Published in Mol Cell Proteomics on November 07, 2005
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest (2007) 3.35
Vectors for co-expression of an unrestricted number of proteins. Nucleic Acids Res (2007) 1.85
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet (2011) 1.72
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci (2010) 1.57
Bin1 attenuation suppresses experimental colitis by enforcing intestinal barrier function. Dig Dis Sci (2012) 1.40
The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Proc Natl Acad Sci U S A (2006) 1.26
A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J Biol Chem (2010) 1.15
Animal models of dystonia: Lessons from a mutant rat. Neurobiol Dis (2010) 0.95
Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Mol Biosyst (2011) 0.88
Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. PLoS One (2008) 0.84
Caytaxin deficiency disrupts signaling pathways in cerebellar cortex. Neuroscience (2006) 0.80
Expression of Caytaxin protein in Cayman Ataxia mouse models correlates with phenotype severity. PLoS One (2012) 0.78
Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma. J Mol Histol (2014) 0.77
Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression. Oncol Lett (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
A human protein-protein interaction network: a resource for annotating the proteome. Cell (2005) 18.97
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol (2008) 5.32
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol Cell (2004) 3.26
The hunt for huntingtin function: interaction partners tell many different stories. Trends Biochem Sci (2003) 3.15
PlnTFDB: updated content and new features of the plant transcription factor database. Nucleic Acids Res (2009) 3.12
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold. Trends Biochem Sci (2002) 3.01
The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res (2012) 2.94
Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science (2010) 2.92
Biochemical and proteomic analysis of the magnetosome membrane in Magnetospirillum gryphiswaldense. Appl Environ Microbiol (2004) 2.74
A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis. Nature (2013) 2.61
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J (2002) 2.56
EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proc Natl Acad Sci U S A (2010) 2.48
UniHI: an entry gate to the human protein interactome. Nucleic Acids Res (2006) 2.45
Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol (2010) 2.45
Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals. J Infect Dis (2002) 2.33
HIPPIE: Integrating protein interaction networks with experiment based quality scores. PLoS One (2012) 2.17
Plant nitric oxide synthase: a never-ending story? Trends Plant Sci (2006) 2.12
Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. J Biol Chem (2005) 2.10
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes. Mol Cell Biol (2005) 2.10
Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell (2012) 2.04
High-throughput generation of small antibacterial peptides with improved activity. Nat Biotechnol (2005) 2.01
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation. J Biol Chem (2005) 2.01
PhosPhAt: the Arabidopsis thaliana phosphorylation site database. An update. Nucleic Acids Res (2009) 1.98
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration. PLoS Biol (2013) 1.96
A directed protein interaction network for investigating intracellular signal transduction. Sci Signal (2011) 1.95
Protein interaction networks by proteome peptide scanning. PLoS Biol (2004) 1.92
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A (2005) 1.88
Sequence requirements and an optimization strategy for short antimicrobial peptides. Chem Biol (2006) 1.84
Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases. Nat Cell Biol (2007) 1.81
Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. PLoS Biol (2009) 1.78
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet (2006) 1.77
High throughput identification of potential Arabidopsis mitogen-activated protein kinases substrates. Mol Cell Proteomics (2005) 1.75
Pathological consequences of VCP mutations on human striated muscle. Brain (2006) 1.68
Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides. J Mol Biol (2004) 1.68
Prions, protein homeostasis, and phenotypic diversity. Trends Cell Biol (2010) 1.63
Comparative proteome analysis of culture supernatant proteins from virulent Mycobacterium tuberculosis H37Rv and attenuated M. bovis BCG Copenhagen. Electrophoresis (2003) 1.57
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol (2011) 1.54
Cooperation of molecular chaperones with the ubiquitin/proteasome system. Biochim Biophys Acta (2004) 1.53
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell (2005) 1.52
The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell (2004) 1.52
Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell (2011) 1.49
Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners. Bioessays (2013) 1.48
WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Sci (2003) 1.46
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J (2006) 1.45
The value of high quality protein-protein interaction networks for systems biology. Curr Opin Chem Biol (2006) 1.44
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol (2013) 1.43
Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks. Nucleic Acids Res (2012) 1.38
Protein disorder, prion propensities, and self-organizing macromolecular collectives. Biochim Biophys Acta (2013) 1.36
Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Mol Cell (2002) 1.36
HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome. Curr Biol (2005) 1.33
Polyglutamine fibrillogenesis: the pathway unfolds. Proc Natl Acad Sci U S A (2002) 1.32
CFP10 discriminates between nonacetylated and acetylated ESAT-6 of Mycobacterium tuberculosis by differential interaction. Proteomics (2004) 1.32
Chaperone-assisted degradation: multiple paths to destruction. Biol Chem (2010) 1.32
An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. Chem Biol (2004) 1.31
The periplasmic chaperone SurA exploits two features characteristic of integral outer membrane proteins for selective substrate recognition. J Biol Chem (2005) 1.30
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay. Proc Natl Acad Sci U S A (2002) 1.30
Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates. Mol Biol Cell (2012) 1.29
Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization. Biochem Biophys Res Commun (2003) 1.29
A molecular pathogenesis for transcription factor associated poly-alanine tract expansions. Hum Mol Genet (2004) 1.29
UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome. Nucleic Acids Res (2008) 1.28
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions. Cell Stress Chaperones (2003) 1.27
Analysis of antigen-specific T-cell responses with synthetic peptides--what kind of peptide for which purpose? Hum Immunol (2004) 1.24
HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2. Stem Cells (2014) 1.23
Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites. J Cell Sci (2006) 1.23
Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals. Mol Biol Cell (2004) 1.22
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. Hum Mol Genet (2005) 1.21
Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem (2003) 1.19
Synthesis of an Array Comprising 837 Variants of the hYAP WW Protein Domain This work was supported by the DFG (INK 16/B1-1), by the Fonds der Chemischen Industrie, and by the Universitätsklinikum Charité Berlin. Angew Chem Int Ed Engl (2001) 1.18
Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation. Elife (2014) 1.17
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2008) 1.17
Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers. J Mol Biol (2012) 1.16
A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells. Mol Cell Proteomics (2008) 1.15
Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease. J Biol Chem (2003) 1.13
Fission yeast does not age under favorable conditions, but does so after stress. Curr Biol (2013) 1.12
Pathophysiology of protein aggregation and extended phenotyping in filaminopathy. Brain (2012) 1.12
GabiPD: the GABI primary database--a plant integrative 'omics' database. Nucleic Acids Res (2008) 1.12
Volatile polydimethylcyclosiloxanes in the ambient laboratory air identified as source of extreme background signals in nanoelectrospray mass spectrometry. J Mass Spectrom (2003) 1.12
Large-scale de novo prediction of physical protein-protein association. Mol Cell Proteomics (2011) 1.11
Characterization of OPA1 isoforms isolated from mouse tissues. J Neurochem (2008) 1.11
Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosome. Curr Protein Pept Sci (2002) 1.11
Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization. EMBO J (2005) 1.11
A Y2H-seq approach defines the human protein methyltransferase interactome. Nat Methods (2013) 1.10