Published in Neurosci Lett on November 11, 2005
Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One (2012) 1.45
A synergistic small-molecule combination directly eradicates diverse prion strain structures. Nat Chem Biol (2009) 1.27
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J Virol (2006) 1.14
Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides. Antimicrob Agents Chemother (2006) 1.08
Abrogation of complex glycosylation by swainsonine results in strain- and cell-specific inhibition of prion replication. J Biol Chem (2011) 1.06
Emergence and natural selection of drug-resistant prions. Mol Biosyst (2010) 1.05
meso-Tetra(pentafluorophenyl)porphyrin as an efficient platform for combinatorial synthesis and the selection of new photodynamic therapeutics using a cancer cell line. J Comb Chem (2007) 1.00
Cellular aspects of prion replication in vitro. Viruses (2013) 0.95
Prion strain- and species-dependent effects of antiprion molecules in primary neuronal cultures. J Virol (2007) 0.92
A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets. J Biol Chem (2011) 0.86
Countering amyloid polymorphism and drug resistance with minimal drug cocktails. Prion (2010) 0.83
Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity. Antimicrob Agents Chemother (2007) 0.83
Flavone derivatives as inhibitors of insulin amyloid-like fibril formation. PLoS One (2015) 0.81
Diphenylpyrazole-derived compounds increase survival time of mice after prion infection. Antimicrob Agents Chemother (2011) 0.79
Quantitative phosphoproteomic analysis of prion-infected neuronal cells. Cell Commun Signal (2010) 0.79
Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice. J Infect Dis (2015) 0.78
Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother (2016) 0.75
Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science (2005) 5.52
The most infectious prion protein particles. Nature (2005) 5.37
Cells release prions in association with exosomes. Proc Natl Acad Sci U S A (2004) 5.17
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nat Methods (2007) 3.74
A test for Creutzfeldt-Jakob disease using nasal brushings. N Engl J Med (2014) 3.58
Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog (2010) 2.63
Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors. J Biol Chem (2010) 2.57
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat Methods (2008) 2.56
Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells. J Biol Chem (2004) 2.54
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease. Ann Neurol (2012) 2.18
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J (2002) 2.16
New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. J Virol (2003) 2.09
Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nat Struct Mol Biol (2011) 1.90
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. J Neurosci (2005) 1.85
Prion disease blood test using immunoprecipitation and improved quaking-induced conversion. MBio (2011) 1.82
Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein. Protein Eng Des Sel (2009) 1.49
Biomedicine. A view from the top--prion diseases from 10,000 feet. Science (2003) 1.48
Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains. J Virol (2007) 1.46
Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion. J Gen Virol (2011) 1.40
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res. J Virol (2006) 1.35
KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism. Chembiochem (2010) 1.32
Highly efficient prion transmission by blood transfusion. PLoS Pathog (2012) 1.30
Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages. J Infect Dis (2002) 1.28
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. Biochemistry (2011) 1.27
Prion diseases--close to effective therapy? Nat Rev Drug Discov (2004) 1.27
Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. J Biol Chem (2009) 1.27
Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PLoS One (2012) 1.25
Exosomes: a bubble ride for prions? Traffic (2005) 1.24
Cultured peripheral neuroglial cells are highly permissive to sheep prion infection. J Virol (2004) 1.19
Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils. Neurobiol Aging (2008) 1.18
Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery. J Biol Chem (2002) 1.15
Efficient dissemination of prions through preferential transmission to nearby cells. J Gen Virol (2007) 1.15
Prion shedding from olfactory neurons into nasal secretions. PLoS Pathog (2010) 1.15
The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein. J Biol Chem (2003) 1.14
Prion strain-dependent differences in conversion of mutant prion proteins in cell culture. J Virol (2006) 1.14
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J Virol (2006) 1.14
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLoS One (2008) 1.13
Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform. J Biol Chem (2003) 1.12
Inhibition of protease-resistant prion protein accumulation in vitro by curcumin. J Virol (2003) 1.12
New generation QuIC assays for prion seeding activity. Prion (2012) 1.12
Prions and exosomes: from PrPc trafficking to PrPsc propagation. Blood Cells Mol Dis (2005) 1.12
Structural insights into the interaction between prion protein and nucleic acid. Biochemistry (2006) 1.10
Rapid antemortem detection of CWD prions in deer saliva. PLoS One (2013) 1.10
Autoacetylation of the histone acetyltransferase Rtt109. J Biol Chem (2011) 1.08
Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides. Antimicrob Agents Chemother (2006) 1.08
A solid-phase assay for identification of modulators of prion protein interactions. Anal Biochem (2003) 1.07
Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation. Protein Sci (2006) 1.07
Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models. Biochemistry (2006) 1.04
Prions and the potential transmissibility of protein misfolding diseases. Annu Rev Microbiol (2013) 1.04
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone. Proc Natl Acad Sci U S A (2010) 1.03
Recent advances in prion chemotherapeutics. Infect Disord Drug Targets (2009) 1.03
Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins. J Virol (2012) 1.01
PrPc does not mediate internalization of PrPSc but is required at an early stage for de novo prion infection of Rov cells. J Virol (2007) 1.01
Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models. J Virol (2011) 1.00
A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrob Agents Chemother (2006) 0.99
PrPSc binding antibodies are potent inhibitors of prion replication in cell lines. J Biol Chem (2004) 0.99
Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations. J Clin Microbiol (2012) 0.99
New in vivo and ex vivo models for the experimental study of sheep scrapie: development and perspectives. C R Biol (2002) 0.99
PrP polymorphisms tightly control sheep prion replication in cultured cells. J Virol (2003) 0.99
Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs. PLoS One (2008) 0.98
Infection of cell lines with experimental and natural ovine scrapie agents. J Virol (2009) 0.95
Hemin interactions and alterations of the subcellular localization of prion protein. J Biol Chem (2007) 0.94
Accelerated shedding of prions following damage to the olfactory epithelium. J Virol (2011) 0.93
Intramolecular versus intermolecular disulfide bonds in prion proteins. J Biol Chem (2002) 0.92
Structure of the flexible amino-terminal domain of prion protein bound to a sulfated glycan. J Mol Biol (2009) 0.91
Searching for anti-prion compounds: cell-based high-throughput in vitro assays and animal testing strategies. Methods Enzymol (2006) 0.90
Prion seeded conversion and amplification assays. Top Curr Chem (2011) 0.88
Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice. J Gen Virol (2004) 0.88
Prion strains are differentially released through the exosomal pathway. Cell Mol Life Sci (2014) 0.86
Using budding yeast to screen for anti-prion drugs. Biotechnol J (2006) 0.86
A simple, versatile and sensitive cell-based assay for prions from various species. PLoS One (2011) 0.86
Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies). Folia Neuropathol (2008) 0.85
Reaction of complement factors varies with prion strains in vitro and in vivo. Virology (2012) 0.84
Enhanced antiscrapie effect using combination drug treatment. Antimicrob Agents Chemother (2006) 0.84
Prion infection of epithelial Rov cells is a polarized event. J Virol (2004) 0.84
A test for Creutzfeldt-Jakob disease using nasal brushings. N Engl J Med (2014) 0.84
Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity. Antimicrob Agents Chemother (2007) 0.83
Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo. J Virol (2006) 0.82
Recovery of small infectious PrP(res) aggregates from prion-infected cultured cells. J Biol Chem (2011) 0.82
A simplified recipe for prions. Proc Natl Acad Sci U S A (2007) 0.82
Molecular heterosis of prion protein beta-oligomers. A potential mechanism of human resistance to disease. J Biol Chem (2006) 0.81
Prion proteins meet protein quality control. Trends Cell Biol (2003) 0.81
Prion diseases: a nucleic-acid accomplice? Nature (2003) 0.81
Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation. Methods Enzymol (2006) 0.80
Correction: Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains. PLoS Pathog (2015) 0.79
Probing for prions: recognizing misfolded PrP. Nat Med (2003) 0.78