Published in J Virol on December 23, 2009
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. Proc Natl Acad Sci U S A (2011) 2.18
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood (2013) 1.74
Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol (2015) 1.66
Dengue virus targets the adaptor protein MITA to subvert host innate immunity. PLoS Pathog (2012) 1.44
Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5. Front Immunol (2014) 1.21
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet (2013) 1.14
Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death. Immunity (2013) 1.07
Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine. J Virol (2010) 0.96
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. Hepatology (2011) 0.95
The role of mitochondria in the mammalian antiviral defense system. Mitochondrion (2010) 0.95
MAVS regulates apoptotic cell death by decreasing K48-linked ubiquitination of voltage-dependent anion channel 1. Mol Cell Biol (2013) 0.95
IRF-3 and Bax: a deadly affair. Cell Cycle (2010) 0.95
Type B coxsackieviruses and their interactions with the innate and adaptive immune systems. Future Microbiol (2010) 0.87
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathog (2015) 0.86
The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis. J Virol (2011) 0.86
Involvement of Noxa in mediating cellular ER stress responses to lytic virus infection. Virology (2011) 0.84
Autophagy and selective deployment of Atg proteins in antiviral defense. Int Immunol (2012) 0.84
Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery. J Interferon Cytokine Res (2014) 0.84
Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factors. PLoS One (2012) 0.80
Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses. Future Virol (2012) 0.79
Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors. Curr Pharm Biotechnol (2013) 0.78
Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses. Front Microbiol (2016) 0.77
Overexpression of the transcription factor Sp1 activates the OAS-RNAse L-RIG-I pathway. PLoS One (2015) 0.77
TAX1BP1 restrains virus-induced apoptosis by facilitating Itch-mediated degradation of the mitochondrial adaptor MAVS. Mol Cell Biol (2016) 0.76
Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways. Int J Mol Sci (2017) 0.75
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell (2005) 14.20
Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature (2008) 10.73
Dengue. Lancet (2007) 10.54
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell (1995) 9.11
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A (2004) 7.51
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol (1998) 7.43
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18
The specific and essential role of MAVS in antiviral innate immune responses. Immunity (2006) 6.74
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature (1997) 5.35
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A (2005) 5.31
Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem (2007) 4.56
NLRX1 is a regulator of mitochondrial antiviral immunity. Nature (2008) 4.55
NLRs at the intersection of cell death and immunity. Nat Rev Immunol (2008) 3.48
Caspases in cell survival, proliferation and differentiation. Cell Death Differ (2006) 3.39
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell (2006) 3.23
Recognition of viruses by innate immunity. Immunol Rev (2007) 3.23
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest (2009) 2.85
Generation of deletion and point mutations with one primer in a single cloning step. Biotechniques (2000) 2.81
Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity (2008) 2.81
Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor. Proc Natl Acad Sci U S A (2007) 2.38
TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity (2008) 2.37
Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity (2004) 2.36
Cell death in the host response to infection. Cell Death Differ (2008) 2.19
Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activation. Microbes Infect (2005) 2.11
Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. J Virol (2006) 2.02
Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. J Biol Chem (2007) 1.81
Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3). J Biochem (1996) 1.77
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A (2008) 1.74
MAVS-mediated apoptosis and its inhibition by viral proteins. PLoS One (2009) 1.67
GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequences. Nucleic Acids Res (2005) 1.57
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol (2006) 1.57
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. Cell Death Differ (2008) 1.51
Regulation of mitochondrial antiviral signaling pathways. Immunity (2008) 1.44
Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling. J Biol Chem (2008) 1.36
Viral regulation and evasion of the host response. Curr Top Microbiol Immunol (2007) 1.28
Cytosolic antiviral RNA recognition pathway activates caspases 1 and 3. J Immunol (2008) 1.24
The mitochondrial antiviral signaling protein, MAVS, is cleaved during apoptosis. Biochem Biophys Res Commun (2008) 1.10
Mechanisms of dengue virus-induced cell death. Adv Virus Res (2003) 0.97
The effect of human bcl-2 and bcl-X genes on dengue virus-induced apoptosis in cultured cells. Virology (2001) 0.84
bcl-X(S)-induced cell death in 3T3 cells does not require or induce caspase activation. Cancer Res (1999) 0.79
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol (2008) 4.21
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell (2002) 3.72
CLEC5A is critical for dengue-virus-induced lethal disease. Nature (2008) 2.79
Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response. J Virol (2002) 2.41
Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activation. Microbes Infect (2005) 2.11
Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. J Virol (2006) 2.02
Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism. J Virol (2006) 2.02
Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection. J Virol (2004) 2.01
A Japanese encephalitis virus vaccine candidate strain is attenuated by decreasing its interferon antagonistic ability. Vaccine (2009) 1.81
Antiviral effects of an iminosugar derivative on flavivirus infections. J Virol (2002) 1.80
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol (2009) 1.73
Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus. J Immunol (2006) 1.70
Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell. J Immunol (2005) 1.63
Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection. J Virol (2005) 1.53
Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells by down-regulating endothelial nitric oxide synthase expression and intracellular calcium levels. Crit Care Med (2005) 1.47
Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J Biol Chem (2008) 1.44
Dengue virus targets the adaptor protein MITA to subvert host innate immunity. PLoS Pathog (2012) 1.44
Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. J Immunol (2009) 1.41
A salivary gland adenocarcinoma mimicking a microcystic adnexal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2010) 1.38
Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. J Immunol (2006) 1.38
Role of pancreatic cancer-derived exosomes in salivary biomarker development. J Biol Chem (2013) 1.37
Cholesterol effectively blocks entry of flavivirus. J Virol (2008) 1.26
CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood (2012) 1.22
Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7. J Immunol (2011) 1.21
SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. J Cell Biol (2008) 1.14
Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J Neurosci (2007) 1.13
Autophagy is involved in the early step of Japanese encephalitis virus infection. Microbes Infect (2011) 1.12
The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. J Virol (2008) 1.10
Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice. Vaccine (2003) 1.10
Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay. Antimicrob Agents Chemother (2010) 1.09
Calcifying odontogenic cyst with odontogenic keratocyst: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2010) 1.04
Identification of Tbr-1/CASK complex target genes in neurons. J Neurochem (2004) 1.04
Restriction of vaccinia virus replication by a ced-3 and ced-4-dependent pathway in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2006) 1.04
Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases. Toxicol Appl Pharmacol (2009) 1.03
Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A. J Virol (2012) 1.03
MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation. Nucleic Acids Res (2013) 1.01
Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein. J Gen Virol (2003) 1.00
Design of microarray probes for virus identification and detection of emerging viruses at the genus level. BMC Bioinformatics (2006) 1.00
CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality. PLoS Pathog (2012) 1.00
Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage. J Agric Food Chem (2010) 1.00
Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution. Biophys J (2004) 0.98
Propofol inhibits lipoteichoic acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFkappaB. Chem Biol Interact (2009) 0.98
Utilizing liver-specific microRNA-122 to modulate replication of dengue virus replicon. Biochem Biophys Res Commun (2010) 0.96
Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway. Neuro Oncol (2012) 0.96
FUSE binding protein 1 interacts with untranslated regions of Japanese encephalitis virus RNA and negatively regulates viral replication. J Virol (2011) 0.96
Minocycline attenuates 5-fluorouracil-induced small intestinal mucositis in mouse model. Biochem Biophys Res Commun (2009) 0.95
Vimentin binding is critical for infection by the virulent strain of Japanese encephalitis virus. Cell Microbiol (2011) 0.95
Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1 beta gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells. Toxicol Appl Pharmacol (2009) 0.94
Effects of provider patient volume and comorbidity on clinical and economic outcomes for total knee arthroplasty: a population-based study. J Arthroplasty (2010) 0.93
Development of a humanized antibody with high therapeutic potential against dengue virus type 2. PLoS Negl Trop Dis (2012) 0.93
Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis. Chembiochem (2006) 0.93
Ebolavirus VP35 interacts with the cytoplasmic dynein light chain 8. J Virol (2009) 0.93
Neurovirulent flavivirus can be attenuated in mice by incorporation of neuron-specific microRNA recognition elements into viral genome. Vaccine (2011) 0.93
The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3. Sci Signal (2013) 0.91
Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system. J Gen Virol (2004) 0.91
Nitric oxide induces osteoblast apoptosis through the de novo synthesis of Bax protein. J Orthop Res (2002) 0.91
Effects of minocycline on Fas-mediated fulminant hepatitis in mice. Br J Pharmacol (2005) 0.91
Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions. Evid Based Complement Alternat Med (2013) 0.90
GATA-3 transduces survival signals in osteoblasts through upregulation of bcl-x(L) gene expression. J Bone Miner Res (2010) 0.89
Preventive effects of taurine on development of hepatic steatosis induced by a high-fat/cholesterol dietary habit. J Agric Food Chem (2010) 0.88
Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner. J Gen Virol (2008) 0.87
Synthesis and characterization of amphiphatic carboxymethyl-hexanoyl chitosan hydrogel: water-retention ability and drug encapsulation. Langmuir (2006) 0.86
Antiobesity and hypolipidemic effects of polyphenol-rich longan (Dimocarpus longans Lour.) flower water extract in hypercaloric-dietary rats. J Agric Food Chem (2010) 0.86
Carvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activity. Cardiovasc Res (2003) 0.85
Nitric oxide protects osteoblasts from oxidative stress-induced apoptotic insults via a mitochondria-dependent mechanism. J Orthop Res (2006) 0.85
Patients with inhibitory and neutralizing auto-antibodies to interferon-γ resemble the sporadic adult-onset phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) lacking Bacille Calmette-Guerin (BCG)-induced diseases. Immunobiology (2012) 0.84
Molecular mechanisms of propofol-involved suppression of no biosynthesis and inducible iNOS gene expression in LPS-stimulated macrophage-like raw 264.7 cells. Shock (2010) 0.84
Localized intermittent delivery of simvastatin hydroxyacid stimulates bone formation in rats. J Periodontol (2008) 0.84
Mitf induction by RANKL is critical for osteoclastogenesis. Mol Biol Cell (2010) 0.84