Published in Am J Physiol Cell Physiol on January 20, 2010
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology (2012) 2.11
The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem (2010) 1.55
Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate. Cancer Res (2012) 1.47
Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control study. PLoS One (2012) 1.43
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res (2013) 1.42
A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Hum Mol Genet (2010) 1.41
Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology (2011) 1.35
Autophagy in nonalcoholic steatohepatitis. Expert Rev Gastroenterol Hepatol (2011) 1.32
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr (2011) 1.31
Autophagy in protists. Autophagy (2011) 1.29
Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J Biol Chem (2010) 1.20
ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy (2011) 1.17
Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress. Mol Pharmacol (2012) 1.08
Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts. Cell Death Dis (2015) 1.07
Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04
The degradation of apolipoprotein B100: multiple opportunities to regulate VLDL triglyceride production by different proteolytic pathways. Biochim Biophys Acta (2012) 1.03
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
Secrets of a successful pathogen: legionella resistance to progression along the autophagic pathway. Front Microbiol (2011) 0.98
Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study. Eur J Appl Physiol (2011) 0.97
Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PLoS One (2012) 0.97
Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies. Acta Neuropathol Commun (2013) 0.94
New insights into the pathology of podocyte loss: mitotic catastrophe. Am J Pathol (2013) 0.94
IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases. PLoS One (2014) 0.93
Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons--dissociation from cholesterol homeostasis. Neuropsychopharmacology (2011) 0.91
Crosstalk between autophagy and inflammasomes. Mol Cells (2013) 0.90
The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice. Neuroscience (2013) 0.89
Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1. Mol Pharmacol (2012) 0.89
Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress. Oncotarget (2014) 0.87
Development of a novel method for quantification of autophagic protein degradation by AHA labeling. Autophagy (2014) 0.86
Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts. Sci Rep (2016) 0.86
Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol (2013) 0.85
ER stress and autophagy dysfunction contribute to fatty liver in diabetic mice. Int J Biol Sci (2015) 0.83
Fatty acid signaling: the new function of intracellular lipases. Int J Mol Sci (2015) 0.83
Cardiovascular autophagy: crossroads of pathology, pharmacology and toxicology. Cardiovasc Toxicol (2013) 0.82
The role of sex differences in autophagy in the heart during coxsackievirus B3-induced myocarditis. J Cardiovasc Transl Res (2013) 0.81
Sphingolipids as cell fate regulators in lung development and disease. Apoptosis (2015) 0.81
Oxidative Stress in Placenta: Health and Diseases. Biomed Res Int (2015) 0.79
Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis. Mol Reprod Dev (2014) 0.79
BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism. Autophagy (2016) 0.78
Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy (2016) 0.78
Atg8 is involved in endosomal and phagosomal acidification in the parasitic protist Entamoeba histolytica. Cell Microbiol (2015) 0.77
Interplay of autophagy and innate immunity in Crohn's disease: a key immunobiologic feature. World J Gastroenterol (2013) 0.77
Survival features of EBV-stabilized cells from centenarians: morpho-functional and transcriptomic analyses. Age (Dordr) (2011) 0.77
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis (2015) 0.77
Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury. World J Gastroenterol (2015) 0.76
Impaired leukocytes autophagy in chronic kidney disease patients. Cardiorenal Med (2013) 0.76
Function of Autophagy in Nonalcoholic Fatty Liver Disease. Dig Dis Sci (2016) 0.76
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies. Acta Neuropathol Commun (2016) 0.75
HO-1 in control of a self-eating kidney. J Am Soc Nephrol (2010) 0.75
NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation. Mol Biol Cell (2016) 0.75
MODULATION OF AUTOPHAGY AND ITS POTENTIAL FOR CANCER THERAPY. Drugs Future (2011) 0.75
Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification. PLoS One (2016) 0.75
Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats. Cell Death Dis (2017) 0.75
Combination of graphene oxide-silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells. Int J Nanomedicine (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol (2004) 3.88
NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. J Biol Chem (2006) 3.67
AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem (2006) 3.53
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest (2006) 3.34
Emerging regulation and functions of autophagy. Nat Cell Biol (2013) 3.24
Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med (2006) 3.12
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem (2006) 2.96
Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie (2007) 2.95
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem (2004) 2.87
Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta (2003) 2.77
Overview of macroautophagy regulation in mammalian cells. Cell Res (2010) 2.68
Autophagy induction by the pathogen receptor CD46. Cell Host Microbe (2009) 2.39
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem (2003) 2.38
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
Functional interaction between autophagy and ciliogenesis. Nature (2013) 2.21
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Autophagic cell death: Loch Ness monster or endangered species? Autophagy (2011) 1.82
Autophagy signaling and the cogwheels of cancer. Autophagy (2006) 1.79
A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome. N Engl J Med (2003) 1.69
AMP-activated protein kinase and autophagy. Autophagy (2007) 1.66
Autophagy and p70S6 kinase. Autophagy (2005) 1.65
Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J Biol Chem (2002) 1.63
Assaying of autophagic protein degradation. Methods Enzymol (2009) 1.59
The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem (2010) 1.55
Autophagy protects renal tubular cells against cyclosporine toxicity. Autophagy (2008) 1.53
The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene. Proc Natl Acad Sci U S A (2002) 1.51
Autophagy: regulation and role in disease. Crit Rev Clin Lab Sci (2009) 1.46
Drug enhanced autophagy to fight mutant protein overload. J Hepatol (2010) 1.43
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res (2013) 1.42
Autophagy regulation and its role in cancer. Semin Cancer Biol (2013) 1.41
Development of autophagy inducers in clinical medicine. J Clin Invest (2015) 1.33
Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism. Autophagy (2007) 1.33
The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1. J Virol (2011) 1.31
Non-canonical autophagy: an exception or an underestimated form of autophagy? Autophagy (2008) 1.28
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? Autophagy (2007) 1.28
Analyses of Galpha-interacting protein and activator of G-protein-signaling-3 functions in macroautophagy. Methods Enzymol (2004) 1.27
Atg5: more than an autophagy factor. Nat Cell Biol (2006) 1.25
The mechanism and physiological function of macroautophagy. J Innate Immun (2013) 1.22
Involvement of autophagy in viral infections: antiviral function and subversion by viruses. J Mol Med (Berl) (2007) 1.21
Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J Biol Chem (2010) 1.20
Autophagy activation by NFkappaB is essential for cell survival after heat shock. Autophagy (2009) 1.20
Autophagy and microtubules - new story, old players. J Cell Sci (2013) 1.19
The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells. J Biol Chem (2003) 1.18
Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation. Autophagy (2011) 1.17
Macroautophagy signaling and regulation. Curr Top Microbiol Immunol (2009) 1.17
Autophagy is a protective mechanism for human melanoma cells under acidic stress. J Biol Chem (2012) 1.17
Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. Autophagy (2010) 1.16
Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance. Autophagy (2013) 1.15
Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. Mol Biol Evol (2002) 1.14
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR. J Virol (2012) 1.12
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res (2009) 1.11
Diversity of signaling controls of macroautophagy in mammalian cells. Cell Struct Funct (2002) 1.10
Ceramide-induced autophagy: to junk or to protect cells? Autophagy (2009) 1.09
PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor. Oncogene (2005) 1.07
Autophagy is a survival force via suppression of necrotic cell death. Exp Cell Res (2012) 1.07
Prion protein: From physiology to cancer biology. Cancer Lett (2009) 1.07
Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy. Mol Pharmacol (2011) 1.05
Lost to translation: when autophagy targets mature ribosomes. Trends Cell Biol (2008) 1.05
Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). Biochim Biophys Acta (2005) 1.04
Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04
Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology (2012) 1.01
Autophagy: regulation by energy sensing. Curr Biol (2011) 1.00
Autophagy: a sweet process in diabetes. Cell Metab (2008) 0.99
Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species. Autophagy (2007) 0.99
Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase. J Biol Chem (2002) 0.98
New targets for acetylation in autophagy. Sci Signal (2012) 0.94
Herpesviruses and autophagy: catch me if you can! Viruses (2010) 0.94
Autophagosomes and human diseases. Int J Biochem Cell Biol (2011) 0.94
c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. Cancer Res (2009) 0.93
Functional characterization of the human FSH receptor with an inactivating Ala189Val mutation. Mol Hum Reprod (2002) 0.92
The nucleotide-sugar transporter family: a phylogenetic approach. Biochimie (2003) 0.92
Regulation of autophagy by sphingolipids. Anticancer Agents Med Chem (2011) 0.91
Autophagy, signaling and obesity. Pharmacol Res (2012) 0.90
Sphingolipids in macroautophagy. Methods Mol Biol (2008) 0.90
Autophagy and CD4+ T lymphocyte destruction by HIV-1. Autophagy (2007) 0.90
Biological function of mutant forms of JAGGED1 proteins in Alagille syndrome: inhibitory effect on Notch signaling. Hum Mol Genet (2007) 0.90
Reactive oxygen species, AMP-activated protein kinase, and the transcription cofactor p300 regulate α-tubulin acetyltransferase-1 (αTAT-1/MEC-17)-dependent microtubule hyperacetylation during cell stress. J Biol Chem (2014) 0.89
Nutrient sensing: TOR's Ragtime. Nat Cell Biol (2008) 0.89
Macroautophagy: protector in the diabetes drama? Autophagy (2007) 0.89