Published in Nature on March 14, 2010
Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1. Cancer Cell (2011) 2.86
Readers of histone modifications. Cell Res (2011) 2.40
Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis. Oncogene (2013) 1.86
Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. J Biol Chem (2011) 1.79
Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol (2013) 1.65
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer. Genes Cancer (2011) 1.47
Quantitative proteomic analysis of histone modifications. Chem Rev (2015) 1.32
Histone H3 phosphorylation - a versatile chromatin modification for different occasions. Biochimie (2012) 1.23
A peek into the complex realm of histone phosphorylation. Mol Cell Biol (2011) 1.22
Molecular basis for chromatin binding and regulation of MLL5. Proc Natl Acad Sci U S A (2013) 1.15
Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events. Nat Struct Mol Biol (2012) 1.15
Histone phosphorylation: a chromatin modification involved in diverse nuclear events. Epigenetics (2012) 1.14
Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma. J Clin Invest (2012) 1.11
Chatting histone modifications in mammals. Brief Funct Genomics (2010) 1.10
Histone modifiers in cancer: friends or foes? Genes Cancer (2011) 1.10
Protein kinase C and cancer: what we know and what we do not. Oncogene (2013) 1.09
NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell (2011) 1.09
Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language". Chembiochem (2010) 1.06
Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation. Proc Natl Acad Sci U S A (2013) 1.05
A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. Mol Cell (2014) 1.02
Negative regulation by nuclear receptors: a plethora of mechanisms. Trends Endocrinol Metab (2010) 1.00
Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain. Curr Opin Struct Biol (2011) 0.97
Sensing core histone phosphorylation - a matter of perfect timing. Biochim Biophys Acta (2014) 0.94
Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity. Cell Rep (2014) 0.93
Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast. BMC Clin Pathol (2012) 0.92
Substitutions in the amino-terminal tail of neurospora histone H3 have varied effects on DNA methylation. PLoS Genet (2011) 0.92
Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster. Nucleic Acids Res (2011) 0.92
Phosphorylation of histone H3 serine 28 modulates RNA polymerase III-dependent transcription. Oncogene (2011) 0.92
Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs. Mol Cell (2015) 0.91
The emerging role of histone lysine demethylases in prostate cancer. Mol Cancer (2012) 0.91
Epigenetic regulation of inducible gene expression in the immune system. Immunology (2013) 0.90
Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling. J Biol Chem (2012) 0.90
The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes. Transcription (2012) 0.89
Identification of an interaction between the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1: implications for prostate cancer. J Biol Chem (2011) 0.88
Chromatin dynamics during lytic infection with herpes simplex virus 1. Viruses (2013) 0.87
Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens (2012) 0.87
Metabolic regulation of histone post-translational modifications. ACS Chem Biol (2015) 0.87
Functional Role of G9a Histone Methyltransferase in Cancer. Front Immunol (2015) 0.87
Ligand-dependent corepressor (LCoR) recruitment by Kruppel-like factor 6 (KLF6) regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene. J Biol Chem (2012) 0.86
Interrogating genomic and epigenomic data to understand prostate cancer. Biochim Biophys Acta (2012) 0.85
Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. Mol Cell Biol (2013) 0.85
Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res (2013) 0.85
General molecular biology and architecture of nuclear receptors. Curr Top Med Chem (2012) 0.84
KDM1 class flavin-dependent protein lysine demethylases. Biopolymers (2015) 0.84
Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB? Front Immunol (2012) 0.84
Role of signaling transduction pathways in development of castration-resistant prostate cancer. Prostate Cancer (2011) 0.83
Altered histone modifications in gliomas. Brain Tumor Res Treat (2014) 0.82
The first European interdisciplinary ewing sarcoma research summit. Front Oncol (2012) 0.82
Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells. PLoS One (2012) 0.82
CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells. Mol Cell Biol (2014) 0.82
Epigenetics and autism. Autism Res Treat (2013) 0.81
Histone demethylases in chromatin biology and beyond. EMBO Rep (2015) 0.81
The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts. J Biol Chem (2012) 0.80
Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape. Nat Rev Cancer (2016) 0.80
Multi-layered epigenetic mechanisms contribute to transcriptional memory in T lymphocytes. BMC Immunol (2015) 0.79
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Nat Struct Mol Biol (2016) 0.79
Protein kinase C in the immune system: from signalling to chromatin regulation. Immunology (2015) 0.79
Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus. World J Virol (2015) 0.79
Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive. Nucleic Acids Res (2016) 0.78
Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells. Stem Cells Int (2015) 0.78
A hypomorphic lsd1 allele results in heart development defects in mice. PLoS One (2013) 0.78
Expanding horizons for nuclear receptors. EMBO Rep (2010) 0.78
BAP18 coactivates androgen receptor action and promotes prostate cancer progression. Nucleic Acids Res (2016) 0.78
Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum". ACS Chem Biol (2015) 0.78
Histone H3 phosphorylation in GBM: a new rational to guide the use of kinase inhibitors in anti-GBM therapy. Theranostics (2015) 0.78
Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast. Sci Rep (2015) 0.78
Androgen and AR contribute to breast cancer development and metastasis: an insight of mechanisms. Oncogene (2016) 0.78
Androgen receptor epigenetics. Transl Androl Urol (2013) 0.77
Duplicity of protein kinase C-θ: Novel insights into human T-cell biology. Transcription (2011) 0.77
PKC-Theta in Regulatory and Effector T-cell Functions. Front Immunol (2015) 0.77
Regulation of Methyllysine Readers through Phosphorylation. ACS Chem Biol (2016) 0.77
Epigenetics in acute kidney injury. Curr Opin Nephrol Hypertens (2015) 0.77
Emerging role of protein kinase C in energy homeostasis: A brief overview. World J Diabetes (2014) 0.77
The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion. Cell Death Dis (2014) 0.76
Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer. Oncotarget (2015) 0.76
Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord. Neuropharmacology (2017) 0.76
Conservation and divergence of the histone code in nucleomorphs. Biol Direct (2016) 0.75
Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch. Sci Rep (2016) 0.75
Expression of the TPα and TPβ isoforms of the thromboxane prostanoid receptor (TP) in prostate cancer: clinical significance and diagnostic potential. Oncotarget (2016) 0.75
PKCβ: Expanding role in hepatic adaptation of cholesterol homeostasis to dietary fat/cholesterol. Am J Physiol Gastrointest Liver Physiol (2017) 0.75
Lysine-Specific Demethylase 1 (LSD1) Inhibitor S2101 Induces Autophagy via the AKT/mTOR Pathway in SKOV3 Ovarian Cancer Cells. Med Sci Monit (2016) 0.75
Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy. Cancers (Basel) (2017) 0.75
Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders. Adv Pharmacol (2016) 0.75
Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4. Cell Death Dis (2017) 0.75
Epigenetic regulation of LSD1 during mammary carcinogenesis. Mol Cell Oncol (2014) 0.75
Histone and DNA methylation control by H3 serine 10/threonine 11 phosphorylation in the mouse zygote. Epigenetics Chromatin (2017) 0.75
ERRα induces H3K9 demethylation by LSD1 to promote cell invasion. Proc Natl Acad Sci U S A (2017) 0.75
Diversity and Divergence of Dinoflagellate Histone Proteins. G3 (Bethesda) (2015) 0.75
Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis. Leukemia (2014) 0.75
DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression. J Cancer Metastasis Treat (2017) 0.75
Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation. Oral Dis (2016) 0.75
Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med (1998) 25.41
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53
JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet (2006) 6.65
Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol (2003) 6.21
A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell (2007) 5.99
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
International trends and patterns of prostate cancer incidence and mortality. Int J Cancer (2000) 3.73
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34
Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol (1995) 2.83
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res (2006) 2.62
Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol (2007) 2.50
Tumor volume in subcutaneous mouse xenografts measured by microCT is more accurate and reproducible than determined by 18F-FDG-microPET or external caliper. BMC Med Imaging (2008) 2.30
Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology (2005) 2.04
The TNM classification of prostate cancer. Prostate Suppl (1992) 1.96
Structural basis of LSD1-CoREST selectivity in histone H3 recognition. J Biol Chem (2007) 1.92
Involvement of proteasome in the dynamic assembly of the androgen receptor transcription complex. J Biol Chem (2002) 1.90
Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor. Mol Endocrinol (2004) 1.86
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59
Nucleosome arrays inhibit both initiation and elongation of transcripts by bacteriophage T7 RNA polymerase. J Mol Biol (1992) 1.19
Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. Oncogene (2008) 1.13
The expanding world of histone lysine demethylases. Nat Struct Mol Biol (2007) 0.98
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med (2010) 6.39
Retracted Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature (2002) 4.18
Bats host major mammalian paramyxoviruses. Nat Commun (2012) 4.15
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell (2008) 3.60
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol (2005) 3.49
PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state. Mol Cell (2006) 3.20
Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin Cancer Res (2006) 3.00
MYCN regulates oncogenic MicroRNAs in neuroblastoma. Int J Cancer (2008) 2.76
hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol (2005) 2.69
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res (2009) 2.65
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res (2006) 2.62
Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell (2009) 2.61
Risks of less common cancers in proven mutation carriers with lynch syndrome. J Clin Oncol (2012) 2.59
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis (2009) 2.54
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell (2011) 2.52
Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol (2007) 2.50
Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis. J Mol Diagn (2007) 2.35
PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev (2007) 2.34
Replication stress interferes with histone recycling and predeposition marking of new histones. Mol Cell (2010) 2.31
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J (2007) 2.19
The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Mol Cell (2004) 2.19
Early prediction of nonprogression in advanced non-small-cell lung cancer treated with erlotinib by using [(18)F]fluorodeoxyglucose and [(18)F]fluorothymidine positron emission tomography. J Clin Oncol (2011) 2.10
Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a. Mol Cell (2007) 1.96
The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J (2002) 1.91
OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Mol Biol Cell (2007) 1.87
Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis. J Infect Dis (2009) 1.87
HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol (2006) 1.84
Connecting threads: epigenetics and metabolism. Cell (2012) 1.75
Clear cell sarcoma-like tumor with osteoclast-like giant cells in the small bowel: further evidence for a new tumor entity. Int J Surg Pathol (2005) 1.74
Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy. Am J Hum Genet (2003) 1.72
MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell (2012) 1.72
The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. EMBO J (2002) 1.72
Attenuation of allergic contact dermatitis through the endocannabinoid system. Science (2007) 1.70
Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium. J Clin Oncol (2006) 1.70
Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations. Genes Dev (2011) 1.69
Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern. Dev Biol (2006) 1.68
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J (2012) 1.61
The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Rep (2009) 1.61
A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Dev Cell (2013) 1.59
Fast signals and slow marks: the dynamics of histone modifications. Trends Biochem Sci (2010) 1.58
Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Mol Cell Biol (2004) 1.57
A combination of different mass spectroscopic techniques for the analysis of dynamic changes of histone modifications. Proteomics (2004) 1.56
Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD). Kidney Int (2005) 1.55
Efficacy of annual colonoscopic surveillance in individuals with hereditary nonpolyposis colorectal cancer. Clin Gastroenterol Hepatol (2009) 1.54
Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study. Int J Colorectal Dis (2006) 1.54
The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104. J Biol Chem (2003) 1.52
Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer. Mod Pathol (2012) 1.50
Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature (2013) 1.46
All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol (2003) 1.46
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet (2011) 1.43
The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5. J Biol Chem (2003) 1.42
Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria. Mol Biol Cell (2009) 1.41
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest (2013) 1.41
PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD). Hum Mutat (2004) 1.40
PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity. EMBO Rep (2010) 1.39
Mutations in multiple PKD genes may explain early and severe polycystic kidney disease. J Am Soc Nephrol (2011) 1.38
Establishment of histone modifications after chromatin assembly. Nucleic Acids Res (2009) 1.36
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol (2006) 1.36
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma. Am J Pathol (2003) 1.36
Tumours from MSH2 mutation carriers show loss of MSH2 expression but many tumours from MLH1 mutation carriers exhibit weak positive MLH1 staining. J Pathol (2005) 1.35
The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity. Biochemistry (2004) 1.34
Microvascular decompression to treat hemifacial spasm: long-term results for a consecutive series of 143 patients. Neurosurgery (2002) 1.33
Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis. Gastroenterology (2005) 1.32
A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. EMBO J (2003) 1.32
A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD). Hepatology (2005) 1.31
Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase. J Cell Biol (2008) 1.28
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem (2007) 1.27
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol (2011) 1.27
Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice. Mol Cell Biol (2004) 1.27
Rapid metagenomic diagnostics for suspected outbreak of severe pneumonia. Emerg Infect Dis (2014) 1.26