Published in Proc Natl Acad Sci U S A on May 26, 2009
HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci (2011) 3.06
Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles. Nat Neurosci (2013) 2.20
Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biol (2010) 2.18
Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference. Biol Psychiatry (2010) 1.98
Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction. Biol Psychiatry (2012) 1.83
HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A (2013) 1.82
Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci (2013) 1.77
Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology (2011) 1.74
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. Nat Neurosci (2014) 1.74
Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification. J Neurosci (2010) 1.65
Post-training reversible inactivation of the hippocampus enhances novel object recognition memory. Learn Mem (2010) 1.65
Epigenetic regulation of memory formation and maintenance. Learn Mem (2013) 1.62
HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. Learn Mem (2011) 1.59
Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdala. PLoS One (2011) 1.58
The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology (2012) 1.53
4- to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning. Hippocampus (2011) 1.47
Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation. Proc Natl Acad Sci U S A (2010) 1.34
p300/CBP histone acetyltransferase activity is required for newly acquired and reactivated fear memories in the lateral amygdala. Learn Mem (2013) 1.31
A naturally-occurring histone acetyltransferase inhibitor derived from Garcinia indica impairs newly acquired and reactivated fear memories. PLoS One (2013) 1.30
Making cellular memories. Cell (2010) 1.30
The epigenetic effects of butyrate: potential therapeutic implications for clinical practice. Clin Epigenetics (2012) 1.26
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol (2015) 1.25
HDAC3 and the molecular brake pad hypothesis. Neurobiol Learn Mem (2011) 1.22
Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus. Neuropsychopharmacology (2010) 1.21
Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory. Learn Mem (2011) 1.19
Loss of histone deacetylase 2 improves working memory and accelerates extinction learning. J Neurosci (2013) 1.18
Histone deacetylase inhibitor, MS-275, exhibits poor brain penetration: PK studies of [C]MS-275 using Positron Emission Tomography. ACS Chem Neurosci (2010) 1.17
HDAC3 is a negative regulator of cocaine-context-associated memory formation. J Neurosci (2013) 1.16
Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learn Mem (2011) 1.16
Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. Learn Mem (2011) 1.14
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. ACS Med Chem Lett (2010) 1.11
Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology (2013) 1.10
Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2. Trends Neurosci (2012) 1.08
Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem (2011) 1.07
Epigenetic treatments for cognitive impairments. Neuropsychopharmacology (2011) 1.05
Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci (2011) 1.04
Epigenetic mechanisms underlying learning and the inheritance of learned behaviors. Trends Neurosci (2014) 1.02
Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain. Behav Pharmacol (2010) 1.00
Epigenetic memory: the Lamarckian brain. EMBO J (2014) 0.99
Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero. Nat Neurosci (2013) 0.99
Hippocampal histone acetylation regulates object recognition and the estradiol-induced enhancement of object recognition. J Neurosci (2012) 0.98
Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation. Nat Commun (2012) 0.98
Current status and future prospects for epigenetic psychopharmacology. Epigenetics (2012) 0.96
Epigenetic mechanisms in memory and synaptic function. Epigenomics (2011) 0.96
Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies. Neurobiol Learn Mem (2013) 0.96
HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand? Biochem Soc Trans (2014) 0.95
Regulation of histone acetylation in the hippocampus of chronically stressed rats: a potential role of sirtuins. Neuroscience (2010) 0.95
p300/CBP-associated factor selectively regulates the extinction of conditioned fear. J Neurosci (2012) 0.94
Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats. Behav Brain Res (2011) 0.93
Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders. Curr Pharm Des (2013) 0.93
Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders. Front Behav Neurosci (2015) 0.93
Building a better hormone therapy? How understanding the rapid effects of sex steroid hormones could lead to new therapeutics for age-related memory decline. Behav Neurosci (2012) 0.92
Examining object location and object recognition memory in mice. Curr Protoc Neurosci (2014) 0.92
Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease. J Exp Med (2015) 0.91
Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-alpha, and ovarian hormones. Endocrinology (2011) 0.90
Gut microbial communities modulating brain development and function. Gut Microbes (2012) 0.90
Unique functional roles for class I and class II histone deacetylases in central nervous system development and function. Int J Dev Neurosci (2013) 0.90
The NR4A orphan nuclear receptors mediate transcription-dependent hippocampal synaptic plasticity. Neurobiol Learn Mem (2013) 0.90
Is an epigenetic switch the key to persistent extinction? Neurobiol Learn Mem (2011) 0.89
Exploring epigenetic regulation of fear memory and biomarkers associated with post-traumatic stress disorder. Front Psychiatry (2013) 0.89
Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila. PLoS One (2011) 0.89
Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior. Mamm Genome (2009) 0.89
Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory. Neurobiol Learn Mem (2011) 0.88
The formation and stability of recognition memory: what happens upon recall? Front Behav Neurosci (2010) 0.88
Pharmacological enhancement of memory or cognition in normal subjects. Front Syst Neurosci (2014) 0.87
Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation. PLoS One (2012) 0.87
Detection of histone acetylation levels in the dorsal hippocampus reveals early tagging on specific residues of H2B and H4 histones in response to learning. PLoS One (2013) 0.87
Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation. J Neurosci (2015) 0.87
Epigenetic mechanisms of Rubinstein-Taybi syndrome. Neuromolecular Med (2014) 0.86
Epigenetic mechanisms of memory formation and reconsolidation. Neurobiol Learn Mem (2014) 0.85
The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference. Pharmacol Biochem Behav (2013) 0.84
The Class I HDAC inhibitor RGFP963 enhances consolidation of cued fear extinction. Learn Mem (2015) 0.84
The path to epigenetic treatment of memory disorders. Neurobiol Learn Mem (2011) 0.83
Mechanisms of epigenetic memory and addiction. EMBO J (2014) 0.83
Epigenetic regulation of estrogen-dependent memory. Front Neuroendocrinol (2014) 0.83
CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging. Neurobiol Aging (2012) 0.83
The epigenetics of estrogen: epigenetic regulation of hormone-induced memory enhancement. Epigenetics (2011) 0.83
Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice. Cell Death Dis (2012) 0.83
Prenatal stress induces spatial memory deficits and epigenetic changes in the hippocampus indicative of heterochromatin formation and reduced gene expression. Behav Brain Res (2014) 0.83
Experience-facilitated improvements in pup retrieval; evidence for an epigenetic effect. Horm Behav (2012) 0.82
Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorder. Trends Neurosci (2014) 0.82
17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice. Learn Mem (2014) 0.82
Molecular brake pad hypothesis: pulling off the brakes for emotional memory. Rev Neurosci (2012) 0.82
Promoter-Specific Effects of DREADD Modulation on Hippocampal Synaptic Plasticity and Memory Formation. J Neurosci (2016) 0.81
GABA-mediated presynaptic inhibition is required for precision of long-term memory. Learn Mem (2014) 0.81
Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learn Mem (2013) 0.81
The histone deacetylase HDAC4 regulates long-term memory in Drosophila. PLoS One (2013) 0.81
Regulation of object recognition and object placement by ovarian sex steroid hormones. Behav Brain Res (2014) 0.81
Histone deacetylase inhibition induces long-lasting changes in maternal behavior and gene expression in female mice. Endocrinology (2014) 0.80
Exposure to histone deacetylase inhibitors during Pavlovian conditioning enhances subsequent cue-induced reinstatement of operant behavior. Behav Pharmacol (2013) 0.80
Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents. Learn Mem (2015) 0.80
Does stress remove the HDAC brakes for the formation and persistence of long-term memory? Neurobiol Learn Mem (2013) 0.80
Epigenetics, oestradiol and hippocampal memory consolidation. J Neuroendocrinol (2013) 0.79
Synaptic therapy in Alzheimer's disease: a CREB-centric approach. Neurotherapeutics (2015) 0.79
A behavioral paradigm to evaluate hippocampal performance in aged rodents for pharmacological and genetic target validation. PLoS One (2013) 0.79
Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration. Curr Neuropharmacol (2016) 0.78
Experience Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging. J Neurosci (2015) 0.78
H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. J Neurosci (2016) 0.78
Early postnatal nicotine exposure causes hippocampus-dependent memory impairments in adolescent mice: Association with altered nicotinic cholinergic modulation of LTP, but not impaired LTP. Neurobiol Learn Mem (2014) 0.78
Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory. Learn Mem (2015) 0.77
Chromatin modifications and their function. Cell (2007) 55.98
Recognition memory: what are the roles of the perirhinal cortex and hippocampus? Nat Rev Neurosci (2001) 7.25
Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem (2004) 5.99
CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron (2004) 5.40
Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron (2004) 5.35
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02
Spatial memory, recognition memory, and the hippocampus. Proc Natl Acad Sci U S A (2004) 3.82
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn Mem (2002) 3.71
Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. Learn Mem (2005) 3.37
Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe. J Neurosci (2004) 2.76
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature (2002) 2.50
A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4. Proc Natl Acad Sci U S A (2003) 2.36
Object recognition and location memory in monkeys with excitotoxic lesions of the amygdala and hippocampus. J Neurosci (1998) 2.34
Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. Behav Neurosci (2007) 2.29
Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem (2008) 2.15
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem (2006) 2.11
The neurobiology of learning and memory: some reminders to remember. Trends Neurosci (2001) 1.91
Drug enhancement of memory consolidation: historical perspective and neurobiological implications. Psychopharmacology (Berl) (2008) 1.66
The consolidation of object and context recognition memory involve different regions of the temporal lobe. Learn Mem (2008) 1.64
The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behav Brain Res (1997) 1.58
Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem (2007) 1.48
Insular cortex is involved in consolidation of object recognition memory. Learn Mem (2005) 1.30
Involvement of the hippocampal CA3-region in acquisition and in memory consolidation of spatial but not in object information in mice. Neurobiol Learn Mem (2003) 1.25
Dissociating learning and performance: drug and hormone enhancement of memory storage. Brain Res Bull (1990) 1.24
Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice. Mol Cell Neurosci (2008) 1.18
A limited role for the hippocampus in the modulation of novel-object preference by contextual cues. Learn Mem (2008) 1.10
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02
HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci (2011) 3.06
Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. Behav Neurosci (2007) 2.29
Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem (2008) 2.15
Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference. Biol Psychiatry (2010) 1.98
HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A (2013) 1.82
Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology (2011) 1.74
BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol (2002) 1.69
Epigenetics in the nervous system. J Neurosci (2008) 1.65
Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification. J Neurosci (2010) 1.65
HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. Learn Mem (2011) 1.59
Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem (2007) 1.48
The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci (2013) 1.36
HDAC3 and the molecular brake pad hypothesis. Neurobiol Learn Mem (2011) 1.22
The role of histone acetylation in cocaine-induced neural plasticity and behavior. Neuropsychopharmacology (2012) 1.19
Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. J Neurosci (2011) 1.17
HDAC3 is a negative regulator of cocaine-context-associated memory formation. J Neurosci (2013) 1.16
Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus. Learn Mem (2006) 1.14
Behavioral epigenetics. Ann N Y Acad Sci (2011) 1.14
Automated scoring of fear-related behavior using EthoVision software. J Neurosci Methods (2008) 1.12
CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors. J Neurosci (2011) 1.12
TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis. Oncogene (2002) 1.11
Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology (2013) 1.10
Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci (2011) 1.04
Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory. Learn Mem (2012) 1.03
Differential role for CBP and p300 CREB-binding domain in motor skill learning. Behav Neurosci (2006) 1.02
Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci (2012) 1.02
Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. Am J Pathol (2005) 1.02
Cancer chemotherapy and cognitive function in rodent models: memory impairment induced by cyclophosphamide in mice. Clin Cancer Res (2006) 1.02
Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero. Nat Neurosci (2013) 0.99
Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory. Neurobiol Learn Mem (2011) 0.99
Epigenetic regulation in substance use disorders. Curr Psychiatry Rep (2010) 0.97
Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats. Behav Brain Res (2011) 0.93
Examining object location and object recognition memory in mice. Curr Protoc Neurosci (2014) 0.92
Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior. Mamm Genome (2009) 0.89
Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation. Behav Brain Res (2011) 0.88
The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference. Pharmacol Biochem Behav (2013) 0.84
Molecular brake pad hypothesis: pulling off the brakes for emotional memory. Rev Neurosci (2012) 0.82
An organic selenium compound attenuates apomorphine-induced stereotypy in mice. Neurosci Lett (2006) 0.82
Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening. J Neural Transm (Vienna) (2013) 0.82
Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence. Learn Mem (2012) 0.81
Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learn Mem (2013) 0.81
NMDA receptors mediate consolidation of contextual memory in the hippocampus after context preexposure. Neurochem Res (2005) 0.76