Published in Cell on January 08, 2010
GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes (2015) 2.07
Emerging biomedical applications of synthetic biology. Nat Rev Genet (2011) 2.05
Rewritable digital data storage in live cells via engineered control of recombination directionality. Proc Natl Acad Sci U S A (2012) 2.03
Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev (2011) 1.81
Foundations for the design and implementation of synthetic genetic circuits. Nat Rev Genet (2012) 1.65
Molecular recordings by directed CRISPR spacer acquisition. Science (2016) 1.34
Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene. Mol Syst Biol (2010) 1.13
Synthetic memory circuits for tracking human cell fate. Genes Dev (2012) 1.11
Informing biological design by integration of systems and synthetic biology. Cell (2011) 1.10
Permanent genetic memory with >1-byte capacity. Nat Methods (2014) 1.00
Sequestration-based bistability enables tuning of the switching boundaries and design of a latch. Mol Syst Biol (2012) 0.99
BiP availability distinguishes states of homeostasis and stress in the endoplasmic reticulum of living cells. Mol Biol Cell (2010) 0.95
Building synthetic memory. Curr Biol (2013) 0.92
Mechanisms of regulating cell topology in proliferating epithelia: impact of division plane, mechanical forces, and cell memory. PLoS One (2012) 0.90
Robust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of pins. Mol Cell (2011) 0.89
The sensitivity of memory consolidation and reconsolidation to inhibitors of protein synthesis and kinases: computational analysis. Learn Mem (2010) 0.88
Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits. J Biol Eng (2010) 0.82
Memory of Germinant Stimuli in Bacterial Spores. MBio (2015) 0.79
Counterbalancing Regulation in Response Memory of a Positively Autoregulated Two-Component System. J Bacteriol (2017) 0.78
Building robust functionality in synthetic circuits using engineered feedback regulation. Curr Opin Biotechnol (2013) 0.78
Chemical memory reactions induced bursting dynamics in gene expression. PLoS One (2013) 0.78
Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye. Neural Dev (2015) 0.76
Characterizing the memory of the GAL regulatory network in Saccharomyces cerevisiae. Syst Synth Biol (2011) 0.76
Synthetic associative learning in engineered multicellular consortia. J R Soc Interface (2017) 0.75
Computational implementation of a tunable multicellular memory circuit for engineered eukaryotic consortia. Front Physiol (2015) 0.75
Quantitative modeling and analytic assessment of the transcription dynamics of the XlnR regulon in Aspergillus niger. BMC Syst Biol (2016) 0.75
Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors. Cell Signal (2017) 0.75
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Construction of a genetic toggle switch in Escherichia coli. Nature (2000) 24.02
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol (2002) 9.17
Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J (2001) 7.03
Teleonomic mechanisms in cellular metabolism, growth, and differentiation. Cold Spring Harb Symp Quant Biol (1961) 6.43
A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature (2003) 6.25
Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell (2003) 6.03
Engineering BioBrick vectors from BioBrick parts. J Biol Eng (2008) 5.98
Prediction and measurement of an autoregulatory genetic module. Proc Natl Acad Sci U S A (2003) 5.07
Programmable cells: interfacing natural and engineered gene networks. Proc Natl Acad Sci U S A (2004) 4.72
Synthetic gene networks that count. Science (2009) 4.54
A tunable synthetic mammalian oscillator. Nature (2009) 4.33
Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos. J Cell Sci (1993) 3.53
Theoretical analysis of epigenetic cell memory by nucleosome modification. Cell (2007) 3.17
Regulation of repressor expression in lambda. Proc Natl Acad Sci U S A (1970) 3.12
An engineered epigenetic transgene switch in mammalian cells. Nat Biotechnol (2004) 3.02
Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci U S A (2009) 2.81
Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev (2001) 2.56
Rational design of memory in eukaryotic cells. Genes Dev (2007) 2.52
Generation of neuronal variability and complexity. Nature (2006) 2.39
Positive-feedback loops as a flexible biological module. Curr Biol (2007) 2.35
Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem (2008) 2.15
Transcriptional dynamics of the embryonic stem cell switch. PLoS Comput Biol (2006) 2.06
Maintenance of chromatin states: an open-and-shut case. Curr Opin Cell Biol (2003) 1.72
A model for a bistable biochemical trigger of mitosis. Biophys Chem (1996) 1.40
A positive feedback signal transduction loop determines timing of cerebellar long-term depression. Neuron (2008) 1.34
Hysteresis vs. graded responses: the connections make all the difference. Sci STKE (2004) 1.12
Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnol Bioeng (2003) 1.04
A genetic time-delay circuitry in mammalian cells. Biotechnol Bioeng (2007) 1.00
Positive feedback circuits and memory. C R Acad Sci III (2000) 0.87
Bistable switches for synaptic plasticity. Sci Signal (2009) 0.84
Genome-wide analysis of estrogen receptor binding sites. Nat Genet (2006) 18.63
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell (2005) 14.32
Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell (2004) 4.95
Organization of intracellular reactions with rationally designed RNA assemblies. Science (2011) 3.65
Programmable bacteria detect and record an environmental signal in the mammalian gut. Proc Natl Acad Sci U S A (2014) 3.50
Learning a prior on regulatory potential from eQTL data. PLoS Genet (2009) 3.31
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell (2003) 3.29
Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet (2003) 3.25
Functional specificity among ribosomal proteins regulates gene expression. Cell (2007) 3.22
Protein and RNA export from the nucleus. Dev Cell (2002) 3.14
Nuclear transport and cancer: from mechanism to intervention. Nat Rev Cancer (2004) 2.85
Designing biological systems. Genes Dev (2007) 2.78
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. J Biol Chem (2004) 2.64
Rational design of memory in eukaryotic cells. Genes Dev (2007) 2.52
An alternative splicing network links cell-cycle control to apoptosis. Cell (2010) 2.43
Human cell proteins and human immunodeficiency virus DNA integration. Front Biosci (2004) 2.32
Engineering cyanobacteria to generate high-value products. Trends Biotechnol (2011) 2.31
Developmentally induced changes in transcriptional program alter spatial organization across chromosomes. Genes Dev (2005) 2.27
Engineering synthetic TAL effectors with orthogonal target sites. Nucleic Acids Res (2012) 2.25
Spatially ordered dynamics of the bacterial carbon fixation machinery. Science (2010) 2.22
Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. Genes Dev (2008) 2.17
Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway. PLoS Biol (2012) 2.15
Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells. Genome Biol (2005) 2.11
The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Mol Cell (2002) 2.10
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol (2005) 2.08
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc Natl Acad Sci U S A (2003) 1.98
A systems view of mRNP biology. Genes Dev (2004) 1.98
Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. ACS Chem Biol (2007) 1.94
Retrovirus-delivered siRNA. BMC Biotechnol (2002) 1.92
Coupling and coordination in gene expression processes: a systems biology view. Nat Rev Genet (2008) 1.90
Emergent cooperation in microbial metabolism. Mol Syst Biol (2010) 1.87
Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure (2005) 1.86
Genome-wide mRNA surveillance is coupled to mRNA export. Genes Dev (2004) 1.83
CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Cancer Res (2008) 1.83
Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. J Biol Chem (2003) 1.82
Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev (2011) 1.81
Intron status and 3'-end formation control cotranscriptional export of mRNA. Genes Dev (2002) 1.79
Global analysis of mRNA splicing. RNA (2007) 1.77
Nuclear transport as a target for cell growth. Drug Discov Today (2003) 1.72
Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors. Genes Dev (2004) 1.66
Intron length increases oscillatory periods of gene expression in animal cells. Genes Dev (2008) 1.63
Requirements for the nuclear export of the small ribosomal subunit. J Cell Sci (2002) 1.62
Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates. Mol Cell (2006) 1.51
Engineering cyanobacteria to synthesize and export hydrophilic products. Appl Environ Microbiol (2010) 1.50
Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors. Genome Biol (2006) 1.49
Dynamics in the mixed microbial concourse. Genes Dev (2010) 1.45
Intron delays and transcriptional timing during development. Dev Cell (2008) 1.43
Transcriptional regulation at the nuclear pore complex. Curr Opin Genet Dev (2007) 1.42
Rerouting carbon flux to enhance photosynthetic productivity. Appl Environ Microbiol (2012) 1.40
Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling. Genetics (2002) 1.40
Natural strategies for the spatial optimization of metabolism in synthetic biology. Nat Chem Biol (2012) 1.39
Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev (2007) 1.38
The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae. Genetics (2006) 1.38
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev (2012) 1.38
Cell-to-cell variability of alternative RNA splicing. Mol Syst Biol (2011) 1.38
PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits. EMBO J (2004) 1.37
Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J Biol Chem (2004) 1.36
A tunable zinc finger-based framework for Boolean logic computation in mammalian cells. Nucleic Acids Res (2012) 1.35
Exon expression profiling reveals stimulus-mediated exon use in neural cells. Genome Biol (2007) 1.35
Eukaryotic systems broaden the scope of synthetic biology. J Cell Biol (2009) 1.34
Tailored fatty acid synthesis via dynamic control of fatty acid elongation. Proc Natl Acad Sci U S A (2013) 1.33
Modularity of a carbon-fixing protein organelle. Proc Natl Acad Sci U S A (2011) 1.29
Differential recruitment of the splicing machinery during transcription predicts genome-wide patterns of mRNA splicing. Mol Cell (2006) 1.27
Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell (2003) 1.26
Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. RNA (2009) 1.23
Defossiling fuel: how synthetic biology can transform biofuel production. ACS Chem Biol (2008) 1.19
Systems perspectives on mRNA processing. Cell Res (2007) 1.17
Insulation of a synthetic hydrogen metabolism circuit in bacteria. J Biol Eng (2010) 1.15
The psammaplysenes, specific inhibitors of FOXO1a nuclear export. J Nat Prod (2005) 1.13
Autoregulation of ribosome biosynthesis by a translational response in fission yeast. Mol Cell Biol (2006) 1.12
Synthetic memory circuits for tracking human cell fate. Genes Dev (2012) 1.11
Informing biological design by integration of systems and synthetic biology. Cell (2011) 1.10
Intracellular transport of human immunodeficiency virus type 1 integrase. J Cell Sci (2003) 1.10
Motion as a phenotype: the use of live-cell imaging and machine visual screening to characterize transcription-dependent chromosome dynamics. BMC Cell Biol (2006) 1.09
Designing biological compartmentalization. Trends Cell Biol (2012) 1.09
Transcriptional regulation by the proteasome as a mechanism for cellular protein homeostasis. Cell Cycle (2006) 1.07
Communication between levels of transcriptional control improves robustness and adaptivity. Mol Syst Biol (2006) 1.06
Rewiring hydrogenase-dependent redox circuits in cyanobacteria. Proc Natl Acad Sci U S A (2011) 1.06
Genomic localization of RNA binding proteins reveals links between pre-mRNA processing and transcription. Genome Res (2006) 1.06
Nuclear protein transport. Methods Enzymol (2002) 1.05
A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. J Cell Biol (2009) 1.03
Two- and three-input TALE-based AND logic computation in embryonic stem cells. Nucleic Acids Res (2013) 1.03
Harnessing nature's toolbox: regulatory elements for synthetic biology. J R Soc Interface (2009) 1.00
Therapeutic potential of retroviral RNAi vectors. Expert Opin Biol Ther (2004) 1.00
The role of protein arginine methylation in the formation of silent chromatin. Genes Dev (2006) 0.99
The bacterial carbon-fixing organelle is formed by shell envelopment of preassembled cargo. PLoS One (2013) 0.99
Identifying proteins that affect mRNA localization in living cells. Methods (2002) 0.98
Designing and using RNA scaffolds to assemble proteins in vivo. Nat Protoc (2012) 0.98
Enhancement of cell type specificity by quantitative modulation of a chimeric ligand. J Biol Chem (2008) 0.97
Parts plus pipes: synthetic biology approaches to metabolic engineering. Metab Eng (2011) 0.97
The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins. Mol Biol Cell (2006) 0.97
DNA ends alter the molecular composition and localization of Ku multicomponent complexes. Mol Cell Proteomics (2012) 0.96
HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. Virology (2005) 0.96
Spatial and temporal organization of chromosome duplication and segregation in the cyanobacterium Synechococcus elongatus PCC 7942. PLoS One (2012) 0.93
Systems-level engineering of nonfermentative metabolism in yeast. Genetics (2009) 0.93
Building synthetic memory. Curr Biol (2013) 0.92