PubRank

Michael Leitges

Author PubWeight™ 170.28‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell 2004 2.65
2 Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med 2009 2.31
3 Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med 2003 2.30
4 Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory. J Biol Chem 2003 2.28
5 Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest 2007 2.17
6 PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol 2002 2.03
7 Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest 2006 2.00
8 Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation. J Invest Dermatol 2006 1.91
9 AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet 2010 1.89
10 Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon. Circ Res 2005 1.86
11 Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol 2009 1.86
12 Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature 2002 1.84
13 Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell 2013 1.68
14 Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. Cardiovasc Res 2005 1.65
15 Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. Metabolism 2012 1.63
16 Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity 2012 1.61
17 Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circ Res 2009 1.58
18 Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood 2011 1.53
19 PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice. Arterioscler Thromb Vasc Biol 2013 1.52
20 Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem 2004 1.49
21 The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev 2004 1.46
22 Role of zeta PKC in B-cell signaling and function. EMBO J 2002 1.45
23 Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell 2013 1.44
24 Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature 2004 1.43
25 NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell 2006 1.41
26 The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity. J Lipid Res 2009 1.40
27 STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol 2011 1.37
28 The T-box transcription factor Tbx15 is required for skeletal development. Mech Dev 2005 1.35
29 Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. Proc Natl Acad Sci U S A 2005 1.34
30 Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. Am J Physiol Heart Circ Physiol 2004 1.34
31 12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol 2007 1.32
32 Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther 2008 1.31
33 Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. Cancer Res 2006 1.27
34 Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO J 2008 1.25
35 Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol Cell Biol 2008 1.23
36 SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity. J Immunol 2002 1.21
37 Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab 2007 1.20
38 Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J 2009 1.19
39 Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A 2002 1.19
40 PKC-theta selectively controls the adhesion-stimulating molecule Rap1. Blood 2008 1.18
41 Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. FASEB J 2003 1.17
42 Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. Cancer Res 2009 1.17
43 PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest 2011 1.15
44 Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice. Diabetes 2004 1.15
45 PKCbeta modulates ischemia-reperfusion injury in the heart. Am J Physiol Heart Circ Physiol 2008 1.12
46 Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis. FASEB J 2008 1.12
47 Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. J Biol Chem 2010 1.12
48 Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model. Diabetes 2007 1.12
49 WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn 2008 1.11
50 Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. J Biol Chem 2006 1.11
51 PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. Int J Cancer 2008 1.11
52 Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem 2003 1.11
53 PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo. Mol Immunol 2009 1.10
54 Loss of PKC-delta alters cardiac metabolism. Am J Physiol Heart Circ Physiol 2004 1.10
55 Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. EMBO J 2004 1.07
56 Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci U S A 2011 1.07
57 Defective IgG2a/2b class switching in PKC alpha-/- mice. J Immunol 2006 1.07
58 Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo. J Am Soc Nephrol 2007 1.07
59 PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes. Mol Immunol 2007 1.07
60 Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J Biol Chem 2009 1.07
61 Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability. J Neurosci 2010 1.06
62 IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood 2005 1.06
63 Differential expression of atypical PKCs in the adult mouse brain. Brain Res Mol Brain Res 2004 1.06
64 Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Mol Endocrinol 2004 1.05
65 PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell Metab 2010 1.04
66 Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport. Mol Endocrinol 2003 1.03
67 Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism. Neuron 2007 1.03
68 Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma. Proc Natl Acad Sci U S A 2009 1.02
69 Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. Cancer Res 2009 1.02
70 Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis. PLoS One 2010 1.01
71 A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A 2003 1.01
72 Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol 2005 0.99
73 Expression of the protein kinase D (PKD) family during mouse embryogenesis. Gene Expr Patterns 2005 0.99
74 Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo. Proc Natl Acad Sci U S A 2009 0.99
75 Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron 2011 0.99
76 PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes. Blood 2006 0.98
77 Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons. EMBO Rep 2003 0.98
78 Isozyme-specific effects of protein kinase C in pain modulation. Anesthesiology 2011 0.98
79 PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells. Eur J Immunol 2010 0.98
80 Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulation. J Immunol 2006 0.97
81 Expression of the atypical protein kinase C (aPKC) isoforms iota/lambda and zeta during mouse embryogenesis. Gene Expr Patterns 2006 0.97
82 Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. FASEB J 2009 0.97
83 Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL. J Immunol 2007 0.97
84 PKC-alpha modulates TGF-beta signaling and impairs podocyte survival. Cell Physiol Biochem 2009 0.96
85 c-Myc phosphorylation by PKCζ represses prostate tumorigenesis. Proc Natl Acad Sci U S A 2013 0.96
86 Protein kinase Cbeta is an effective target for chemoprevention of colon cancer. Cancer Res 2009 0.96
87 Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1. FEBS Lett 2002 0.96
88 Immunolocalization of protein kinase C isoenzymes alpha, beta I, beta II, delta, and epsilon in mouse kidney. Am J Physiol Renal Physiol 2004 0.95
89 Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem 2011 0.95
90 Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondii. J Cell Sci 2006 0.95
91 aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation. J Cell Biol 2013 0.94
92 Wnt6 is expressed in granulomatous lesions of Mycobacterium tuberculosis-infected mice and is involved in macrophage differentiation and proliferation. J Immunol 2013 0.93
93 UV irradiation increases ROS production via PKCdelta signaling in primary murine fibroblasts. J Cell Biochem 2008 0.93
94 Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells. Diabetes 2009 0.92
95 Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation. PLoS One 2009 0.92
96 Evidence for a role of protein kinase C-alpha in urine concentration. Am J Physiol Renal Physiol 2004 0.92
97 Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria. FASEB J 2010 0.91
98 Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter. J Neurochem 2013 0.91
99 Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes. Proc Natl Acad Sci U S A 2007 0.91
100 Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo. J Biol Chem 2004 0.91
101 Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Int J Biochem Cell Biol 2010 0.91
102 Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. J Biol Chem 2012 0.88
103 PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes. PLoS One 2013 0.88
104 Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells. Cell Signal 2008 0.88
105 ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε. Mol Cell Neurosci 2011 0.88
106 Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis. Inflamm Bowel Dis 2010 0.88
107 Protein kinase Cα activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle. Am J Physiol Regul Integr Comp Physiol 2011 0.88
108 PKCdelta is involved in signal attenuation in CD3+ T cells. Immunol Lett 2005 0.88
109 Foxb1-driven Cre expression in somites and the neuroepithelium of diencephalon, brainstem, and spinal cord. Genesis 2007 0.87
110 Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy. FASEB J 2012 0.87
111 Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation. Cell Signal 2006 0.86
112 PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control. PLoS Biol 2013 0.85
113 aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation. J Am Soc Nephrol 2013 0.85
114 Microarray analysis and functional genomics identify novel components of melanopsin signaling. Curr Biol 2007 0.85
115 Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia. PLoS One 2012 0.85
116 Association of protein kinase C-delta with the B cell antigen receptor complex. Cell Signal 2006 0.85
117 Isoform-specific contribution of protein kinase C to prion processing. Mol Cell Neurosci 2008 0.84
118 Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta. J Immunol 2009 0.84
119 Protein kinase Cepsilon is dispensable for TCR/CD3-signaling. Mol Immunol 2005 0.84
120 Wnt6 is essential for stromal cell proliferation during decidualization in mice. Biol Reprod 2013 0.83
121 Surfactant protein A activation of atypical protein kinase C zeta in IkappaB-alpha-dependent anti-inflammatory immune regulation. J Immunol 2007 0.83
122 Central role of PKCbeta in neointimal expansion triggered by acute arterial injury. Circ Res 2005 0.83
123 Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake. Am J Physiol Endocrinol Metab 2009 0.83
124 A redundant role for PKC-epsilon in mast cell signaling and effector function. Int Immunol 2006 0.82
125 Decay-accelerating factor induction by tumour necrosis factor-alpha, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition. Immunology 2003 0.82
126 Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held. J Neurosci 2012 0.82
127 PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Mol Endocrinol 2014 0.82
128 PKCδ regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. Eur J Immunol 2011 0.82
129 PKC{alpha} is essential for the proper activation and termination of rod bipolar cell response. Invest Ophthalmol Vis Sci 2010 0.82
130 The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses. Immunity 2013 0.81
131 Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One 2013 0.81
132 Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKC. J Neurosci 2012 0.81
133 Different regulation of Purkinje cell dendritic development in cerebellar slice cultures by protein kinase Calpha and -beta. J Neurobiol 2003 0.81
134 Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway. Exp Hematol 2006 0.81
135 Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors. Mol Pain 2015 0.81
136 Expression pattern of protein kinase Cδ during mouse embryogenesis. BMC Dev Biol 2013 0.80
137 Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex. FASEB J 2012 0.80
138 Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein kinase C-alpha. Hypertension 2003 0.80
139 Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression. Oncogene 2002 0.80
140 Protein kinase C beta is dispensable for TCR-signaling. Mol Immunol 2004 0.80
141 PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription. Immunol Lett 2013 0.79
142 Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis. Arterioscler Thromb Vasc Biol 2011 0.79
143 C57BL/6 and 129/Sv mice: genetic difference to renal ischemia-reperfusion. J Nephrol 2012 0.79
144 PKCδ impaired vessel formation and angiogenic factor expression in diabetic ischemic limbs. Diabetes 2013 0.78
145 Effect of PKCbeta on retinal oxygenation response in experimental diabetes. Invest Ophthalmol Vis Sci 2004 0.78
146 The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation. Neural Dev 2012 0.78
147 Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι. Am J Pathol 2013 0.78
148 Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol 2014 0.78
149 Mice lacking protein kinase C beta present modest increases in systolic blood pressure and NH4Cl-induced metabolic acidosis. Kidney Blood Press Res 2006 0.78
150 The expression pattern of three mast cell specific proteases during mouse development. Mol Immunol 2006 0.77
151 Expression pattern of protein kinase C ϵ during mouse embryogenesis. BMC Dev Biol 2013 0.77
152 Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling. Biol Open 2012 0.77
153 The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PKCbeta. Microb Pathog 2008 0.77
154 Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance. Adipocyte 2012 0.76
155 Involvement of atypical protein kinase C in the regulation of cardiac glucose and long-chain fatty acid uptake. Front Physiol 2012 0.76
156 Pancreatic oncogenic signaling cascades converge at Protein Kinase D1. Cell Cycle 2015 0.76
157 Stringent time-dependent transregulation of calcium calmodulin kinase II (CaMKII) is implicated in anti-apoptotic control. Biochim Biophys Acta 2007 0.75
158 PKD1 protein is involved in reactive oxygen species-mediated mitochondrial depolarization in cooperation with protein kinase Cδ (PKCδ). J Biol Chem 2016 0.75