ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma.

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Published in BMC Cancer on December 17, 2009

Authors

Silke Götze1, Valeska Feldhaus, Thilo Traska, Marietta Wolter, Guido Reifenberger, Andrea Tannapfel, Cornelius Kuhnen, Dirk Martin, Oliver Müller, Sonja Sievers

Author Affiliations

1: Max-Planck-Institut für molekulare Physiologie, Dortmund, Germany. silke.goetze@mpi-dortmund.mpg.de

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A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst (1973) 10.64

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Classification of human colorectal adenocarcinoma cell lines. Cancer Res (1976) 7.00

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BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing. Bioinformatics (2005) 5.95

Long term culture of normal and neoplastic human glia. Acta Pathol Microbiol Scand (1968) 4.82

Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst (1977) 4.35

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T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro. J Cell Physiol (1979) 2.22

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