Published in EMBO J on December 01, 1989
Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev (2008) 2.90
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J Physiol (2006) 2.62
An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A (2002) 2.48
NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proc Natl Acad Sci U S A (1998) 2.44
NaV1.1 channels and epilepsy. J Physiol (2010) 2.21
The roles of sodium channels in nociception: Implications for mechanisms of pain. Pain (2007) 2.06
Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J (1995) 2.06
Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J Neurophysiol (1994) 1.94
Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy. Proc Natl Acad Sci U S A (2009) 1.85
Molecular identity of dendritic voltage-gated sodium channels. Science (2010) 1.79
Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophys J (2000) 1.79
Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia (2010) 1.59
Members of the RCK potassium channel family are differentially expressed in the rat nervous system. EMBO J (1990) 1.55
A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter. Proc Natl Acad Sci U S A (1997) 1.52
Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J (1990) 1.47
An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. Neuroscientist (2008) 1.43
A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis (2009) 1.32
The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression. Proc Natl Acad Sci U S A (1992) 1.19
Functional distribution of three types of Na+ channel on soma and processes of dorsal horn neurones of rat spinal cord. J Physiol (1997) 1.16
Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways. J Cell Biol (1993) 1.16
Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs. Nucleic Acids Res (1991) 1.16
Developmental expression of the novel voltage-gated sodium channel auxiliary subunit beta3, in rat CNS. J Physiol (2001) 1.13
Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury. Exp Brain Res (2006) 1.09
Pacemaker neurons within newborn spinal pain circuits. J Neurosci (2011) 1.01
Comparison of spike parameters from optically identified GABAergic and glutamatergic neurons in sparse cortical cultures. Front Cell Neurosci (2015) 0.99
Down-regulation of voltage-dependent sodium channels initiated by sodium influx in developing neurons. Proc Natl Acad Sci U S A (1990) 0.98
The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells. J Cell Biol (1992) 0.97
Major channels involved in neuropsychiatric disorders and therapeutic perspectives. Front Genet (2013) 0.97
SCN1A mutations in Dravet syndrome: impact of interneuron dysfunction on neural networks and cognitive outcome. Epilepsy Behav (2012) 0.97
Activity-induced internalization and rapid degradation of sodium channels in cultured fetal neurons. J Cell Biol (1996) 0.96
The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions. J Biol Chem (2010) 0.93
Brain and heart sodium channel subtype mRNA expression in rat cerebral cortex. Proc Natl Acad Sci U S A (1991) 0.93
Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice. J Physiol (2012) 0.92
Axonal expression of sodium channels in rat spinal neurones during postnatal development. J Physiol (1999) 0.91
The neuron as a dynamic electrogenic machine: modulation of sodium-channel expression as a basis for functional plasticity in neurons. Philos Trans R Soc Lond B Biol Sci (2000) 0.90
Block of voltage-operated sodium channels by 2,6-dimethylphenol, a structural analogue of lidocaine's aromatic tail. Br J Pharmacol (2002) 0.88
Kinetic characterization of rat brain type IIA sodium channel alpha-subunit stably expressed in a somatic cell line. J Physiol (1995) 0.87
Dual roles of voltage-gated sodium channels in development and cancer. Int J Dev Biol (2015) 0.84
Releasing the peri-neuronal net to patch-clamp neurons in adult CNS. Pflugers Arch (2004) 0.83
Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn. Neuroscience (2012) 0.82
Sodium currents during differentiation in a human neuroblastoma cell line. J Gen Physiol (1991) 0.82
Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome. Channels (Austin) (2013) 0.81
Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons. Mol Pain (2011) 0.80
Excitability of the soma in central nervous system neurons. Biophys J (2000) 0.79
Sodium channel carboxyl-terminal residue regulates fast inactivation. J Biol Chem (2010) 0.78
Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4. Toxins (Basel) (2014) 0.78
Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels. Front Cell Neurosci (2015) 0.78
Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy. Neurosci Bull (2017) 0.76
Localization of receptor site on insect sodium channel for depressant β-toxin BmK IT2. PLoS One (2011) 0.76
SCN3A deficiency associated with increased seizure susceptibility. Neurobiol Dis (2017) 0.75
Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice. PeerJ (2016) 0.75
Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys (2016) 0.75
Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons. Mol Pain (2015) 0.75
Pacemaking Property of RVLM Presympathetic Neurons. Front Physiol (2016) 0.75
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Structural parts involved in activation and inactivation of the sodium channel. Nature (1989) 8.72
The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science (1988) 8.21
Existence of distinct sodium channel messenger RNAs in rat brain. Nature (1986) 7.87
A rat brain Na+ channel alpha subunit with novel gating properties. Neuron (1988) 3.48
Regressive events in neurogenesis. Science (1984) 3.24
Expression of functional sodium channels from cloned cDNA. Nature (1986) 2.95
Primary structure of rat brain sodium channel III deduced from the cDNA sequence. FEBS Lett (1988) 2.39
Patch clamp characterization of sodium channels expressed from rat brain cDNA. Eur Biophys J (1987) 1.95
Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component. J Neurophysiol (1988) 1.76
Tissue-specific expression of the RI and RII sodium channel subtypes. Proc Natl Acad Sci U S A (1987) 1.75
Distribution and lateral mobility of voltage-dependent sodium channels in neurons. J Cell Biol (1988) 1.68
A large intracellular pool of inactive Na channel alpha subunits in developing rat brain. Proc Natl Acad Sci U S A (1985) 1.67
Functional expression of cloned cDNA encoding sodium channel III. FEBS Lett (1988) 1.62
Morphological and physiological differentiation of Purkinje neurons in cultures of rat cerebellum. J Neurosci (1987) 1.61
Glial and neuronal forms of the voltage-dependent sodium channel: characteristics and cell-type distribution. Neuron (1989) 1.54
The development of the rat spinal cord. Adv Anat Embryol Cell Biol (1984) 1.44
Ionic channels in mouse astrocytes in culture. J Neurosci (1987) 1.34
Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone. Proc Natl Acad Sci U S A (1984) 1.14
Developmental expression of glial-specific mRNAs in primary cultures of rat brain visualized by in situ hybridization. J Neurosci Res (1988) 1.10
Ultrastructural visualization of Na+-channel associated [125I]alpha-scorpion toxin binding sites on fetal mouse nerve cells in culture. Brain Res (1985) 1.04
Ontogenic appearance of Na+ channels characterized as high affinity binding sites for tetrodotoxin during development of the rat nervous and skeletal muscle systems. Biochem Biophys Res Commun (1983) 1.03
Sodium and potassium conductances in somatic membranes of rat Purkinje cells from organotypic cerebellar cultures. J Physiol (1989) 1.02
Development of the brain stem in the rat. V. Thymidine-radiographic study of the time of origin of neurons in the midbrain tegmentum. J Comp Neurol (1981) 1.00
Na+-channel-associated scorpion toxin receptor sites as probes for neuronal evolution in vivo and in vitro. Proc Natl Acad Sci U S A (1981) 1.00
Neurotoxin-sensitive sodium channels in neurons developing in vivo and in vitro. J Neurosci (1986) 0.97
Sodium channel expression and assembly during development of retinal ganglion cells. Neuron (1988) 0.91
A correlation between the appearance and the evolution of tetanus toxin binding cells and neurogenesis. Brain Res (1982) 0.83
Early appearance of cells bearing Na+ channels in developing mouse brain. A quantitative analysis using light microscopic autoradiography. Brain Res (1987) 0.81
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
Structural parts involved in activation and inactivation of the sodium channel. Nature (1989) 8.72
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature (1984) 8.02
Existence of distinct sodium channel messenger RNAs in rat brain. Nature (1986) 7.87
Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature (1987) 6.66
Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature (1979) 6.56
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature (1988) 6.35
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflugers Arch (1986) 6.15
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A (1996) 5.93
A ras-related gene with transformation suppressor activity. Cell (1989) 5.81
Restoration of excitation-contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA. Nature (1988) 5.73
Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature (1989) 5.21
Calcium channel characteristics conferred on the sodium channel by single mutations. Nature (1992) 4.90
Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol (2001) 4.82
Structural homology of Torpedo californica acetylcholine receptor subunits. Nature (1983) 4.70
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest (2001) 4.63
Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng (1999) 4.37
Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature (1986) 4.30
Regions of the skeletal muscle dihydropyridine receptor critical for excitation-contraction coupling. Nature (1990) 4.26
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev (1994) 4.19
Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature (1982) 3.69
Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun (1992) 3.66
Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett (1991) 3.29
Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature (1985) 3.28
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature (2001) 3.24
SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J Biol Chem (2000) 3.20
Intramembrane charge movement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor cDNAs. Nature (1990) 3.16
Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun. Mol Cell Biol (1994) 3.15
Nomenclature of voltage-gated sodium channels. Neuron (2000) 3.10
Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor. Nature (1982) 3.09
The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell (2001) 2.97
Expression of functional sodium channels from cloned cDNA. Nature (1986) 2.95
Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature (1985) 2.82
Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin. Nature (1982) 2.79
Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor. Nature (1983) 2.78
A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II. FEBS Lett (1989) 2.73
Long-term (6 and 12 months) follow-up of two prospective, randomized, controlled phase III trials of photodynamic therapy with BF-200 ALA and methyl aminolaevulinate for the treatment of actinic keratosis. Br J Dermatol (2013) 2.70
In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell (1995) 2.68
Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes Dev (1997) 2.60
Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature (1983) 2.55
Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J Bone Miner Res (1998) 2.49
Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci U S A (1998) 2.48
Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes. Proc Natl Acad Sci U S A (1983) 2.44
Expression of functional acetylcholine receptor from cloned cDNAs. Nature (1984) 2.41
Primary structure of rat brain sodium channel III deduced from the cDNA sequence. FEBS Lett (1988) 2.39
Primary structure and functional expression from cDNA of the cardiac ryanodine receptor/calcium release channel. FEBS Lett (1990) 2.24
Osteopontin expression and function: role in bone remodeling. J Cell Biochem Suppl (1998) 2.20
Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci U S A (2000) 2.15
Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A (1991) 2.11
Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol Cell Biol (1995) 2.10
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A (1997) 2.07
Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci U S A (1999) 2.04
Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell (2000) 2.01
Angiographic findings of Takayasu arteritis: new classification. Int J Cardiol (1996) 2.00
Repeat I of the dihydropyridine receptor is critical in determining calcium channel activation kinetics. Nature (1991) 2.00
Cardiac-type excitation-contraction coupling in dysgenic skeletal muscle injected with cardiac dihydropyridine receptor cDNA. Nature (1990) 2.00
Structural analysis of repetitive DNA sequences in the bovine corticotropin-beta-lipotropin precursor gene region. Nucleic Acids Res (1982) 1.99
Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Mol Cell Biol (1995) 1.97
Patch clamp characterization of sodium channels expressed from rat brain cDNA. Eur Biophys J (1987) 1.95
A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction. Proc Natl Acad Sci U S A (2001) 1.88
Clinical manifestations of Takayasu arteritis in India and Japan--new classification of angiographic findings. Angiology (1997) 1.87
Suppression of tropomyosin synthesis, a common biochemical feature of oncogenesis by structurally diverse retroviral oncogenes. Mol Cell Biol (1985) 1.85
Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett (1989) 1.82
Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proc Natl Acad Sci U S A (1986) 1.79
Transcription of overlapping sets of RNAs from the genome of Autographa californica nuclear polyhedrosis virus: a novel method for mapping RNAs. J Virol (1984) 1.78
MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun. Mol Cell Biol (1994) 1.77
Borg proteins control septin organization and are negatively regulated by Cdc42. Nat Cell Biol (2001) 1.76
Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison with a registered methyl-5-aminolaevulinate cream and placebo. Br J Dermatol (2011) 1.75
Isolation and structural organization of the human preproenkephalin gene. Nature (1982) 1.73
Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett (1995) 1.73
Primary structure of the alpha-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence. Nature (1985) 1.71
Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. Proc Natl Acad Sci U S A (1998) 1.70
Mother-infant skin-to-skin contact after delivery results in early recognition of own mother's milk odour. Acta Paediatr (2004) 1.68
Detection of norovirus and sapovirus infection among children with gastroenteritis in Ho Chi Minh City, Vietnam. Arch Virol (2004) 1.67
Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. J Biol Chem (1988) 1.67
Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. J Exp Med (2001) 1.66
Purification of rat liver acetyl coenzyme A carboxylase and immunochemical studies on its synthesis and degradation. Eur J Biochem (1970) 1.65
Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a prospective, randomized, double-blind, placebo-controlled phase III study. Br J Dermatol (2010) 1.65
cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. Genomics (1997) 1.64
Role of acetylcholine receptor subunits in gating of the channel. Nature (1986) 1.63
Functional expression of cloned cDNA encoding sodium channel III. FEBS Lett (1988) 1.62
Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs. FEBS Lett (1987) 1.62
Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. J Exp Med (1997) 1.61
Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel. Proc Biol Sci (1991) 1.59
Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence. FEBS Lett (1986) 1.57
Crystallization and properties of staphylococcal leukocidin. Biochim Biophys Acta (1980) 1.56
Cloning of a cDNA which encodes a novel ubiquitin-like protein. Biochem Biophys Res Commun (1993) 1.56