Published in Eur J Immunol on February 01, 2011
Regulation of miR-24, miR-30b, and miR-142-3p during macrophage and dendritic cell differentiation potentiates innate immunity. J Leukoc Biol (2015) 0.96
Deception and manipulation: the arms of leishmania, a successful parasite. Front Immunol (2014) 0.93
Characterisation of the ex vivo virulence of Leishmania infantum isolates from Phlebotomus perniciosus from an outbreak of human leishmaniosis in Madrid, Spain. Parasit Vectors (2014) 0.79
The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ. Sci Rep (2016) 0.76
Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice. Sci Rep (2016) 0.75
Endogenous and tumour-derived microRNAs regulate cross-presentation in dendritic cells and consequently cytotoxic T cell function. Cytotechnology (2016) 0.75
Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev (2017) 0.75
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest (2006) 6.61
Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity (2004) 6.46
A promoter-level mammalian expression atlas. Nature (2014) 6.25
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature (2011) 4.71
Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med (2006) 4.38
Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol (2002) 3.89
IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med (2007) 3.69
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J Immunol (2007) 3.25
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell (2004) 2.65
IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J Immunol (2007) 2.48
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med (2009) 2.31
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med (2003) 2.30
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J Leukoc Biol (2004) 2.30
Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory. J Biol Chem (2003) 2.28
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest (2007) 2.17
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol (2002) 2.03
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest (2006) 2.00
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med (2009) 1.97
Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation. J Invest Dermatol (2006) 1.91
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet (2010) 1.89
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science (2011) 1.88
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol (2009) 1.86
Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon. Circ Res (2005) 1.86
Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection. J Immunol (2005) 1.86
Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature (2002) 1.84
Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice. J Immunol (2006) 1.76
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med (2007) 1.75
Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med (2003) 1.75
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. J Exp Med (2013) 1.73
Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis. J Allergy Clin Immunol (2006) 1.70
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell (2013) 1.68
Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. Cardiovasc Res (2005) 1.65
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. Metabolism (2012) 1.63
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity (2012) 1.61
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nat Commun (2013) 1.58
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circ Res (2009) 1.58
Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood (2011) 1.53
PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice. Arterioscler Thromb Vasc Biol (2013) 1.52
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem (2004) 1.49
IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa. J Immunol (2009) 1.48
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev (2004) 1.46
Role of zeta PKC in B-cell signaling and function. EMBO J (2002) 1.45
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell (2013) 1.44
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature (2004) 1.43
Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions. Blood (2006) 1.43
NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell (2006) 1.41
The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity. J Lipid Res (2009) 1.40
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol (2011) 1.37
Host-directed drug targeting of factors hijacked by pathogens. Sci Signal (2008) 1.36
The T-box transcription factor Tbx15 is required for skeletal development. Mech Dev (2005) 1.35
Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. Proc Natl Acad Sci U S A (2005) 1.34
Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. Am J Physiol Heart Circ Physiol (2004) 1.34
12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol (2007) 1.32
Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther (2008) 1.31
Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity. Infect Immun (2003) 1.28
IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol (2005) 1.28
IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii. Eur J Immunol (2010) 1.27
Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. Cancer Res (2006) 1.27
IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis. Am J Pathol (2009) 1.27
Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation. J Infect Dis (2013) 1.26
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO J (2008) 1.25
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol Cell Biol (2008) 1.23
The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol (2005) 1.23
SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity. J Immunol (2002) 1.21
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab (2007) 1.20
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J (2009) 1.19
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A (2002) 1.19
PKC-theta selectively controls the adhesion-stimulating molecule Rap1. Blood (2008) 1.18
Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. FASEB J (2003) 1.17
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. Cancer Res (2009) 1.17
Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice. Diabetes (2004) 1.15
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest (2011) 1.15
A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis. J Immunol (2007) 1.13
Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia. J Cereb Blood Flow Metab (2003) 1.13
Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages. Med Microbiol Immunol (2002) 1.13
Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice. J Exp Med (2011) 1.13
PKCbeta modulates ischemia-reperfusion injury in the heart. Am J Physiol Heart Circ Physiol (2008) 1.12
Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections. J Infect Dis (2006) 1.12
Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis. FASEB J (2008) 1.12
Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice. PLoS Pathog (2007) 1.12
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. J Biol Chem (2010) 1.12
Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model. Diabetes (2007) 1.12
WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn (2008) 1.11
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. Int J Cancer (2008) 1.11
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. J Biol Chem (2006) 1.11
Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem (2003) 1.11
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo. Mol Immunol (2009) 1.10
Loss of PKC-delta alters cardiac metabolism. Am J Physiol Heart Circ Physiol (2004) 1.10
The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog (2008) 1.09