Published in J Gen Physiol on December 01, 2002
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A (2009) 1.80
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification. J Exp Med (2009) 1.29
Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes. Physiology (Bethesda) (2010) 1.22
Voltage-gated proton channels: what's next? J Physiol (2008) 1.21
Voltage-gated proton channels. Cell Mol Life Sci (2008) 1.06
Physiological roles of voltage-gated proton channels in leukocytes. J Physiol (2010) 1.03
Electrophysiology of reactive oxygen production in signaling endosomes. Antioxid Redox Signal (2009) 1.02
Electron and proton transport by NADPH oxidases. Philos Trans R Soc Lond B Biol Sci (2005) 0.97
Consequences of the electrogenic function of the phagocytic NADPH oxidase. Philos Trans R Soc Lond B Biol Sci (2005) 0.95
Interactions between electron and proton currents in excised patches from human eosinophils. J Gen Physiol (2003) 0.94
Molecular and functional characterization of Hv1 proton channel in human granulocytes. PLoS One (2010) 0.92
Evidence for transmembrane proton transfer in a dihaem-containing membrane protein complex. EMBO J (2006) 0.91
The requirement of cytosolic phospholipase A2 for the PMA activation of proton efflux through the N-terminal 230-amino-acid fragment of gp91phox. Biochem J (2003) 0.82
Insights into the structure and function of HV1 from a meta-analysis of mutation studies. J Gen Physiol (2016) 0.78
The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase. Immunol Rev (2016) 0.75
NADPH oxidase: an update. Blood (1999) 7.65
A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc Natl Acad Sci U S A (1997) 4.03
Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones. Nature (1982) 3.82
Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel. Neuron (1997) 3.29
The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem J (1987) 3.19
The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue. J Biol Chem (2002) 3.01
Histidine scanning mutagenesis of basic residues of the S4 segment of the shaker k+ channel. J Gen Physiol (2001) 2.79
A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem (2001) 2.56
A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science (2000) 2.36
A novel H(+) conductance in eosinophils: unique characteristics and absence in chronic granulomatous disease. J Exp Med (1999) 1.87
Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase. Proc Natl Acad Sci U S A (1998) 1.82
Electron currents generated by the human phagocyte NADPH oxidase. Nature (1998) 1.77
Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases. Curr Opin Hematol (2002) 1.74
Proton currents in human granulocytes: regulation by membrane potential and intracellular pH. J Physiol (1993) 1.56
Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system. Blood (2002) 1.54
The arachidonate-activable, NADPH oxidase-associated H+ channel. Evidence that gp91-phox functions as an essential part of the channel. J Biol Chem (1995) 1.53
NADPH oxidase of neutrophils. Biochim Biophys Acta (1996) 1.49
Evidence that the product of the human X-linked CGD gene, gp91-phox, is a voltage-gated H(+) pathway. J Gen Physiol (1999) 1.38
The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps. J Biol Chem (2001) 1.32
Voltage-gated proton channels in microglia. Prog Neurobiol (2001) 1.31
Phorbol 12-myristate 13-acetate activates an electrogenic H(+)-conducting pathway in the membrane of neutrophils. Biochem J (1992) 1.30
A voltage-dependent proton current in cultured human skeletal muscle myotubes. J Physiol (1993) 1.26
Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components. J Gen Physiol (2002) 1.23
The arachidonate-activatable, NADPH oxidase-associated H+ channel is contained within the multi-membrane-spanning N-terminal region of gp91-phox. Biochem J (1997) 1.21
Heme histidine ligands within gp91(phox) modulate proton conduction by the phagocyte NADPH oxidase. J Biol Chem (2001) 1.13
Role of histidines identified by mutagenesis in the NADPH oxidase-associated H+ channel. J Biol Chem (1998) 1.10
Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes. J Biol Chem (1994) 1.07
Development of a H(+)-selective conductance during granulocytic differentiation of HL-60 cells. Am J Physiol (1994) 1.04
The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance. J Gen Physiol (1995) 1.03
A highly temperature-sensitive proton current in mouse bone marrow-derived mast cells. J Gen Physiol (1997) 1.01
Electron transfer across the O2- generating flavocytochrome b of neutrophils. Evidence for a transition from a low-spin state to a high-spin state of the heme iron component. Biochemistry (1996) 0.94
Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function. J Clin Invest (1994) 0.93
Proton channels, plasma membrane potential, and respiratory burst in human neutrophils. Eur J Haematol (1993) 0.84
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Ageing and infection. Lancet Infect Dis (2002) 3.79
The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J Immunol (2002) 3.48
Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol (2005) 2.98
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev (2005) 2.78
HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse. Traffic (2005) 2.47
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem (2002) 2.41
NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal (2009) 2.38
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
Pneumonia in the very old. Lancet Infect Dis (2004) 2.19
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17
Decreased blood pressure in NOX1-deficient mice. FEBS Lett (2005) 2.10
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol (2009) 2.01
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. EMBO J (2009) 1.85
Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1. J Biol Chem (2004) 1.84
Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal (2009) 1.80
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell (2006) 1.76
A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells. Stem Cells (2009) 1.71
Sustained Ca2+ transfer across mitochondria is Essential for mitochondrial Ca2+ buffering, sore-operated Ca2+ entry, and Ca2+ store refilling. J Biol Chem (2003) 1.71
From the Cover: STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum. Proc Natl Acad Sci U S A (2009) 1.71
NOX family NADPH oxidases: not just in mammals. Biochimie (2007) 1.68
Dynamic regulation of the mitochondrial proton gradient during cytosolic calcium elevations. J Biol Chem (2011) 1.66
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.65
Does dementia predict adverse hospitalization outcomes? A prospective study in aged inpatients. Int J Geriatr Psychiatry (2009) 1.62
Calcium uptake mechanisms of mitochondria. Biochim Biophys Acta (2010) 1.61
Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors. Stem Cells (2005) 1.48
Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci U S A (2013) 1.42
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci (2008) 1.34
Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age Ageing (2007) 1.32
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.30
VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification. J Exp Med (2009) 1.29
NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertension (2007) 1.29
Aging and infectious diseases in the developing world. Clin Infect Dis (2004) 1.29
STIM1 knockdown reveals that store-operated Ca2+ channels located close to sarco/endoplasmic Ca2+ ATPases (SERCA) pumps silently refill the endoplasmic reticulum. J Biol Chem (2007) 1.28
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol (2005) 1.27
STIM1- and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation. J Biol Chem (2008) 1.25
NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Mol Cell Biol (2010) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. J Biol Chem (2008) 1.25
Perspectives on: SGP symposium on mitochondrial physiology and medicine: the renaissance of mitochondrial pH. J Gen Physiol (2012) 1.23
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans (2008) 1.20
Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria. J Biol Chem (2002) 1.18
Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections. Cell Microbiol (2014) 1.18
NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie (2007) 1.17
Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats. Biol Psychiatry (2009) 1.17
OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange. EMBO J (2013) 1.16
A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells (2007) 1.13
Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res (2009) 1.12
GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci (2006) 1.12
Prospective comparison of 6 comorbidity indices as predictors of 1-year post-hospital discharge institutionalization, readmission, and mortality in elderly individuals. J Am Med Dir Assoc (2011) 1.11
Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion. Endocrinology (2008) 1.09
NOX5: from basic biology to signaling and disease. Free Radic Biol Med (2011) 1.08
Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation. J Cell Sci (2006) 1.08
Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes. J Neurosci (2011) 1.08
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX (2010) 1.06
ARF1 regulates Nef-induced CD4 degradation. Curr Biol (2004) 1.06
New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. Oncogene (2005) 1.03
The role of calcium signaling in phagocytosis. J Leukoc Biol (2010) 1.03
Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations. Stem Cells Dev (2012) 1.02
A role for NOX NADPH oxidases in Alzheimer's disease and other types of dementia? IUBMB Life (2003) 1.02
A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover. J Cell Sci (2003) 1.02
The HIV-1 Nef protein and phagocyte NADPH oxidase activation. J Biol Chem (2002) 1.02
Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase. Biochem J (2005) 1.01
A key role for the microglial NADPH oxidase in APP-dependent killing of neurons. Neurobiol Aging (2005) 1.01
Mitochondrial regulation of sarcoplasmic reticulum Ca2+ content in vascular smooth muscle cells. Circ Res (2008) 1.01
Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. Circulation (2010) 1.00
Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production. J Biol Chem (2011) 1.00
Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activity. Oncogene (2004) 0.98
Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress. Antioxid Redox Signal (2013) 0.98
Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. Int J Cancer (2006) 0.98
Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis. J Cell Biol (2002) 0.97
Telomere length and ApoE polymorphism in mild cognitive impairment, degenerative and vascular dementia. J Neurol Sci (2010) 0.97
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion. Diabetes (2012) 0.97
The chemokine receptor CCR5 in the central nervous system. Prog Neurobiol (2010) 0.96
Geriatrics index of comorbidity was the most accurate predictor of death in geriatric hospital among six comorbidity scores. J Clin Epidemiol (2010) 0.96
Detection of reactive oxygen species derived from the family of NOX NADPH oxidases. Free Radic Biol Med (2012) 0.96
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow. Blood (2011) 0.96
Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation. Hum Mutat (2009) 0.95
Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis. Traffic (2013) 0.95
The NADPH oxidase NOX2 controls glutamate release: a novel mechanism involved in psychosis-like ketamine responses. J Neurosci (2010) 0.95
Targeting NOX enzymes in the central nervous system: therapeutic opportunities. Cell Mol Life Sci (2012) 0.95
Calnexin deficiency leads to dysmyelination. J Biol Chem (2010) 0.94
Severe life stress and oxidative stress in the brain: from animal models to human pathology. Antioxid Redox Signal (2012) 0.94
Interactions between electron and proton currents in excised patches from human eosinophils. J Gen Physiol (2003) 0.94
Regulation of NOX1 expression by GATA, HNF-1alpha, and Cdx transcription factors. Free Radic Biol Med (2007) 0.94
Comprehensive metagenomic analysis of glioblastoma reveals absence of known virus despite antiviral-like type I interferon gene response. Int J Cancer (2014) 0.94
Subplasmalemmal mitochondria modulate the activity of plasma membrane Ca2+-ATPases. J Biol Chem (2005) 0.94
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. ALTEX (2008) 0.93
Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells. J Pathol (2012) 0.93
Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells. J Cell Mol Med (2009) 0.93
Redox regulation of store-operated Ca2+ entry. Antioxid Redox Signal (2013) 0.93