Autophagy in the pathogenesis of disease.

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

Methods in mammalian autophagy research. Cell (2010) 20.08

A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21

Network organization of the human autophagy system. Nature (2010) 11.38

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29

Autophagy and the integrated stress response. Mol Cell (2010) 11.21

Autophagy in immunity and inflammation. Nature (2011) 11.16

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45

Autophagy suppresses tumorigenesis through elimination of p62. Cell (2009) 9.95

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell (2009) 9.24

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02

TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87

Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83

The essence of senescence. Genes Dev (2010) 8.21

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43

The BCL-2 family reunion. Mol Cell (2010) 7.32

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14

Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10

Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88

Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78

The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol (2010) 6.28

Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17

Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer (2012) 6.14

Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet (2010) 5.75

The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol (2012) 5.60

The double-edged sword of autophagy modulation in cancer. Clin Cancer Res (2009) 5.46

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med (2009) 5.43

Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26

Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23

Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84

Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72

Endogenous HMGB1 regulates autophagy. J Cell Biol (2010) 4.71

Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol (2008) 4.47

Identification of aneuploidy-selective antiproliferation compounds. Cell (2011) 4.45

Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42

p53 status determines the role of autophagy in pancreatic tumour development. Nature (2013) 4.31

The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe (2008) 4.16

The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. Trends Cell Biol (2010) 4.15

The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13

An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell (2009) 4.07

Autophagy: cellular and molecular mechanisms. J Pathol (2010) 3.96

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci U S A (2008) 3.92

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med (2011) 3.89

Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe (2010) 3.79

Autophagy genes in immunity. Nat Immunol (2009) 3.76

Identification of a candidate therapeutic autophagy-inducing peptide. Nature (2013) 3.76

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74

Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol (2013) 3.73

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep (2009) 3.69

The dynamic nature of autophagy in cancer. Genes Dev (2011) 3.57

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal (2012) 3.40

Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal (2010) 3.35

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proc Natl Acad Sci U S A (2013) 3.33

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol (2011) 3.28

Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science (2012) 3.24

Emerging regulation and functions of autophagy. Nat Cell Biol (2013) 3.24

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest (2009) 3.23

A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol (2010) 3.17

ER stress-induced cell death mechanisms. Biochim Biophys Acta (2013) 3.07

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev (2011) 3.05

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev (2009) 3.03

Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration. Nat Med (2010) 3.01

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci U S A (2010) 3.00

An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol (2010) 2.98

FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. Cell Metab (2012) 2.96

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) (2009) 2.94

The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94

Autophagy mediates degradation of nuclear lamina. Nature (2015) 2.93

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83

ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell (2010) 2.83

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res (2010) 2.82

FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol (2009) 2.81

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci U S A (2011) 2.80

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle (2010) 2.80

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain (2011) 2.76

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. Proc Natl Acad Sci U S A (2011) 2.73

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis (2010) 2.69

Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation. Proc Natl Acad Sci U S A (2011) 2.67

Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One (2008) 2.67

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology (2008) 2.66

Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Cancer Cell (2014) 2.66

Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64

EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell (2013) 2.63

A small molecule inhibitor of inducible heat shock protein 70. Mol Cell (2009) 2.63

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39

Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62

The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73

Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68

Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60

Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81

Functions of lysosomes. Annu Rev Physiol (1966) 17.76

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59

Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72

Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88

Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol (2007) 10.79

The plasticity of aging: insights from long-lived mutants. Cell (2005) 9.88

Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell (2006) 9.47

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol (2006) 9.36

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33

Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science (2003) 9.17

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med (2007) 8.82

Potential therapeutic applications of autophagy. Nat Rev Drug Discov (2007) 8.56

Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res (2007) 8.44

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29

Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24

Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19

LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74

Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer (2006) 7.53

Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol (2007) 7.43

Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41

The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A (2005) 7.38

HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe (2007) 7.34

Ambra1 regulates autophagy and development of the nervous system. Nature (2007) 6.94

Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol (2007) 6.45

Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell (2007) 6.39

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature (2000) 6.34

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22

Inflammatory bowel disease: cause and immunobiology. Lancet (2007) 6.07

A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78

Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75

Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature (2000) 5.71

Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91

Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem (2006) 4.57

Cell biology: autophagy and cancer. Nature (2007) 4.40

A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron (2002) 4.27

Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22

Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ (2007) 4.12

Innate and adaptive immunity through autophagy. Immunity (2007) 4.11

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77

Role of autophagy in cancer: management of metabolic stress. Autophagy (2007) 3.40

Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet (2005) 3.39

Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest (2006) 3.34

Tuberous sclerosis complex: advances in diagnosis, genetics, and management. J Am Acad Dermatol (2007) 3.29

Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol (2007) 3.18

The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains. Autophagy (2007) 3.14

Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med (2006) 3.12

DAPk protein family and cancer. Autophagy (2006) 3.02

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Curr Top Dev Biol (2006) 3.02

Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Curr Biol (2005) 2.86

Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev (2007) 2.80

Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy (2007) 2.71

Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 2.68

Eating the endoplasmic reticulum: quality control by autophagy. Trends Cell Biol (2007) 2.60

Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem (2005) 2.60

Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56

Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54

Mutations that increase the life span of C. elegans inhibit tumor growth. Science (2006) 2.48

Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem (2005) 2.44

Distal spinal and bulbar muscular atrophy caused by dynactin mutation. Ann Neurol (2005) 2.34

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem (2006) 2.34

Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J Biol Chem (2005) 2.33

Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease. Autophagy (2007) 2.30

Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol (2007) 2.25

Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis. Ann Neurol (2007) 2.18

Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis. Exp Gerontol (2003) 2.17

Autophagy in development and stress responses of plants. Autophagy (2006) 1.93

Autophagy and mistargeting of therapeutic enzyme in skeletal muscle in Pompe disease. Mol Ther (2006) 1.88

Inclusion-body myositis: a myodegenerative conformational disorder associated with Abeta, protein misfolding, and proteasome inhibition. Neurology (2006) 1.87

Autophagic vacuolar myopathy. Semin Pediatr Neurol (2006) 1.79

Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res (2005) 1.76

Targets for antiageing drugs. Expert Opin Ther Targets (2005) 1.56

Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J Neurosci (2007) 1.52

The role of autophagy in alpha-1-antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins. Autophagy (2006) 1.46

Beclin 1 gene inhibits tumor growth in colon cancer cell lines. Anticancer Res (2007) 1.43

Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy (2007) 1.40

Mutated genes in juvenile and variant late infantile neuronal ceroid lipofuscinoses encode lysosomal proteins. Curr Mol Med (2002) 1.15

Contribution of genetic factors to the pathogenesis of Paget's disease of bone and related disorders. J Bone Miner Res (2006) 1.14

Short-term stimulation by propranolol and verapamil of cardiac cellular autophagy. J Mol Cell Cardiol (1987) 1.13

Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease. Am J Hematol (2005) 1.12

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47

The hallmarks of aging. Cell (2013) 14.29

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90

The pathophysiology of mitochondrial cell death. Science (2004) 13.87

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72

Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54

Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27

Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73

Immunological aspects of cancer chemotherapy. Nat Rev Immunol (2008) 6.61

Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol (2006) 6.13

Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov (2006) 5.99

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Autophagy and aging. Cell (2011) 5.96

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science (2011) 5.62

Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23

Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00

Cell death by mitotic catastrophe: a molecular definition. Oncogene (2004) 4.75

Cell death by necrosis: towards a molecular definition. Trends Biochem Sci (2006) 4.67

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60

Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42

An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35

Immunogenic and tolerogenic cell death. Nat Rev Immunol (2009) 4.34

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 4.32

Targeting mitochondria for cancer therapy. Nat Rev Drug Discov (2010) 4.07

The anticancer immune response: indispensable for therapeutic success? J Clin Invest (2008) 4.01

The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity (2013) 3.73

Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64

The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov (2012) 3.60

Decoding cell death signals in inflammation and immunity. Cell (2010) 3.41

Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol (2011) 3.41

Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol (2011) 3.40

Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity (2013) 3.26

Does autophagy contribute to cell death? Autophagy (2005) 3.21

A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21

AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96

Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle (2009) 2.72

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72

Platelet formation is the consequence of caspase activation within megakaryocytes. Blood (2002) 2.62

Necroptosis: a specialized pathway of programmed necrosis. Cell (2008) 2.61

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56

Autophagy regulation by p53. Curr Opin Cell Biol (2010) 2.56

Can autophagy promote longevity? Nat Cell Biol (2010) 2.55

Cell death assays for drug discovery. Nat Rev Drug Discov (2011) 2.51

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47

The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41

Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle (2010) 2.37

Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36

An AIF orthologue regulates apoptosis in yeast. J Cell Biol (2004) 2.33

Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway. Clin Cancer Res (2010) 2.29

Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28

miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res (2010) 2.24

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23

Viral control of mitochondrial apoptosis. PLoS Pathog (2008) 2.21

Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. Mol Cell (2007) 2.20

Prognostic and predictive impact of intra- and peritumoral immune infiltrates. Cancer Res (2011) 2.16

Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell (2012) 2.14

Alternative cell death mechanisms in development and beyond. Genes Dev (2010) 2.14

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene (2003) 2.09

Involvement of p38alpha in the mitotic progression of p53(-/-) tetraploid cells. Cell Cycle (2010) 2.08

Decoding cell death signals in liver inflammation. J Hepatol (2013) 2.05

To die or not to die: that is the autophagic question. Curr Mol Med (2008) 2.05

Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med (2011) 2.04

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Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle (2008) 2.03

A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02

A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00

Methods for assessing autophagy and autophagic cell death. Methods Mol Biol (2008) 1.96

Chemotherapy and radiotherapy: cryptic anticancer vaccines. Semin Immunol (2010) 1.94

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Apoptosis and genomic instability. Nat Rev Mol Cell Biol (2004) 1.92

Anti- and pro-tumor functions of autophagy. Biochim Biophys Acta (2009) 1.92

Mitochondria, the killer organelles and their weapons. J Cell Physiol (2002) 1.92

Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest (2005) 1.91

Autophagy is required for the activation of NFκB. Cell Cycle (2012) 1.89

High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab (2011) 1.89

Apoptosis regulation in tetraploid cancer cells. EMBO J (2006) 1.89

Immunogenic cancer cell death: a key-lock paradigm. Curr Opin Immunol (2008) 1.89

Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology (2012) 1.88

A dual role of p53 in the control of autophagy. Autophagy (2008) 1.88

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci (2002) 1.88

Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease. J Clin Invest (2011) 1.86

Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol (2012) 1.85

Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci (2009) 1.85

Autophagic removal of micronuclei. Cell Cycle (2012) 1.85

Chemotherapy induces ATP release from tumor cells. Cell Cycle (2009) 1.83

Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity. Cancer Res (2010) 1.82

DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol (2002) 1.81

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Oncogene (2004) 1.79