Published in Mol Aspects Med on September 14, 2006
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.45
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum Mol Genet (2010) 2.22
An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver. Proc Natl Acad Sci U S A (2007) 2.10
Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev (2011) 2.09
A review of the mammalian unfolded protein response. Biotechnol Bioeng (2011) 1.83
Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One (2010) 1.62
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. J Biol Chem (2009) 1.52
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy (2008) 1.46
Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol (2010) 1.45
Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles. Autophagy (2011) 1.44
Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res (2009) 1.39
A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J Pharmacol Exp Ther (2010) 1.37
Why sick cells produce tumors: the protective role of autophagy. Autophagy (2007) 1.34
Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy. Exp Gerontol (2011) 1.31
Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal (2009) 1.28
Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease. Cell Rep (2013) 1.28
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. J Virol (2011) 1.27
Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev (2013) 1.25
A yeast MAPK cascade regulates pexophagy but not other autophagy pathways. J Cell Biol (2010) 1.24
Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials? Toxicol Sci (2008) 1.23
Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation. Autophagy (2011) 1.17
Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes. J Biol Chem (2013) 1.15
HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3. PLoS One (2010) 1.14
Autophagy and misfolded proteins in neurodegeneration. Exp Neurol (2010) 1.10
RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats. Acta Pharmacol Sin (2009) 1.07
Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury. Autophagy (2012) 1.05
Permanent embryo arrest: molecular and cellular concepts. Mol Hum Reprod (2008) 1.03
IP(3) Receptors, Mitochondria, and Ca Signaling: Implications for Aging. J Aging Res (2011) 1.02
Mass spectrometry analysis of proteome-wide proteolytic post-translational degradation of proteins. Anal Chem (2008) 1.02
Physical exercise improves functional recovery through mitigation of autophagy, attenuation of apoptosis and enhancement of neurogenesis after MCAO in rats. BMC Neurosci (2013) 0.95
Herpesviruses and autophagy: catch me if you can! Viruses (2010) 0.94
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors. Autophagy (2014) 0.94
Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque. PLoS One (2014) 0.90
Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging (2014) 0.85
Autophagy: mechanism and physiological relevance 'brewed' from yeast studies. Front Biosci (Schol Ed) (2012) 0.85
Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis. FEBS J (2009) 0.85
The Role of Gammaherpesviruses in Cancer Pathogenesis. Pathogens (2016) 0.83
Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury. J Cell Mol Med (2015) 0.83
A new autophagy-related checkpoint in the degradation of an ERAD-M target. J Biol Chem (2011) 0.82
Oyaksungisan, a Traditional Herbal Formula, Inhibits Cell Proliferation by Induction of Autophagy via JNK Activation in Human Colon Cancer Cells. Evid Based Complement Alternat Med (2013) 0.81
Lipopolysaccharides may aggravate apoptosis through accumulation of autophagosomes in alveolar macrophages of human silicosis. Autophagy (2015) 0.81
Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro. Autophagy (2012) 0.80
Autophagy and mesenchymal cell fibrogenesis. Biochim Biophys Acta (2012) 0.78
Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats. Age (Dordr) (2016) 0.77
Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK. Sci Rep (2016) 0.77
Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo. PeerJ (2016) 0.77
Bif-1 is overexpressed in hepatocellular carcinoma and correlates with shortened patient survival. Oncol Lett (2012) 0.77
Autophagy as an antimicrobial strategy. Expert Rev Anti Infect Ther (2009) 0.76
SnapShot: Macroautophagy. Cell (2008) 0.76
Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila. Dev Biol (2016) 0.76
Circulating MicroRNA Profiles Differ between Qi-Stagnation and Qi-Deficiency in Coronary Heart Disease Patients with Blood Stasis Syndrome. Evid Based Complement Alternat Med (2014) 0.76
Daily supplementation with GrandFusion(®) improves memory and learning in aged rats. Aging (Albany NY) (2017) 0.75
Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy. Autophagy (2016) 0.75
Metabolomic Analysis of Mouse Embryonic Fibroblast Cells in Response to Autophagy Induced by Acute Starvation. Sci Rep (2016) 0.75
miR-140-5p attenuates chemotherapeutic drug-induced cell death by regulating autophagy through inositol 1,4,5-trisphosphate kinase 2 (IP3k2) in human osteosarcoma cells. Biosci Rep (2016) 0.75
Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Autophagy (2017) 0.75
Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Front Mol Neurosci (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol (2004) 3.88
NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. J Biol Chem (2006) 3.67
AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem (2006) 3.53
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest (2006) 3.34
Emerging regulation and functions of autophagy. Nat Cell Biol (2013) 3.24
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem (2006) 2.96
Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie (2007) 2.95
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem (2004) 2.87
Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta (2003) 2.77
Overview of macroautophagy regulation in mammalian cells. Cell Res (2010) 2.68
Autophagy induction by the pathogen receptor CD46. Cell Host Microbe (2009) 2.39
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem (2003) 2.38
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
Functional interaction between autophagy and ciliogenesis. Nature (2013) 2.21
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Autophagic cell death: Loch Ness monster or endangered species? Autophagy (2011) 1.82
Autophagy signaling and the cogwheels of cancer. Autophagy (2006) 1.79
AMP-activated protein kinase and autophagy. Autophagy (2007) 1.66
Autophagy and p70S6 kinase. Autophagy (2005) 1.65
Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J Biol Chem (2002) 1.63
Assaying of autophagic protein degradation. Methods Enzymol (2009) 1.59
Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview. Am J Physiol Cell Physiol (2010) 1.57
The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem (2010) 1.55
Autophagy protects renal tubular cells against cyclosporine toxicity. Autophagy (2008) 1.53
Autophagy: regulation and role in disease. Crit Rev Clin Lab Sci (2009) 1.46
Drug enhanced autophagy to fight mutant protein overload. J Hepatol (2010) 1.43
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res (2013) 1.42
Autophagy regulation and its role in cancer. Semin Cancer Biol (2013) 1.41
Development of autophagy inducers in clinical medicine. J Clin Invest (2015) 1.33
Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism. Autophagy (2007) 1.33
The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1. J Virol (2011) 1.31
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? Autophagy (2007) 1.28
Non-canonical autophagy: an exception or an underestimated form of autophagy? Autophagy (2008) 1.28
Analyses of Galpha-interacting protein and activator of G-protein-signaling-3 functions in macroautophagy. Methods Enzymol (2004) 1.27
Atg5: more than an autophagy factor. Nat Cell Biol (2006) 1.25
The mechanism and physiological function of macroautophagy. J Innate Immun (2013) 1.22
Involvement of autophagy in viral infections: antiviral function and subversion by viruses. J Mol Med (Berl) (2007) 1.21
Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J Biol Chem (2010) 1.20
Autophagy activation by NFkappaB is essential for cell survival after heat shock. Autophagy (2009) 1.20
Autophagy and microtubules - new story, old players. J Cell Sci (2013) 1.19
The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells. J Biol Chem (2003) 1.18
Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation. Autophagy (2011) 1.17
Macroautophagy signaling and regulation. Curr Top Microbiol Immunol (2009) 1.17
Autophagy is a protective mechanism for human melanoma cells under acidic stress. J Biol Chem (2012) 1.17
Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. Autophagy (2010) 1.16
Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance. Autophagy (2013) 1.15
Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. Mol Biol Evol (2002) 1.14
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR. J Virol (2012) 1.12
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res (2009) 1.11
Diversity of signaling controls of macroautophagy in mammalian cells. Cell Struct Funct (2002) 1.10
Ceramide-induced autophagy: to junk or to protect cells? Autophagy (2009) 1.09
PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor. Oncogene (2005) 1.07
Autophagy is a survival force via suppression of necrotic cell death. Exp Cell Res (2012) 1.07
Prion protein: From physiology to cancer biology. Cancer Lett (2009) 1.07
Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy. Mol Pharmacol (2011) 1.05
Lost to translation: when autophagy targets mature ribosomes. Trends Cell Biol (2008) 1.05
Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). Biochim Biophys Acta (2005) 1.04
Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04
Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology (2012) 1.01
Autophagy: regulation by energy sensing. Curr Biol (2011) 1.00
Autophagy: a sweet process in diabetes. Cell Metab (2008) 0.99
Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species. Autophagy (2007) 0.99
Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase. J Biol Chem (2002) 0.98
New targets for acetylation in autophagy. Sci Signal (2012) 0.94
Autophagosomes and human diseases. Int J Biochem Cell Biol (2011) 0.94
c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. Cancer Res (2009) 0.93
The nucleotide-sugar transporter family: a phylogenetic approach. Biochimie (2003) 0.92
Regulation of autophagy by sphingolipids. Anticancer Agents Med Chem (2011) 0.91
Autophagy, signaling and obesity. Pharmacol Res (2012) 0.90
Autophagy and CD4+ T lymphocyte destruction by HIV-1. Autophagy (2007) 0.90
Sphingolipids in macroautophagy. Methods Mol Biol (2008) 0.90
Nutrient sensing: TOR's Ragtime. Nat Cell Biol (2008) 0.89
Reactive oxygen species, AMP-activated protein kinase, and the transcription cofactor p300 regulate α-tubulin acetyltransferase-1 (αTAT-1/MEC-17)-dependent microtubule hyperacetylation during cell stress. J Biol Chem (2014) 0.89
Macroautophagy: protector in the diabetes drama? Autophagy (2007) 0.89
The roles of BECN1 and autophagy in cancer are context dependent. Autophagy (2012) 0.87
In vivo effect of an antilipolytic drug (3,5'-dimethylpyrazole) on autophagic proteolysis and autophagy-related gene expression in rat liver. Biochem Biophys Res Commun (2007) 0.87
Lysosome positioning coordinates mTORC1 activity and autophagy. Nat Cell Biol (2011) 0.87
SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors. Cell Cycle (2015) 0.87
Pathogen recognition by the cell surface receptor CD46 induces autophagy. Autophagy (2010) 0.86
A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation. J Biol Chem (2002) 0.86
Beclin 1 or not Beclin 1... Autophagy (2011) 0.86
Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy. Autophagy (2013) 0.85
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins. Neurobiol Aging (2012) 0.85
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. Biol Chem (2002) 0.84
What is the role of autophagy in HIV-1 infection? Autophagy (2007) 0.82
Regulation of cell death by sphingosine 1-phosphate lyase. Autophagy (2010) 0.82
Novel inducers of BECN1-independent autophagy: cis-unsaturated fatty acids. Autophagy (2015) 0.82
Autophagy joins the game to regulate NF-kappaB signaling pathways. Cell Res (2007) 0.81
Regulation of autophagy by extracellular matrix glycoproteins in HeLa cells. Autophagy (2011) 0.81
Dual suppressive effect of MTORC1 on autophagy: tame the dragon by shackling both the head and the tail. Autophagy (2013) 0.79
[Autophagy and CD4 T lymphocyte destruction by HIV-1]. Med Sci (Paris) (2006) 0.78
Autophagy and ubiquitination in cardiovascular diseases. DNA Cell Biol (2015) 0.78
Micronucleophagy: a new mechanism to protect against chromosomal instability? Cell Cycle (2012) 0.78