Published in Proc Natl Acad Sci U S A on May 17, 2010
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing. Proc Natl Acad Sci U S A (2012) 3.26
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem Biol (2012) 2.29
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol (2011) 2.05
Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates. Curr Opin Chem Biol (2011) 1.67
Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol (2010) 1.58
Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56
Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A (2012) 1.53
Substrate control in stereoselective lanthionine biosynthesis. Nat Chem (2014) 1.51
Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family. BMC Biol (2010) 1.49
Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium. Cell Chem Biol (2016) 1.45
Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44
Streptolysin S-like virulence factors: the continuing sagA. Nat Rev Microbiol (2011) 1.42
Linking chemistry and genetics in the growing cyanobactin natural products family. Chem Biol (2011) 1.29
Variation in tropical reef symbiont metagenomes defined by secondary metabolism. PLoS One (2011) 1.24
Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18
Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc (2011) 1.15
Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15
A tribute to disorder in the genome of the bloom-forming freshwater cyanobacterium Microcystis aeruginosa. PLoS One (2013) 1.15
Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes. Beilstein J Org Chem (2011) 1.14
Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules. Curr Opin Microbiol (2010) 1.12
Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage. Appl Environ Microbiol (2010) 1.11
Response of Prochlorococcus ecotypes to co-culture with diverse marine bacteria. ISME J (2011) 1.11
Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria. PLoS One (2011) 1.11
Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives. J Am Chem Soc (2013) 1.11
An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc (2012) 1.09
Accessing the hidden majority of marine natural products through metagenomics. Chembiochem (2011) 1.06
Recognition sequences and substrate evolution in cyanobactin biosynthesis. ACS Synth Biol (2014) 1.04
In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria. BMC Genomics (2010) 1.04
A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. J Am Chem Soc (2014) 0.96
A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization. J Am Chem Soc (2013) 0.95
Comparative transcriptomics of two environmentally relevant cyanobacteria reveals unexpected transcriptome diversity. ISME J (2014) 0.95
Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis. ACS Chem Biol (2013) 0.94
Catalytic DNA with phosphatase activity. Proc Natl Acad Sci U S A (2013) 0.93
Insights into the evolution of lanthipeptide biosynthesis. Protein Sci (2013) 0.93
Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM. J Am Chem Soc (2014) 0.92
Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS. Proc Natl Acad Sci U S A (2014) 0.92
Role of a microcin-C-like biosynthetic gene cluster in allelopathic interactions in marine Synechococcus. Proc Natl Acad Sci U S A (2013) 0.91
High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis. ACS Chem Biol (2014) 0.90
The hidden diversity of ribosomal peptide natural products. BMC Biol (2010) 0.89
Genome-derived insights into the biology of the hepatotoxic bloom-forming cyanobacterium Anabaena sp. strain 90. BMC Genomics (2012) 0.89
Insights into the physiology and ecology of the brackish-water-adapted Cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome analysis. PLoS One (2013) 0.89
The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles. BMC Genomics (2015) 0.88
Novel LanT associated lantibiotic clusters identified by genome database mining. PLoS One (2014) 0.85
Product Formation by the Promiscuous Lanthipeptide Synthetase ProcM is under Kinetic Control. J Am Chem Soc (2015) 0.84
Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase. J Biol Chem (2015) 0.84
Lessons learned from the transformation of natural product discovery to a genome-driven endeavor. J Ind Microbiol Biotechnol (2013) 0.83
Post-translational Introduction of d-Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJ. J Am Chem Soc (2015) 0.82
Gene cluster analysis for the biosynthesis of elgicins, novel lantibiotics produced by Paenibacillus elgii B69. BMC Microbiol (2012) 0.81
Michael-type cyclizations in lantibiotic biosynthesis are reversible. ACS Chem Biol (2015) 0.81
Metabolic model for diversity-generating biosynthesis. Proc Natl Acad Sci U S A (2016) 0.81
ApnI, a transmembrane protein responsible for subtilomycin immunity, unveils a novel model for lantibiotic immunity. Appl Environ Microbiol (2014) 0.80
Transcriptional response of Prochlorococcus to co-culture with a marine Alteromonas: differences between strains and the involvement of putative infochemicals. ISME J (2016) 0.80
YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function. Chem Rev (2017) 0.79
Pseudomycoicidin, a Class II Lantibiotic from Bacillus pseudomycoides. Appl Environ Microbiol (2015) 0.79
An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase. Chem Commun (Camb) (2012) 0.79
Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found in both filamentous and unicellular marine strains. PLoS One (2013) 0.79
Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid. J Am Chem Soc (2015) 0.79
Global genetic capacity for mixotrophy in marine picocyanobacteria. ISME J (2016) 0.78
Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides. Beilstein J Org Chem (2016) 0.77
Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family. Appl Environ Microbiol (2013) 0.77
Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis. J Am Chem Soc (2016) 0.77
Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO. ACS Chem Biol (2014) 0.77
Lanthipeptides: chemical synthesis versus in vivo biosynthesis as tools for pharmaceutical production. Microb Cell Fact (2016) 0.76
Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates. Front Microbiol (2015) 0.76
Tiny Microbes with a Big Impact: The Role of Cyanobacteria and Their Metabolites in Shaping Our Future. Mar Drugs (2016) 0.75
Bacterial display and screening of posttranslationally thioether-stabilized peptides. Appl Environ Microbiol (2011) 0.75
Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates. J Am Chem Soc (2016) 0.75
Combinatorial biosynthesis of RiPPs: docking with marine life. Curr Opin Chem Biol (2015) 0.75
Two flavoenzymes catalyze the post-translational generation of 5-chlorotryptophan and 2-aminovinyl-cysteine during NAI-107 biosynthesis. ACS Chem Biol (2016) 0.75
Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM. Biopolymers (2016) 0.75
Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes. Chem Rev (2017) 0.75
Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products. ACS Cent Sci (2017) 0.75
Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways. Sci Rep (2017) 0.75
Templating α-amylase peptide inhibitors with organotin compounds. J Biol Inorg Chem (2011) 0.75
The Sorcerer II Global Ocean Sampling expedition: northwest Atlantic through eastern tropical Pacific. PLoS Biol (2007) 23.58
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature (2002) 19.35
Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation. Nature (2003) 8.53
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol (2003) 7.84
Niche partitioning among Prochlorococcus ecotypes along ocean-scale environmental gradients. Science (2006) 5.58
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci U S A (2005) 5.02
Biosynthesis and mode of action of lantibiotics. Chem Rev (2005) 4.59
Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature (1988) 4.41
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nat Chem Biol (2006) 4.12
Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00
Autoregulation of nisin biosynthesis in Lactococcus lactis by signal transduction. J Biol Chem (1995) 3.46
Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A (2008) 3.20
Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16
Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc Natl Acad Sci U S A (2003) 3.15
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83
Phosphate acquisition genes in Prochlorococcus ecotypes: evidence for genome-wide adaptation. Proc Natl Acad Sci U S A (2006) 2.78
Clade-specific 16S ribosomal DNA oligonucleotides reveal the predominance of a single marine Synechococcus clade throughout a stratified water column in the Red Sea. Appl Environ Microbiol (2003) 2.39
Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds. Nat Prod Rep (2009) 2.32
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A (2009) 2.22
Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J Am Chem Soc (2009) 2.19
Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74
Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. Appl Environ Microbiol (2009) 1.68
Abundant and diverse bacteria involved in DMSP degradation in marine surface waters. Environ Microbiol (2008) 1.63
One pathway, many products. Nat Chem Biol (2007) 1.63
The evolution of secondary metabolism - a unifying model. Mol Microbiol (2000) 1.54
The genome and structural proteome of an ocean siphovirus: a new window into the cyanobacterial 'mobilome'. Environ Microbiol (2009) 1.53
Gene family encoding the major toxins of lethal Amanita mushrooms. Proc Natl Acad Sci U S A (2007) 1.45
Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design. Mol Microbiol (2006) 1.45
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc (2009) 1.37
Morphogenetic surfactants and their role in the formation of aerial hyphae in Streptomyces coelicolor. Mol Microbiol (2006) 1.30
Prospects for the bioengineering of isoprenoid biosynthesis. Adv Biochem Eng Biotechnol (1997) 1.22
Enzymatic synthesis of cyclic triterpenes. Nat Prod Rep (2007) 1.18
Biomimetic studies on the mechanism of stereoselective lanthionine formation. Org Biomol Chem (2003) 1.15
Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol (2009) 1.13
Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase. J Am Chem Soc (2010) 1.01
Environmental genome shotgun sequencing of the Sargasso Sea. Science (2004) 45.23
Community genomics among stratified microbial assemblages in the ocean's interior. Science (2006) 13.31
Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation. Nature (2003) 8.53
Sequencing genomes from single cells by polymerase cloning. Nat Biotechnol (2006) 7.64
Microbial community gene expression in ocean surface waters. Proc Natl Acad Sci U S A (2008) 6.50
Niche partitioning among Prochlorococcus ecotypes along ocean-scale environmental gradients. Science (2006) 5.58
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Genomic islands and the ecology and evolution of Prochlorococcus. Science (2006) 5.07
Unlocking short read sequencing for metagenomics. PLoS One (2010) 4.88
Genome sequence of the lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78. Nat Biotechnol (2004) 4.85
Whole genome amplification and de novo assembly of single bacterial cells. PLoS One (2009) 4.65
Biosynthesis and mode of action of lantibiotics. Chem Rev (2005) 4.59
Cyanophages infecting the oceanic cyanobacterium Prochlorococcus. Nature (2003) 4.57
Three Prochlorococcus cyanophage genomes: signature features and ecological interpretations. PLoS Biol (2005) 4.55
Resolution of Prochlorococcus and Synechococcus ecotypes by using 16S-23S ribosomal DNA internal transcribed spacer sequences. Appl Environ Microbiol (2002) 4.35
Patterns and implications of gene gain and loss in the evolution of Prochlorococcus. PLoS Genet (2007) 4.25
Emergent biogeography of microbial communities in a model ocean. Science (2007) 4.03
Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00
Prevalence and evolution of core photosystem II genes in marine cyanobacterial viruses and their hosts. PLoS Biol (2006) 3.63
MODBASE: a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res (2006) 3.56
Transfer of photosynthesis genes to and from Prochlorococcus viruses. Proc Natl Acad Sci U S A (2004) 3.38
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (2006) 3.29
Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16
LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources. Bioinformatics (2005) 3.05
Efficient and robust RNA-seq process for cultured bacteria and complex community transcriptomes. Genome Biol (2012) 3.02
Photosynthesis genes in marine viruses yield proteins during host infection. Nature (2005) 2.99
Bacterial vesicles in marine ecosystems. Science (2014) 2.94
Bacterial community assembly based on functional genes rather than species. Proc Natl Acad Sci U S A (2011) 2.92
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83
Microbial community transcriptomes reveal microbes and metabolic pathways associated with dissolved organic matter turnover in the sea. Proc Natl Acad Sci U S A (2010) 2.82
Phosphate acquisition genes in Prochlorococcus ecotypes: evidence for genome-wide adaptation. Proc Natl Acad Sci U S A (2006) 2.78
Single-cell genomics reveals hundreds of coexisting subpopulations in wild Prochlorococcus. Science (2014) 2.58
Genome-wide expression dynamics of a marine virus and host reveal features of co-evolution. Nature (2007) 2.27
Genomic analysis of oceanic cyanobacterial myoviruses compared with T4-like myoviruses from diverse hosts and environments. Environ Microbiol (2010) 2.23
Biosynthesis of phosphonic and phosphinic acid natural products. Annu Rev Biochem (2009) 2.19
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19
The Human Microbiome Project: a community resource for the healthy human microbiome. PLoS Biol (2012) 2.17
Cyanobacterial photosynthesis in the oceans: the origins and significance of divergent light-harvesting strategies. Trends Microbiol (2002) 2.16
Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus. Nat Struct Mol Biol (2010) 2.12
Ecosystem-specific selection pressures revealed through comparative population genomics. Proc Natl Acad Sci U S A (2010) 2.12
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
MODBASE, a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res (2008) 2.02
Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem (2012) 2.01
Properties of overlapping genes are conserved across microbial genomes. Genome Res (2004) 2.01
The evolution of two-component systems in bacteria reveals different strategies for niche adaptation. PLoS Comput Biol (2006) 1.98
Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95
PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res (2010) 1.93
Prochlorococcus ecotype abundances in the North Atlantic Ocean as revealed by an improved quantitative PCR method. Appl Environ Microbiol (2006) 1.81
Taxonomic resolution, ecotypes and the biogeography of Prochlorococcus. Environ Microbiol (2008) 1.79
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76
Code and context: Prochlorococcus as a model for cross-scale biology. Trends Microbiol (2007) 1.75
The challenge of regulation in a minimal photoautotroph: non-coding RNAs in Prochlorococcus. PLoS Genet (2008) 1.74
Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72
Functional genomic signatures of sponge bacteria reveal unique and shared features of symbiosis. ISME J (2010) 1.68
Salt stress in Desulfovibrio vulgaris Hildenborough: an integrated genomics approach. J Bacteriol (2006) 1.68
Analysis of high-throughput sequencing and annotation strategies for phage genomes. PLoS One (2010) 1.64
Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism. Proc Natl Acad Sci U S A (2011) 1.62
Global gene expression of Prochlorococcus ecotypes in response to changes in nitrogen availability. Mol Syst Biol (2006) 1.62
Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol (2010) 1.58
Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56
Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol (2006) 1.56
Identification and structural analysis of a novel carboxysome shell protein with implications for metabolite transport. J Mol Biol (2009) 1.56
The genome and structural proteome of an ocean siphovirus: a new window into the cyanobacterial 'mobilome'. Environ Microbiol (2009) 1.53
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (2012) 1.53
Measurement of Prochlorococcus ecotypes using real-time polymerase chain reaction reveals different abundances of genotypes with similar light physiologies. Environ Microbiol (2006) 1.53
New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (2006) 1.53
Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A (2012) 1.53
An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Nature (2009) 1.51
Choreography of the transcriptome, photophysiology, and cell cycle of a minimal photoautotroph, prochlorococcus. PLoS One (2009) 1.51
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47
The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46
Temporal dynamics of Prochlorococcus ecotypes in the Atlantic and Pacific oceans. ISME J (2010) 1.44
Sublancin is not a lantibiotic but an S-linked glycopeptide. Nat Chem Biol (2011) 1.44
Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy. Epilepsia (2007) 1.43
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc (2009) 1.37
Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36
Use of stable isotope-labelled cells to identify active grazers of picocyanobacteria in ocean surface waters. Environ Microbiol (2009) 1.33
Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria. Curr Biol (2008) 1.33
Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33
Portal protein diversity and phage ecology. Environ Microbiol (2008) 1.33
Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol (2009) 1.32
The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31
Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol (2010) 1.30
Comparison of human solute carriers. Protein Sci (2010) 1.29
Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem (2007) 1.25
Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol (2004) 1.24
Biomimetic stereoselective formation of methyllanthionine. Org Lett (2002) 1.23
SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry (2003) 1.23
Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus. Genome Biol (2010) 1.23
Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22
Cross-scale ecological dynamics and microbial size spectra in marine ecosystems. Proc Biol Sci (2002) 1.22