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell (2009) 1.33
Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases. J Cell Biol (2004) 1.33
Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. J Biol Chem (2005) 1.30
Red cell distribution width improves the simplified acute physiology score for risk prediction in unselected critically ill patients. Crit Care (2012) 1.26
Direct effects of apelin on cardiomyocyte contractility and electrophysiology. Biochem Biophys Res Commun (2007) 1.23
Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation. J Biol Chem (2003) 1.20
Cerebrospinal fluid leaks following cervical spine surgery. J Bone Joint Surg Am (2008) 1.20
Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest. J Biol Chem (2003) 1.12
Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. Cell Cycle (2010) 1.11
Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks. Mol Biol Cell (2010) 1.10
Aven-dependent activation of ATM following DNA damage. Curr Biol (2008) 1.08
Accelerated aging of intervertebral discs in a mouse model of progeria. J Orthop Res (2010) 1.08
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Genes Dev (2006) 1.07
A Database-driven Decision Support System: Customized Mortality Prediction. J Pers Med (2012) 1.06
Laminoplasty versus laminectomy and fusion for multilevel cervical spondylotic myelopathy. Clin Orthop Relat Res (2011) 1.05
Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure. J Mol Cell Cardiol (2009) 1.01
Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure. Cardiovasc Res (2008) 0.98
Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and nuclear factor-κB activation. Arterioscler Thromb Vasc Biol (2013) 0.98
Dissection of c-MOS degron. EMBO J (2002) 0.97
Choice of cell-delivery route for skeletal myoblast transplantation for treating post-infarction chronic heart failure in rat. PLoS One (2008) 0.97
Time-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines. Exp Mol Med (2011) 0.95
The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell (2013) 0.94
SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin. Cell Cycle (2015) 0.94
WIP1, a homeostatic regulator of the DNA damage response, is targeted by HIPK2 for phosphorylation and degradation. Mol Cell (2013) 0.92
How cells activate ATR. Cell Cycle (2006) 0.92
Endovascular repair of a portal hypertension-related splenic artery aneurysm using a self-expanding stent-graft. Cardiovasc Intervent Radiol (2009) 0.91
Motion path of the instant center of rotation in the cervical spine during in vivo dynamic flexion-extension: implications for artificial disc design and evaluation of motion quality after arthrodesis. Spine (Phila Pa 1976) (2013) 0.91
The association between perioperative allogeneic transfusion volume and postoperative infection in patients following lumbar spine surgery. J Bone Joint Surg Am (2013) 0.89
Differential effects of nicotine and tobacco smoke condensate on human annulus fibrosus cell metabolism. J Orthop Res (2011) 0.89
Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Mol Biol Cell (2011) 0.88
Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast. Eukaryot Cell (2006) 0.88
Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation. FASEB J (2006) 0.87
Collective Experience: A Database-Fuelled, Inter-Disciplinary Team-Led Learning System. J Comput Sci Eng (2012) 0.86
Prolonged mechanical unloading reduces myofilament sensitivity to calcium and sarcoplasmic reticulum calcium uptake leading to contractile dysfunction. J Heart Lung Transplant (2008) 0.86
Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy. Biochem Biophys Res Commun (2011) 0.85
Obesity, Acute Kidney Injury, and Mortality in Critical Illness. Crit Care Med (2016) 0.85
Respiration and heart rate complexity: effects of age and gender assessed by band-limited transfer entropy. Respir Physiol Neurobiol (2013) 0.84
Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores. J Phys Chem B (2014) 0.83
Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer. Biochem Biophys Res Commun (2012) 0.83
Association of hypermagnesemia and blood pressure in the critically ill. J Hypertens (2013) 0.83
Transcriptional regulation and environmental induction of gene encoding copper- and zinc-containing superoxide dismutase. Methods Enzymol (2002) 0.82
Severity of acute kidney injury and two-year outcomes in critically ill patients. Chest (2013) 0.82
The role of the cardiac Na+/Ca2+ exchanger in reverse remodeling: relevance for LVAD-recovery. Ann N Y Acad Sci (2007) 0.81
Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. Cell Cycle (2012) 0.81
TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases. Mol Cancer (2014) 0.80
CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts. Cell Cycle (2011) 0.80
Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay. Ann Hematol (2013) 0.80
Energetically biased DNA motor containing a thermodynamically stable partial strand displacement state. Langmuir (2014) 0.79
Photoplethysmograph quality estimation through multichannel filtering. Conf Proc IEEE Eng Med Biol Soc (2011) 0.78
Drf1-dependent kinase interacts with Claspin through a conserved protein motif. J Biol Chem (2010) 0.78
Prognostic implications of the DNA damage response pathway in glioblastoma. Oncol Rep (2011) 0.77
DNA nano-carrier for repeatable capture and release of biomolecules. Nanoscale (2015) 0.77
Cervical disc deformation during flexion-extension in asymptomatic controls and single-level arthrodesis patients. J Orthop Res (2013) 0.77
Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts. ACS Chem Neurosci (2017) 0.76
Integrated copy number and gene expression profiling analysis of Epstein-Barr virus-positive diffuse large B-cell lymphoma. Genes Chromosomes Cancer (2015) 0.76
Errors, Omissions, and Outliers in Hourly Vital Signs Measurements in Intensive Care. Crit Care Med (2016) 0.76
The expression of DNA damage checkpoint proteins and prognostic implication in metastatic brain tumors. Oncol Res (2011) 0.76
Signal quality estimation with multichannel adaptive filtering in intensive care settings. IEEE Trans Biomed Eng (2012) 0.75
Primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma on upper eyelid. Indian J Ophthalmol (2015) 0.75
Sex Differences in Hippocampal Neuronal Sensitization by Nicotine in M. gerbils. Korean J Physiol Pharmacol (2013) 0.75
Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea. J Dermatol (2012) 0.75
Clinical indications for arterial imaging in cervical trauma. Spine (Phila Pa 1976) (2012) 0.75
Epidural Injections for Spinal Stenosis. J Spinal Disord Tech (2015) 0.75
Adamts5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. Spine (Phila Pa 1976) (2017) 0.75
Alcohol-related injuries requiring surgery. N Z Med J (2013) 0.75
Vancomycin Powder Regimen for Prevention of Surgical Site Infection in Complex Spine Surgeries. Clin Spine Surg (2017) 0.75