Published in J Exp Med on December 21, 2009
Ion channels in innate and adaptive immunity. Annu Rev Immunol (2015) 1.99
Myeloperoxidase: a front-line defender against phagocytosed microorganisms. J Leukoc Biol (2012) 1.60
The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat Immunol (2011) 1.55
A specialized molecular motion opens the Hv1 voltage-gated proton channel. Nat Struct Mol Biol (2015) 1.45
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner. EMBO J (2011) 1.15
Water wires in atomistic models of the Hv1 proton channel. Biochim Biophys Acta (2011) 1.07
Calcium and ROS: A mutual interplay. Redox Biol (2015) 1.05
Physiological roles of voltage-gated proton channels in leukocytes. J Physiol (2010) 1.03
pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1. Trends Cell Biol (2010) 1.01
Subunit interactions during cooperative opening of voltage-gated proton channels. Neuron (2013) 0.99
NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem (2012) 0.98
Redox regulation of store-operated Ca2+ entry. Antioxid Redox Signal (2013) 0.93
Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment. Philos Trans R Soc Lond B Biol Sci (2014) 0.92
Molecular and functional characterization of Hv1 proton channel in human granulocytes. PLoS One (2010) 0.92
Philosophy of voltage-gated proton channels. J R Soc Interface (2013) 0.90
Chloride transport in functionally active phagosomes isolated from Human neutrophils. Free Radic Biol Med (2012) 0.89
Hv1 proton channel opening is preceded by a voltage-independent transition. Biophys J (2014) 0.88
Long α helices projecting from the membrane as the dimer interface in the voltage-gated H(+) channel. J Gen Physiol (2014) 0.87
Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives. Proc Natl Acad Sci U S A (2014) 0.86
Voltage-gated proton channels. Compr Physiol (2012) 0.85
Na⁺/H⁺ exchanger 1 participates in tobacco disease defence against Phytophthora parasitica var. nicotianae by affecting vacuolar pH and priming the antioxidative system. J Exp Bot (2014) 0.85
Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology. Antioxid Redox Signal (2014) 0.83
The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma. Biochemistry (2015) 0.83
Function of Proton Channels in Lung Epithelia. Wiley Interdiscip Rev Membr Transp Signal (2011) 0.83
Proton channel HVCN1 is required for effector functions of mouse eosinophils. BMC Immunol (2013) 0.83
Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage. J Neurochem (2015) 0.82
Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity. PLoS One (2015) 0.80
Salt, chloride, bleach, and innate host defense. J Leukoc Biol (2015) 0.79
Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia. J Physiol (2011) 0.78
Consequences of dimerization of the voltage-gated proton channel. Prog Mol Biol Transl Sci (2013) 0.78
Insights into the structure and function of HV1 from a meta-analysis of mutation studies. J Gen Physiol (2016) 0.78
Voltage control for B cell activation. Nat Immunol (2010) 0.78
Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling. Sci Rep (2015) 0.78
A contribution to the history of the proton channel. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.77
HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats. Hypertension (2014) 0.77
Biophysical properties of the voltage gated proton channel H(V)1. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.77
Regulation of immune responses by proton channels. Immunology (2014) 0.76
Proton channels in non-phagocytic cells of the immune system. Wiley Interdiscip Rev Membr Transp Signal (2013) 0.75
Neutrophils, from cradle to grave and beyond. Immunol Rev (2016) 0.75
Posttranslational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating. J Physiol (2016) 0.75
Intracellular shunting of O2(-) contributes to charge compensation and preservation of neutrophil respiratory burst in the absence of voltage-gated proton channel activity. Exp Cell Res (2013) 0.75
The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase. Immunol Rev (2016) 0.75
The inhibition of voltage-gated H(+) channel (HVCN1) induces acidification of leukemic Jurkat T cells promoting cell death by apoptosis. Pflugers Arch (2016) 0.75
Molecular and functional characterization of the voltage-gated proton channel in zebrafish neutrophils. Physiol Rep (2017) 0.75
Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature (2002) 7.53
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85
A voltage sensor-domain protein is a voltage-gated proton channel. Science (2006) 5.07
Voltage-gated proton channels and other proton transfer pathways. Physiol Rev (2003) 5.06
A voltage-gated proton-selective channel lacking the pore domain. Nature (2006) 4.89
The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature (1981) 4.01
How human neutrophils kill and degrade microbes: an integrated view. Immunol Rev (2007) 3.97
Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones. Nature (1982) 3.82
The neutrophil NADPH oxidase. Arch Biochem Biophys (2002) 3.71
Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel. Neuron (1997) 3.29
The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem J (1987) 3.19
Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron (2005) 2.94
The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels. Nature (2003) 2.45
A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science (2000) 2.36
The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26
Multimeric nature of voltage-gated proton channels. Proc Natl Acad Sci U S A (2008) 2.00
Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity. Am J Physiol Cell Physiol (2007) 1.99
Absence of both cytochrome b-245 subunits from neutrophils in X-linked chronic granulomatous disease. Nature (1987) 1.98
Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. Proc Natl Acad Sci U S A (2008) 1.95
A novel H(+) conductance in eosinophils: unique characteristics and absence in chronic granulomatous disease. J Exp Med (1999) 1.87
Retracted The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature (2004) 1.85
Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils. J Cell Biol (1990) 1.85
Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages. Proc Natl Acad Sci U S A (2007) 1.81
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A (2009) 1.80
Electron currents generated by the human phagocyte NADPH oxidase. Nature (1998) 1.77
The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels. J Gen Physiol (2006) 1.48
Charge compensation during the phagocyte respiratory burst. Biochim Biophys Acta (2006) 1.44
Voltage-gated proton channel is expressed on phagosomes. Biochem Biophys Res Commun (2009) 1.43
In situ measurement of the electrical potential across the phagosomal membrane using FRET and its contribution to the proton-motive force. Proc Natl Acad Sci U S A (2007) 1.40
Cytosolic free Ca(2+) changes and calpain activation are required for beta integrin-accelerated phagocytosis by human neutrophils. J Cell Biol (2002) 1.37
Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity. J Physiol (2006) 1.32
Oxidase activation in individual neutrophils is dependent on the onset and magnitude of the Ca2+ signal. Cell Calcium (1991) 1.30
Identification of formyl peptides from Listeria monocytogenes and Staphylococcus aureus as potent chemoattractants for mouse neutrophils. J Immunol (2008) 1.30
A noninvasive fluorimetric procedure for measurement of membrane potential. Quantification of the NADPH oxidase-induced depolarization in activated neutrophils. J Biol Chem (1999) 1.27
Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components. J Gen Physiol (2002) 1.23
Regulation of capacitative Ca2+ influx in human neutrophil granulocytes. Alterations in chronic granulomatous disease. J Biol Chem (1997) 1.22
Characterization of receptor-mediated and store-regulated Ca2+ influx in human neutrophils. Biochem J (1994) 1.22
Regulation of Ca2+ influx in myeloid cells. Role of plasma membrane potential, inositol phosphates, cytosolic free [Ca2+], and filling state of intracellular Ca2+ stores. J Clin Invest (1992) 1.22
The pH dependence of NADPH oxidase in human eosinophils. J Physiol (2005) 1.19
Intracellular pH regulation during spreading of human neutrophils. J Cell Biol (1996) 1.19
Analysis of reactive oxygen species generated by neutrophils using a chemiluminescence probe L-012. Anal Biochem (1999) 1.18
Heme histidine ligands within gp91(phox) modulate proton conduction by the phagocyte NADPH oxidase. J Biol Chem (2001) 1.13
BK channels in innate immune functions of neutrophils and macrophages. Blood (2008) 1.07
Regulation of cytosolic calcium in blood cells. Physiol Rev (1993) 1.07
Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes. J Biol Chem (1994) 1.07
Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase. Biochem J (2005) 1.01
The intimate and mysterious relationship between proton channels and NADPH oxidase. FEBS Lett (2008) 0.97
NOX family NADPH oxidases: do they have built-in proton channels? J Gen Physiol (2002) 0.97
Electron and proton transport by NADPH oxidases. Philos Trans R Soc Lond B Biol Sci (2005) 0.97
Calcium signalling is altered in myeloid cells with a deficiency in NADPH oxidase activity. Clin Exp Immunol (2003) 0.95
Consequences of the electrogenic function of the phagocytic NADPH oxidase. Philos Trans R Soc Lond B Biol Sci (2005) 0.95
Interactions between electron and proton currents in excised patches from human eosinophils. J Gen Physiol (2003) 0.94
Dynamic ca(2+)changes in neutrophil phagosomes A source for intracellular ca(2+)during phagolysosome formation? Cell Calcium (2000) 0.92
Voltage-gated proton "channels": a spectator's viewpoint. J Gen Physiol (2002) 0.89
Gelsolin mediates calcium-dependent disassembly of Listeria actin tails. Proc Natl Acad Sci U S A (2005) 0.83
Chloride channels activated by swell can regulate the NADPH oxidase generated membrane depolarisation in activated human neutrophils. Biochem Biophys Res Commun (2007) 0.82
Role of nucleotides and phosphoinositides in the stability of electron and proton currents associated with the phagocytic NADPH oxidase. Biochem J (2006) 0.81
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85
A voltage sensor-domain protein is a voltage-gated proton channel. Science (2006) 5.07
The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J Immunol (2002) 3.48
Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol (2005) 2.98
Improving membrane voltage measurements using FRET with new fluorescent proteins. Nat Methods (2008) 2.74
HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse. Traffic (2005) 2.47
Depolarization activates the phosphoinositide phosphatase Ci-VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2. J Physiol (2007) 2.31
alx, a zebrafish homolog of Chx10, marks ipsilateral descending excitatory interneurons that participate in the regulation of spinal locomotor circuits. J Neurosci (2006) 2.09
Multimeric nature of voltage-gated proton channels. Proc Natl Acad Sci U S A (2008) 2.00
A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2008) 1.85
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. EMBO J (2009) 1.85
Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1. J Biol Chem (2004) 1.84
Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases. J Biol Chem (2008) 1.83
Sustained Ca2+ transfer across mitochondria is Essential for mitochondrial Ca2+ buffering, sore-operated Ca2+ entry, and Ca2+ store refilling. J Biol Chem (2003) 1.71
From the Cover: STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum. Proc Natl Acad Sci U S A (2009) 1.71
Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. J Cell Biol (2005) 1.69
Dynamic regulation of the mitochondrial proton gradient during cytosolic calcium elevations. J Biol Chem (2011) 1.66
Calcium uptake mechanisms of mitochondria. Biochim Biophys Acta (2010) 1.61
Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet (2008) 1.56
Voltage-gated proton channel is expressed on phagosomes. Biochem Biophys Res Commun (2009) 1.43
Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci U S A (2013) 1.42
STIM1 knockdown reveals that store-operated Ca2+ channels located close to sarco/endoplasmic Ca2+ ATPases (SERCA) pumps silently refill the endoplasmic reticulum. J Biol Chem (2007) 1.28
STIM1- and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation. J Biol Chem (2008) 1.25
Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. J Biol Chem (2008) 1.25
Perspectives on: SGP symposium on mitochondrial physiology and medicine: the renaissance of mitochondrial pH. J Gen Physiol (2012) 1.23
The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1. Nat Commun (2012) 1.23
Two-photon voltage imaging using a genetically encoded voltage indicator. Sci Rep (2013) 1.20
STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+ release. J Cell Biol (2011) 1.20
Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria. J Biol Chem (2002) 1.18
Functionality of the voltage-gated proton channel truncated in S4. Proc Natl Acad Sci U S A (2009) 1.18
NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie (2007) 1.17
Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans. EMBO J (2011) 1.17
OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange. EMBO J (2013) 1.16
GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci (2006) 1.12
Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion. Endocrinology (2008) 1.09
Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor. J Physiol (2013) 1.08
Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes. J Neurosci (2011) 1.08
Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence. J Cell Physiol (2011) 1.07
3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc Natl Acad Sci U S A (2012) 1.07
The neurobiology of the ascidian tadpole larva: recent developments in an ancient chordate. Annu Rev Neurosci (2004) 1.07
Regulation of Na v channels in sensory neurons. Trends Pharmacol Sci (2005) 1.07
ARF1 regulates Nef-induced CD4 degradation. Curr Biol (2004) 1.06
The role of calcium signaling in phagocytosis. J Leukoc Biol (2010) 1.03
A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover. J Cell Sci (2003) 1.02
Improved detection of electrical activity with a voltage probe based on a voltage-sensing phosphatase. J Physiol (2013) 1.01
Coupling of the phosphatase activity of Ci-VSP to its voltage sensor activity over the entire range of voltage sensitivity. J Physiol (2011) 1.01
Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase. Biochem J (2005) 1.01
Mitochondrial regulation of sarcoplasmic reticulum Ca2+ content in vascular smooth muscle cells. Circ Res (2008) 1.01
Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production. J Biol Chem (2011) 1.00
Human muscle economy myoblast differentiation and excitation-contraction coupling use the same molecular partners, STIM1 and STIM2. J Biol Chem (2010) 0.99
Visualizing voltage dynamics in zebrafish heart. J Physiol (2010) 0.99
Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation. J Biol Chem (2004) 0.98
NOX family NADPH oxidases: do they have built-in proton channels? J Gen Physiol (2002) 0.97
Three children with plastic bronchitis associated with 2009 H1N1 influenza virus infection. Pediatr Infect Dis J (2011) 0.96
Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian. Gene Expr Patterns (2010) 0.95
Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis. Traffic (2013) 0.95
A self-limiting regulation of vasoconstrictor-activated TRPC3/C6/C7 channels coupled to PI(4,5)P₂-diacylglycerol signalling. J Physiol (2011) 0.94
Interactions between electron and proton currents in excised patches from human eosinophils. J Gen Physiol (2003) 0.94
Subplasmalemmal mitochondria modulate the activity of plasma membrane Ca2+-ATPases. J Biol Chem (2005) 0.94
STIM1 juxtaposes ER to phagosomes, generating Ca²⁺ hotspots that boost phagocytosis. Curr Biol (2012) 0.93
Redox regulation of store-operated Ca2+ entry. Antioxid Redox Signal (2013) 0.93
Subplasmalemmal endoplasmic reticulum controls K(Ca) channel activity upon stimulation with a moderate histamine concentration in a human umbilical vein endothelial cell line. J Physiol (2002) 0.92
Remodelling of the endoplasmic reticulum during store-operated calcium entry. Biol Cell (2011) 0.92
Local cytosolic Ca2+ elevations are required for stromal interaction molecule 1 (STIM1) de-oligomerization and termination of store-operated Ca2+ entry. J Biol Chem (2011) 0.91
PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels. J Gen Physiol (2014) 0.91
Mitochondrial calcium handling during ischemia-induced cell death in neurons. Biochimie (2011) 0.90
Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P2. J Cell Physiol (2014) 0.90
In vitro activated human T lymphocytes very efficiently attach to allogenic multipotent mesenchymal stromal cells and transmigrate under them. J Cell Physiol (2008) 0.89
Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6. J Neurophysiol (2006) 0.89
Reactive oxygen species are NOXious for neurons. Nat Neurosci (2009) 0.87
Long α helices projecting from the membrane as the dimer interface in the voltage-gated H(+) channel. J Gen Physiol (2014) 0.87
Optically detected structural change in the N-terminal region of the voltage-sensor domain. Biophys J (2013) 0.87
Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail. Biochim Biophys Acta (2002) 0.86
Crowned dens syndrome. Intern Med (2005) 0.86
Pax6-induced alteration of cell fate: shape changes, expression of neuronal alpha tubulin, postmitotic phenotype, and cell migration. J Neurobiol (2006) 0.86
Gating of the designed trimeric/tetrameric voltage-gated H+ channel. J Physiol (2012) 0.86
Regulation of the mitochondrial proton gradient by cytosolic Ca²⁺ signals. Pflugers Arch (2012) 0.85
Autoimmune disorder phenotypes in Hvcn1-deficient mice. Biochem J (2013) 0.85
Structural characteristics of the redox-sensing coiled coil in the voltage-gated H+ channel. J Biol Chem (2013) 0.85
Local and global calcium signals associated with the opening of neuronal alpha7 nicotinic acetylcholine receptors. Cell Calcium (2008) 0.85
Comparison of clinical profile in elderly patients with nursing and healthcare-associated pneumonia, and those with community-acquired pneumonia. Geriatr Gerontol Int (2013) 0.85
Regulation of synaptotagmin gene expression during ascidian embryogenesis. Dev Biol (2002) 0.85
Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics (2010) 0.85
[New role of voltage sensor: voltage-regulated phosphatase recently identified from ascidian genome]. Tanpakushitsu Kakusan Koso (2006) 0.84
Do Hv1 proton channels regulate the ionic and redox homeostasis of phagosomes? Mol Cell Endocrinol (2011) 0.83