Published in Proc Natl Acad Sci U S A on January 06, 2010
PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor. Mol Ther (2011) 1.32
Hyperactive piggyBac gene transfer in human cells and in vivo. Hum Gene Ther (2011) 1.21
Manipulating piggyBac transposon chromosomal integration site selection in human cells. Mol Ther (2011) 1.12
The expanding universe of transposon technologies for gene and cell engineering. Mob DNA (2010) 1.08
Propranolol blocks cardiac and neuronal voltage-gated sodium channels. Front Pharmacol (2010) 1.03
Simple piggyBac transposon-based mammalian cell expression system for inducible protein production. Proc Natl Acad Sci U S A (2013) 0.98
Packaging HIV- or FIV-based lentivector expression constructs and transduction of VSV-G pseudotyped viral particles. J Vis Exp (2012) 0.96
Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes. J Immunother (2013) 0.94
KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1. J Biol Chem (2010) 0.90
Mechanism of sodium channel NaV1.9 potentiation by G-protein signaling. J Gen Physiol (2013) 0.90
piggyBac-ing models and new therapeutic strategies. Trends Biotechnol (2015) 0.89
Modular assembly of transposon integratable multigene vectors using RecWay assembly. Nucleic Acids Res (2013) 0.84
Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. Proc Natl Acad Sci U S A (2015) 0.82
Evaluating the potential for undesired genomic effects of the piggyBac transposon system in human cells. Nucleic Acids Res (2015) 0.81
Nontruncating SCN1A mutations associated with severe myoclonic epilepsy of infancy impair cell surface expression. J Biol Chem (2012) 0.81
piggyBac transposon system modification of primary human T cells. J Vis Exp (2012) 0.80
PiggyBac transposon-mediated gene delivery efficiently generates stable transfectants derived from cultured primary human deciduous tooth dental pulp cells (HDDPCs) and HDDPC-derived iPS cells. Int J Oral Sci (2015) 0.80
Somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes. PLoS Genet (2011) 0.79
Gene therapy strategies for cardiac electrical dysfunction. J Mol Cell Cardiol (2010) 0.79
Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model. PLoS One (2015) 0.77
Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis. Sci Rep (2014) 0.76
CHO cell lines generated by PiggyBac transposition. BMC Proc (2011) 0.76
Transposon mediated co-integration and co-expression of transgenes in CHO-DG44 cells. BMC Proc (2011) 0.75
PiggyBac mediated multiplex gene transfer in mouse embryonic stem cell. PLoS One (2014) 0.75
A transposon-mediated system for flexible control of transgene expression in stem and progenitor-derived lineages. Stem Cell Reports (2015) 0.75
Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability. J Clin Invest (2017) 0.75
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27
Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature (2009) 9.29
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell (1997) 8.68
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell (2005) 7.29
Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2008) 4.98
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 4.27
PiggyBac transposon-mediated gene transfer in human cells. Mol Ther (2007) 4.07
Transposon mutagenesis of baculoviruses: analysis of Trichoplusia ni transposon IFP2 insertions within the FP-locus of nuclear polyhedrosis viruses. Virology (1989) 3.91
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat Genet (2009) 3.86
Generation of an inducible and optimized piggyBac transposon system. Nucleic Acids Res (2007) 3.09
Precise excision of TTAA-specific lepidopteran transposons piggyBac (IFP2) and tagalong (TFP3) from the baculovirus genome in cell lines from two species of Lepidoptera. Insect Mol Biol (1996) 3.02
Assay for movement of Lepidopteran transposon IFP2 in insect cells using a baculovirus genome as a target DNA. Virology (1995) 1.90
piggyBac internal sequences are necessary for efficient transformation of target genomes. Insect Mol Biol (2005) 1.76
A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells. Genome Res (2009) 1.48
The minimum internal and external sequence requirements for transposition of the eukaryotic transformation vector piggyBac. Mol Genet Genomics (2001) 1.33
Robotic multiwell planar patch-clamp for native and primary mammalian cells. Nat Protoc (2009) 1.25
Divergent sodium channel defects in familial hemiplegic migraine. Proc Natl Acad Sci U S A (2008) 1.13
Cell-based assays in GPCR drug discovery. Biotechnol J (2008) 1.04
Analysis of the cis-acting DNA elements required for piggyBac transposable element excision. Mol Gen Genet (1997) 0.97
Proteins from nuclear extracts of two lepidopteran cell lines recognize the ends of TTAA-specific transposons piggyBac and tagalong. Insect Mol Biol (1999) 0.91
Design and implementation of cell-based assays to model human disease. ACS Chem Biol (2007) 0.89
Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation (2007) 4.10
PiggyBac transposon-mediated gene transfer in human cells. Mol Ther (2007) 4.07
Molecular basis of an inherited epilepsy. Neuron (2002) 3.77
Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest (2003) 3.00
Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation (2002) 2.98
KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome. Circulation (2005) 2.78
Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation (2013) 2.66
Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation (2008) 2.56
Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study. J Infect Dis (2005) 2.43
Impact of genetics on the clinical management of channelopathies. J Am Coll Cardiol (2013) 2.30
Cardiac sodium channel dysfunction in sudden infant death syndrome. Circulation (2007) 2.28
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry (2008) 2.22
Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J Am Soc Nephrol (2008) 2.04
Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women. Pharmacogenetics (2003) 2.03
Long QT syndrome-associated mutations in intrauterine fetal death. JAMA (2013) 2.00
NOS1AP is a genetic modifier of the long-QT syndrome. Circulation (2009) 2.00
Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. J Am Coll Cardiol (2008) 1.91
Cardiac ion channels. Annu Rev Physiol (2002) 1.90
Myotonia congenita. Adv Genet (2008) 1.80
Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J Neurosci (2003) 1.77
Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: characteristic T-U-wave patterns predict the KCNJ2 genotype. Circulation (2005) 1.77
Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks). J Mol Cell Cardiol (2005) 1.70
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest (2008) 1.69
Polymorphic ventricular tachycardia and KCNJ2 mutations. Heart Rhythm (2004) 1.68
Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block. Circulation (2002) 1.65
Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. Proc Natl Acad Sci U S A (2004) 1.65
piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies. Hum Gene Ther (2010) 1.64
KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes. Am J Hum Genet (2002) 1.60
A KCNH2 branch point mutation causing aberrant splicing contributes to an explanation of genotype-negative long QT syndrome. Heart Rhythm (2008) 1.59
Vagal reflexes following an exercise stress test: a simple clinical tool for gene-specific risk stratification in the long QT syndrome. J Am Coll Cardiol (2012) 1.58
Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel. Circ Arrhythm Electrophysiol (2008) 1.53
Genome-wide mapping of PiggyBac transposon integrations in primary human T cells. J Immunother (2009) 1.52
The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet (2002) 1.51
A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet (2011) 1.48
Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population. Circulation (2005) 1.48
Structural models for the KCNQ1 voltage-gated potassium channel. Biochemistry (2007) 1.38
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation (2011) 1.38
Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome. Biochemistry (2007) 1.35
Functional zinc finger/sleeping beauty transposase chimeras exhibit attenuated overproduction inhibition. FEBS Lett (2005) 1.35
Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users. J Affect Disord (2007) 1.34
The genetic basis of variability in drug responses. Nat Rev Drug Discov (2002) 1.34
Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes. J Immunother (2009) 1.32
PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor. Mol Ther (2011) 1.32
Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption. Hum Hered (2007) 1.30
Brain activity and desire for Internet video game play. Compr Psychiatry (2011) 1.28
Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet (2014) 1.27
Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27
Improved DNA sequencing quality and efficiency using an optimized fast cycle sequencing protocol. Biotechniques (2007) 1.26
Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice. Kidney Int (2004) 1.24
Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. Brain Res Mol Brain Res (2002) 1.24
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet (2013) 1.23
PiggyBac transposon-based inducible gene expression in vivo after somatic cell gene transfer. Mol Ther (2009) 1.23
Divergent biophysical defects caused by mutant sodium channels in dilated cardiomyopathy with arrhythmia. Circ Res (2007) 1.23
The effect of methylphenidate on Internet video game play in children with attention-deficit/hyperactivity disorder. Compr Psychiatry (2008) 1.22
Hyperactive piggyBac gene transfer in human cells and in vivo. Hum Gene Ther (2011) 1.21
Strategy for encoding and comparison of gene expression signatures. Genome Biol (2007) 1.18
Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Clin Infect Dis (2006) 1.18
Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics (2009) 1.16
Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia. J Am Coll Cardiol (2012) 1.15
Single-channel properties of human NaV1.1 and mechanism of channel dysfunction in SCN1A-associated epilepsy. J Gen Physiol (2006) 1.14
Divergent sodium channel defects in familial hemiplegic migraine. Proc Natl Acad Sci U S A (2008) 1.13
Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures. J Physiol (2005) 1.12
Manipulating piggyBac transposon chromosomal integration site selection in human cells. Mol Ther (2011) 1.12
Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia. Heart Rhythm (2011) 1.11
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties. Proc Natl Acad Sci U S A (2006) 1.11
Coupled analysis of gene expression and chromosomal location. Genomics (2005) 1.10
KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex. FEBS J (2008) 1.10
Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives. Heart Rhythm (2005) 1.10
Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia (2008) 1.09
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. Proc Natl Acad Sci U S A (2004) 1.07
Nav 1.1 dysfunction in genetic epilepsy with febrile seizures-plus or Dravet syndrome. Eur J Neurosci (2011) 1.07
Functional repair of a mutant chloride channel using a trans-splicing ribozyme. J Clin Invest (2002) 1.07
Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells. J Physiol (2002) 1.07
Nonfunctional SCN1A is common in severe myoclonic epilepsy of infancy. Epilepsia (2006) 1.07
Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. J Neurosci (2006) 1.06
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse. Brain (2002) 1.06
SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs. Epilepsia (2011) 1.06
Molecular physiology of renal ClC chloride channels/transporters. Curr Opin Nephrol Hypertens (2006) 1.04
Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. PLoS One (2013) 1.04
Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome. Circ Cardiovasc Genet (2013) 1.03
Expression and transcriptional control of human KCNE genes. Genomics (2005) 1.03
Combining mTor inhibitors with rapamycin-resistant T cells: a two-pronged approach to tumor elimination. Mol Ther (2011) 1.03
Propranolol blocks cardiac and neuronal voltage-gated sodium channels. Front Pharmacol (2010) 1.03
Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol (2003) 1.02
Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility. Proc Natl Acad Sci U S A (2011) 1.02
Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations. Br J Pharmacol (2010) 1.00
Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proc Natl Acad Sci U S A (2002) 0.99
Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation (2003) 0.97
Cardiac potassium channel dysfunction in sudden infant death syndrome. J Mol Cell Cardiol (2007) 0.96
Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome. J Cardiovasc Pharmacol (2012) 0.95
Transcriptional networks in epithelial-mesenchymal transition. PLoS One (2011) 0.95
The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. FASEB J (2003) 0.95
Extracellular sodium interacts with the HERG channel at an outer pore site. J Gen Physiol (2002) 0.95
High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot. Genomics (2003) 0.94
Web-based interrogation of gene expression signatures using EXALT. BMC Bioinformatics (2009) 0.94