Published in J Biol Chem on July 11, 2003
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories. PLoS Biol (2008) 2.58
How does PKMζ maintain long-term memory? Nat Rev Neurosci (2010) 2.47
PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory. Nature (2013) 2.26
PKM zeta maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. J Neurosci (2008) 2.26
Prkcz null mice show normal learning and memory. Nature (2013) 2.06
Neural and cellular mechanisms of fear and extinction memory formation. Neurosci Biobehav Rev (2012) 1.94
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem (2010) 1.75
Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol (2007) 1.36
Dendritic transport and localization of protein kinase Mzeta mRNA: implications for molecular memory consolidation. J Biol Chem (2004) 1.34
Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus. Behav Neurosci (2009) 1.28
Protein kinase C pharmacology: refining the toolbox. Biochem J (2013) 1.27
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation. Proc Natl Acad Sci U S A (2011) 1.25
Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory. J Biol Chem (2012) 1.21
Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons. Neuropharmacology (2012) 1.20
TrkB as a potential synaptic and behavioral tag. J Neurosci (2011) 1.11
PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP. EMBO J (2013) 1.10
The atypical protein kinase C in Aplysia can form a protein kinase M by cleavage. J Neurochem (2009) 1.09
KIBRA: A New Gateway to Learning and Memory? Front Aging Neurosci (2010) 1.09
Role of protein kinase C in the induction and maintenance of serotonin-dependent enhancement of the glutamate response in isolated siphon motor neurons of Aplysia californica. J Neurosci (2009) 1.08
Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase Mzeta (PKMzeta). Proc Natl Acad Sci U S A (2011) 1.08
Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice. Elife (2016) 1.05
New tricks for an old slug: the critical role of postsynaptic mechanisms in learning and memory in Aplysia. Prog Brain Res (2008) 1.03
Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia. Elife (2014) 1.03
Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia. J Neurosci (2011) 1.02
Memory maintenance by PKMζ--an evolutionary perspective. Mol Brain (2012) 1.01
Pin1 and PKMzeta sequentially control dendritic protein synthesis. Sci Signal (2010) 1.00
A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophys J (2006) 1.00
Synaptic distributions of GluA2 and PKMζ in the monkey dentate gyrus and their relationships with aging and memory. J Neurosci (2012) 0.99
Genetic enhancement of visual learning by activation of protein kinase C pathways in small groups of rat cortical neurons. J Neurosci (2005) 0.96
AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62. Hippocampus (2009) 0.95
KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ. J Neurochem (2013) 0.95
Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ. J Neurophysiol (2011) 0.94
PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain. Mol Pain (2011) 0.94
Nonclassical mechanisms of progesterone action in the brain: I. Protein kinase C activation in the hypothalamus of female rats. Endocrinology (2008) 0.93
Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat. Mol Pain (2011) 0.93
ZIPping to pain relief: the role (or not) of PKMζ in chronic pain. Mol Pain (2013) 0.93
Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain. J Mol Med (Berl) (2011) 0.93
Improved spatial learning in aged rats by genetic activation of protein kinase C in small groups of hippocampal neurons. Hippocampus (2009) 0.93
PKMζ is necessary and sufficient for synaptic clustering of PSD-95. Hippocampus (2011) 0.90
Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci (2015) 0.89
PKM and the maintenance of memory. F1000 Biol Rep (2013) 0.89
Does PKM(zeta) maintain memory? Brain Res Bull (2013) 0.89
Competing molecular interactions of aPKC isoforms regulate neuronal polarity. Proc Natl Acad Sci U S A (2013) 0.86
Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Mol Brain (2012) 0.85
Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control. J Cell Biol (2014) 0.85
Molecular determinants of the spacing effect. Neural Plast (2012) 0.85
KIBRA: In the brain and beyond. Cell Signal (2014) 0.85
The KIBRA-aPKC connection: A potential regulator of membrane trafficking and cell polarity. Commun Integr Biol (2012) 0.83
The less things change, the more they are different: contributions of long-term synaptic plasticity and homeostasis to memory. Learn Mem (2014) 0.83
Overexpression of PKMζ alters morphology and function of dendritic spines in cultured cortical neurons. Cereb Cortex (2011) 0.83
Splice variant PRKC-ζ(-PrC) is a novel biomarker of human prostate cancer. Br J Cancer (2012) 0.82
A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity. HFSP J (2007) 0.82
Cellular and subcellular localization of PKMζ. Philos Trans R Soc Lond B Biol Sci (2013) 0.82
Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One (2013) 0.81
Atypical PKCs in memory maintenance: the roles of feedback and redundancy. Learn Mem (2015) 0.80
Computational principles of memory. Nat Neurosci (2016) 0.80
Dendritic protein synthesis in the normal and diseased brain. Neuroscience (2012) 0.79
PKMζ differentially utilized between sexes for remote long-term spatial memory. PLoS One (2013) 0.79
Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats. J Drug Alcohol Res (2013) 0.79
Evolutionary conservation of the signaling proteins upstream of cyclic AMP-dependent kinase and protein kinase C in gastropod mollusks. Brain Behav Evol (2009) 0.79
Mapping molecular memory: navigating the cellular pathways of learning. Cell Mol Neurobiol (2012) 0.79
Deletion of Prkcz increases intermittent ethanol consumption in mice. Alcohol Clin Exp Res (2013) 0.79
Ethanol dose-dependently elicits opposing regulatory effects on hippocampal AMPA receptor GluA2 subunits through a zeta inhibitory peptide-sensitive kinase in adolescent and adult Sprague-Dawley rats. Neuroscience (2014) 0.78
PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse. J Neurosci (2015) 0.78
Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci (2015) 0.78
Metabotropic actions of the volatile anaesthetic sevoflurane increase protein kinase M synthesis and induce immediate preconditioning protection of rat hippocampal slices. J Physiol (2012) 0.78
Overexpression of Protein Kinase Mζ in the Hippocampus Enhances Long-Term Potentiation and Long-Term Contextual But Not Cued Fear Memory in Rats. J Neurosci (2016) 0.78
Zeta Inhibitory Peptide as a Novel Therapy to Control Chronic Visceral Hypersensitivity in a Rat Model. PLoS One (2016) 0.78
PKCλ: a new player in LTP coming to the rescue of PKCζ's faltering role in LTP? EMBO J (2013) 0.77
PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity. Leukemia (2014) 0.77
Both PKMζ and KIBRA are closely related to reference memory but not working memory in a T-maze task in rats. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2013) 0.77
A PKM generated by calpain cleavage of a classical PKC is required for activity-dependent intermediate-term facilitation in the presynaptic sensory neuron of Aplysia. Learn Mem (2016) 0.76
Dopamine agonist signalling in the hypothalamus of female rats is independent of calcium-dependent kinases. J Neuroendocrinol (2009) 0.76
Advances in cortical modulation of pain. J Pain Res (2013) 0.76
Epigenetic modification of PKMζ rescues aging-related cognitive impairment. Sci Rep (2016) 0.75
Intra-hippocampal administration of ZIP alleviates depressive and anxiety-like responses in an animal model of posttraumatic stress disorder. Behav Brain Funct (2014) 0.75
Accurate, fast and cost-effective diagnostic test for monosomy 1p36 using real-time quantitative PCR. Dis Markers (2014) 0.75
Intracerebellar infusion of the protein kinase M zeta (PKMζ) inhibitor zeta-inhibitory peptide (ZIP) disrupts eyeblink classical conditioning. Behav Neurosci (2016) 0.75
Upstream Open Reading Frames Located in the Leader of Protein Kinase Mζ mRNA Regulate Its Translation. Front Mol Neurosci (2016) 0.75
Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiol Stress (2016) 0.75
Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function. Mol Cell Neurosci (2017) 0.75
Storage of spatial information by the maintenance mechanism of LTP. Science (2006) 6.71
Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta. Science (2007) 3.91
Protein kinase Mzeta is necessary and sufficient for LTP maintenance. Nat Neurosci (2002) 3.21
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell (2004) 2.65
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med (2009) 2.31
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med (2003) 2.30
PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat Neurosci (2010) 2.28
PKM zeta maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. J Neurosci (2008) 2.26
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest (2007) 2.17
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol (2002) 2.03
Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster. Nat Neurosci (2002) 2.00
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest (2006) 2.00
Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation. J Invest Dermatol (2006) 1.91
AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet (2010) 1.89
Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation. J Neurosci (2005) 1.86
Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon. Circ Res (2005) 1.86
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol (2009) 1.86
Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature (2002) 1.84
Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex. Science (2011) 1.84
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell (2013) 1.68
Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. Cardiovasc Res (2005) 1.65
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. Metabolism (2012) 1.63
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity (2012) 1.61
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circ Res (2009) 1.58
Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiation. J Neurosci (2007) 1.55
Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depression. J Neurosci (2005) 1.53
Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood (2011) 1.53
PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice. Arterioscler Thromb Vasc Biol (2013) 1.52
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem (2004) 1.49
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev (2004) 1.46
Role of zeta PKC in B-cell signaling and function. EMBO J (2002) 1.45
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell (2013) 1.44
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature (2004) 1.43
NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell (2006) 1.41
Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci (2011) 1.40
The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity. J Lipid Res (2009) 1.40
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol (2011) 1.37
The T-box transcription factor Tbx15 is required for skeletal development. Mech Dev (2005) 1.35
Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. Proc Natl Acad Sci U S A (2005) 1.34
Dendritic transport and localization of protein kinase Mzeta mRNA: implications for molecular memory consolidation. J Biol Chem (2004) 1.34
Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. Am J Physiol Heart Circ Physiol (2004) 1.34
12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol (2007) 1.32
Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther (2008) 1.31
Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. Cancer Res (2006) 1.27
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO J (2008) 1.25
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol Cell Biol (2008) 1.23
SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity. J Immunol (2002) 1.21
Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons. Neuropharmacology (2012) 1.20
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab (2007) 1.20
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J (2009) 1.19
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A (2002) 1.19
PKC-theta selectively controls the adhesion-stimulating molecule Rap1. Blood (2008) 1.18
PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathol (2015) 1.17
Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. FASEB J (2003) 1.17
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. Cancer Res (2009) 1.17
Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice. Diabetes (2004) 1.15
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest (2011) 1.15
Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol (2015) 1.12
Protein synthesis-dependent LTP in isolated dendrites of CA1 pyramidal cells. Hippocampus (2005) 1.12
PKCbeta modulates ischemia-reperfusion injury in the heart. Am J Physiol Heart Circ Physiol (2008) 1.12
Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis. FASEB J (2008) 1.12
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. J Biol Chem (2010) 1.12
Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model. Diabetes (2007) 1.12
WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn (2008) 1.11
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. J Biol Chem (2006) 1.11
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. Int J Cancer (2008) 1.11
Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem (2003) 1.11
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo. Mol Immunol (2009) 1.10
Loss of PKC-delta alters cardiac metabolism. Am J Physiol Heart Circ Physiol (2004) 1.10
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. EMBO J (2004) 1.07
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci U S A (2011) 1.07
Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo. J Am Soc Nephrol (2007) 1.07
Defective IgG2a/2b class switching in PKC alpha-/- mice. J Immunol (2006) 1.07
PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes. Mol Immunol (2007) 1.07
Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J Biol Chem (2009) 1.07
Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability. J Neurosci (2010) 1.06
IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood (2005) 1.06
Differential expression of atypical PKCs in the adult mouse brain. Brain Res Mol Brain Res (2004) 1.06
Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Mol Endocrinol (2004) 1.05
The MAPT H1 haplotype is associated with tangle-predominant dementia. Acta Neuropathol (2012) 1.05
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell Metab (2010) 1.04
Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport. Mol Endocrinol (2003) 1.03
Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism. Neuron (2007) 1.03
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma. Proc Natl Acad Sci U S A (2009) 1.02
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. Cancer Res (2009) 1.02
ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. J Neurosci (2013) 1.02
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A (2003) 1.01
Actin polymerization regulates the synthesis of PKMzeta in LTP. Neuropharmacology (2006) 1.01
Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis. PLoS One (2010) 1.01
Erasing sensorimotor memories via PKMzeta inhibition. PLoS One (2010) 1.00
Expression of the protein kinase D (PKD) family during mouse embryogenesis. Gene Expr Patterns (2005) 0.99
Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol (2005) 0.99
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo. Proc Natl Acad Sci U S A (2009) 0.99
Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau. J Clin Invest (2015) 0.99
Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron (2011) 0.99
Isozyme-specific effects of protein kinase C in pain modulation. Anesthesiology (2011) 0.98
Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons. EMBO Rep (2003) 0.98