Published in J Biol Chem on May 29, 2003
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat Cell Biol (2011) 2.03
The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin. Proc Natl Acad Sci U S A (2005) 1.78
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol (2009) 1.51
Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. Proc Natl Acad Sci U S A (2006) 1.50
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. EMBO J (2008) 1.48
Breaking up is hard to do - membrane traffic in cytokinesis. J Cell Sci (2008) 1.43
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol (2006) 1.38
The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery. Genes Cancer (2011) 1.32
Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med (2008) 1.23
A requirement for epsin in mitotic membrane and spindle organization. J Cell Biol (2009) 1.18
RLIP76 in defense of radiation poisoning. Int J Radiat Oncol Biol Phys (2008) 1.10
RLIP76 and Cancer. Clin Cancer Res (2008) 1.07
Mitotic moonlighting functions for membrane trafficking proteins. Traffic (2011) 1.06
The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis. Mol Biol Cell (2008) 1.06
RLIP76: A novel glutathione-conjugate and multi-drug transporter. Biochem Pharmacol (2008) 0.99
RLIP76: a versatile transporter and an emerging target for cancer therapy. Biochem Pharmacol (2010) 0.97
Regression of prostate cancer xenografts by RLIP76 depletion. Biochem Pharmacol (2008) 0.96
The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector. Mol Cell Biol (2012) 0.95
RLIP76, a non-ABC transporter, and drug resistance in epilepsy. BMC Neurosci (2005) 0.94
Identification of genes that interact with Drosophila liquid facets. Genetics (2006) 0.94
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. Elife (2014) 0.94
Role of RLIP76 in doxorubicin resistance in lung cancer. Int J Oncol (2009) 0.94
The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion. J Biol Chem (2010) 0.93
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis. Mol Cancer Ther (2011) 0.93
Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. Mol Cancer Res (2010) 0.92
Ral GTPases in tumorigenesis: emerging from the shadows. Exp Cell Res (2013) 0.91
Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb. Mol Cell Proteomics (2012) 0.91
Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochim Biophys Acta (2014) 0.90
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization. Cancer Res (2012) 0.90
Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis. J Biol Chem (2010) 0.89
Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates. Int J Oncol (2009) 0.88
Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis. Cancer Lett (2009) 0.85
Endocytic adaptor protein epsin is elevated in prostate cancer and required for cancer progression. ISRN Oncol (2013) 0.84
Targeting p53-null neuroblastomas through RLIP76. Cancer Prev Res (Phila) (2011) 0.84
A central role of RLIP76 in regulation of glycemic control. Diabetes (2009) 0.83
Overexpression of RalBP1 in colorectal cancer is an independent predictor of poor survival and early tumor relapse. Cancer Biol Ther (2012) 0.83
RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome. PLoS One (2011) 0.83
Epsin Family of Endocytic Adaptor Proteins as Oncogenic Regulators of Cancer Progression. J Can Res Updates (2013) 0.82
Protein adaptation: mitotic functions for membrane trafficking proteins. Nat Rev Mol Cell Biol (2013) 0.81
Predicting physical interactions between protein complexes. Mol Cell Proteomics (2013) 0.80
The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration. Biochem Biophys Res Commun (2014) 0.79
Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter. Lung Cancer (Auckl) (2013) 0.77
Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells. Cell Death Discov (2016) 0.77
RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma. Pharm Res (2017) 0.76
The structure of the RLIP76 RhoGAP-Ral binding domain dyad: fixed position of the domains leads to dual engagement of small G proteins at the membrane. Structure (2013) 0.76
Breaking up is hard to do: RalA, mitochondrial fission and cancer. Small GTPases (2011) 0.76
Ral inhibits ligand-independent Notch signaling in Drosophila. Small GTPases (2012) 0.76
Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C. Oncotarget (2016) 0.75
Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence. PLoS One (2015) 0.75
Vestiges of Ent3p/Ent5p function in the giardial epsin homolog. Biochim Biophys Acta (2016) 0.75
RLIP76 Targeted Therapy for Kidney Cancer. Pharm Res (2015) 0.75
Identification and characterization of the RLIP/RALBP1 interacting protein Xreps1 in Xenopus laevis early development. PLoS One (2012) 0.75
Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. Biochim Biophys Acta (2017) 0.75
Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features. Proc Natl Acad Sci U S A (2006) 4.52
Protein interaction mapping: a Drosophila case study. Genome Res (2005) 4.15
Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Dev Cell (2005) 2.75
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem (2003) 2.23
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J Cell Biol (2003) 2.02
[A plea for clear language on vaccine safety]. CMAJ (2009) 2.01
RalB mobilizes the exocyst to drive cell migration. Mol Cell Biol (2006) 1.91
A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A (2003) 1.86
Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene (2002) 1.82
Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol (2005) 1.79
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther (2009) 1.66
The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity (2002) 1.66
p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. FEBS Lett (2002) 1.66
The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy. EMBO J (2008) 1.59
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. EMBO J (2008) 1.48
The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J (2004) 1.41
Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci (2003) 1.16
Automated velocity mapping of migrating cell populations (AVeMap). Nat Methods (2012) 1.13
"Media, politics and science policy: MS and evidence from the CCSVI Trenches". BMC Med Ethics (2013) 1.12
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. Biochemistry (2009) 1.12
A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol Cell Biol (2003) 1.09
Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl- channels. J Biol Chem (2006) 1.08
CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation. Curr Biol (2004) 1.08
Caspase-8 sumoylation is associated with nuclear localization. Oncogene (2005) 1.06
The Small GTPase RalA controls exocytosis of large dense core secretory granules by interacting with ARF6-dependent phospholipase D1. J Biol Chem (2005) 1.04
High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway. Mol Cancer Ther (2012) 1.03
IKs response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules. Cardiovasc Res (2008) 1.03
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol Cell Biol (2006) 1.01
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers. Autophagy (2014) 0.99
Novel CLCN5 mutations in patients with Dent's disease result in altered ion currents or impaired exchanger processing. Kidney Int (2009) 0.94
Trio controls the mature organization of neuronal clusters in the hindbrain. J Neurosci (2007) 0.94
Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet (2010) 0.92
Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J Neurosci (2012) 0.92
AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism. J Biol Chem (2005) 0.91
The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction. Structure (2010) 0.90
Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins. J Biol Chem (2002) 0.90
Heterogeneity in the processing of CLCN5 mutants related to Dent disease. Hum Mutat (2011) 0.89
A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation. Carcinogenesis (2013) 0.89
Dissecting activation of the PAK1 kinase at protrusions in living cells. J Biol Chem (2009) 0.89
Interaction of pyrin with 14.3.3 in an isoform-specific and phosphorylation-dependent manner regulates its translocation to the nucleus. Arthritis Rheum (2005) 0.88
Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac. Oncogene (2005) 0.88
Compartmentalization of the functions and regulation of the mitotic cyclin Clb2 in S. cerevisiae. J Cell Sci (2007) 0.86
On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates. Cell Rep (2012) 0.86
Characterization of single chain antibody targets through yeast two hybrid. BMC Biotechnol (2010) 0.85
MAP kinases regulate unfertilized egg apoptosis and fertilization suppresses death via Ca2+ signaling. Mol Reprod Dev (2004) 0.84
Molecular cloning, gene localization, and structure of human cyclin B3. Biochem Biophys Res Commun (2002) 0.83
Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst. EMBO J (2013) 0.83
Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. Cell Signal (2008) 0.83
RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane. J Biol Chem (2012) 0.83
DLG1/SAP97 modulates transforming growth factor alpha bioavailability. Biochim Biophys Acta (2008) 0.80
A MAPK pathway is involved in the control of mitosis after fertilization of the sea urchin egg. Dev Biol (2005) 0.80
CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development (2013) 0.79
Nuclear envelope breakdown may deliver an inhibitor of protein phosphatase 1 which triggers cyclin B translation in starfish oocytes. Dev Biol (2005) 0.79
CLCNKB mutations causing mild Bartter syndrome profoundly alter the pH and Ca2+ dependence of ClC-Kb channels. Pflugers Arch (2013) 0.78
Mutations in SLC2A2 gene reveal hGLUT2 function in pancreatic β cell development. J Biol Chem (2013) 0.77
[Evolution and cancer: expansion of dangerous gene repertoire by whole genome duplications]. Med Sci (Paris) (2013) 0.75
Cell motility: The necessity of Rac1 GDP/GTP flux. Commun Integr Biol (2011) 0.75
To promote vaccination, physicians need to provide booster shots of information. Paediatr Child Health (2015) 0.75
Cybip, a starfish cyclin B-binding protein, is involved in meiotic M-phase exit. Biochem Biophys Res Commun (2003) 0.75
[A contribution of the C. elegans model to the role of glial cells to the neuronal response]. Med Sci (Paris) (2009) 0.75
Towards a shared understanding: Perspectives from Toronto's first media forum for suicide prevention. Can J Public Health (2016) 0.75