Published in J Cell Sci on January 19, 2010
Development and validation of a biomarker for diarrhea-predominant irritable bowel syndrome in human subjects. PLoS One (2015) 3.37
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol (2010) 3.25
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling. J Cell Biol (2012) 2.12
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev (2011) 2.06
Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens. Curr Biol (2014) 2.05
Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Proc Natl Acad Sci U S A (2010) 1.68
Vinculin, an adapter protein in control of cell adhesion signalling. Eur J Cell Biol (2010) 1.44
Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res (2014) 1.21
Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol (2014) 1.19
α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction. J Cell Sci (2014) 1.17
α-Catenin uses a novel mechanism to activate vinculin. J Biol Chem (2012) 1.14
Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation. Biol Open (2012) 1.10
Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states. Curr Biol (2014) 1.07
Dimer asymmetry defines α-catenin interactions. Nat Struct Mol Biol (2013) 1.07
Conserved F-actin dynamics and force transmission at cell adhesions. Curr Opin Cell Biol (2010) 1.06
A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell (2016) 0.99
ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions. J Cell Sci (2013) 0.96
The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model. J Biol Chem (2011) 0.95
Neighborly relations: cadherins and mechanotransduction. J Cell Biol (2010) 0.95
Myosin II activity dependent and independent vinculin recruitment to the sites of E-cadherin-mediated cell-cell adhesion. BMC Cell Biol (2011) 0.93
Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells. PLoS One (2012) 0.93
Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions. Protoplasma (2012) 0.88
Crossroads of integrins and cadherins in epithelia and stroma remodeling. Cell Adh Migr (2012) 0.88
Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci (2014) 0.88
beta-Catenin protects the epidermis from mechanical stresses. J Cell Biol (2013) 0.87
The mechanotransduction machinery at work at adherens junctions. Integr Biol (Camb) (2015) 0.86
Functional analysis of a de novo ACTB mutation in a patient with atypical Baraitser-Winter syndrome. Hum Mutat (2013) 0.86
Nongenomic Mechanisms of PTEN Regulation. Int J Cell Biol (2012) 0.86
The evolutionary origin of epithelial cell-cell adhesion mechanisms. Curr Top Membr (2013) 0.84
Cardiomyocyte growth and sarcomerogenesis at the intercalated disc. Cell Mol Life Sci (2013) 0.84
Nanoscale architecture of cadherin-based cell adhesions. Nat Cell Biol (2016) 0.83
Vinculin activators target integrins from within the cell to increase melanoma sensitivity to chemotherapy. Mol Cancer Res (2011) 0.83
Sustained α-catenin Activation at E-cadherin Junctions in the Absence of Mechanical Force. Biophys J (2016) 0.81
Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer. Mol Cancer (2014) 0.81
Synaptopodin couples epithelial contractility to α-actinin-4-dependent junction maturation. J Cell Biol (2015) 0.80
Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet (2014) 0.80
Dual role of vinculin in barrier-disruptive and barrier-enhancing endothelial cell responses. Cell Signal (2016) 0.79
α-Catenin-mediated cadherin clustering couples cadherin and actin dynamics. J Cell Biol (2015) 0.79
Cadherin-11 localizes to focal adhesions and promotes cell-substrate adhesion. Nat Commun (2016) 0.79
Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function. J Biol Chem (2010) 0.78
Cell adhesion in epidermal development and barrier formation. Curr Top Dev Biol (2015) 0.77
β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths. Biophys J (2013) 0.77
Clonorchis sinensis infestation promotes three-dimensional aggregation and invasion of cholangiocarcinoma cells. PLoS One (2014) 0.76
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis. Oncotarget (2016) 0.75
Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk. World J Biol Chem (2016) 0.75
Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc Natl Acad Sci U S A (2016) 0.75
Poly(ADP-ribosylation) is present in murine sciatic nerve fibers and is altered in a Charcot-Marie-Tooth-1E neurodegenerative model. PeerJ (2017) 0.75
Vinculin in cell-cell and cell-matrix adhesions. Cell Mol Life Sci (2017) 0.75
Zygotic vinculin is not essential for embryonic development in zebrafish. PLoS One (2017) 0.75
Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell (1996) 14.75
A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells. Cell (1979) 8.80
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A (1996) 8.53
Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39
Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci (2001) 6.66
Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin. Cell (1980) 4.87
A core function for p120-catenin in cadherin turnover. J Cell Biol (2003) 4.85
Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28
Immunoelectron microscope studies of membrane-microfilament interactions: distributions of alpha-actinin, tropomyosin, and vinculin in intestinal epithelial brush border and chicken gizzard smooth muscle cells. J Cell Biol (1981) 4.15
F-actin binding site masked by the intramolecular association of vinculin head and tail domains. Nature (1995) 4.07
A novel role for p120 catenin in E-cadherin function. J Cell Biol (2002) 4.01
Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol (2003) 3.67
Structural basis for vinculin activation at sites of cell adhesion. Nature (2004) 3.62
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol (1997) 3.52
The structure and regulation of vinculin. Trends Cell Biol (2006) 3.52
Cadherin engagement regulates Rho family GTPases. J Biol Chem (2001) 3.47
Vinculin knockout results in heart and brain defects during embryonic development. Development (1998) 3.44
Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J Cell Biol (2003) 3.39
Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J Cell Biol (2002) 2.99
alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells. J Cell Biol (1998) 2.74
The ins and outs of E-cadherin trafficking. Trends Cell Biol (2004) 2.70
Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. J Cell Biol (1999) 2.62
Structure of the dimerization and beta-catenin-binding region of alpha-catenin. Mol Cell (2000) 2.61
Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion. J Cell Biol (1999) 2.59
Cadherins in embryonic and neural morphogenesis. Nat Rev Mol Cell Biol (2000) 2.41
Vinculin is part of the cadherin-catenin junctional complex: complex formation between alpha-catenin and vinculin. J Cell Biol (1998) 2.33
Retracted Regulation of beta-catenin structure and activity by tyrosine phosphorylation. J Biol Chem (2001) 2.31
Vinculin activation by talin through helical bundle conversion. Nature (2003) 2.26
Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin Cancer Res (2003) 2.18
Structural dynamics of alpha-actinin-vinculin interactions. Mol Cell Biol (2005) 2.12
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem (2005) 2.04
Role of vinculin in regulating focal adhesion turnover. Eur J Cell Biol (2006) 2.03
Myosin VI and vinculin cooperate during the morphogenesis of cadherin cell cell contacts in mammalian epithelial cells. J Cell Biol (2007) 2.02
Making and breaking contacts: the cellular biology of cadherin regulation. Curr Opin Cell Biol (2007) 1.93
A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions. J Biol Chem (2006) 1.90
Phospho-regulation of Beta-catenin adhesion and signaling functions. Physiology (Bethesda) (2007) 1.89
Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion. Proc Natl Acad Sci U S A (1995) 1.82
Coincidence of actin filaments and talin is required to activate vinculin. J Biol Chem (2006) 1.81
Cadherin-mediated cellular signaling. Curr Opin Cell Biol (2003) 1.80
Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin. J Biol Chem (2005) 1.79
Spatial distribution and functional significance of activated vinculin in living cells. J Cell Biol (2005) 1.77
Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene (2008) 1.76
Vinculin is associated with the E-cadherin adhesion complex. J Biol Chem (1997) 1.73
Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculin. J Cell Sci (1998) 1.69
Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol (2007) 1.63
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet (2008) 1.62
A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells. J Biol Chem (2001) 1.59
Shigella applies molecular mimicry to subvert vinculin and invade host cells. J Cell Biol (2006) 1.50
Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol (2004) 1.38
alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation (2006) 1.28
High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast. Proteomics (2003) 1.27
Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. J Biol Chem (2004) 1.20
Endogenous Wnt signaling promotes proliferation and suppresses osteogenic differentiation in human adipose derived stromal cells. Tissue Eng (2006) 1.16
Retracted Beta-catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to beta-catenin. J Biol Chem (2002) 1.16
Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. J Biol Chem (1999) 1.16
The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin. Cell Microbiol (2007) 1.10
Adhesion systems in normal breast and in invasive breast carcinoma. Am J Pathol (1995) 1.06
The intercalated disk protein, mXinalpha, is capable of interacting with beta-catenin and bundling actin filaments [corrected]. J Biol Chem (2007) 1.03
The 4-pregnene and 5alpha-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion. Cancer Res (2000) 1.00
Cell configuration and adhesive properties of metastasizing and non-metastasizing BSp73 rat adenocarcinoma cells. Exp Cell Res (1986) 0.99
Expression of the adherens junction protein vinculin in human basal and squamous cell tumors: relationship to invasiveness and metastatic potential. Hum Pathol (1997) 0.89
The cadherin cell adhesion receptor family: roles in multicellular organization and neurogenesis. Prog Clin Biol Res (1994) 0.87
Vinculin: its possible use as a marker of normal collecting ducts and renal neoplasms with collecting duct system phenotype. Mod Pathol (2000) 0.86
Migratory phenotypes of HSC-3 squamous carcinoma cell line induced by EGF and PMA: relevance to migration of loosening of adhesion and vinculin-associated focal contacts with prominent filopodia. Cell Biol Int (1999) 0.81
Immunohistochemical detection of vinculin in human rhabdomyosarcomas. Gen Diagn Pathol (1997) 0.80
Differential expression of vinculin between weakly and highly metastatic B16-melanoma cell lines. Jpn J Cancer Res (1992) 0.77
Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin. Pathol Int (2001) 0.77
New insights into vinculin function and regulation. Int Rev Cell Mol Biol (2011) 1.47
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Mol Biol Cell (2004) 1.42
Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol (2014) 1.19
Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts. J Cell Sci (2009) 1.17
α-Catenin uses a novel mechanism to activate vinculin. J Biol Chem (2012) 1.14
Vinculin nucleates actin polymerization and modifies actin filament structure. J Biol Chem (2009) 1.04
ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions. J Cell Sci (2013) 0.96
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J Mol Biol (2010) 0.93
Minimally invasive transforaminal lumbar interbody fusion: a perspective on current evidence and clinical knowledge. Minim Invasive Surg (2012) 0.93
Outcome following unilateral versus bilateral instrumentation in patients undergoing minimally invasive transforaminal lumbar interbody fusion: a single-center randomized prospective study. Neurosurg Focus (2013) 0.92
Incidence of lumbar spine pedicle breach after percutaneous screw fixation: a radiographic evaluation of 601 screws in 151 patients. J Spinal Disord Tech (2014) 0.86
Vinculin activators target integrins from within the cell to increase melanoma sensitivity to chemotherapy. Mol Cancer Res (2011) 0.83
Copy number change: evolving views on gene amplification. Future Microbiol (2013) 0.81
Genome-wide selection for increased copy number in Acinetobacter baylyi ADP1: locus and context-dependent variation in gene amplification. Mol Microbiol (2011) 0.79
Intraoperative and perioperative complications in minimally invasive transforaminal lumbar interbody fusion: a review of 513 patients. J Neurosurg Spine (2015) 0.78
Evidence-based management of central cord syndrome. Neurosurg Focus (2013) 0.77
Divergence of Rho residue 43 impacts GEF activity. Small GTPases (2012) 0.76
Signals regulating adhesion dynamics. J Signal Transduct (2012) 0.75