Published in J Biol Chem on January 20, 2010
Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy. Ann Clin Transl Neurol (2015) 0.93
Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. Br J Pharmacol (2012) 0.80
The role of continuous peripheral nerve blocks. Anesthesiol Res Pract (2012) 0.79
Heterologous expression of NaV1.9 chimeras in various cell systems. Pflugers Arch (2015) 0.77
De novo and inherited SCN8A epilepsy mutations detected by gene panel analysis. Epilepsy Res (2016) 0.75
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron (2000) 9.51
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature (1998) 7.26
Molecular mechanism for an inherited cardiac arrhythmia. Nature (1995) 6.09
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science (1992) 4.44
Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science (2002) 4.40
A helix propensity scale based on experimental studies of peptides and proteins. Biophys J (1998) 3.95
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation. Neuron (1999) 3.74
A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Circ Res (2000) 3.68
A rat brain Na+ channel alpha subunit with novel gating properties. Neuron (1988) 3.48
Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell (1995) 2.51
Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation (2002) 2.49
Mutations of sodium channel alpha subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures. Brain (2003) 2.44
Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum Mol Genet (1995) 2.30
Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes. Cardiovasc Res (2000) 2.19
Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel. Circ Res (2000) 2.17
Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system. Brain Res Mol Brain Res (1997) 2.12
Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus. Am J Hum Genet (2001) 2.01
Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. EMBO J (1989) 1.91
beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc Natl Acad Sci U S A (2000) 1.89
Expression of ion channels by injection of mRNA into Xenopus oocytes. Methods Cell Biol (1991) 1.87
Calmodulin mediates Ca2+ sensitivity of sodium channels. J Biol Chem (2004) 1.85
Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes. J Biol Chem (2001) 1.78
Secondary structure of the human cardiac Na+ channel C terminus: evidence for a role of helical structures in modulation of channel inactivation. J Biol Chem (2001) 1.78
The Na+ channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain. J Gen Physiol (2004) 1.77
A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. J Neurosci (2004) 1.77
Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains. J Gen Physiol (1997) 1.72
Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel. Circ Res (2001) 1.72
A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia. Cardiovasc Res (2007) 1.64
Isoform-specific modulation of voltage-gated Na(+) channels by calmodulin. Circ Res (2002) 1.62
An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability. Nat Struct Mol Biol (2004) 1.59
Novel LQT-3 mutation affects Na+ channel activity through interactions between alpha- and beta1-subunits. Circ Res (1998) 1.56
Role of the C-terminal domain in inactivation of brain and cardiac sodium channels. Proc Natl Acad Sci U S A (2001) 1.54
Molecular genetic insights into cardiovascular disease. Science (1996) 1.50
Spectrum of SCN1A mutations in severe myoclonic epilepsy of infancy. Neurology (2003) 1.45
A molecular link between activation and inactivation of sodium channels. J Gen Physiol (1995) 1.42
Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis. Circulation (2000) 1.41
A voltage-dependent gating transition induces use-dependent block by tetrodotoxin of rat IIA sodium channels expressed in Xenopus oocytes. Neuron (1991) 1.41
Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes. Brain Res Mol Brain Res (1990) 1.39
Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilization. J Gen Physiol (1999) 1.37
Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch. Proc Natl Acad Sci U S A (2006) 1.36
Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5. J Biol Chem (2008) 1.32
Novel interaction of the voltage-dependent sodium channel (VDSC) with calmodulin: does VDSC acquire calmodulin-mediated Ca2+-sensitivity? Biochemistry (2000) 1.23
Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin. J Biol Chem (2009) 1.22
Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits. Mol Cell Neurosci (2001) 1.21
Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure. J Biol Chem (2001) 1.19
A carboxyl-terminal hydrophobic interface is critical to sodium channel function. Relevance to inherited disorders. J Biol Chem (2006) 1.13
Human sodium channel gating defects caused by missense mutations in S6 segments associated with myotonia: S804F and V1293I. J Physiol (1998) 1.11
Solution structure of the NaV1.2 C-terminal EF-hand domain. J Biol Chem (2009) 1.08
Implication of the C-terminal region of the alpha-subunit of voltage-gated sodium channels in fast inactivation. J Membr Biol (2001) 1.03
Characterization of a new sodium channel mutation at arginine 1448 associated with moderate Paramyotonia congenita in humans. J Physiol (1999) 1.01
Calmodulin regulation of Nav1.4 current: role of binding to the carboxyl terminus. J Gen Physiol (2008) 1.00
The neuronal voltage-dependent sodium channel type II IQ motif lowers the calcium affinity of the C-domain of calmodulin. Biochemistry (2007) 1.00
A de novo missense mutation of human cardiac Na+ channel exhibiting novel molecular mechanisms of long QT syndrome. FEBS Lett (1998) 0.98
Distribution of I, II and III subtypes of voltage-sensitive Na+ channel mRNA in the rat brain. Brain Res Mol Brain Res (1993) 0.97
Regulatory interaction of sodium channel IQ-motif with calmodulin C-terminal lobe. Biochem Biophys Res Commun (2003) 0.92
Regional and temporal expression of sodium channel messenger RNAs in the rat brain during development. Exp Brain Res (1991) 0.90
Primary motor neurons fail to up-regulate voltage-gated sodium channel Na(v)1.3/brain type III following axotomy resulting from spinal cord injury. J Neurosci Res (2002) 0.82
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev (2005) 5.40
Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. J Neurosci (2002) 1.80
Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem (2010) 1.70
Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia (2010) 1.59
International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels. Pharmacol Rev (2003) 1.40
A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis (2009) 1.32
A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. Neuron (2004) 1.24
An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability. J Neurosci (2006) 1.17
Increased neuronal firing in computer simulations of sodium channel mutations that cause generalized epilepsy with febrile seizures plus. J Neurophysiol (2003) 1.09
Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels. J Biol Chem (2002) 0.98
Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci (2013) 0.89
Role of the amino and carboxy termini in isoform-specific sodium channel variation. J Physiol (2008) 0.88
Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proc Natl Acad Sci U S A (2012) 0.84
Role of the terminal domains in sodium channel localization. Channels (Austin) (2009) 0.83
Semliki Forest virus vectors with mutations in the nonstructural protein 2 gene permit extended superinfection of neuronal and non-neuronal cells. J Neurovirol (2007) 0.80
The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics (2015) 0.79
Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. J Biol Chem (2011) 0.77
Sodium channel blocking and antiarrhythmic actions of the novel arylpiperazine rsd992. Pharmacol Res (2002) 0.77
Complex genetic interactions in a mouse model of absence epilepsy. Epilepsy Curr (2015) 0.75