Published in PLoS Genet on December 11, 2009
Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches. PLoS Genet (2011) 2.38
Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell (2011) 1.81
Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF. EMBO J (2014) 1.54
Regulating the chromatin landscape: structural and mechanistic perspectives. Annu Rev Biochem (2014) 1.29
A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature (2013) 1.21
Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27. Mol Cell Biol (2012) 1.20
Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription. Biochemistry (2011) 1.10
SWI/SNF complexes, chromatin remodeling and skeletal myogenesis: it's time to exchange! Exp Cell Res (2010) 1.10
Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Biol (2014) 1.09
Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signaling. AIDS (2014) 1.05
Citrullination of histone H3 interferes with HP1-mediated transcriptional repression. PLoS Genet (2012) 1.04
Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics (2012) 1.02
Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation. PLoS Pathog (2015) 1.02
Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome. J Biol Chem (2012) 0.95
A new, highly conserved domain in Swi2/Snf2 is required for SWI/SNF remodeling. Nucleic Acids Res (2011) 0.94
HP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster. PLoS Genet (2012) 0.91
Characterization of chromoshadow domain-mediated binding of heterochromatin protein 1α (HP1α) to histone H3. J Biol Chem (2012) 0.86
Role of the epigenetic regulator HP1γ in the control of embryonic stem cell properties. PLoS One (2010) 0.85
The SnAC domain of SWI/SNF is a histone anchor required for remodeling. Mol Cell Biol (2012) 0.83
DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression. EMBO Rep (2014) 0.83
HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth. Nucleic Acids Res (2015) 0.82
Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-α gene in acute kidney injury. PLoS One (2013) 0.80
LIA4 encodes a chromoshadow domain protein required for genomewide DNA rearrangements in Tetrahymena thermophila. Eukaryot Cell (2014) 0.79
Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein. Oncotarget (2016) 0.78
HP1α is not necessary for the structural maintenance of centromeric heterochromatin. Epigenetics (2011) 0.77
Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1α down-regulation in metastatic cells. BMC Cancer (2016) 0.77
Beyond the histone tale: HP1α deregulation in breast cancer epigenetics. Cancer Biol Ther (2015) 0.77
Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1. J Biol Chem (2017) 0.75
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
Rb targets histone H3 methylation and HP1 to promoters. Nature (2001) 8.26
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science (2002) 7.33
The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nat Struct Mol Biol (2005) 6.60
Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell (2005) 5.96
Chromatin compaction by a polycomb group protein complex. Science (2004) 4.95
Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science (2003) 4.74
Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature (1998) 4.68
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature (2009) 4.60
Reconstitution of a functional core polycomb repressive complex. Mol Cell (2001) 4.39
Acetylation in histone H3 globular domain regulates gene expression in yeast. Cell (2005) 3.82
Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. Mol Cell (2001) 3.70
Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev (2007) 3.43
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha. EMBO Rep (2002) 3.00
Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev (1998) 2.93
An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Nat Genet (2002) 2.87
Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin. EMBO J (2004) 2.79
Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control. EMBO J (2007) 2.75
The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. EMBO J (1996) 2.71
H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding. Mol Cell (2004) 2.63
The HP1 chromo shadow domain binds a consensus peptide pentamer. Curr Biol (2000) 2.47
Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency. EMBO J (2007) 2.37
The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest. Cancer Res (2006) 2.36
High- and low-mobility populations of HP1 in heterochromatin of mammalian cells. Mol Biol Cell (2004) 2.29
Heterochromatin protein 1 is recruited to various types of DNA damage. J Cell Biol (2009) 2.26
Heterochromatin protein 1: don't judge the book by its cover! Curr Opin Genet Dev (2006) 2.20
Chromatin components as part of a putative transcriptional repressing complex. Proc Natl Acad Sci U S A (1998) 2.14
Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol Cell (2006) 2.13
The Heterochromatin Protein 1 family. Genome Biol (2006) 2.05
The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. Biochem Biophys Res Commun (2005) 2.00
Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat Cell Biol (2002) 1.91
Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter. EMBO J (2006) 1.87
HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol (2006) 1.84
Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol (2002) 1.73
Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability. Mol Cell Biol (2007) 1.73
HP1: a functionally multifaceted protein. Curr Opin Genet Dev (2008) 1.72
The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol (2004) 1.64
The activity of mammalian brm/SNF2alpha is dependent on a high-mobility-group protein I/Y-like DNA binding domain. Mol Cell Biol (1999) 1.48
Swapping function of two chromatin remodeling complexes. Mol Cell (2005) 1.46
Propagation of silencing; recruitment and repression of naive chromatin in trans by polycomb repressed chromatin. Mol Cell (2004) 1.41
HP1 binding to native chromatin in vitro is determined by the hinge region and not by the chromodomain. EMBO J (2003) 1.39
Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha. EMBO J (2002) 1.35
Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J (2002) 1.34
Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin. Mol Cell Biol (2004) 1.34
Regulation of an inducible promoter by an HP1beta-HP1gamma switch. EMBO Rep (2008) 1.33
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. PLoS Genet (2009) 1.30
HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions. J Cell Biol (2008) 1.27
Global analysis of functional surfaces of core histones with comprehensive point mutants. Genes Cells (2007) 1.25
A mechanism regulating the onset of Sox2 expression in the embryonic neural plate. PLoS Biol (2008) 1.23
Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions. Nucleic Acids Res (2009) 1.06
Methylation-independent binding to histone H3 and cell cycle-dependent incorporation of HP1beta into heterochromatin. J Biol Chem (2006) 1.02
A model for chromatin remodeling by the SWI/SNF family. Cold Spring Harb Symp Quant Biol (1998) 0.88
RNAi off-targeting: Light at the end of the tunnel. J RNAi Gene Silencing (2006) 0.80
Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell (2002) 13.05
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
Cooperation between complexes that regulate chromatin structure and transcription. Cell (2002) 10.38
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
Characterization of the piRNA complex from rat testes. Science (2006) 7.86
Super-enhancers in the control of cell identity and disease. Cell (2013) 7.50
Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell (2010) 6.88
The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nat Struct Mol Biol (2005) 6.60
Chromatin compaction by a polycomb group protein complex. Science (2004) 4.95
Retracted Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature (2002) 4.18
Purification of proteins associated with specific genomic Loci. Cell (2009) 3.53
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol Cell (2013) 3.50
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol (2005) 3.49
An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses. Nat Immunol (2006) 3.41
A region of the human HOXD cluster that confers polycomb-group responsiveness. Cell (2010) 3.27
PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state. Mol Cell (2006) 3.20
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol (2002) 3.13
hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol (2005) 2.69
Division of labor in polycomb group repression. Trends Biochem Sci (2004) 2.66
Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell (2009) 2.61
The genomic binding sites of a noncoding RNA. Proc Natl Acad Sci U S A (2011) 2.34
PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev (2007) 2.34
Replication stress interferes with histone recycling and predeposition marking of new histones. Mol Cell (2010) 2.31
The coming of age for Piwi proteins. Mol Cell (2007) 2.20
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J (2007) 2.19
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature (2010) 2.01
SWI/SNF chromatin remodeling and cancer. Curr Opin Genet Dev (2002) 2.00
Epigenomics: a roadmap, but to where? Science (2008) 1.99
Distinct strategies to make nucleosomal DNA accessible. Mol Cell (2003) 1.96
Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a. Mol Cell (2007) 1.96
Structural basis of histone H4 recognition by p55. Genes Dev (2008) 1.95
Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science (2011) 1.93
Splicing, transcription, and chromatin: a ménage à trois. Curr Opin Genet Dev (2008) 1.92
The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J (2002) 1.91
OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Mol Biol Cell (2007) 1.87
Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis. J Infect Dis (2009) 1.87
Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons. Nat Struct Mol Biol (2011) 1.86
Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci U S A (2007) 1.86
HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol (2006) 1.84
Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A (2008) 1.83
Argonaute proteins couple chromatin silencing to alternative splicing. Nat Struct Mol Biol (2012) 1.80
WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. J Biol Chem (2008) 1.77
Connecting threads: epigenetics and metabolism. Cell (2012) 1.75
Comparative analysis of H2A.Z nucleosome organization in the human and yeast genomes. Genome Res (2009) 1.74
SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation. Cancer Res (2005) 1.68
Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation. Genes Dev (2003) 1.61
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J (2012) 1.61
The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Rep (2009) 1.61
A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Dev Cell (2013) 1.59
Fast signals and slow marks: the dynamics of histone modifications. Trends Biochem Sci (2010) 1.58
A combination of different mass spectroscopic techniques for the analysis of dynamic changes of histone modifications. Proteomics (2004) 1.56
The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104. J Biol Chem (2003) 1.52
Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3. EMBO Rep (2004) 1.48
Native and recombinant polycomb group complexes establish a selective block to template accessibility to repress transcription in vitro. Mol Cell Biol (2002) 1.47
Swapping function of two chromatin remodeling complexes. Mol Cell (2005) 1.46
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet (2011) 1.43
SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. Mol Biol Cell (2009) 1.41
Propagation of silencing; recruitment and repression of naive chromatin in trans by polycomb repressed chromatin. Mol Cell (2004) 1.41
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet (2012) 1.40
Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA. Genes Dev (2003) 1.39
Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation. Cell Stress Chaperones (2004) 1.38
HOTAIR lifts noncoding RNAs to new levels. Cell (2007) 1.36
Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function. Mol Cell Biol (2005) 1.36
Establishment of histone modifications after chromatin assembly. Nucleic Acids Res (2009) 1.36
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol (2006) 1.36
The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity. Biochemistry (2004) 1.34
Regulation of an inducible promoter by an HP1beta-HP1gamma switch. EMBO Rep (2008) 1.33
Effect of delays in primary care referral on survival of women with epithelial ovarian cancer: retrospective audit. BMJ (2002) 1.33
Human ACF1 alters the remodeling strategy of SNF2h. J Biol Chem (2006) 1.33
Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet (2009) 1.32
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30
An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome. PLoS Genet (2008) 1.29
The spring-loaded genome: nucleosome redistributions are widespread, transient, and DNA-directed. Genome Res (2013) 1.27
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem (2007) 1.27
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol (2011) 1.27
Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge. Genes Dev (2011) 1.26
Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi. EMBO J (2009) 1.25
The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev (2009) 1.24
Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment. Mol Cell Biol (2003) 1.24
UV-induced association of the CSB remodeling protein with chromatin requires ATP-dependent relief of N-terminal autorepression. Mol Cell (2010) 1.24
Homology-driven chromatin remodeling by human RAD54. Nat Struct Mol Biol (2007) 1.24
Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression. Genetics (2004) 1.23
The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation. EMBO J (2005) 1.23
Nucleosome positioning in human HOX gene clusters. Genome Res (2008) 1.23
Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Res (2013) 1.23
ESC, ESCL and their roles in Polycomb Group mechanisms. Mech Dev (2008) 1.23
The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer. Cancer Res (2008) 1.21
H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction. Genome Res (2013) 1.20
Independent and complementary methods for large-scale structural analysis of mammalian chromatin. Genome Res (2007) 1.19