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NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41

The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84

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The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. Nat Cell Biol (2008) 2.53

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Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal (2008) 1.67

Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res (2006) 1.62

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Dicer is required for maintaining adult pancreas. PLoS One (2009) 1.59

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest (2011) 1.54

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Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development (2009) 1.50

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Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet (2008) 1.37

Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis. Neuron (2007) 1.37

Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol (2006) 1.36

ATP-citrate lyase deficiency in the mouse. J Biol Chem (2003) 1.35

Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol (2008) 1.32

Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol Cell Biol (2007) 1.32

Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood (2007) 1.30

The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol (2006) 1.28

Fibulin-1 is required for morphogenesis of neural crest-derived structures. Dev Biol (2008) 1.26

Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23

The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab (2011) 1.19

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res (2012) 1.18

Decreased survival and hepato-renal pathology in mice with C-terminally truncated GP73 (GOLPH2). Int J Clin Exp Pathol (2008) 1.15

The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development. Mol Cell Biol (2011) 1.14

cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol Cell Biol (2007) 1.14

Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis. Oncogene (2009) 1.14

Cdk8 is essential for preimplantation mouse development. Mol Cell Biol (2007) 1.13

Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. J Biol Chem (2010) 1.11

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol (2009) 1.11

Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. Mol Cell Biol (2007) 1.10

Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. J Biol Chem (2008) 1.09

Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab (2013) 1.09

DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory. J Biol Chem (2010) 1.07

RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells. Stem Cells (2009) 1.05

Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function. PLoS One (2010) 1.04

Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A (2007) 1.04

Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proc Natl Acad Sci U S A (2012) 1.02

Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). PLoS One (2012) 1.02

mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin/β-catenin. PLoS One (2012) 1.01

The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis. Biochim Biophys Acta (2009) 1.01

A gene trap knockout of the abundant sperm tail protein, outer dense fiber 2, results in preimplantation lethality. Genesis (2006) 1.01

Mouse models in male fertility research. Asian J Androl (2010) 1.01

Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival. PLoS Genet (2012) 0.99

Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans. Am J Hum Genet (2010) 0.99

Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis. Am J Med Genet A (2008) 0.99

The UniTrap resource: tools for the biologist enabling optimized use of gene trap clones. Nucleic Acids Res (2007) 0.98

Tagging genes with cassette-exchange sites. Nucleic Acids Res (2005) 0.98

A recessive genetic screen for host factors required for retroviral infection in a library of insertionally mutated Blm-deficient embryonic stem cells. Genome Biol (2007) 0.97

Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood (2013) 0.97

A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. FEBS J (2011) 0.97

A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes. PLoS Genet (2015) 0.97

Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Mol Cell Biol (2009) 0.97

Legal agreements and the governance of research commons: lessons from materials sharing in mouse genomics. OMICS (2014) 0.96

Duplication of GTF2I results in separation anxiety in mice and humans. Am J Hum Genet (2012) 0.96

Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci (2012) 0.95

Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS One (2007) 0.95

Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice. Proc Natl Acad Sci U S A (2009) 0.95

Abnormal placental development and early embryonic lethality in EpCAM-null mice. PLoS One (2009) 0.95

High-throughput trapping of secretory pathway genes in mouse embryonic stem cells. Nucleic Acids Res (2006) 0.94

Pigs taking wing with transposons and recombinases. Genome Biol (2007) 0.94

Understanding the roles of nuclear A- and B-type lamins in brain development. J Biol Chem (2012) 0.93

Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta. PLoS Genet (2014) 0.93

Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Genome Res (2005) 0.93

Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol (2010) 0.93

A spontaneous mutation in Srebf2 leads to cataracts and persistent skin wounds in the lens opacity 13 (lop13) mouse. Mamm Genome (2011) 0.92

Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn (2012) 0.91

Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. Cell Cycle (2008) 0.91

Disruption of the Sec24d gene results in early embryonic lethality in the mouse. PLoS One (2013) 0.91

Atrap deficiency increases arterial blood pressure and plasma volume. J Am Soc Nephrol (2010) 0.90

Enhanced gene trapping in mouse embryonic stem cells. Nucleic Acids Res (2008) 0.89

RBM19 is essential for preimplantation development in the mouse. BMC Dev Biol (2008) 0.89

O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling? J Biol Chem (2014) 0.89

A forward genetic screen in mice identifies mutants with abnormal cortical patterning. Cereb Cortex (2013) 0.88

The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. Mamm Genome (2010) 0.87

Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. Dev Biol (2009) 0.87

Viruses, autophagy genes, and Crohn's disease. Viruses (2011) 0.86

The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas. Am J Pathol (2009) 0.86

Activation of cryptic 3' splice sites within introns of cellular genes following gene entrapment. Nucleic Acids Res (2004) 0.86

Tslc1 (nectin-like molecule-2) is essential for spermatozoa motility and male fertility. J Androl (2006) 0.85

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A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59

The Mouse Genome Database (MGD): the model organism database for the laboratory mouse. Nucleic Acids Res (2002) 7.47

Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol (1993) 6.38

Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet (2001) 5.67

Gene-trap mutagenesis: past, present and beyond. Nat Rev Genet (2001) 3.89

Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice. Genome Res (1997) 1.61

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Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77

Visualizing density maps with UCSF Chimera. J Struct Biol (2006) 5.75

Development of a rational scale to assess the harm of drugs of potential misuse. Lancet (2007) 5.42

Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol (2007) 5.09

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab (2007) 5.04

Annotation error in public databases: misannotation of molecular function in enzyme superfamilies. PLoS Comput Biol (2009) 4.76

A large-scale evaluation of computational protein function prediction. Nat Methods (2013) 4.61

MODBASE, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2004) 4.54

Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science (2003) 4.18

A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96

Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods (2009) 3.68

Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab (2011) 3.49

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci U S A (2005) 3.30

ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr Biol (2007) 3.27

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc Natl Acad Sci U S A (2002) 3.26

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ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A (2008) 3.15

Designed divergent evolution of enzyme function. Nature (2006) 3.09

Using sequence similarity networks for visualization of relationships across diverse protein superfamilies. PLoS One (2009) 3.03

Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem (2006) 3.02

Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler Thromb Vasc Biol (2009) 2.99

ModBase, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2010) 2.96

Laminopathies and the long strange trip from basic cell biology to therapy. J Clin Invest (2009) 2.94

Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping. Nature (2006) 2.92

Lamin B1 is required for mouse development and nuclear integrity. Proc Natl Acad Sci U S A (2004) 2.89

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc Natl Acad Sci U S A (2005) 2.85

DOCK 6: combining techniques to model RNA-small molecule complexes. RNA (2009) 2.75

GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab (2010) 2.75

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science (2006) 2.71

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Leveraging enzyme structure-function relationships for functional inference and experimental design: the structure-function linkage database. Biochemistry (2006) 2.65

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev (2009) 2.59

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Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol (2010) 2.55

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development (2004) 2.45

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest (2006) 2.39

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A (2004) 2.39

Tools for integrated sequence-structure analysis with UCSF Chimera. BMC Bioinformatics (2006) 2.38

Evolution of enzyme superfamilies. Curr Opin Chem Biol (2006) 2.30

Prediction and assignment of function for a divergent N-succinyl amino acid racemase. Nat Chem Biol (2007) 2.29

Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest (2006) 2.23

Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation (2009) 2.20

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res (2013) 2.20

Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity. Arch Biochem Biophys (2005) 2.18

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev (2004) 2.16

Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation (2006) 2.13

Software extensions to UCSF chimera for interactive visualization of large molecular assemblies. Structure (2005) 2.12

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12

UCSF Chimera, MODELLER, and IMP: an integrated modeling system. J Struct Biol (2011) 2.10

Dual RMCE for efficient re-engineering of mouse mutant alleles. Nat Methods (2010) 2.05

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A (2003) 2.03

Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes Dev (2004) 1.93

Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening. Structure (2008) 1.91

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res (2008) 1.91

The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J Biol Chem (2008) 1.91

Extensive genomic copy number variation in embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.91

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A (2005) 1.91

Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Dev Cell (2010) 1.90

Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A (2010) 1.89

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science (2013) 1.88

The Enzyme Function Initiative. Biochemistry (2011) 1.87

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell (2011) 1.86

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Mol Biol Cell (2005) 1.85

The posttranslational processing of prelamin A and disease. Annu Rev Genomics Hum Genet (2009) 1.81

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest (2004) 1.81