| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
Nat Genet
|
2008
|
35.06
|
|
2
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
|
3
|
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|
Nat Genet
|
2008
|
22.35
|
|
4
|
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial.
|
Lancet
|
2005
|
21.91
|
|
5
|
Common variants at 30 loci contribute to polygenic dyslipidemia.
|
Nat Genet
|
2008
|
20.66
|
|
6
|
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
|
Cell
|
2006
|
19.16
|
|
7
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
|
8
|
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
Nat Genet
|
2010
|
16.96
|
|
9
|
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
Nature
|
2011
|
13.25
|
|
10
|
Genome-wide association study identifies eight loci associated with blood pressure.
|
Nat Genet
|
2009
|
12.44
|
|
11
|
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
Nat Genet
|
2012
|
11.09
|
|
12
|
Variants in MTNR1B influence fasting glucose levels.
|
Nat Genet
|
2008
|
10.85
|
|
13
|
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD).
|
Eur Heart J
|
2007
|
9.80
|
|
14
|
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial.
|
Lancet
|
2002
|
9.48
|
|
15
|
Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial.
|
JAMA
|
2003
|
8.47
|
|
16
|
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
|
Nat Genet
|
2010
|
7.94
|
|
17
|
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
Nat Genet
|
2012
|
7.59
|
|
18
|
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|
Nat Genet
|
2010
|
6.66
|
|
19
|
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
|
PLoS Genet
|
2009
|
5.81
|
|
20
|
Effect of valsartan on the incidence of diabetes and cardiovascular events.
|
N Engl J Med
|
2010
|
5.46
|
|
21
|
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
|
Nat Genet
|
2008
|
4.84
|
|
22
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
|
23
|
Effect of nateglinide on the incidence of diabetes and cardiovascular events.
|
N Engl J Med
|
2010
|
4.38
|
|
24
|
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
Nat Genet
|
2012
|
4.37
|
|
25
|
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
Nat Genet
|
2014
|
4.13
|
|
26
|
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
|
Diabetes
|
2010
|
4.07
|
|
27
|
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
|
PLoS Med
|
2011
|
3.94
|
|
28
|
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.
|
PLoS Genet
|
2011
|
3.56
|
|
29
|
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
|
J Clin Invest
|
2008
|
3.51
|
|
30
|
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
|
Mol Cell
|
2011
|
3.33
|
|
31
|
Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort.
|
Diabetologia
|
2015
|
3.28
|
|
32
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
|
33
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
|
34
|
Common variants associated with plasma triglycerides and risk for coronary artery disease.
|
Nat Genet
|
2013
|
2.92
|
|
35
|
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).
|
Nat Genet
|
2004
|
2.86
|
|
36
|
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
|
PLoS Genet
|
2013
|
2.83
|
|
37
|
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
|
Nat Genet
|
2011
|
2.73
|
|
38
|
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.
|
Nat Genet
|
2012
|
2.55
|
|
39
|
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men.
|
Diabetes
|
2009
|
2.51
|
|
40
|
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT).
|
Circulation
|
2003
|
2.48
|
|
41
|
The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns.
|
Eur Heart J
|
2007
|
2.44
|
|
42
|
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.
|
Diabetes
|
2010
|
2.44
|
|
43
|
The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland.
|
Stroke
|
2008
|
2.23
|
|
44
|
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
|
Diabetes
|
2011
|
2.21
|
|
45
|
Gender difference in the impact of type 2 diabetes on coronary heart disease risk.
|
Diabetes Care
|
2004
|
2.19
|
|
46
|
Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects.
|
Diabetes Care
|
2007
|
2.15
|
|
47
|
Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women.
|
Diabetes Care
|
2007
|
2.13
|
|
48
|
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
|
Cell Metab
|
2011
|
2.08
|
|
49
|
Type 2 diabetes as a "coronary heart disease equivalent": an 18-year prospective population-based study in Finnish subjects.
|
Diabetes Care
|
2005
|
2.07
|
|
50
|
Physical activity and insulin sensitivity: the RISC study.
|
Diabetes
|
2008
|
2.03
|
|
51
|
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.
|
Lancet
|
2003
|
2.02
|
|
52
|
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
|
Cell
|
2008
|
1.97
|
|
53
|
Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial.
|
Lancet
|
2009
|
1.88
|
|
54
|
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
|
Diabetes
|
2009
|
1.87
|
|
55
|
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men.
|
Diabetes
|
2012
|
1.78
|
|
56
|
A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy.
|
Eur Heart J
|
2004
|
1.78
|
|
57
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
|
58
|
Lipids and glucose in type 2 diabetes: what is the cause and effect?
|
Diabetes Care
|
2004
|
1.69
|
|
59
|
Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome.
|
Circulation
|
2004
|
1.65
|
|
60
|
Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus.
|
Ann Intern Med
|
2004
|
1.64
|
|
61
|
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.
|
Hum Mol Genet
|
2009
|
1.61
|
|
62
|
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
Circ Cardiovasc Genet
|
2012
|
1.60
|
|
63
|
Underlying genetic models of inheritance in established type 2 diabetes associations.
|
Am J Epidemiol
|
2009
|
1.60
|
|
64
|
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis.
|
J Clin Endocrinol Metab
|
2004
|
1.58
|
|
65
|
Circulating metabolite predictors of glycemia in middle-aged men and women.
|
Diabetes Care
|
2012
|
1.57
|
|
66
|
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.
|
PLoS Genet
|
2013
|
1.57
|
|
67
|
Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy.
|
Heart
|
2012
|
1.54
|
|
68
|
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.
|
PLoS Genet
|
2013
|
1.51
|
|
69
|
The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study.
|
J Clin Endocrinol Metab
|
2004
|
1.50
|
|
70
|
Baroreflex sensitivity in essential and secondary hypertension.
|
Clin Auton Res
|
2002
|
1.50
|
|
71
|
Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic finnish offspring of type 2 diabetic individuals.
|
J Clin Endocrinol Metab
|
2010
|
1.49
|
|
72
|
Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data.
|
Radiology
|
2008
|
1.48
|
|
73
|
High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study.
|
Diabetes Care
|
2006
|
1.46
|
|
74
|
The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes.
|
Cell Metab
|
2013
|
1.45
|
|
75
|
Prolonged P wave duration predicts stroke mortality among type 2 diabetic patients with prevalent non-major macrovascular disease.
|
BMC Cardiovasc Disord
|
2014
|
1.40
|
|
76
|
Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography.
|
Diabetes
|
2006
|
1.37
|
|
77
|
Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.
|
Diabetes
|
2004
|
1.34
|
|
78
|
Genetic screening for the risk of type 2 diabetes: worthless or valuable?
|
Diabetes Care
|
2013
|
1.34
|
|
79
|
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.
|
J Clin Endocrinol Metab
|
2008
|
1.31
|
|
80
|
WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4.
|
Proc Natl Acad Sci U S A
|
2013
|
1.30
|
|
81
|
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study.
|
PLoS One
|
2009
|
1.29
|
|
82
|
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
|
Mol Cell Biol
|
2007
|
1.28
|
|
83
|
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.
|
Diabetes
|
2007
|
1.27
|
|
84
|
High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men: a population-based 18-year follow-up study.
|
Arterioscler Thromb Vasc Biol
|
2005
|
1.27
|
|
85
|
Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men.
|
J Lipid Res
|
2003
|
1.27
|
|
86
|
The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study.
|
Obesity (Silver Spring)
|
2009
|
1.26
|
|
87
|
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
|
Diabetes
|
2013
|
1.25
|
|
88
|
Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury.
|
Circ Res
|
2010
|
1.20
|
|
89
|
Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q.
|
Am J Hum Genet
|
2003
|
1.19
|
|
90
|
The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth.
|
Diabetes
|
2002
|
1.18
|
|
91
|
Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice.
|
Am J Physiol Endocrinol Metab
|
2003
|
1.18
|
|
92
|
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
|
Diabetes
|
2010
|
1.18
|
|
93
|
Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.
|
Eur Heart J
|
2009
|
1.17
|
|
94
|
Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study.
|
Diabetes
|
2002
|
1.16
|
|
95
|
Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention.
|
J Clin Endocrinol Metab
|
2007
|
1.15
|
|
96
|
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.
|
Scand J Gastroenterol
|
2006
|
1.15
|
|
97
|
Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans.
|
J Hepatol
|
2011
|
1.14
|
|
98
|
Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.
|
Diabetes
|
2003
|
1.14
|
|
99
|
Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis.
|
Circ Res
|
2011
|
1.12
|
|
100
|
Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects.
|
Diabetes Care
|
2006
|
1.11
|
|
101
|
Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism.
|
Diabetes
|
2012
|
1.10
|
|
102
|
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.
|
J Clin Endocrinol Metab
|
2004
|
1.10
|
|
103
|
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.
|
Cell Metab
|
2009
|
1.10
|
|
104
|
Visfatin is an adipokine, but it is not regulated by thiazolidinediones.
|
J Clin Endocrinol Metab
|
2006
|
1.10
|
|
105
|
Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland.
|
J Mol Med (Berl)
|
2002
|
1.10
|
|
106
|
Pleiotropic effects of GIP on islet function involve osteopontin.
|
Diabetes
|
2011
|
1.08
|
|
107
|
The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
|
Diabetes
|
2005
|
1.07
|
|
108
|
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production.
|
EMBO Mol Med
|
2012
|
1.07
|
|
109
|
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
|
Am J Hum Genet
|
2008
|
1.06
|
|
110
|
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
|
Diabetes
|
2013
|
1.06
|
|
111
|
The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects.
|
Diabetes
|
2005
|
1.06
|
|
112
|
Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men.
|
Mol Genet Metab
|
2005
|
1.05
|
|
113
|
Serum zinc level and coronary heart disease events in patients with type 2 diabetes.
|
Diabetes Care
|
2007
|
1.04
|
|
114
|
Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure.
|
Eur J Heart Fail
|
2008
|
1.03
|
|
115
|
Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy.
|
Eur J Heart Fail
|
2004
|
1.03
|
|
116
|
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
|
Cell Metab
|
2011
|
1.03
|
|
117
|
An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance.
|
Obes Res
|
2005
|
1.02
|
|
118
|
Identification of undiagnosed type 2 diabetic individuals by the finnish diabetes risk score and biochemical and genetic markers: a population-based study of 7232 Finnish men.
|
J Clin Endocrinol Metab
|
2010
|
1.02
|
|
119
|
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.
|
Am J Med Genet A
|
2004
|
1.02
|
|
120
|
Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects.
|
Ann Noninvasive Electrocardiol
|
2008
|
1.01
|
|
121
|
The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity.
|
Diabetes
|
2003
|
1.01
|
|
122
|
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.
|
PLoS Genet
|
2009
|
1.00
|
|
123
|
Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men.
|
Diabetes
|
2011
|
0.99
|
|
124
|
The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.
|
Diabetes Care
|
2003
|
0.99
|
|
125
|
Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose.
|
Diabetes
|
2009
|
0.99
|
|
126
|
The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns.
|
Atherosclerosis
|
2009
|
0.99
|
|
127
|
Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation.
|
Diabetes
|
2013
|
0.99
|
|
128
|
Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes.
|
Am J Clin Nutr
|
2013
|
0.98
|
|
129
|
Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.
|
Diabetes
|
2005
|
0.98
|
|
130
|
The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function.
|
Diabetes
|
2011
|
0.98
|
|
131
|
Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia.
|
Circ Res
|
2007
|
0.98
|
|
132
|
Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study.
|
J Clin Endocrinol Metab
|
2008
|
0.97
|
|
133
|
Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
|
Diabetes
|
2007
|
0.97
|
|
134
|
Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure.
|
Mediators Inflamm
|
2009
|
0.97
|
|
135
|
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits.
|
Hum Mol Genet
|
2013
|
0.97
|
|
136
|
Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.
|
BMC Med Genet
|
2009
|
0.96
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