Published in J Biol Chem on December 05, 2004
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71
Tumours and tremors: how PTEN regulation underlies both. Br J Cancer (2006) 1.70
Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol (2007) 1.63
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62
Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci (2010) 1.60
MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell (2005) 1.59
Overexpression of DPAGT1 leads to aberrant N-glycosylation of E-cadherin and cellular discohesion in oral cancer. Cancer Res (2009) 1.13
Phosphoinositides in cell architecture. Cold Spring Harb Perspect Biol (2011) 1.13
Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells. Cancer Res (2009) 1.08
Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function. J Med Genet (2006) 1.03
Fetal genetic risk of isolated cleft lip only versus isolated cleft lip and palate: a subphenotype analysis using two population-based studies of orofacial clefts in Scandinavia. Birth Defects Res A Clin Mol Teratol (2010) 1.01
Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation. J Cell Physiol (2010) 0.94
NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN. J Cell Biochem (2007) 0.93
Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. J Biol Chem (2012) 0.90
Redox modifier genes and pathways in amyotrophic lateral sclerosis. Antioxid Redox Signal (2009) 0.88
PTEN modulators: a patent review. Expert Opin Ther Pat (2013) 0.88
Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci (2014) 0.88
Nongenomic Mechanisms of PTEN Regulation. Int J Cell Biol (2012) 0.86
Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen. FASEB J (2015) 0.84
The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo. J Neurosci (2010) 0.84
Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis. J Biol Chem (2013) 0.81
Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer. Mol Cancer (2014) 0.81
Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis. Mol Ther (2014) 0.80
Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye. Development (2015) 0.78
Novel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas. Cancer Lett (2013) 0.76
Magi Is Associated with the Par Complex and Functions Antagonistically with Bazooka to Regulate the Apical Polarity Complex. PLoS One (2016) 0.75
A genetically encoded photoactivatable Rac controls the motility of living cells. Nature (2009) 7.25
Spatiotemporal dynamics of RhoA activity in migrating cells. Nature (2006) 6.84
Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54
Activation of endogenous Cdc42 visualized in living cells. Science (2004) 3.57
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Nat Cell Biol (2002) 3.50
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell (2010) 3.19
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol (2010) 2.65
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52
Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat Cell Biol (2010) 2.45
Engineered allosteric activation of kinases in living cells. Nat Biotechnol (2010) 2.44
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol (2008) 2.31
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA. Mol Biol Cell (2008) 2.24
Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol (2006) 2.10
Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Curr Biol (2002) 2.01
Designing photoswitchable peptides using the AsLOV2 domain. Chem Biol (2012) 1.99
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol (2013) 1.89
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83
Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis? Trends Cell Biol (2008) 1.80
Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67
High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. PLoS One (2011) 1.63
Vimentin organization modulates the formation of lamellipodia. Mol Biol Cell (2011) 1.60
Imaging and photobleach correction of Mero-CBD, sensor of endogenous Cdc42 activation. Methods Enzymol (2006) 1.60
Designing biosensors for Rho family proteins--deciphering the dynamics of Rho family GTPase activation in living cells. J Cell Sci (2004) 1.58
Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J Cell Biol (2003) 1.52
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci (2012) 1.50
Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res (2005) 1.48
Imaging the coordination of multiple signalling activities in living cells. Nat Rev Mol Cell Biol (2011) 1.47
Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Mol Cell (2004) 1.38
Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol (2004) 1.38
Merocyanine dyes with improved photostability. Org Lett (2007) 1.37
Egr1 promotes growth and survival of prostate cancer cells. Identification of novel Egr1 target genes. J Biol Chem (2003) 1.33
Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. J Cell Biol (2007) 1.25
Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP. J Am Chem Soc (2010) 1.23
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22
Design and optimization of genetically encoded fluorescent biosensors: GTPase biosensors. Methods Cell Biol (2008) 1.20
Spatiotemporal control of small GTPases with light using the LOV domain. Methods Enzymol (2011) 1.18
Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. J Leukoc Biol (2007) 1.17
Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microsc Res Tech (2011) 1.15
A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics. Biochemistry (2007) 1.10
A biosensor generated via high-throughput screening quantifies cell edge Src dynamics. Nat Chem Biol (2011) 1.09
Endogenous RhoG is rapidly activated after epidermal growth factor stimulation through multiple guanine-nucleotide exchange factors. Mol Biol Cell (2010) 1.08
Rational design of a ligand-controlled protein conformational switch. Proc Natl Acad Sci U S A (2013) 1.08
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. J Cell Sci (2007) 1.07
PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol Cell Biol (2006) 1.07
CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries. J Cell Biol (2014) 1.04
Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development. Mol Cell Neurosci (2006) 1.02
From imaging to understanding: Frontiers in Live Cell Imaging, Bethesda, MD, April 19-21, 2006. J Cell Biol (2006) 1.01
External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat Cell Biol (2012) 1.00
Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc Natl Acad Sci U S A (2012) 1.00
Simple one-pot preparation of water-soluble, cysteine-reactive cyanine and merocyanine dyes for biological imaging. Bioconjug Chem (2007) 1.00
Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop. Free Radic Res (2005) 0.98
Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnol (2007) 0.98
Insulin-like growth factor-II regulates PTEN expression in the mammary gland. J Biol Chem (2003) 0.98
Processing of naturally occurring sense/antisense transcripts of the vertebrate Slc34a gene into short RNAs. Physiol Genomics (2008) 0.98
Protective effects of the mTOR inhibitor everolimus on cytoskeletal injury in human podocytes are mediated by RhoA signaling. PLoS One (2013) 0.98
RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. J Immunol (2009) 0.94
Knowledge-based design of a biosensor to quantify localized ERK activation in living cells. Chem Biol (2013) 0.93
Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides. ACS Synth Biol (2014) 0.93
Digital differential interference contrast autofocus for high-resolution oil-immersion microscopy. Cytometry A (2008) 0.93
A theoretical study of the UV/visible absorption and emission solvatochromic properties of solvent-sensitive dyes. Chemphyschem (2003) 0.93
A RhoC biosensor reveals differences in the activation kinetics of RhoA and RhoC in migrating cells. PLoS One (2013) 0.92
Environment-sensing merocyanine dyes for live cell imaging applications. Bioconjug Chem (2013) 0.90
Hold me tightly LOV. Nat Methods (2010) 0.88
In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1. J Biol Chem (2003) 0.86
Redesign of the PAK1 autoinhibitory domain for enhanced stability and affinity in biosensor applications. J Mol Biol (2011) 0.84
Facile synthesis of thiol-reactive Cy3 and Cy5 derivatives with enhanced water solubility. Bioconjug Chem (2002) 0.84
Allosteric activation of kinases: design and application of RapR kinases. Curr Protoc Cell Biol (2011) 0.83
Experimental and DFT studies: novel structural modifications greatly enhance the solvent sensitivity of live cell imaging dyes. J Phys Chem A (2007) 0.83
Combining surface chemistry with a FRET-based biosensor to study the dynamics of RhoA GTPase activation in cells on patterned substrates. J Am Chem Soc (2007) 0.82
FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers. J Cell Sci (2014) 0.81
Regulation of the NPT gene by a naturally occurring antisense transcript. Cell Biochem Biophys (2002) 0.81
Co-factors p300 and CBP catch Egr1 in their network. Prostate (2005) 0.79
A High-Content Assay for Biosensor Validation and for Examining Stimuli that Affect Biosensor Activity. Curr Protoc Cell Biol (2014) 0.75
Optochemical activation of kinase function in live cells. Methods Mol Biol (2014) 0.75
Engineering Pak1 Allosteric Switches. ACS Synth Biol (2017) 0.75