PubRank

Marylyn D Ritchie

Author PubWeight™ 229.33‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 2003 9.91
2 The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics 2011 9.20
3 Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med 2008 7.13
4 PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics 2010 7.07
5 Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol 2013 4.85
6 The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med 2013 4.37
7 A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol 2007 4.15
8 A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood 2008 4.02
9 Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet 2011 3.85
10 Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet 2012 3.71
11 Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation 2010 3.35
12 Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genet Med 2012 3.29
13 Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation 2004 3.02
14 The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol 2011 2.98
15 Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans. Pharmacogenet Genomics 2006 2.66
16 Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm 2007 2.62
17 Visualizing SNP statistics in the context of linkage disequilibrium using LD-Plus. Bioinformatics 2010 2.59
18 Machine learning for detecting gene-gene interactions: a review. Appl Bioinformatics 2006 2.56
19 Data simulation software for whole-genome association and other studies in human genetics. Pac Symp Biocomput 2006 2.49
20 Quality control procedures for genome-wide association studies. Curr Protoc Hum Genet 2011 2.48
21 Biofilter: a knowledge-integration system for the multi-locus analysis of genome-wide association studies. Pac Symp Biocomput 2009 2.26
22 Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Genet Med 2010 2.09
23 Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. PLoS Biol 2013 2.08
24 Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Hum Genet 2011 2.00
25 Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood 2008 1.99
26 STUDENTJAMA. The challenges of whole-genome approaches to common diseases. JAMA 2004 1.95
27 An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics 2004 1.95
28 Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study. J Infect Dis 2010 1.91
29 Multilocus analysis of hypertension: a hierarchical approach. Hum Hered 2004 1.82
30 Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology. Genet Epidemiol 2008 1.75
31 Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. J Biol Chem 2004 1.74
32 Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. PLoS Genet 2013 1.70
33 Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. J Am Med Inform Assoc 2011 1.67
34 Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. Am J Hum Genet 2011 1.66
35 Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics 2012 1.66
36 Finding unique filter sets in PLATO: a precursor to efficient interaction analysis in GWAS data. Pac Symp Biocomput 2010 1.64
37 A comparison of analytical methods for genetic association studies. Genet Epidemiol 2008 1.61
38 Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet 2009 1.59
39 Parallel multifactor dimensionality reduction: a tool for the large-scale analysis of gene-gene interactions. Bioinformatics 2006 1.53
40 Routine Discovery of Complex Genetic Models using Genetic Algorithms. Appl Soft Comput 2004 1.53
41 Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants. Pharmacogenet Genomics 2012 1.52
42 Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem 2006 1.51
43 Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction. BMC Bioinformatics 2008 1.50
44 Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study. Atherosclerosis 2013 1.48
45 A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet 2011 1.48
46 A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum Genet 2013 1.47
47 Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genet Epidemiol 2011 1.47
48 Application of Genetic Algorithms to the Discovery of Complex Models for Simulation Studies in Human Genetics. Proc Genet Evol Comput Conf 2002 1.46
49 Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis 2006 1.46
50 Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. PLoS One 2011 1.42
51 Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. AIDS 2005 1.39
52 Problems with genome-wide association studies. Science 2007 1.39
53 Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Hum Mol Genet 2005 1.38
54 Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis. BioData Min 2010 1.37
55 Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Hum Genomics 2006 1.37
56 A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. PLoS Genet 2011 1.35
57 FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. PLoS One 2010 1.34
58 Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study. J Infect Dis 2006 1.31
59 Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring) 2013 1.28
60 Novel methods for detecting epistasis in pharmacogenomics studies. Pharmacogenomics 2007 1.27
61 Fine Mapping and Identification of BMI Loci in African Americans. Am J Hum Genet 2013 1.27
62 Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genet Epidemiol 2011 1.26
63 GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease. BMC Bioinformatics 2006 1.26
64 The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction. Genet Epidemiol 2006 1.25
65 The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenet Genomics 2012 1.21
66 Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise. Ann Hum Genet 2010 1.21
67 Genetic analysis of biological pathway data through genomic randomization. Hum Genet 2011 1.20
68 Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. J Biol Chem 2002 1.19
69 Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View. BioData Min 2012 1.17
70 Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics 2009 1.16
71 High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Clin Transl Sci 2012 1.13
72 Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing. Pharmacogenomics 2007 1.12
73 Genetic heterogeneity is not as threatening as you might think. Genet Epidemiol 2007 1.08
74 Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models. Hum Hered 2008 1.08
75 Alternative Cross-Over Strategies and Selection Techniques for Grammatical Evolution Optimized Neural Networks. Genet Evol Comput Conf 2006 1.07
76 An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. Am J Med Genet B Neuropsychiatr Genet 2009 1.05
77 Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet 2013 1.05
78 Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits. Mayo Clin Proc 2012 1.05
79 Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. PLoS One 2013 1.04
80 Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy. AIDS 2006 1.03
81 Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study. Pharmacogenet Genomics 2006 1.03
82 Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using Biofilter, and gene-environment interactions using the PhenX Toolkit. Pac Symp Biocomput 2013 1.02
83 A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data. J Am Med Inform Assoc 2012 1.02
84 Leveraging Epidemiologic and Clinical Collections for Genomic Studies of Complex Traits. Hum Hered 2015 1.00
85 Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study. G3 (Bethesda) 2013 1.00
86 ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci. BioData Min 2010 1.00
87 African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy. J Infect Dis 2010 0.99
88 Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Ann Hum Genet 2013 0.99
89 Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield Personalized Medicine Research Project Biobank. Pac Symp Biocomput 2014 0.98
90 Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. Neurogenetics 2006 0.97
91 Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome. J Am Coll Cardiol 2008 0.97
92 Risk factor interactions and genetic effects associated with post-operative atrial fibrillation. Pac Symp Biocomput 2006 0.96
93 ABCB1 and GST polymorphisms associated with TP53 status in breast cancer. Pharmacogenet Genomics 2007 0.96
94 ATHENA: a tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels. Pac Symp Biocomput 2013 0.95
95 Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202. Pharmacogenet Genomics 2014 0.95
96 Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records. PLoS One 2013 0.94
97 Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. Am J Epidemiol 2013 0.94
98 Enabling high-throughput genotype-phenotype associations in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Pac Symp Biocomput 2013 0.93
99 Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. PLoS One 2013 0.93
100 Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. Psychiatr Genet 2007 0.93
101 European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142. AIDS 2011 0.93
102 Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error. BMC Res Notes 2008 0.92
103 Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study. Mitochondrion 2006 0.92
104 Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Pharmacogenomics 2013 0.91
105 Estrogens, enzyme variants, and breast cancer: a risk model. Cancer Epidemiol Biomarkers Prev 2006 0.91
106 Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants. Pac Symp Biocomput 2011 0.91
107 Visual integration of results from a large DNA biobank (BioVU) using synthesis-view. Pac Symp Biocomput 2011 0.91
108 ATHENA: the analysis tool for heritable and environmental network associations. Bioinformatics 2013 0.90
109 BioBin: a bioinformatics tool for automating the binning of rare variants using publicly available biological knowledge. BMC Med Genomics 2013 0.90
110 Validation of PhenX measures in the personalized medicine research project for use in gene/environment studies. BMC Med Genomics 2014 0.90
111 Understanding the Evolutionary Process of Grammatical Evolution Neural Networks for Feature Selection in Genetic Epidemiology. Proc IEEE Symp Comput Intell Bioinforma Comput Biol 2006 0.90
112 Human genomic association studies: a primer for the infectious diseases specialist. J Infect Dis 2007 0.89
113 LD-spline: mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium. BioData Min 2009 0.87
114 Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. Schizophr Res 2008 0.86
115 Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. BMC Med Genet 2013 0.85
116 Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. J Neurovirol 2012 0.85
117 Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384. J Acquir Immune Defic Syndr 2011 0.85
118 Linkage Disequilibrium in Genetic Association Studies Improves the Performance of Grammatical Evolution Neural Networks. Proc IEEE Symp Comput Intell Bioinforma Comput Biol 2007 0.85
119 A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT. PLoS One 2010 0.85
120 Integrating heterogeneous high-throughput data for meta-dimensional pharmacogenomics and disease-related studies. Pharmacogenomics 2012 0.84
121 Pharmacogenomics of HIV therapy: summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases. HIV Clin Trials 2011 0.84
122 Initialization Parameter Sweep in ATHENA: Optimizing Neural Networks for Detecting Gene-Gene Interactions in the Presence of Small Main Effects. Genet Evol Comput Conf 2010 0.84
123 Genomic architecture of pharmacological efficacy and adverse events. Pharmacogenomics 2014 0.83
124 Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky. Genet Epidemiol 2007 0.82
125 Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies. BioData Min 2011 0.82
126 Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis. Curr Pharmacogenomics Person Med 2011 0.82
127 Using BioBin to explore rare variant population stratification. Pac Symp Biocomput 2013 0.81
128 Clinical applications of whole-genome association studies: future applications at the bedside. Expert Rev Mol Diagn 2006 0.81
129 Filling the gap between biology and computer science. BioData Min 2008 0.81
130 Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. Int J Cancer 2011 0.80
131 Phenome-Wide Association Studies: Embracing Complexity for Discovery. Hum Hered 2015 0.80
132 Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice. Neurosci Lett 2004 0.80
133 Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. Pharmacogenet Genomics 2013 0.80
134 Methods for optimizing statistical analyses in pharmacogenomics research. Expert Rev Clin Pharmacol 2009 0.79
135 Pacific Symposium on Biocomputing--computational approaches for pharmacogenomics. Pharmacogenomics 2005 0.79
136 Characterization of the Metabochip in diverse populations from the International HapMap Project in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project. Pac Symp Biocomput 2013 0.79
137 A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test. Genet Epidemiol 2010 0.79
138 A Balanced Accuracy Fitness Function Leads to Robust Analysis using Grammatical Evolution Neural Networks in the Case of Class Imbalance. Genet Evol Comput Conf 2008 0.79
139 Association Rule Discovery Has the Ability to Model Complex Genetic Effects. IEEE Symp Comput Intell Data Min 2007 0.78
140 Binning somatic mutations based on biological knowledge for predicting survival: an application in renal cell carcinoma. Pac Symp Biocomput 2015 0.78
141 Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. AIDS Res Hum Retroviruses 2013 0.77
142 The effects of linkage disequilibrium in large scale SNP datasets for MDR. BioData Min 2011 0.77
143 KNOWLEDGE DRIVEN BINNING AND PHEWAS ANALYSIS IN MARSHFIELD PERSONALIZED MEDICINE RESEARCH PROJECT USING BIOBIN. Pac Symp Biocomput 2016 0.77
144 Methods for analysis in pharmacogenomics: lessons from the Pharmacogenetics Research Network Analysis Group. Pharmacogenomics 2009 0.77
145 PHENOME-WIDE INTERACTION STUDY (PheWIS) IN AIDS CLINICAL TRIALS GROUP DATA (ACTG). Pac Symp Biocomput 2016 0.75
146 Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202. Pharmacogenet Genomics 2017 0.75
147 INTEGRATING CLINICAL LABORATORY MEASURES AND ICD-9 CODE DIAGNOSES IN PHENOME-WIDE ASSOCIATION STUDIES. Pac Symp Biocomput 2016 0.75
148 BIOFILTER AS A FUNCTIONAL ANNOTATION PIPELINE FOR COMMON AND RARE COPY NUMBER BURDEN. Pac Symp Biocomput 2016 0.75
149 How powerful are summary-based methods for identifying expression-trait associations under different genetic architectures? Pac Symp Biocomput 2018 0.75
150 The central role of biological data mining in connecting diverse disciplines. BioData Min 2013 0.75
151 Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. Pac Symp Biocomput 2018 0.75
152 Basic statistics. Curr Protoc Hum Genet 2003 0.75
153 IDENTIFYING GENETIC ASSOCIATIONS WITH VARIABILITY IN METABOLIC HEALTH AND BLOOD COUNT LABORATORY VALUES: DIVING INTO THE QUANTITATIVE TRAITS BY LEVERAGING LONGITUDINAL DATA FROM AN EHR. Pac Symp Biocomput 2016 0.75
154 Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using biofilter, and gene-environment interactions using the Phenx Toolkit*. Pac Symp Biocomput 2015 0.75
155 Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. Am J Epidemiol 2017 0.75
156 Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions. Am J Epidemiol 2017 0.75
157 Identification of unique venous thromboembolism-susceptibility variants in African-Americans. Thromb Haemost 2017 0.75