Published in Am J Physiol Cell Physiol on January 06, 2010
Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. Front Physiol (2011) 1.14
MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location. Proc Natl Acad Sci U S A (2013) 1.09
Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res (2011) 1.00
Physiology of potassium channels in the inner membrane of mitochondria. Pflugers Arch (2011) 0.99
Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine. Biochim Biophys Acta (2011) 0.98
Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms. Biophys J (2010) 0.89
Early effects of the antineoplastic agent salinomycin on mitochondrial function. Cell Death Dis (2015) 0.88
KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. PLoS One (2014) 0.88
Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen species generation. Free Radic Biol Med (2012) 0.86
Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane. Biochim Biophys Acta (2012) 0.86
A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel. PeerJ (2013) 0.86
Enhanced charge-independent mitochondrial free Ca(2+) and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection. Biochim Biophys Acta (2011) 0.83
Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Bioenerg Biomembr (2012) 0.82
Mitochondrial BKCa channel. Front Physiol (2015) 0.81
Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats. Am J Physiol Heart Circ Physiol (2010) 0.81
Reversible blockade of complex I or inhibition of PKCβ reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia. PLoS One (2014) 0.78
Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging. Biochim Biophys Acta (2012) 0.77
BKCa channel activation increases cardiac contractile recovery following hypothermic ischemia/reperfusion. Am J Physiol Heart Circ Physiol (2015) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature (1961) 17.36
Inhibition of the calcium-induced increase in the potassium permeability of human red blood cells by quinine. J Physiol (1975) 2.35
Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science (2002) 2.23
Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res (2004) 2.06
Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria. Am J Physiol Heart Circ Physiol (2001) 1.95
Mitochondrial ion channels: gatekeepers of life and death. Physiology (Bethesda) (2005) 1.94
Mitochondrial potassium transport: the K(+) cycle. Biochim Biophys Acta (2003) 1.77
The direct physiological effects of mitoK(ATP) opening on heart mitochondria. Am J Physiol Heart Circ Physiol (2005) 1.59
Swelling and contraction of the mitochondrial matrix. I. A structural interpretation of the relationship between light scattering and matrix volume. J Biol Chem (1985) 1.37
Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart. Am J Physiol Heart Circ Physiol (2002) 1.35
The effect of N,N'-dicyclohexylcarbodiimide on enzymes of bioenergetic relevance. Biochim Biophys Acta (1984) 1.21
Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage. Circulation (2004) 1.21
Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential. Am J Physiol Cell Physiol (2006) 1.20
Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS Lett (2004) 1.18
Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation. Am J Physiol Heart Circ Physiol (2005) 1.17
Studies on the mechanism of uncoupling by amine local anesthetics. Evidence for mitochondrial proton transport mediated by lipophilic ion pairs. J Biol Chem (1983) 1.14
Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning. J Pharmacol Exp Ther (2004) 1.09
Opening mitochondrial K(ATP) in the heart--what happens, and what does not happen. Basic Res Cardiol (2000) 1.07
Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels. Am J Physiol Heart Circ Physiol (2007) 1.07
Calcium-dependent spontaneously reversible remodeling of brain mitochondria. J Biol Chem (2006) 1.07
The mechanism of ion translocation in mitochondria. 2. Active transport and proton pump. Eur J Biochem (1970) 1.06
Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury. Pflugers Arch (2008) 1.05
Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity. J Pharmacol Exp Ther (2001) 0.99
Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons. Pflugers Arch (2001) 0.99
Pharmacological and physiological stimuli do not promote Ca(2+)-sensitive K+ channel activity in isolated heart mitochondria. Cardiovasc Res (2006) 0.97
Mitochondrial cation-hydrogen ion exchange. Sodium selective transport by mitochondria and submitochondrial particles. J Biol Chem (1974) 0.93
On the mechanism by which dicyclohexylcarbodiimide and quinine inhibit K+ transport in rat liver mitochondria. J Biol Chem (1986) 0.93
Determination of the rate of K(+) movement through potassium channels in isolated rat heart and liver mitochondria. Biochim Biophys Acta (2008) 0.92
Attenuation of mitochondrial respiration by sevoflurane in isolated cardiac mitochondria is mediated in part by reactive oxygen species. Anesthesiology (2004) 0.91
Dinitrophenol pretreatment of rat ventricular myocytes protects against damage by metabolic inhibition and reperfusion. J Mol Cell Cardiol (2002) 0.91
Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem Pharmacol (2003) 0.90
Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers. Anesth Analg (2007) 0.90
Estimation of matrix pH in isolated heart mitochondria using a fluorescent probe. Anal Biochem (1989) 0.89
Quinine inhibition of Na+ and K+ transport provides evidence for two cation/H+ exchangers in rat liver mitochondria. J Biol Chem (1982) 0.88
Induction of electroneutral exchanges of H+ with K+ in rat liver mitochondria. FEBS Lett (1978) 0.87
Identification of an 82,000-dalton protein responsible for K+/H+ antiport in rat liver mitochondria. J Biol Chem (1984) 0.86
Inhibition of K+ transport in liver mitochondria. Biochim Biophys Acta (1967) 0.86
Some effects of local anesthetics on isolated mitochondria. J Pharmacol Exp Ther (1969) 0.85
Purification of a reconstitutively active K+/H+ antiporter from rat liver mitochondria. J Biol Chem (1990) 0.84
Quinine inhibits mitochondrial ATP-regulated potassium channel from bovine heart. J Membr Biol (2004) 0.84
On the molecular action of local anesthetics. 1. The mitochondrian as a model membrane system for studying local anesthetic action. Mol Pharmacol (1973) 0.84
Electroneutral H+-K+ exchange in liver mitochondria. Regulation by membrane potential. Biochim Biophys Acta (1983) 0.83
Passive permeability and energy-linked ion movements in isolated heart mitochondria. Ann N Y Acad Sci (1974) 0.83
Action of local anaesthetics on passive and energy-linked ion translocation in the inner mitochondrial membrane. J Bioenerg (1972) 0.83
Sodium/proton antiporter of rat liver mitochondria. FEBS Lett (1980) 0.82
Isoflurane activates rat mitochondrial ATP-sensitive K+ channels reconstituted in lipid bilayers. Am J Physiol Heart Circ Physiol (2003) 0.81
K+/H+ antiport in heart mitochondria. J Biol Chem (1984) 0.81
K+-H+ exchange and volume homeostasis in brown adipose tissue mitochondria. Am J Physiol (1986) 0.81
Effect of quinine on mitochondrial K+ and Mg++ flux. Biochem Biophys Res Commun (1986) 0.80
Effects of quinine on K+ transport in heart mitochondria. J Bioenerg Biomembr (1984) 0.78
Permeability transition pore closure promoted by quinine. J Bioenerg Biomembr (1999) 0.77
Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion. Am J Physiol Cell Physiol (2006) 2.16
Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. Antioxid Redox Signal (2009) 1.89
Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro. Am J Physiol Heart Circ Physiol (2005) 1.57
Anesthetic preconditioning: effects on latency to ischemic injury in isolated hearts. Anesthesiology (2003) 1.49
Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion. Am J Physiol Heart Circ Physiol (2002) 1.43
Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal (2010) 1.40
Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics (2003) 1.37
Reduced reactive O2 species formation and preserved mitochondrial NADH and [Ca2+] levels during short-term 17 degrees C ischemia in intact hearts. Cardiovasc Res (2004) 1.36
Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice. Anesth Analg (2005) 1.32
Cardioprotection with volatile anesthetics: mechanisms and clinical implications. Anesth Analg (2005) 1.29
Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential. Am J Physiol Cell Physiol (2006) 1.20
The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. J Pharmacol Exp Ther (2007) 1.19
Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation. Am J Physiol Heart Circ Physiol (2005) 1.17
Painful peripheral nerve injury decreases calcium current in axotomized sensory neurons. Anesthesiology (2006) 1.15
Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. Front Physiol (2011) 1.14
Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts. Anesth Analg (2003) 1.14
Gabapentin decreases membrane calcium currents in injured as well as in control mammalian primary afferent neurons. Reg Anesth Pain Med (2002) 1.14
Loss of T-type calcium current in sensory neurons of rats with neuropathic pain. Anesthesiology (2003) 1.12
Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea pig intact hearts. Am J Physiol Heart Circ Physiol (2002) 1.11
Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart. Am J Physiol Heart Circ Physiol (2003) 1.10
Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release. Cardiovasc Res (2008) 1.10
Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. J Neurosci (2011) 1.09
Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels. Am J Physiol Heart Circ Physiol (2007) 1.07
Cardiac pharmacological preconditioning with volatile anesthetics: from bench to bedside? Am J Physiol Heart Circ Physiol (2004) 1.05
Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomy. Proc Natl Acad Sci U S A (2009) 1.04
Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation. Mol Pain (2009) 1.04
Mitochondrial depolarization underlies delay in permeability transition by preconditioning with isoflurane: roles of ROS and Ca2+. Am J Physiol Cell Physiol (2010) 1.03
Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereoselective properties. Anesthesiology (2002) 1.03
Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons. Brain Res (2006) 1.01
Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res (2011) 1.00
Anesthetic preconditioning: the role of free radicals in sevoflurane-induced attenuation of mitochondrial electron transport in Guinea pig isolated hearts. Anesth Analg (2005) 0.98
Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine. Biochim Biophys Acta (2011) 0.98
Anesthetic preconditioning improves adenosine triphosphate synthesis and reduces reactive oxygen species formation in mitochondria after ischemia by a redox dependent mechanism. Anesthesiology (2003) 0.97
Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts. Am J Physiol Heart Circ Physiol (2002) 0.97
Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake. J Physiol (2014) 0.95
Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid. Anesth Analg (2002) 0.94
Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid. Anesthesiology (2003) 0.94
Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution. Am J Physiol Heart Circ Physiol (2007) 0.94
ROS scavenging before 27 degrees C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state. Am J Physiol Cell Physiol (2007) 0.94
Reactive oxygen species precede the epsilon isoform of protein kinase C in the anesthetic preconditioning signaling cascade. Anesthesiology (2003) 0.94
Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function. J Cardiovasc Pharmacol (2008) 0.94
Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism. J Heart Lung Transplant (2008) 0.91
Attenuation of mitochondrial respiration by sevoflurane in isolated cardiac mitochondria is mediated in part by reactive oxygen species. Anesthesiology (2004) 0.91
KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. J Cardiovasc Pharmacol (2008) 0.91
Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. J Mol Cell Cardiol (2009) 0.90
ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin. Neurosci Lett (2003) 0.90
Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers. Anesth Analg (2007) 0.90
Beta-escin diminishes voltage-gated calcium current rundown in perforated patch-clamp recordings from rat primary afferent neurons. J Neurosci Methods (2004) 0.89
Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection. J Cardiovasc Pharmacol (2009) 0.89
Warm ischemic preconditioning improves mitochondrial redox balance during and after mild hypothermic ischemia in guinea pig isolated hearts. Am J Physiol Heart Circ Physiol (2005) 0.89
Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms. Biophys J (2010) 0.89
Sevoflurane before or after ischemia improves contractile and metabolic function while reducing myoplasmic Ca(2+) loading in intact hearts. Anesthesiology (2002) 0.89
Cross-bridge kinetics modeled from myoplasmic [Ca2+] and LV pressure at 17 degrees C and after 37 degrees C and 17 degrees C ischemia. Am J Physiol Heart Circ Physiol (2002) 0.88
Protein kinase C-epsilon primes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane. Anesthesiology (2004) 0.88
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett (2010) 0.86
Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen species generation. Free Radic Biol Med (2012) 0.86
Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane. Biochim Biophys Acta (2012) 0.86
How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts. J Cardiovasc Pharmacol (2003) 0.86
Cardiac mitochondrial ATP-sensitive potassium channel is activated by nitric oxide in vitro. FEBS Lett (2007) 0.85
Cardiac preconditioning with 4-h, 17 degrees C ischemia reduces [Ca(2+)](i) load and damage in part via K(ATP) channel opening. Am J Physiol Heart Circ Physiol (2002) 0.85
Ca²⁺-dependent regulation of Ca²⁺ currents in rat primary afferent neurons: role of CaMKII and the effect of injury. J Neurosci (2012) 0.85
Na+/H+ exchange inhibition with cardioplegia reduces cytosolic [Ca2+] and myocardial damage after cold ischemia. J Cardiovasc Pharmacol (2003) 0.84
The effects of isoflurane on the cardiac slowly activating delayed-rectifier potassium channel in Guinea pig ventricular myocytes. Anesth Analg (2003) 0.84
Adding ROS quenchers to cold K+ cardioplegia reduces superoxide emission during 2-hour global cold cardiac ischemia. J Cardiovasc Pharmacol Ther (2011) 0.83
Increasing heart size and age attenuate anesthetic preconditioning in guinea pig isolated hearts. Anesth Analg (2005) 0.83
Comparison of cumulative planimetry versus manual dissection to assess experimental infarct size in isolated hearts. J Pharmacol Toxicol Methods (2009) 0.83
Enhanced charge-independent mitochondrial free Ca(2+) and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection. Biochim Biophys Acta (2011) 0.83
Isoflurane-induced facilitation of the cardiac sarcolemmal K(ATP) channel. Anesthesiology (2002) 0.83