Published in J Virol on December 23, 2009
A bovine cell line that can be infected by natural sheep scrapie prions. PLoS One (2015) 1.44
Cellular aspects of prion replication in vitro. Viruses (2013) 0.95
The standard scrapie cell assay: development, utility and prospects. Viruses (2015) 0.86
Prion disease and the innate immune system. Viruses (2012) 0.86
A simple, versatile and sensitive cell-based assay for prions from various species. PLoS One (2011) 0.86
Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions. Acta Neuropathol Commun (2016) 0.84
Absolute quantification of prion protein (90-231) using stable isotope-labeled chymotryptic peptide standards in a LC-MRM AQUA workflow. J Am Soc Mass Spectrom (2012) 0.83
Alimentary prion infections: Touchdown in the intestine. Prion (2011) 0.79
Susceptibility of GT1-7 cells to mouse-passaged field scrapie isolates with a long incubation. Prion (2014) 0.78
Enzymatic formulation capable of degrading scrapie prion under mild digestion conditions. PLoS One (2013) 0.77
A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation. Prion (2016) 0.75
Methods for Differentiating Prion Types in Food-Producing Animals. Biology (Basel) (2015) 0.75
Chronic wasting disease prion infection of differentiated neurospheres. Prion (2017) 0.75
The sequential development of the brain lesion of scrapie in three strains of mice. J Comp Pathol (1968) 3.60
Truncated forms of the human prion protein in normal brain and in prion diseases. J Biol Chem (1995) 3.20
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. Proc Natl Acad Sci U S A (2003) 2.94
PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J Gen Virol (1994) 2.63
Cultured cell sublines highly susceptible to prion infection. J Virol (2000) 2.38
Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol (2007) 2.31
Prion strain discrimination in cell culture: the cell panel assay. Proc Natl Acad Sci U S A (2007) 2.30
Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J Virol (2000) 2.18
Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein. Proc Natl Acad Sci U S A (2001) 2.16
Scrapie strain variation and mutation. Br Med Bull (1993) 2.06
Strain characterization of natural sheep scrapie and comparison with BSE. J Gen Virol (2002) 2.04
High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo. J Biol Chem (2007) 1.93
In vitro replication of scrapie agent in a neuronal model: infection of PC12 cells. J Gen Virol (1984) 1.80
Risk of scrapie in British sheep of different prion protein genotype. J Gen Virol (2004) 1.73
Reciprocal interference between specific CJD and scrapie agents in neural cell cultures. Science (2005) 1.34
Ovine infection with the agents of scrapie (CH1641 isolate) and bovine spongiform encephalopathy: immunochemical similarities can be resolved by immunohistochemistry. J Comp Pathol (2005) 1.26
Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. J Infect Dis (2004) 1.25
The unusual properties of CH1641, a sheep-passaged isolate of scrapie. Vet Rec (1988) 1.22
A cell line infectible by prion strains from different species. J Gen Virol (2008) 1.21
Cultured peripheral neuroglial cells are highly permissive to sheep prion infection. J Virol (2004) 1.19
Scrapie in sheep and goats. Front Biol (1976) 1.18
Accumulation and dissemination of prion protein in experimental sheep scrapie in the natural host. BMC Vet Res (2009) 1.17
Cell models of prion infection. Vet Res (2007) 1.16
Efficient dissemination of prions through preferential transmission to nearby cells. J Gen Virol (2007) 1.15
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J Virol (2006) 1.14
Assaying prions in cell culture: the standard scrapie cell assay (SSCA) and the scrapie cell assay in end point format (SCEPA). Methods Mol Biol (2008) 1.06
Microglial cell line established from prion protein-overexpressing mice is susceptible to various murine prion strains. J Virol (2006) 1.05
Prion propagation in cultured cells. Br Med Bull (2003) 1.04
PrPc does not mediate internalization of PrPSc but is required at an early stage for de novo prion infection of Rov cells. J Virol (2007) 1.01
Serum-dependent and cell cycle-dependent expression from a cytomegalovirus-based mammalian expression vector. Gene (1997) 1.01
High-resolution differentiation of transmissible spongiform encephalopathy strains by quantitative N-terminal amino acid profiling (N-TAAP) of PK-digested abnormal prion protein. J Mass Spectrom (2009) 0.86
Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteins. J Biol Chem (2007) 0.85
Selection of ovine PrP high-producer subclones from a transfected epithelial cell line. Biochem Biophys Res Commun (2005) 0.79
Cells release prions in association with exosomes. Proc Natl Acad Sci U S A (2004) 5.17
Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells. J Biol Chem (2004) 2.54
A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proc Natl Acad Sci U S A (2005) 2.47
BSE agent signatures in a goat. Vet Rec (2005) 2.35
Facilitated cross-species transmission of prions in extraneural tissue. Science (2012) 2.26
Prion agent diversity and species barrier. Vet Res (2008) 1.80
Identification of the epitope region capable of inducing neutralizing antibodies against the porcine epidemic diarrhea virus. Mol Cells (2002) 1.77
A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission. J Neurosci (2007) 1.75
The physical relationship between infectivity and prion protein aggregates is strain-dependent. PLoS Pathog (2010) 1.59
Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome. J Virol (2002) 1.57
Isolation from cattle of a prion strain distinct from that causing bovine spongiform encephalopathy. PLoS Pathog (2006) 1.55
Identification of differentially expressed genes in scrapie-infected mouse brains by using global gene expression technology. J Virol (2004) 1.50
Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic mice. PLoS Pathog (2011) 1.38
Transmission of atypical bovine prions to mice transgenic for human prion protein. Emerg Infect Dis (2008) 1.38
Transgenesis applied to transmissible spongiform encephalopathies. Transgenic Res (2002) 1.38
Highly efficient prion transmission by blood transfusion. PLoS Pathog (2012) 1.30
Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death. Proc Natl Acad Sci U S A (2004) 1.27
Atypical/Nor98 scrapie infectivity in sheep peripheral tissues. PLoS Pathog (2011) 1.26
Prominent and persistent extraneural infection in human PrP transgenic mice infected with variant CJD. PLoS One (2008) 1.24
Exosomes: a bubble ride for prions? Traffic (2005) 1.24
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. J Biol Chem (2004) 1.23
Prion protein amino acid determinants of differential susceptibility and molecular feature of prion strains in mice and voles. PLoS Pathog (2008) 1.21
Clinical findings in two cases of atypical scrapie in sheep: a case report. BMC Vet Res (2007) 1.20
Cultured peripheral neuroglial cells are highly permissive to sheep prion infection. J Virol (2004) 1.19
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. Vet J (2010) 1.19
Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo. J Biol Chem (2006) 1.17
Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery. J Biol Chem (2002) 1.15
Efficient dissemination of prions through preferential transmission to nearby cells. J Gen Virol (2007) 1.15
Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom. Vet Res (2011) 1.14
Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent. J Biol Chem (2010) 1.14
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLoS One (2008) 1.13
Prions and exosomes: from PrPc trafficking to PrPsc propagation. Blood Cells Mol Dis (2005) 1.12
Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment. Acta Neuropathol (2005) 1.09
Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases. J Biol Chem (2001) 1.08
Transcriptome analysis reveals altered cholesterol metabolism during the neurodegeneration in mouse scrapie model. J Neurochem (2007) 1.07
Loss of glycosylation associated with the T183A mutation in human prion disease. Acta Neuropathol (2004) 1.06
Marked influence of the route of infection on prion strain apparent phenotype in a scrapie transgenic mouse model. Neurobiol Dis (2010) 1.04
High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age. Vet Res (2009) 1.03
The prion or the related Shadoo protein is required for early mouse embryogenesis. FEBS Lett (2009) 1.03
Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapie. Neurosci Lett (2005) 1.02
PrPc does not mediate internalization of PrPSc but is required at an early stage for de novo prion infection of Rov cells. J Virol (2007) 1.01
Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models. J Virol (2011) 1.00
New in vivo and ex vivo models for the experimental study of sheep scrapie: development and perspectives. C R Biol (2002) 0.99
PrPSc binding antibodies are potent inhibitors of prion replication in cell lines. J Biol Chem (2004) 0.99
PrP polymorphisms tightly control sheep prion replication in cultured cells. J Virol (2003) 0.99
Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs. PLoS One (2008) 0.98
Binding of transmissible gastroenteritis coronavirus to cell surface sialoglycoproteins. J Virol (2002) 0.97
Activation of phosphatidylinositol 3-kinase by cellular prion protein and its role in cell survival. Biochem Biophys Res Commun (2005) 0.97
Use of murine bioassay to resolve ovine transmissible spongiform encephalopathy cases showing a bovine spongiform encephalopathy molecular profile. Brain Pathol (2011) 0.95
Characterization of atypical scrapie cases from Great Britain in transgenic ovine PrP mice. J Gen Virol (2010) 0.95
Glycan-controlled epitopes of prion protein include a major determinant of susceptibility to sheep scrapie. J Virol (2004) 0.92
Prion strain- and species-dependent effects of antiprion molecules in primary neuronal cultures. J Virol (2007) 0.92
Glycoform-selective prion formation in sporadic and familial forms of prion disease. PLoS One (2013) 0.91
Latrogenic Creutzfeldt-Jakob disease with florid plaques. Brain Pathol (2003) 0.90
Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics. PLoS Pathog (2013) 0.90
Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification. MBio (2013) 0.89
Clinical course in young patients with sporadic Creutzfeldt-Jakob disease. Ann Neurol (2005) 0.89
Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease. Ann Neurol (2005) 0.89
Prion propagation in cells expressing PrP glycosylation mutants. J Virol (2011) 0.88
Infection by ME7 prion is not modified in transgenic mice expressing the yeast chaperone Hsp104 in neurons. Neurosci Lett (2006) 0.88
Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis. PLoS One (2011) 0.88
Atypical scrapie isolates involve a uniform prion species with a complex molecular signature. PLoS One (2011) 0.87
Endogenous prion protein conversion is required for prion-induced neuritic alterations and neuronal death. FASEB J (2012) 0.87
Prion protein and Shadoo are involved in overlapping embryonic pathways and trophoblastic development. PLoS One (2012) 0.87
Proteasome inhibitors promote the sequestration of PrPSc into aggresomes within the cytosol of prion-infected CAD neuronal cells. J Gen Virol (2009) 0.87
A simple, versatile and sensitive cell-based assay for prions from various species. PLoS One (2011) 0.86
Using budding yeast to screen for anti-prion drugs. Biotechnol J (2006) 0.86
Prion strains are differentially released through the exosomal pathway. Cell Mol Life Sci (2014) 0.86
Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy. PLoS One (2010) 0.85
Scrg1 is induced in TSE and brain injuries, and associated with autophagy. Eur J Neurosci (2005) 0.84
Prion infection of epithelial Rov cells is a polarized event. J Virol (2004) 0.84
Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse. BMC Genomics (2010) 0.84
Transcriptional changes in the brains of cattle orally infected with the bovine spongiform encephalopathy agent precede detection of infectivity. J Virol (2009) 0.83
Integrity of helix 2-helix 3 domain of the PrP protein is not mandatory for prion replication. J Biol Chem (2012) 0.82
A retrospective immunohistochemical study reveals atypical scrapie has existed in the United Kingdom since at least 1987. J Vet Diagn Invest (2009) 0.82
Creutzfeldt-Jakob disease associated with an R148H mutation of the prion protein gene. Neurogenetics (2005) 0.82
In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation. BMC Vet Res (2012) 0.82
Identification of atypical scrapie in Canadian sheep. J Vet Diagn Invest (2010) 0.82
Prions impair bioaminergic functions through serotonin- or catecholamine-derived neurotoxins in neuronal cells. J Biol Chem (2008) 0.82
Recovery of small infectious PrP(res) aggregates from prion-infected cultured cells. J Biol Chem (2011) 0.82
Generation of Sprn-regulated reporter mice reveals gonadic spatial expression of the prion-like protein Shadoo in mice. Biochem Biophys Res Commun (2011) 0.82
Evidence for a pathogenic role of different mutations at codon 188 of PRNP. PLoS One (2008) 0.81
Clinical findings in sporadic Creutzfeldt-Jakob disease correlate with thalamic pathology. Brain (2002) 0.81
Characterization of spontaneously generated prion-like conformers in cultured cells. Aging (Albany NY) (2011) 0.81
SCRG1, a potential marker of autophagy in transmissible spongiform encephalopathies. Autophagy (2006) 0.81
The sialic acid binding activity of the S protein facilitates infection by porcine transmissible gastroenteritis coronavirus. Virol J (2011) 0.81
Prnp knockdown in transgenic mice using RNA interference. Transgenic Res (2008) 0.80
Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse. Glycobiology (2009) 0.80
Plasminogen-based capture combined with amplification technology for the detection of PrP(TSE) in the pre-clinical phase of infection. PLoS One (2013) 0.80