Regulation and role of autophagy in mammalian cells.

Autophagy in health and disease: a double-edged sword. Science (2004) 13.69

Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70

Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83

The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A (2005) 7.38

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16

Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol (2005) 5.84

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91

Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci (2009) 2.82

Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy (2010) 2.62

Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis (2008) 2.56

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum (2010) 2.43

Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy (2006) 2.37

Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J (2009) 2.31

Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum Mol Genet (2010) 2.22

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009) 2.20

A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1. J Biol Chem (2009) 2.19

Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology (2012) 2.11

Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy (2009) 2.09

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms. Cell Death Dis (2011) 1.76

Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol (2009) 1.74

Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp Gerontol (2009) 1.74

AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells. J Cell Mol Med (2009) 1.67

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging (Albany NY) (2009) 1.62

Integration of clearance mechanisms: the proteasome and autophagy. Cold Spring Harb Perspect Biol (2010) 1.52

Induction of macroautophagy by exogenously introduced calcium. Autophagy (2008) 1.48

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proc Natl Acad Sci U S A (2008) 1.45

Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment. J Biol Chem (2009) 1.41

Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection. Arthritis Rheum (2011) 1.38

A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell (2011) 1.32

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J Biol Chem (2010) 1.30

Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J Neurosci (2011) 1.28

Autophagy and ethanol-induced liver injury. World J Gastroenterol (2009) 1.26

Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components. J Biol Chem (2008) 1.25

TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. Cell Death Differ (2012) 1.20

Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. Am J Physiol Regul Integr Comp Physiol (2010) 1.20

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation. Autophagy (2011) 1.17

The alpha-kinase family: an exceptional branch on the protein kinase tree. Cell Mol Life Sci (2009) 1.16

Protein kinase C inhibits autophagy and phosphorylates LC3. Biochem Biophys Res Commun (2010) 1.16

Inhibition of autophagosome formation by the benzoporphyrin derivative verteporfin. J Biol Chem (2010) 1.15

The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer (2009) 1.11

ANG II promotes autophagy in podocytes. Am J Physiol Cell Physiol (2010) 1.11

Huntington's Disease. Cold Spring Harb Perspect Biol (2011) 1.11

MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5. Autophagy (2013) 1.10

High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A (2011) 1.07

A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling. Cell Death Dis (2011) 1.07

Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass. J Cachexia Sarcopenia Muscle (2012) 1.06

To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Autophagy (2007) 1.05

Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PLoS One (2011) 1.05

Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. EMBO Mol Med (2012) 1.03

The role of p53 in cell metabolism. Acta Pharmacol Sin (2010) 1.03

Autophagy in human embryonic stem cells. PLoS One (2011) 1.01

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinsons Dis (2011) 0.99

TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1. Sci Rep (2013) 0.98

In yeast, loss of Hog1 leads to osmosensitivity of autophagy. Biochem J (2006) 0.97

Live-cell imaging of autophagy induction and autophagosome-lysosome fusion in primary cultured neurons. Methods Enzymol (2009) 0.97

Insulin-like growth factor-I prevents the accumulation of autophagic vesicles and cell death in Purkinje neurons by increasing the rate of autophagosome-to-lysosome fusion and degradation. J Biol Chem (2009) 0.96

Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations. Br J Pharmacol (2014) 0.96

High glucose induces autophagy in podocytes. Exp Cell Res (2013) 0.95

Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor. Cell Death Dis (2014) 0.95

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors. Autophagy (2014) 0.94

Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle. J Biol Chem (2013) 0.94

Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy. Int J Mol Sci (2013) 0.93

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. J Physiol (2012) 0.91

Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells. Int J Oncol (2014) 0.89

Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact. Biochemistry (2012) 0.89

Fasting induces a biphasic adaptive metabolic response in murine small intestine. BMC Genomics (2007) 0.88

Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy. Cell Death Dis (2014) 0.88

Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice. J Nutr Biochem (2012) 0.88

Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis. J Toxicol (2009) 0.88

Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. PLoS One (2013) 0.88

Autophagy: A protective mechanism in response to stress and inflammation. Curr Opin Investig Drugs (2006) 0.88

Autophagy modulation as a potential therapeutic target for liver diseases. J Clin Exp Hepatol (2014) 0.87

Mechanisms of autophagy and apoptosis: Recent developments in breast cancer cells. World J Biol Chem (2011) 0.87

The C/EBPbeta isoform, liver-inhibitory protein (LIP), induces autophagy in breast cancer cell lines. Exp Cell Res (2010) 0.87

The role of autophagy in Drosophila metamorphosis. Curr Top Dev Biol (2013) 0.87

Wip1 phosphatase: between p53 and MAPK kinases pathways. Oncotarget (2016) 0.86

ATG7 contributes to plant basal immunity towards fungal infection. Plant Signal Behav (2011) 0.86

Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro. Cancer Biol Ther (2014) 0.85

A role of autophagy in PTP4A3-driven cancer progression. Autophagy (2014) 0.85

Mitochondrial Ca2+ homeostasis in lysosomal storage diseases. Cell Calcium (2008) 0.84

Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function. Cell Death Dis (2015) 0.83

Nutritional status and cardiac autophagy. Diabetes Metab J (2013) 0.82

The synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrence. PLoS One (2013) 0.82

Is PML a Tumor Suppressor? Front Oncol (2013) 0.82

Interplay between autophagy and programmed cell death in mammalian neural stem cells. BMB Rep (2013) 0.82

The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses. Nutrients (2013) 0.82

Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells. Histochem Cell Biol (2017) 0.81

Decreased autophagy in rat heart induced by anti-β1-adrenergic receptor autoantibodies contributes to the decline in mitochondrial membrane potential. PLoS One (2013) 0.81

Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One (2015) 0.81

Neuroprotective effect of TAT-14-3-3ε fusion protein against cerebral ischemia/reperfusion injury in rats. PLoS One (2014) 0.81

Moderate Hypothermia Significantly Decreases Hippocampal Cell Death Involving Autophagy Pathway after Moderate Traumatic Brain Injury. J Neurotrauma (2015) 0.81

Resveratrol-induced autophagy in human U373 glioma cells. Oncol Lett (2010) 0.81

Using enhanced-mitophagy to measure autophagic flux. Methods (2014) 0.81

An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication. J Cell Biol (2016) 0.81

Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes. J Cell Mol Med (2013) 0.80

Effect of tankyrase 1 on autophagy in the corpus cavernosum smooth muscle cells from ageing rats with erectile dysfunction and its potential mechanism. Asian J Androl (2010) 0.80

Apoptosis and antitumor effects induced by the combination of an mTOR inhibitor and an autophagy inhibitor in human osteosarcoma MG63 cells. Int J Oncol (2015) 0.80

Ethanol and vitamin D receptor in T cell apoptosis. J Neuroimmune Pharmacol (2012) 0.80

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26

NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. J Biol Chem (2006) 3.67

AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem (2006) 3.53

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45

Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest (2006) 3.34

Emerging regulation and functions of autophagy. Nat Cell Biol (2013) 3.24

Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med (2006) 3.12

Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem (2006) 2.96

Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie (2007) 2.95

Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem (2004) 2.87

Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta (2003) 2.77

Overview of macroautophagy regulation in mammalian cells. Cell Res (2010) 2.68

Autophagy induction by the pathogen receptor CD46. Cell Host Microbe (2009) 2.39

Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem (2003) 2.38

Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31

Functional interaction between autophagy and ciliogenesis. Nature (2013) 2.21

A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02

A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00

Autophagic cell death: Loch Ness monster or endangered species? Autophagy (2011) 1.82

Autophagy signaling and the cogwheels of cancer. Autophagy (2006) 1.79

AMP-activated protein kinase and autophagy. Autophagy (2007) 1.66

Autophagy and p70S6 kinase. Autophagy (2005) 1.65

Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J Biol Chem (2002) 1.63

Assaying of autophagic protein degradation. Methods Enzymol (2009) 1.59

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview. Am J Physiol Cell Physiol (2010) 1.57

The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem (2010) 1.55

Autophagy protects renal tubular cells against cyclosporine toxicity. Autophagy (2008) 1.53

Autophagy: regulation and role in disease. Crit Rev Clin Lab Sci (2009) 1.46

Drug enhanced autophagy to fight mutant protein overload. J Hepatol (2010) 1.43

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res (2013) 1.42

Autophagy regulation and its role in cancer. Semin Cancer Biol (2013) 1.41

Development of autophagy inducers in clinical medicine. J Clin Invest (2015) 1.33

Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism. Autophagy (2007) 1.33

The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1. J Virol (2011) 1.31

Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? Autophagy (2007) 1.28

Non-canonical autophagy: an exception or an underestimated form of autophagy? Autophagy (2008) 1.28

Analyses of Galpha-interacting protein and activator of G-protein-signaling-3 functions in macroautophagy. Methods Enzymol (2004) 1.27

Atg5: more than an autophagy factor. Nat Cell Biol (2006) 1.25

The mechanism and physiological function of macroautophagy. J Innate Immun (2013) 1.22

Involvement of autophagy in viral infections: antiviral function and subversion by viruses. J Mol Med (Berl) (2007) 1.21

Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J Biol Chem (2010) 1.20

Autophagy activation by NFkappaB is essential for cell survival after heat shock. Autophagy (2009) 1.20

Autophagy and microtubules - new story, old players. J Cell Sci (2013) 1.19

The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells. J Biol Chem (2003) 1.18

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation. Autophagy (2011) 1.17

Macroautophagy signaling and regulation. Curr Top Microbiol Immunol (2009) 1.17

Autophagy is a protective mechanism for human melanoma cells under acidic stress. J Biol Chem (2012) 1.17

Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. Autophagy (2010) 1.16

Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance. Autophagy (2013) 1.15

Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. Mol Biol Evol (2002) 1.14

The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR. J Virol (2012) 1.12

Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res (2009) 1.11

Diversity of signaling controls of macroautophagy in mammalian cells. Cell Struct Funct (2002) 1.10

Ceramide-induced autophagy: to junk or to protect cells? Autophagy (2009) 1.09

PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor. Oncogene (2005) 1.07

Autophagy is a survival force via suppression of necrotic cell death. Exp Cell Res (2012) 1.07

Prion protein: From physiology to cancer biology. Cancer Lett (2009) 1.07

Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy. Mol Pharmacol (2011) 1.05

Lost to translation: when autophagy targets mature ribosomes. Trends Cell Biol (2008) 1.05

Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). Biochim Biophys Acta (2005) 1.04

Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04

Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology (2012) 1.01

Autophagy: regulation by energy sensing. Curr Biol (2011) 1.00

Autophagy: a sweet process in diabetes. Cell Metab (2008) 0.99

Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species. Autophagy (2007) 0.99

Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase. J Biol Chem (2002) 0.98

New targets for acetylation in autophagy. Sci Signal (2012) 0.94

Autophagosomes and human diseases. Int J Biochem Cell Biol (2011) 0.94

c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. Cancer Res (2009) 0.93

The nucleotide-sugar transporter family: a phylogenetic approach. Biochimie (2003) 0.92

Regulation of autophagy by sphingolipids. Anticancer Agents Med Chem (2011) 0.91

Autophagy and CD4+ T lymphocyte destruction by HIV-1. Autophagy (2007) 0.90

Sphingolipids in macroautophagy. Methods Mol Biol (2008) 0.90

Autophagy, signaling and obesity. Pharmacol Res (2012) 0.90

Nutrient sensing: TOR's Ragtime. Nat Cell Biol (2008) 0.89

Reactive oxygen species, AMP-activated protein kinase, and the transcription cofactor p300 regulate α-tubulin acetyltransferase-1 (αTAT-1/MEC-17)-dependent microtubule hyperacetylation during cell stress. J Biol Chem (2014) 0.89

Macroautophagy: protector in the diabetes drama? Autophagy (2007) 0.89

Lysosome positioning coordinates mTORC1 activity and autophagy. Nat Cell Biol (2011) 0.87

The roles of BECN1 and autophagy in cancer are context dependent. Autophagy (2012) 0.87

In vivo effect of an antilipolytic drug (3,5'-dimethylpyrazole) on autophagic proteolysis and autophagy-related gene expression in rat liver. Biochem Biophys Res Commun (2007) 0.87

SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors. Cell Cycle (2015) 0.87

A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation. J Biol Chem (2002) 0.86

Pathogen recognition by the cell surface receptor CD46 induces autophagy. Autophagy (2010) 0.86

Beclin 1 or not Beclin 1... Autophagy (2011) 0.86

Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy. Autophagy (2013) 0.85

PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins. Neurobiol Aging (2012) 0.85

Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. Biol Chem (2002) 0.84

Regulation of cell death by sphingosine 1-phosphate lyase. Autophagy (2010) 0.82

What is the role of autophagy in HIV-1 infection? Autophagy (2007) 0.82

Novel inducers of BECN1-independent autophagy: cis-unsaturated fatty acids. Autophagy (2015) 0.82

Autophagy joins the game to regulate NF-kappaB signaling pathways. Cell Res (2007) 0.81

Regulation of autophagy by extracellular matrix glycoproteins in HeLa cells. Autophagy (2011) 0.81

Dual suppressive effect of MTORC1 on autophagy: tame the dragon by shackling both the head and the tail. Autophagy (2013) 0.79

Autophagy and ubiquitination in cardiovascular diseases. DNA Cell Biol (2015) 0.78

[Autophagy and CD4 T lymphocyte destruction by HIV-1]. Med Sci (Paris) (2006) 0.78

Micronucleophagy: a new mechanism to protect against chromosomal instability? Cell Cycle (2012) 0.78