Published in Science on January 31, 2003
Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell (2006) 8.53
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
From silencing to gene expression: real-time analysis in single cells. Cell (2004) 7.73
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50
Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol Cell Biol (2004) 4.41
Transcription and RNA interference in the formation of heterochromatin. Nature (2007) 4.08
Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev (2007) 3.43
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J (2004) 2.87
Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet (2011) 2.86
Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin. EMBO J (2004) 2.79
Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin. EMBO J (2009) 2.78
Fast chromatin immunoprecipitation assay. Nucleic Acids Res (2006) 2.39
Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency. EMBO J (2007) 2.37
Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol Cell Biol (2004) 2.33
High- and low-mobility populations of HP1 in heterochromatin of mammalian cells. Mol Biol Cell (2004) 2.29
Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1. Mol Cell Biol (2005) 2.27
Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Nat Biotechnol (2011) 2.27
Heterochromatin protein 1 is recruited to various types of DNA damage. J Cell Biol (2009) 2.26
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol (2010) 2.18
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology (2009) 2.17
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. Genome Res (2008) 2.10
gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One (2007) 2.07
Visualizing telomere dynamics in living mammalian cells using PNA probes. EMBO J (2003) 1.99
Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo. Nat Struct Mol Biol (2006) 1.94
Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation. J Cell Biol (2005) 1.91
A CAF-1 dependent pool of HP1 during heterochromatin duplication. EMBO J (2004) 1.88
Gene regulation and large-scale chromatin organization in the nucleus. Chromosome Res (2006) 1.87
Canonical and non-canonical JAK-STAT signaling. Trends Cell Biol (2008) 1.85
HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol (2006) 1.84
CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin. EMBO J (2005) 1.81
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet (2007) 1.79
Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells. J Cell Biol (2004) 1.74
Tip60: connecting chromatin to DNA damage signaling. Cell Cycle (2010) 1.73
PTEN interacts with histone H1 and controls chromatin condensation. Cell Rep (2014) 1.60
The PHD domain of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin. Mol Biol Cell (2008) 1.53
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proc Natl Acad Sci U S A (2014) 1.51
Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3. EMBO Rep (2004) 1.48
Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals. Genome Res (2005) 1.46
DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer (2011) 1.45
Formation of facultative heterochromatin in the absence of HP1. EMBO J (2003) 1.45
Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation. Mol Cell Biol (2003) 1.44
Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene. FASEB J (2009) 1.41
HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol Cell Biol (2006) 1.40
Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol (2006) 1.38
Regulation of TATA-binding protein dynamics in living yeast cells. Proc Natl Acad Sci U S A (2008) 1.38
Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization. Proc Natl Acad Sci U S A (2010) 1.38
Mobility and immobility of chromatin in transcription and genome stability. Curr Opin Genet Dev (2007) 1.37
The FMR1 gene and fragile X-associated tremor/ataxia syndrome. Am J Med Genet B Neuropsychiatr Genet (2009) 1.37
The emerging role of HP1 in the DNA damage response. Mol Cell Biol (2009) 1.35
A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex. Nat Cell Biol (2009) 1.31
Dynamics and function of compact nucleosome arrays. Nat Struct Mol Biol (2009) 1.30
MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. Nucleic Acids Res (2007) 1.29
Monitoring dynamic protein interactions with photoquenching FRET. Nat Methods (2006) 1.28
Molecular determinants of NOTCH4 transcription in vascular endothelium. Mol Cell Biol (2005) 1.27
Analysis of human histone H2AZ deposition in vivo argues against its direct role in epigenetic templating mechanisms. Mol Cell Biol (2006) 1.27
MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites. Mol Cell Biol (2010) 1.27
HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions. J Cell Biol (2008) 1.27
Microplate-based chromatin immunoprecipitation method, Matrix ChIP: a platform to study signaling of complex genomic events. Nucleic Acids Res (2008) 1.27
Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase. Nucleic Acids Res (2005) 1.26
Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo. J Cell Sci (2008) 1.26
Changes in the distributions and dynamics of polycomb repressive complexes during embryonic stem cell differentiation. Mol Cell Biol (2008) 1.26
In vivo dynamics of Swi6 in yeast: evidence for a stochastic model of heterochromatin. Mol Cell Biol (2004) 1.26
Aging by epigenetics--a consequence of chromatin damage? Exp Cell Res (2008) 1.25
Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy. Biophys J (2009) 1.23
Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem (2008) 1.21
Chromatin decondensation and nuclear reprogramming by nucleoplasmin. Mol Cell Biol (2006) 1.20
Chromatin dynamics and the evolution of alternate promoter states. Chromosome Res (2006) 1.19
Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation. Nat Commun (2012) 1.19
Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression. PLoS Genet (2009) 1.19
Origins and formation of histone methylation across the human cell cycle. Mol Cell Biol (2012) 1.16
Toward convergence of experimental studies and theoretical modeling of the chromatin fiber. J Biol Chem (2011) 1.15
Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages. Proc Natl Acad Sci U S A (2005) 1.14
Replication of heterochromatin: insights into mechanisms of epigenetic inheritance. Chromosoma (2005) 1.14
Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy. Epigenetics Chromatin (2008) 1.13
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin. Genes Dev (2013) 1.13
Regulation of ubiquitin ligase dynamics by the nucleolus. J Cell Biol (2005) 1.13
Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology. EMBO Mol Med (2009) 1.12
A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. J Cell Biol (2005) 1.10
Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription. Biochemistry (2011) 1.10
Identification and analysis of plasticity-induced late-response genes. Proc Natl Acad Sci U S A (2004) 1.10
Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Biol (2014) 1.09
Histone exchange and histone modifications during transcription and aging. Biochim Biophys Acta (2014) 1.09
Loss of YY1 impacts the heterochromatic state and meiotic double-strand breaks during mouse spermatogenesis. Mol Cell Biol (2009) 1.07
Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment. Chromosoma (2005) 1.06
The ageing epigenome: damaged beyond repair? Ageing Res Rev (2009) 1.05
N-terminal phosphorylation of HP1{alpha} promotes its chromatin binding. Mol Cell Biol (2011) 1.04
H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Nucleic Acids Res (2012) 1.03
"Seq-ing" insights into the epigenetics of neuronal gene regulation. Neuron (2013) 1.03
Mutations in the nucleosome core enhance transcriptional silencing. Mol Cell Biol (2005) 1.02
Nonlinear optical imaging and Raman microspectrometry of the cell nucleus throughout the cell cycle. Biophys J (2010) 1.01
The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells. Mol Cell Biol (2006) 1.01
Histones: at the crossroads of peptide and protein chemistry. Chem Rev (2014) 1.01
Detection of selective sweeps in cattle using genome-wide SNP data. BMC Genomics (2013) 1.01
Nascent RNA synthesis in the context of chromatin architecture. Chromosome Res (2004) 1.00
HP1a: a structural chromosomal protein regulating transcription. Trends Genet (2014) 0.99
The end adjusts the means: heterochromatin remodelling during terminal cell differentiation. Chromosome Res (2006) 0.99
Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres. Elife (2014) 0.99
Different domains control the localization and mobility of LIKE HETEROCHROMATIN PROTEIN1 in Arabidopsis nuclei. Plant Cell (2005) 0.98
Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth. Proc Natl Acad Sci U S A (2013) 0.97
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature (2002) 19.77
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature (2011) 10.77
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell (2006) 8.53
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
Regulation of alternative splicing by histone modifications. Science (2010) 7.98
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
Lamin A-dependent nuclear defects in human aging. Science (2006) 6.71
The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01
Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86
Global transcription in pluripotent embryonic stem cells. Cell Stem Cell (2008) 5.81
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci U S A (2003) 5.59
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J (2002) 5.33
Chromatin in pluripotent embryonic stem cells and differentiation. Nat Rev Mol Cell Biol (2006) 5.18
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med (2005) 5.01
Epigenetics in alternative pre-mRNA splicing. Cell (2011) 4.74
Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. Genome Res (2010) 4.67
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51
Global reorganization of replication domains during embryonic stem cell differentiation. PLoS Biol (2008) 4.50
An epigenetic road map for histone lysine methylation. J Cell Sci (2003) 4.43
A kinetic framework for a mammalian RNA polymerase in vivo. Science (2002) 4.42
Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol Cell Biol (2004) 4.41
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Transcription dynamics. Mol Cell (2009) 4.15
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15
Spatial proximity of translocation-prone gene loci in human lymphomas. Nat Genet (2003) 3.91
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. Genome Res (2009) 3.36
Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24
Activation of the cellular DNA damage response in the absence of DNA lesions. Science (2008) 3.17
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Res (2008) 3.09
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08
Measurement of dynamic protein binding to chromatin in vivo, using photobleaching microscopy. Methods Enzymol (2004) 3.02
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol (2008) 2.93
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91
In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet (2012) 2.70
Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. Mol Cell (2007) 2.69
Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27. EMBO J (2006) 2.68
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66
G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64
TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression. Proc Natl Acad Sci U S A (2008) 2.58
Tissue-specific spatial organization of genomes. Genome Biol (2004) 2.57
Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.53
Cell biology: chromosome territories. Nature (2007) 2.47
Ageing-related chromatin defects through loss of the NURD complex. Nat Cell Biol (2009) 2.40
Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus. J Cell Sci (2006) 2.37
Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol Cell Biol (2004) 2.33
Chromosome positioning in the interphase nucleus. Trends Cell Biol (2002) 2.32
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature (2007) 2.30
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22
The meaning of gene positioning. Cell (2008) 2.16
A transcription factor-based mechanism for mouse heterochromatin formation. Nat Struct Mol Biol (2012) 2.15
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol (2003) 2.14
Functional implications of genome topology. Nat Struct Mol Biol (2013) 2.13
Actin up in the nucleus. Nat Rev Mol Cell Biol (2004) 2.13
Spatial genome organization in the formation of chromosomal translocations. Semin Cancer Biol (2006) 2.12
Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol (2004) 2.09
gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One (2007) 2.07
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J (2005) 2.04
Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma (2002) 2.03
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell (2012) 2.02
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02
Histone modification patterns associated with the human X chromosome. EMBO Rep (2006) 1.99
Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J Cell Sci (2004) 1.98
HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat Med (2004) 1.97
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res (2007) 1.96
Spatial dynamics of chromosome translocations in living cells. Science (2013) 1.95
Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo. Nat Struct Mol Biol (2006) 1.94
EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells. J Biol Chem (2005) 1.93
In vivo kinetics of Cajal body components. J Cell Biol (2004) 1.91
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
G9a selectively represses a class of late-replicating genes at the nuclear periphery. Proc Natl Acad Sci U S A (2009) 1.91